Q5QD23 (TAAR5_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trace amine-associated receptor 5
Short name=TaR-5
Short name=Trace amine receptor 5

Gene names

Name:

Taar5

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Orphan receptor. Ligands are likely small molecules, either sharing some similarities with trace amine as, e.g. derivatives of indolamines (such as 5-methoxytryptamine) or of phenylethylamines (such as phenylethanolamine) or being any kind of metabolite of amino acids or biogenic amine neurotransmitters.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Trace amine-associated receptor 5		PRO_0000070157
Regions
	Topological domain	1 – 38	38	Extracellular Potential
	Transmembrane	39 – 59	21	Helical; Name=1; Potential
	Topological domain	60 – 70	11	Cytoplasmic Potential
	Transmembrane	71 – 91	21	Helical; Name=2; Potential
	Topological domain	92 – 109	18	Extracellular Potential
	Transmembrane	110 – 130	21	Helical; Name=3; Potential
	Topological domain	131 – 154	24	Cytoplasmic Potential
	Transmembrane	155 – 175	21	Helical; Name=4; Potential
	Topological domain	176 – 204	29	Extracellular Potential
	Transmembrane	205 – 225	21	Helical; Name=5; Potential
	Topological domain	226 – 253	28	Cytoplasmic Potential
	Transmembrane	254 – 274	21	Helical; Name=6; Potential
	Topological domain	275 – 284	10	Extracellular Potential
	Transmembrane	285 – 307	23	Helical; Name=7; Potential
	Topological domain	308 – 337	30	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	21	1	N-linked (GlcNAc...) Potential
	Disulfide bond	99 ↔ 192		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5QD23 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: DB013609BDAD6C67	FASTA	337	38,218
	10 20 30 40 50 60 MRAVLLPGSG EQPAAFCYQV NGSCPRTVHP LAIRVLIYLA CAVGMLITVL GNLFVVFAVS 70 80 90 100 110 120 YFKVLHTPTN FLLLSLALAD MLLGLLVLPL STVRSVESCW FFGDFLCRLH TYLDTLFCLT 130 140 150 160 170 180 SIFHLCFISI DRHCAICDPL LYPSKFTVRI ALRYIAAGWG IPAAYTAFFL YTDVVERALS 190 200 210 220 230 240 QWLEEMPCVG SCQLLFNKFW GWLNFPAFFI PCLIMISLYL KIFVVATRQA QQIRTLSQSL 250 260 270 280 290 300 SGAVKRERKA AKTLGIAVGI YLVCWLPFTV DTLVDSLLNF VTPPLVFDIF IWFAYFNSAC 310 320 330 NPIIYVFSYR WFRKALKLLL SREILSPRTQ TADLFHD

References

[1]

"Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors." Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K., Hoener M.C. Genomics 85:372-385(2005) [PubMed: 15718104] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: WIST/Crl.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY702318 Genomic DNA. Translation: AAV70130.1.
IPI	IPI00368259.
RefSeq	NP_001009650.1. NM_001009650.1.
UniGene	Rn.140571.
3D structure databases
ProteinModelPortal	Q5QD23.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5QD23.
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000061209; ENSRNOP00000057922; ENSRNOG00000039869.
GeneID	294123.
KEGG	rno:294123.
Organism-specific databases
CTD	9038.
RGD	1359185. Taar5.
Phylogenomic databases
eggNOG	roNOG05218.
GeneTree	ENSGT00550000074214.
HOVERGEN	HBG106962.
InParanoid	Q5QD23.
OMA	AFCYQVN.
OrthoDB	EOG495ZS8.
Gene expression databases
Genevestigator	Q5QD23.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017981. GPCR_2-like. IPR017452. GPCR_Rhodpsn_supfam. IPR009132. Trace_amine_rcpt. [Graphical view]
KO	K05051.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01830. TRACEAMINER.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	637613.

Entry information

Entry name

TAAR5_RAT

Accession

Primary (citable) accession number: Q5QD23

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	January 4, 2005
Last modified:	November 16, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program