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Protein

Trace amine-associated receptor 2

Gene

Taar2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan olfactory receptor specific for trace amines.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 2
Short name:
TaR-2
Short name:
Trace amine receptor 2
Short name:
mTaar2
Alternative name(s):
G-protein coupled receptor 58
Gene namesi
Name:Taar2
Synonyms:Gm225, Gpr58
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2685071. Taar2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636ExtracellularSequence analysisAdd
BLAST
Transmembranei37 – 5721Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini58 – 6710CytoplasmicSequence analysis
Transmembranei68 – 8821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini89 – 10618ExtracellularSequence analysisAdd
BLAST
Transmembranei107 – 12721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini128 – 15023CytoplasmicSequence analysisAdd
BLAST
Transmembranei151 – 17121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini172 – 19524ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini217 – 25135CytoplasmicSequence analysisAdd
BLAST
Transmembranei252 – 27221Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini273 – 28715ExtracellularSequence analysisAdd
BLAST
Transmembranei288 – 31023Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini311 – 33929CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6, Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and Taar9 show no visible phenotype or behavioral deficits. They however show an absence of aversion to low concentrations of amines such as 2-phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Trace amine-associated receptor 2PRO_0000070147Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence analysis
Disulfide bondi104 ↔ 189PROSITE-ProRule annotation
Glycosylationi277 – 2771N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5QD17.
PRIDEiQ5QD17.

PTM databases

iPTMnetiQ5QD17.
PhosphoSiteiQ5QD17.

Expressioni

Tissue specificityi

Specifically expressed in neurons of the olfactory epithelium.1 Publication

Gene expression databases

BgeeiQ5QD17.
CleanExiMM_TAAR2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078137.

Structurei

3D structure databases

ProteinModelPortaliQ5QD17.
SMRiQ5QD17. Positions 33-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ5QD17.
KOiK05051.
OMAiVRVAMYS.
OrthoDBiEOG7HXCR8.
PhylomeDBiQ5QD17.
TreeFamiTF343107.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5QD17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASFEAQQET FDCSEYGNGS CPENERSLGV RAAMYSLMAC AIFITIFGNL
60 70 80 90 100
AMIISISYFK QLHTPTNLLI LSMAVTDFLL GFTIMPYSMV RSVENCWYFG
110 120 130 140 150
LTFCKIHYSF DLMLSITSIF HLCSVAVDRF YAICHPLHYC TKMTIPVVRR
160 170 180 190 200
LLLVCWSVPG AFAFGVVFSE AYADGIEGYD ILVACSSSCP VMFNKLWGTT
210 220 230 240 250
LFVAGFFTPS SMMVGIYGKI FAVSKKHARV IDNLPENQNN QMRKDKKAAK
260 270 280 290 300
TLGIVMGVFL LCWFPCFFTI LLDPFLNFST PAVLFDALTW FGYFNSTCNP
310 320 330
LIYGFFYPWF RRALKYILLG KIFSSHFHNT NLFTQKETE
Length:339
Mass (Da):38,517
Last modified:January 4, 2005 - v1
Checksum:i8F38253A3C677B20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702326 mRNA. Translation: AAV70136.1.
BC139118 mRNA. Translation: AAI39119.1.
BC145814 mRNA. Translation: AAI45815.1.
AY255589 mRNA. Translation: AAO85101.1.
CCDSiCCDS35869.1.
RefSeqiNP_001007267.1. NM_001007266.1.
UniGeneiMm.300611.

Genome annotation databases

EnsembliENSMUST00000079134; ENSMUSP00000078137; ENSMUSG00000059763.
GeneIDi209512.
KEGGimmu:209512.
UCSCiuc007eqe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702326 mRNA. Translation: AAV70136.1.
BC139118 mRNA. Translation: AAI39119.1.
BC145814 mRNA. Translation: AAI45815.1.
AY255589 mRNA. Translation: AAO85101.1.
CCDSiCCDS35869.1.
RefSeqiNP_001007267.1. NM_001007266.1.
UniGeneiMm.300611.

3D structure databases

ProteinModelPortaliQ5QD17.
SMRiQ5QD17. Positions 33-318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078137.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ5QD17.
PhosphoSiteiQ5QD17.

Proteomic databases

PaxDbiQ5QD17.
PRIDEiQ5QD17.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079134; ENSMUSP00000078137; ENSMUSG00000059763.
GeneIDi209512.
KEGGimmu:209512.
UCSCiuc007eqe.1. mouse.

Organism-specific databases

CTDi9287.
MGIiMGI:2685071. Taar2.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ5QD17.
KOiK05051.
OMAiVRVAMYS.
OrthoDBiEOG7HXCR8.
PhylomeDBiQ5QD17.
TreeFamiTF343107.

Miscellaneous databases

PROiQ5QD17.
SOURCEiSearch...

Gene expression databases

BgeeiQ5QD17.
CleanExiMM_TAAR2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors."
    Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K., Hoener M.C.
    Genomics 85:372-385(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 169-313.
  4. "A second class of chemosensory receptors in the olfactory epithelium."
    Liberles S.D., Buck L.B.
    Nature 442:645-650(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Non-redundant coding of aversive odours in the main olfactory pathway."
    Dewan A., Pacifico R., Zhan R., Rinberg D., Bozza T.
    Nature 497:486-489(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiTAAR2_MOUSE
AccessioniPrimary (citable) accession number: Q5QD17
Secondary accession number(s): A6H6B2, Q80T53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 4, 2005
Last modified: June 8, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.