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Protein

Trace amine-associated receptor 3

Gene

Taar3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Olfactory receptor activated by several primary trace amines, including isoamylamine. Activated by isoamylamine and cyclohexylamine, but not to the corresponding alcohols, isoamylalcohol and cyclohexanol. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase.1 Publication

GO - Molecular functioni

  • trace-amine receptor activity Source: UniProtKB

GO - Biological processi

  • sensory perception of chemical stimulus Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 3
Short name:
TaR-3
Short name:
Trace amine receptor 3
Short name:
mTaar3
Gene namesi
Name:Taar3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:3527427. Taar3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535ExtracellularSequence analysisAdd
BLAST
Transmembranei36 – 5621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini57 – 6812CytoplasmicSequence analysisAdd
BLAST
Transmembranei69 – 8921Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini90 – 15061ExtracellularSequence analysisAdd
BLAST
Transmembranei151 – 16818Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini169 – 1724CytoplasmicSequence analysis
Transmembranei173 – 19321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini194 – 1985ExtracellularSequence analysis
Transmembranei199 – 22325Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini224 – 25734CytoplasmicSequence analysisAdd
BLAST
Transmembranei258 – 27821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini279 – 2879ExtracellularSequence analysis
Transmembranei288 – 30821Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini309 – 34335CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6, Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and Taar9 show no visible phenotype or behavioral deficits. They however show an absence of aversion to low concentrations of amines such as 2-phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine.1 Publication

Chemistry

GuidetoPHARMACOLOGYi168.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Trace amine-associated receptor 3PRO_0000070150Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence analysis
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence analysis
Disulfide bondi104 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5QD16.
PRIDEiQ5QD16.

Expressioni

Tissue specificityi

Specifically expressed in neurons of the olfactory epithelium.1 Publication

Gene expression databases

CleanExiMM_TAAR3.
ExpressionAtlasiQ5QD16. differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036817.

Structurei

3D structure databases

ProteinModelPortaliQ5QD16.
SMRiQ5QD16. Positions 34-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ5QD16.
KOiK05051.
OMAiMGVFLAC.
OrthoDBiEOG7HXCR8.
PhylomeDBiQ5QD16.
TreeFamiTF343107.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5QD16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLIYIPEDL SSCPKFGNKS CPPTNRSFRV RMIMYLFMTG AMVITIFGNL
60 70 80 90 100
VIIISISHFK QLHSPTNFLI LSMATTDFLL GFVIMPYSMV RSVESCWYFG
110 120 130 140 150
DSFCKFHASF DMMLSLTSIF HLCSIAIDRF YAVCDPLHYT TTMTVSMIKR
160 170 180 190 200
LLAFCWAAPA LFSFGLVLSE ANVSGMQSYE ILVACFNFCA LTFNKFWGTI
210 220 230 240 250
LFTTCFFTPG SIMVGIYGKI FIVSRRHARA LSDMPANTKG AVGKNLSKKK
260 270 280 290 300
DRKAAKTLGI VMGVFLACWL PCFLAVLIDP YLDYSTPIIV LDLLVWLGYF
310 320 330 340
NSTCNPLIHG FFYPWFRKAL QFIVSGKIFR SNSDTANLFP EAH
Length:343
Mass (Da):38,745
Last modified:January 4, 2005 - v1
Checksum:i2A3F7D7BFC93AABF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702327 Genomic DNA. Translation: AAV70137.1.
BC139171 mRNA. Translation: AAI39172.1.
BC139172 mRNA. Translation: AAI39173.1.
CCDSiCCDS23736.1.
RefSeqiNP_001008429.1. NM_001008429.1.
UniGeneiMm.379737.

Genome annotation databases

EnsembliENSMUST00000045152; ENSMUSP00000036817; ENSMUSG00000069708.
GeneIDi493809.
KEGGimmu:493809.
UCSCiuc007eqf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702327 Genomic DNA. Translation: AAV70137.1.
BC139171 mRNA. Translation: AAI39172.1.
BC139172 mRNA. Translation: AAI39173.1.
CCDSiCCDS23736.1.
RefSeqiNP_001008429.1. NM_001008429.1.
UniGeneiMm.379737.

3D structure databases

ProteinModelPortaliQ5QD16.
SMRiQ5QD16. Positions 34-321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036817.

Chemistry

GuidetoPHARMACOLOGYi168.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ5QD16.
PRIDEiQ5QD16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045152; ENSMUSP00000036817; ENSMUSG00000069708.
GeneIDi493809.
KEGGimmu:493809.
UCSCiuc007eqf.1. mouse.

Organism-specific databases

CTDi9288.
MGIiMGI:3527427. Taar3.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ5QD16.
KOiK05051.
OMAiMGVFLAC.
OrthoDBiEOG7HXCR8.
PhylomeDBiQ5QD16.
TreeFamiTF343107.

Miscellaneous databases

NextBioi411734.
PROiQ5QD16.
SOURCEiSearch...

Gene expression databases

CleanExiMM_TAAR3.
ExpressionAtlasiQ5QD16. differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors."
    Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K., Hoener M.C.
    Genomics 85:372-385(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "A second class of chemosensory receptors in the olfactory epithelium."
    Liberles S.D., Buck L.B.
    Nature 442:645-650(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  4. "Non-redundant coding of aversive odours in the main olfactory pathway."
    Dewan A., Pacifico R., Zhan R., Rinberg D., Bozza T.
    Nature 497:486-489(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiTAAR3_MOUSE
AccessioniPrimary (citable) accession number: Q5QD16
Secondary accession number(s): B2RT86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 4, 2005
Last modified: May 11, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.