Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Trace amine-associated receptor 4

Gene

Taar4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Olfactory receptor specific for 2-phenylethylamine, a trace amine present at high concentration in the urine of carnivore species, playing a key role in fear and avoidance responses. 2-phenylethylamine acts as a kairomone in the chemical detection of carnivore odor and triggers fear in mice. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase.3 Publications

GO - Molecular functioni

GO - Biological processi

  • behavioral fear response Source: UniProtKB
  • chemosensory behavior Source: UniProtKB
  • sensory perception of chemical stimulus Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processBehavior

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 4
Short name:
TaR-4
Short name:
Trace amine receptor 4
Short name:
mTaar4
Alternative name(s):
2-phenylethylamine receptor
Gene namesi
Name:Taar4
Synonyms:Gm226
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2685072. Taar4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37ExtracellularSequence analysisAdd BLAST37
Transmembranei38 – 58Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini59 – 69CytoplasmicSequence analysisAdd BLAST11
Transmembranei70 – 90Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini91 – 110ExtracellularSequence analysisAdd BLAST20
Transmembranei111 – 129Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini130 – 149CytoplasmicSequence analysisAdd BLAST20
Transmembranei150 – 170Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini171 – 197ExtracellularSequence analysisAdd BLAST27
Transmembranei198 – 218Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini219 – 260CytoplasmicSequence analysisAdd BLAST42
Transmembranei261 – 281Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini282 – 296ExtracellularSequence analysisAdd BLAST15
Transmembranei297 – 317Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini318 – 347CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice lacking Taar4 show an absence of aversion to low concentrations of volatile amines and to the odor of predator urine.1 Publication

Chemistry databases

GuidetoPHARMACOLOGYi169.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701521 – 347Trace amine-associated receptor 4Add BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi20N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi106 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5QD15.
PRIDEiQ5QD15.

Expressioni

Tissue specificityi

Specifically expressed in neurons of the olfactory epithelium, to discrete glomeruli predominantly localized to a confined bulb region. Present in the dorsal area of the main olfactory epithelium.2 Publications

Gene expression databases

BgeeiENSMUSG00000069707.
CleanExiMM_TAAR4.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090330.

Structurei

3D structure databases

ProteinModelPortaliQ5QD15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00890000139340.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ5QD15.
KOiK05051.
OMAiCTGLCVL.
OrthoDBiEOG091G0BXO.
PhylomeDBiQ5QD15.
TreeFamiTF343107.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5QD15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTPDPWSSP EVQFCFAAAN SSCPRKARPA LVVCAMYLIM IGAIVMTMLG
60 70 80 90 100
NMAVIISIAH FKQLHSPTNF LILSMATTDF LLSCVVMPFS MIRSIESCWY
110 120 130 140 150
FGDLFCKVHS CCDIMLCTTS IFHLCFISVD RHYAVCDPLH YVTQITTRVV
160 170 180 190 200
GVFLLISWSV PIFFAFGLVF SELNLIGAED FVAAIDCTGL CVLIFNKLWG
210 220 230 240 250
VLASFIAFFL PGTVMVGIYI HIFTVAQKHA RQIGTGPRTK QALSESKMKA
260 270 280 290 300
TSKKESKATK TLSIVMGVFV LCWLPFFVLT ITDPFIDFTT PEDLYNVFLW
310 320 330 340
LGYFNSTFNP IIYGMFYPWF RKALRMIVTG TIFRSDSSTS SLHPAHP
Length:347
Mass (Da):38,904
Last modified:January 4, 2005 - v1
Checksum:iB1564F458416C9C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702328 Genomic DNA. Translation: AAV70138.1.
CCDSiCCDS23737.1.
RefSeqiNP_001008499.1. NM_001008499.1.
UniGeneiMm.300612.

Genome annotation databases

EnsembliENSMUST00000092660; ENSMUSP00000090330; ENSMUSG00000069707.
GeneIDi209513.
KEGGimmu:209513.
UCSCiuc007eqg.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiTAAR4_MOUSE
AccessioniPrimary (citable) accession number: Q5QD15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 4, 2005
Last modified: August 30, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families