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Protein

Trace amine-associated receptor 4

Gene

Taar4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Olfactory receptor specific for 2-phenylethylamine, a trace amine present at high concentration in the urine of carnivore species, playing a key role in fear and avoidance responses. 2-phenylethylamine acts as a kairomone in the chemical detection of carnivore odor and triggers fear in mice. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase.3 Publications

GO - Molecular functioni

GO - Biological processi

  • behavioral fear response Source: UniProtKB
  • chemosensory behavior Source: UniProtKB
  • sensory perception of chemical stimulus Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Behavior

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 4
Short name:
TaR-4
Short name:
Trace amine receptor 4
Short name:
mTaar4
Alternative name(s):
2-phenylethylamine receptor
Gene namesi
Name:Taar4
Synonyms:Gm226
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2685072. Taar4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737ExtracellularSequence analysisAdd
BLAST
Transmembranei38 – 5821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini59 – 6911CytoplasmicSequence analysisAdd
BLAST
Transmembranei70 – 9021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini91 – 11020ExtracellularSequence analysisAdd
BLAST
Transmembranei111 – 12919Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini130 – 14920CytoplasmicSequence analysisAdd
BLAST
Transmembranei150 – 17021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini171 – 19727ExtracellularSequence analysisAdd
BLAST
Transmembranei198 – 21821Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini219 – 26042CytoplasmicSequence analysisAdd
BLAST
Transmembranei261 – 28121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini282 – 29615ExtracellularSequence analysisAdd
BLAST
Transmembranei297 – 31721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini318 – 34730CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice lacking Taar4 show an absence of aversion to low concentrations of volatile amines and to the odor of predator urine.1 Publication

Chemistry

GuidetoPHARMACOLOGYi169.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Trace amine-associated receptor 4PRO_0000070152Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi20 – 201N-linked (GlcNAc...)Sequence analysis
Disulfide bondi106 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5QD15.
PRIDEiQ5QD15.

Expressioni

Tissue specificityi

Specifically expressed in neurons of the olfactory epithelium, to discrete glomeruli predominantly localized to a confined bulb region. Present in the dorsal area of the main olfactory epithelium.2 Publications

Gene expression databases

BgeeiENSMUSG00000069707.
CleanExiMM_TAAR4.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090330.

Structurei

3D structure databases

ProteinModelPortaliQ5QD15.
SMRiQ5QD15. Positions 32-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ5QD15.
KOiK05051.
OMAiANNSCAR.
OrthoDBiEOG091G0BXO.
PhylomeDBiQ5QD15.
TreeFamiTF343107.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5QD15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTPDPWSSP EVQFCFAAAN SSCPRKARPA LVVCAMYLIM IGAIVMTMLG
60 70 80 90 100
NMAVIISIAH FKQLHSPTNF LILSMATTDF LLSCVVMPFS MIRSIESCWY
110 120 130 140 150
FGDLFCKVHS CCDIMLCTTS IFHLCFISVD RHYAVCDPLH YVTQITTRVV
160 170 180 190 200
GVFLLISWSV PIFFAFGLVF SELNLIGAED FVAAIDCTGL CVLIFNKLWG
210 220 230 240 250
VLASFIAFFL PGTVMVGIYI HIFTVAQKHA RQIGTGPRTK QALSESKMKA
260 270 280 290 300
TSKKESKATK TLSIVMGVFV LCWLPFFVLT ITDPFIDFTT PEDLYNVFLW
310 320 330 340
LGYFNSTFNP IIYGMFYPWF RKALRMIVTG TIFRSDSSTS SLHPAHP
Length:347
Mass (Da):38,904
Last modified:January 4, 2005 - v1
Checksum:iB1564F458416C9C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702328 Genomic DNA. Translation: AAV70138.1.
CCDSiCCDS23737.1.
RefSeqiNP_001008499.1. NM_001008499.1.
UniGeneiMm.300612.

Genome annotation databases

EnsembliENSMUST00000092660; ENSMUSP00000090330; ENSMUSG00000069707.
GeneIDi209513.
KEGGimmu:209513.
UCSCiuc007eqg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702328 Genomic DNA. Translation: AAV70138.1.
CCDSiCCDS23737.1.
RefSeqiNP_001008499.1. NM_001008499.1.
UniGeneiMm.300612.

3D structure databases

ProteinModelPortaliQ5QD15.
SMRiQ5QD15. Positions 32-328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090330.

Chemistry

GuidetoPHARMACOLOGYi169.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ5QD15.
PRIDEiQ5QD15.

Protocols and materials databases

DNASUi209513.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000092660; ENSMUSP00000090330; ENSMUSG00000069707.
GeneIDi209513.
KEGGimmu:209513.
UCSCiuc007eqg.1. mouse.

Organism-specific databases

CTDi209513.
MGIiMGI:2685072. Taar4.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ5QD15.
KOiK05051.
OMAiANNSCAR.
OrthoDBiEOG091G0BXO.
PhylomeDBiQ5QD15.
TreeFamiTF343107.

Miscellaneous databases

PROiQ5QD15.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000069707.
CleanExiMM_TAAR4.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAAR4_MOUSE
AccessioniPrimary (citable) accession number: Q5QD15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 4, 2005
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.