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Q5QGZ2

- NSP4_ROTGA

UniProt

Q5QGZ2 - NSP4_ROTGA

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Protein

Non-structural glycoprotein 4

Gene
N/A
Organism
Rotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in virus morphogenesis. Functions as a receptor for the immature double-layered inner capsid particle (ICP) which transiently buds into the lumen of the rough endoplasmic reticulum during viral maturation By similarity.
Enterotoxin that causes a phospholipase C-dependent elevation of the intracellular calcium concentration in host intestinal mucosa cells. Increased concentration of intracellular calcium disrupts the cytoskeleton and the tight junctions, raising the paracellular permeability. Potentiates chloride ion secretion through a calcium ion-dependent signaling pathway, inducing age-dependent diarrhea. To perform this enterotoxigenic role in vivo, NSP4 is probably released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with the plasma membrane receptors on neighboring epithelial cells By similarity.

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Enterotoxin, Toxin

Keywords - Biological processi

Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural glycoprotein 4
Short name:
NSP4
OrganismiRotavirus B (isolate Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
Taxonomic identifieri10942 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Chain Non-structural glycoprotein 4 : Host rough endoplasmic reticulum membrane; Single-pass type III membrane protein By similarity. Host membranehost caveola; Single-pass type III membrane protein. Secreted By similarity
Note: Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles. NSP4 also localizes in vesicular structures, which contain an autophagosomal marker and associate with viroplasms in virus-infected cells By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242Lumenal By similarityAdd
BLAST
Transmembranei43 – 6018Helical; Reviewed predictionAdd
BLAST
Topological domaini61 – 219159Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. host caveola Source: UniProtKB-SubCell
  2. host cell rough endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Non-structural glycoprotein 4PRO_0000369864Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi36 – 394Poly-Ser

Domaini

The coiled coil region mediates oligomerization By similarity.

Sequence similaritiesi

Belongs to the rotavirus NSP4 family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Sequencei

Sequence statusi: Complete.

Q5QGZ2-1 [UniParc]FASTAAdd to Basket

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MAESSDMQEL FVQATYEEIL KLASSVNHEQ IRETISSSSP QKILTGTMLT    50
LGALLTTLIV KKKGTKFLTT KVQSNVAYLA EMVVWKANQT VKTICDEVLH 100
QRKVIEKLQC LDKMCSEIEK LRYDMEHFQG MDVTKELIQM CEQKMIDIDS 150
KVKEVERSCD RRIRDYDWKI ATLTAHPTQQ LPAHIDIINQ HIEDDAETQI 200
IQQHMNKQAR VKLNSRNRL 219
Length:219
Mass (Da):25,347
Last modified:January 4, 2005 - v1
Checksum:i9569C7E9763005BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY548957 Genomic RNA. Translation: AAT36306.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY548957 Genomic RNA. Translation: AAT36306.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of the rotavirus NSP4 enterotoxin homologue from group B rotavirus."
    Guzman E., McCrae M.A.
    Virus Res. 110:151-160(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiNSP4_ROTGA
AccessioniPrimary (citable) accession number: Q5QGZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 4, 2005
Last modified: February 19, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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