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Protein

Trace amine-associated receptor 2

Gene

Taar2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 2
Short name:
TaR-2
Short name:
Trace amine receptor 2
Alternative name(s):
G-protein coupled receptor 58
Gene namesi
Name:Taar2
Synonyms:Gpr58
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1311240. Taar2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636ExtracellularSequence analysisAdd
BLAST
Transmembranei37 – 5721Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini58 – 6710CytoplasmicSequence analysis
Transmembranei68 – 8821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini89 – 10618ExtracellularSequence analysisAdd
BLAST
Transmembranei107 – 12721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini128 – 15023CytoplasmicSequence analysisAdd
BLAST
Transmembranei151 – 17121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini172 – 19524ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini217 – 25135CytoplasmicSequence analysisAdd
BLAST
Transmembranei252 – 27221Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini273 – 28715ExtracellularSequence analysisAdd
BLAST
Transmembranei288 – 31023Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini311 – 33929CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Trace amine-associated receptor 2PRO_0000070148Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence analysis
Disulfide bondi104 ↔ 189PROSITE-ProRule annotation
Glycosylationi277 – 2771N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5QD25.

PTM databases

PhosphoSiteiQ5QD25.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030671.

Structurei

3D structure databases

ProteinModelPortaliQ5QD25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ5QD25.
KOiK05051.
OMAiVRVAMYS.
OrthoDBiEOG7HXCR8.
PhylomeDBiQ5QD25.
TreeFamiTF343107.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5QD25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSFEAQQET FDCSEYGNGS CPENERSLGV RAAMYSLMAG AIFITIFGNL
60 70 80 90 100
VMIISISYFK QLHTPTNLLI LSMAVTDFLL GFTIMPYSMV RSVENCWYFG
110 120 130 140 150
LTFCKIHYSF DLMLSITSIF HLCSVAIDRF YAICHPLHYC TKMTIPVVKR
160 170 180 190 200
LLLVCWSVPG AFAFGVVFSE AYADGIEGYD ILVACSSSCP VMFNKLWGTT
210 220 230 240 250
LFVAGFFTPS SMMVGIYGKI FAVSKKHARV IDNLPENQNN QMRKDKKAAK
260 270 280 290 300
TLGIVMGVFL LCWFPCFFTI LLDPFLNFST PAILFDALTW FGYFNSTCNP
310 320 330
LIYGFFYPWF RRALRYILLG KIFSSHFHNT NLFTQKETE
Length:339
Mass (Da):38,557
Last modified:January 4, 2005 - v1
Checksum:i9F70097B9B8CA9C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702316 mRNA. Translation: AAV70128.1.
RefSeqiNP_001008512.1. NM_001008512.1.
UniGeneiRn.162403.

Genome annotation databases

EnsembliENSRNOT00000035424; ENSRNOP00000030671; ENSRNOG00000025951.
GeneIDi294121.
KEGGirno:294121.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702316 mRNA. Translation: AAV70128.1.
RefSeqiNP_001008512.1. NM_001008512.1.
UniGeneiRn.162403.

3D structure databases

ProteinModelPortaliQ5QD25.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030671.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ5QD25.

Proteomic databases

PaxDbiQ5QD25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000035424; ENSRNOP00000030671; ENSRNOG00000025951.
GeneIDi294121.
KEGGirno:294121.

Organism-specific databases

CTDi9287.
RGDi1311240. Taar2.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ5QD25.
KOiK05051.
OMAiVRVAMYS.
OrthoDBiEOG7HXCR8.
PhylomeDBiQ5QD25.
TreeFamiTF343107.

Miscellaneous databases

NextBioi637605.
PROiQ5QD25.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors."
    Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K., Hoener M.C.
    Genomics 85:372-385(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: WIST/Crl.

Entry informationi

Entry nameiTAAR2_RAT
AccessioniPrimary (citable) accession number: Q5QD25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 4, 2005
Last modified: May 11, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.