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Protein

Trace amine-associated receptor 3

Gene

Taar3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Olfactory receptor activated by several primary trace amines, including isoamylamine. Activated by isoamylamine and cyclohexylamine, but not to the corresponding alcohols, isoamylalcohol and cyclohexanol. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 3
Short name:
TaR-3
Short name:
Trace amine receptor 3
Gene namesi
Name:Taar3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1359566. Taar3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
Transmembranei36 – 56Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini57 – 68CytoplasmicSequence analysisAdd BLAST12
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini90 – 150ExtracellularSequence analysisAdd BLAST61
Transmembranei151 – 168Helical; Name=3Sequence analysisAdd BLAST18
Topological domaini169 – 172CytoplasmicSequence analysis4
Transmembranei173 – 193Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini194 – 198ExtracellularSequence analysis5
Transmembranei199 – 223Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini224 – 256CytoplasmicSequence analysisAdd BLAST33
Transmembranei257 – 277Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini278 – 286ExtracellularSequence analysis9
Transmembranei287 – 307Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini308 – 342CytoplasmicSequence analysisAdd BLAST35

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701511 – 342Trace amine-associated receptor 3Add BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi18N-linked (GlcNAc...)Sequence analysis1
Glycosylationi25N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi104 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5QD24.
PRIDEiQ5QD24.

Expressioni

Gene expression databases

BgeeiENSRNOG00000025982.
ExpressionAtlasiQ5QD24. differential.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035248.

Structurei

3D structure databases

ProteinModelPortaliQ5QD24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ5QD24.
KOiK05051.
OMAiMGVFLAC.
OrthoDBiEOG091G06VI.
PhylomeDBiQ5QD24.
TreeFamiTF343107.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5QD24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLIYIPEDL SSCPKFGNKS CPPTNRSFRV RLIMYLLMTG AMVITIFGNL
60 70 80 90 100
VIIISISHFK QLHSPTNFLI LSMATTDFLL GFVIMPYSMV RSVESCWYFG
110 120 130 140 150
DSFCKFHASF DMMLSLTSIF HLCSIAIDRF YAVCAPLHYT TTMTASMIKR
160 170 180 190 200
LLFFCWAAPA LFSFGLVLSE ANVSGMQSYE ILIACFNFCA LTFNKFWGTI
210 220 230 240 250
LFTTCFFTPG SIMVGIYGKI FIVSRRHARA LGNMPENTKG AGRNLSKKKD
260 270 280 290 300
RKAAKTLGIV MGVFLACWLP CFLAVLIDPY LDYSTPIIVL DLLVWLGYFN
310 320 330 340
STCNPLIHGF FYPWFRKALE HIVSGKIFRS NSDTANLFPE AH
Length:342
Mass (Da):38,658
Last modified:January 4, 2005 - v1
Checksum:i2473C99F1793C1BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702317 Genomic DNA. Translation: AAV70129.1.
RefSeqiNP_001009532.1. NM_001009532.1.
UniGeneiRn.142016.

Genome annotation databases

EnsembliENSRNOT00000035539; ENSRNOP00000035248; ENSRNOG00000025982.
GeneIDi494319.
KEGGirno:494319.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702317 Genomic DNA. Translation: AAV70129.1.
RefSeqiNP_001009532.1. NM_001009532.1.
UniGeneiRn.142016.

3D structure databases

ProteinModelPortaliQ5QD24.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035248.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ5QD24.
PRIDEiQ5QD24.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000035539; ENSRNOP00000035248; ENSRNOG00000025982.
GeneIDi494319.
KEGGirno:494319.

Organism-specific databases

CTDi9288.
RGDi1359566. Taar3.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ5QD24.
KOiK05051.
OMAiMGVFLAC.
OrthoDBiEOG091G06VI.
PhylomeDBiQ5QD24.
TreeFamiTF343107.

Miscellaneous databases

PROiQ5QD24.

Gene expression databases

BgeeiENSRNOG00000025982.
ExpressionAtlasiQ5QD24. differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAAR3_RAT
AccessioniPrimary (citable) accession number: Q5QD24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 4, 2005
Last modified: November 30, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.