Q5QD15 (TAAR4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trace amine-associated receptor 4
Short name=TaR-4
Short name=Trace amine receptor 4

Gene names

Name:	Taar4
Synonyms:	Gm226

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor. Could be a receptor for trace amines. Of the biogenic trace amine tested, activated only by beta-phenylethylamine (beta-PEA) and tryptamine; however, the response is of low potency. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. This receptor seems to be mediated by the G(s)-class of G-proteins which activate adenylate cyclase By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 347	347	Trace amine-associated receptor 4		PRO_0000070152
Regions
	Topological domain	1 – 37	37	Extracellular Potential
	Transmembrane	38 – 58	21	Helical; Name=1; Potential
	Topological domain	59 – 69	11	Cytoplasmic Potential
	Transmembrane	70 – 90	21	Helical; Name=2; Potential
	Topological domain	91 – 110	20	Extracellular Potential
	Transmembrane	111 – 129	19	Helical; Name=3; Potential
	Topological domain	130 – 149	20	Cytoplasmic Potential
	Transmembrane	150 – 170	21	Helical; Name=4; Potential
	Topological domain	171 – 197	27	Extracellular Potential
	Transmembrane	198 – 218	21	Helical; Name=5; Potential
	Topological domain	219 – 260	42	Cytoplasmic Potential
	Transmembrane	261 – 281	21	Helical; Name=6; Potential
	Topological domain	282 – 296	15	Extracellular Potential
	Transmembrane	297 – 317	21	Helical; Name=7; Potential
	Topological domain	318 – 347	30	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	20	1	N-linked (GlcNAc...) Potential
	Disulfide bond	106 ↔ 191		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5QD15 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: B1564F458416C9C0	FASTA	347	38,904
	10 20 30 40 50 60 MNTPDPWSSP EVQFCFAAAN SSCPRKARPA LVVCAMYLIM IGAIVMTMLG NMAVIISIAH 70 80 90 100 110 120 FKQLHSPTNF LILSMATTDF LLSCVVMPFS MIRSIESCWY FGDLFCKVHS CCDIMLCTTS 130 140 150 160 170 180 IFHLCFISVD RHYAVCDPLH YVTQITTRVV GVFLLISWSV PIFFAFGLVF SELNLIGAED 190 200 210 220 230 240 FVAAIDCTGL CVLIFNKLWG VLASFIAFFL PGTVMVGIYI HIFTVAQKHA RQIGTGPRTK 250 260 270 280 290 300 QALSESKMKA TSKKESKATK TLSIVMGVFV LCWLPFFVLT ITDPFIDFTT PEDLYNVFLW 310 320 330 340 LGYFNSTFNP IIYGMFYPWF RKALRMIVTG TIFRSDSSTS SLHPAHP

References

[1]	"Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors." Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K., Hoener M.C. Genomics 85:372-385(2005) [PubMed: 15718104] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C57BL/6.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY702328 Genomic DNA. Translation: AAV70138.1.
IPI	IPI00515273.
RefSeq	NP_001008499.1. NM_001008499.1.
UniGene	Mm.300612.
3D structure databases
ProteinModelPortal	Q5QD15.
SMR	Q5QD15. Positions 33-331.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5QD15.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	Q5QD15.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000092660; ENSMUSP00000090330; ENSMUSG00000069707.
GeneID	209513.
KEGG	mmu:209513.
UCSC	uc007eqg.1. mouse.
Organism-specific databases
CTD	209513.
MGI	MGI:2685072. Taar4.
Phylogenomic databases
HOGENOM	HBG445348.
HOVERGEN	HBG106962.
InParanoid	Q5QD15.
OMA	AIDCTGL.
OrthoDB	EOG4V6ZGZ.
PhylomeDB	Q5QD15.
Gene expression databases
Bgee	Q5QD15.
CleanEx	MM_TAAR4.
Genevestigator	Q5QD15.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR009132. Trace_amine_rcpt. [Graphical view]
KO	K05051.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01830. TRACEAMINER.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	372701.
SOURCE	Search...

Entry information

Entry name

TAAR4_MOUSE

Accession

Primary (citable) accession number: Q5QD15

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	January 4, 2005
Last modified:	November 16, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program