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Protein

Trace amine-associated receptor 2

Gene

Taar2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 2
Short name:
TaR-2
Short name:
Trace amine receptor 2
Alternative name(s):
G-protein coupled receptor 58
Gene namesi
Name:Taar2
Synonyms:Gpr58
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1311240. Taar2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36ExtracellularSequence analysisAdd BLAST36
Transmembranei37 – 57Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini58 – 67CytoplasmicSequence analysis10
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini89 – 106ExtracellularSequence analysisAdd BLAST18
Transmembranei107 – 127Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini128 – 150CytoplasmicSequence analysisAdd BLAST23
Transmembranei151 – 171Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini172 – 195ExtracellularSequence analysisAdd BLAST24
Transmembranei196 – 216Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini217 – 251CytoplasmicSequence analysisAdd BLAST35
Transmembranei252 – 272Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini273 – 287ExtracellularSequence analysisAdd BLAST15
Transmembranei288 – 310Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini311 – 339CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701481 – 339Trace amine-associated receptor 2Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi18N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi104 ↔ 189PROSITE-ProRule annotation
Glycosylationi277N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5QD25.

PTM databases

PhosphoSitePlusiQ5QD25.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030671.

Structurei

3D structure databases

ProteinModelPortaliQ5QD25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ5QD25.
KOiK05051.
OMAiVRVAMYS.
OrthoDBiEOG091G06VI.
PhylomeDBiQ5QD25.
TreeFamiTF343107.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5QD25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSFEAQQET FDCSEYGNGS CPENERSLGV RAAMYSLMAG AIFITIFGNL
60 70 80 90 100
VMIISISYFK QLHTPTNLLI LSMAVTDFLL GFTIMPYSMV RSVENCWYFG
110 120 130 140 150
LTFCKIHYSF DLMLSITSIF HLCSVAIDRF YAICHPLHYC TKMTIPVVKR
160 170 180 190 200
LLLVCWSVPG AFAFGVVFSE AYADGIEGYD ILVACSSSCP VMFNKLWGTT
210 220 230 240 250
LFVAGFFTPS SMMVGIYGKI FAVSKKHARV IDNLPENQNN QMRKDKKAAK
260 270 280 290 300
TLGIVMGVFL LCWFPCFFTI LLDPFLNFST PAILFDALTW FGYFNSTCNP
310 320 330
LIYGFFYPWF RRALRYILLG KIFSSHFHNT NLFTQKETE
Length:339
Mass (Da):38,557
Last modified:January 4, 2005 - v1
Checksum:i9F70097B9B8CA9C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702316 mRNA. Translation: AAV70128.1.
RefSeqiNP_001008512.1. NM_001008512.1.
UniGeneiRn.162403.

Genome annotation databases

EnsembliENSRNOT00000035424; ENSRNOP00000030671; ENSRNOG00000025951.
GeneIDi294121.
KEGGirno:294121.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702316 mRNA. Translation: AAV70128.1.
RefSeqiNP_001008512.1. NM_001008512.1.
UniGeneiRn.162403.

3D structure databases

ProteinModelPortaliQ5QD25.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030671.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ5QD25.

Proteomic databases

PaxDbiQ5QD25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000035424; ENSRNOP00000030671; ENSRNOG00000025951.
GeneIDi294121.
KEGGirno:294121.

Organism-specific databases

CTDi9287.
RGDi1311240. Taar2.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ5QD25.
KOiK05051.
OMAiVRVAMYS.
OrthoDBiEOG091G06VI.
PhylomeDBiQ5QD25.
TreeFamiTF343107.

Miscellaneous databases

PROiQ5QD25.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAAR2_RAT
AccessioniPrimary (citable) accession number: Q5QD25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 4, 2005
Last modified: November 2, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.