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Protein

Trace amine-associated receptor 5

Gene

Taar5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Olfactory receptor specific for trimethylamine, a trace amine. Also activated at lower level by dimethylethylamine. Trimethylamine is a bacterial metabolite found in some animal odors, and is a repulsive odor associated with bad breath and spoiled food. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 5
Short name:
TaR-5
Short name:
Trace amine receptor 5
Gene namesi
Name:Taar5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1359185. Taar5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838ExtracellularSequence analysisAdd
BLAST
Transmembranei39 – 5921Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini60 – 7011CytoplasmicSequence analysisAdd
BLAST
Transmembranei71 – 9121Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini92 – 10918ExtracellularSequence analysisAdd
BLAST
Transmembranei110 – 13021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini131 – 15424CytoplasmicSequence analysisAdd
BLAST
Transmembranei155 – 17521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini176 – 20429ExtracellularSequence analysisAdd
BLAST
Transmembranei205 – 22521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini226 – 25328CytoplasmicSequence analysisAdd
BLAST
Transmembranei254 – 27421Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini275 – 28410ExtracellularSequence analysis
Transmembranei285 – 30723Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini308 – 33730CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Trace amine-associated receptor 5PRO_0000070157Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence analysis
Disulfide bondi99 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5QD23.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000057922.

Structurei

3D structure databases

ProteinModelPortaliQ5QD23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ5QD23.
KOiK05051.
OMAiCPRTVHT.
OrthoDBiEOG7CVPZ0.
PhylomeDBiQ5QD23.
TreeFamiTF343107.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5QD23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAVLLPGSG EQPAAFCYQV NGSCPRTVHP LAIRVLIYLA CAVGMLITVL
60 70 80 90 100
GNLFVVFAVS YFKVLHTPTN FLLLSLALAD MLLGLLVLPL STVRSVESCW
110 120 130 140 150
FFGDFLCRLH TYLDTLFCLT SIFHLCFISI DRHCAICDPL LYPSKFTVRI
160 170 180 190 200
ALRYIAAGWG IPAAYTAFFL YTDVVERALS QWLEEMPCVG SCQLLFNKFW
210 220 230 240 250
GWLNFPAFFI PCLIMISLYL KIFVVATRQA QQIRTLSQSL SGAVKRERKA
260 270 280 290 300
AKTLGIAVGI YLVCWLPFTV DTLVDSLLNF VTPPLVFDIF IWFAYFNSAC
310 320 330
NPIIYVFSYR WFRKALKLLL SREILSPRTQ TADLFHD
Length:337
Mass (Da):38,218
Last modified:January 4, 2005 - v1
Checksum:iDB013609BDAD6C67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702318 Genomic DNA. Translation: AAV70130.1.
RefSeqiNP_001009650.1. NM_001009650.1.
UniGeneiRn.140571.

Genome annotation databases

EnsembliENSRNOT00000061209; ENSRNOP00000057922; ENSRNOG00000039869.
GeneIDi294123.
KEGGirno:294123.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702318 Genomic DNA. Translation: AAV70130.1.
RefSeqiNP_001009650.1. NM_001009650.1.
UniGeneiRn.140571.

3D structure databases

ProteinModelPortaliQ5QD23.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000057922.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ5QD23.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000061209; ENSRNOP00000057922; ENSRNOG00000039869.
GeneIDi294123.
KEGGirno:294123.

Organism-specific databases

CTDi9038.
RGDi1359185. Taar5.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ5QD23.
KOiK05051.
OMAiCPRTVHT.
OrthoDBiEOG7CVPZ0.
PhylomeDBiQ5QD23.
TreeFamiTF343107.

Miscellaneous databases

PROiQ5QD23.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors."
    Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K., Hoener M.C.
    Genomics 85:372-385(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: WIST/Crl.

Entry informationi

Entry nameiTAAR5_RAT
AccessioniPrimary (citable) accession number: Q5QD23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 4, 2005
Last modified: June 8, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.