Q5QD14 (TAAR5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trace amine-associated receptor 5
Short name=TaR-5
Short name=Trace amine receptor 5

Gene names

Name:	Taar5
Synonyms:	Gm227

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor. Ligands are likely small molecules, either sharing some similarities with trace amine as, e.g. derivatives of indolamines (such as 5-methoxytryptamine) or of phenylethylamines (such as phenylethanolamine) or being any kind of metabolite of amino acids or biogenic amine neurotransmitters.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	trace-amine receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Trace amine-associated receptor 5		PRO_0000070155
Regions
	Topological domain	1 – 38	38	Extracellular Potential
	Transmembrane	39 – 59	21	Helical; Name=1; Potential
	Topological domain	60 – 70	11	Cytoplasmic Potential
	Transmembrane	71 – 91	21	Helical; Name=2; Potential
	Topological domain	92 – 109	18	Extracellular Potential
	Transmembrane	110 – 130	21	Helical; Name=3; Potential
	Topological domain	131 – 154	24	Cytoplasmic Potential
	Transmembrane	155 – 175	21	Helical; Name=4; Potential
	Topological domain	176 – 204	29	Extracellular Potential
	Transmembrane	205 – 225	21	Helical; Name=5; Potential
	Topological domain	226 – 253	28	Cytoplasmic Potential
	Transmembrane	254 – 274	21	Helical; Name=6; Potential
	Topological domain	275 – 284	10	Extracellular Potential
	Transmembrane	285 – 307	23	Helical; Name=7; Potential
	Topological domain	308 – 337	30	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	21	1	N-linked (GlcNAc...) Potential
	Disulfide bond	99 ↔ 192		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5QD14 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: 25B14CDEE31CB915	FASTA	337	38,220
	10 20 30 40 50 60 MRAVLLPGSG EQPTAFCYQV NGSCPRTVHP LAIQVVIYLA CAVGVLITVL GNLFVVFAVS 70 80 90 100 110 120 YFKVLHTPTN FLLLSLALAD MLLGLLVLPL STVRSVESCW FFGDFLCRLH TYLDTLFCLT 130 140 150 160 170 180 SIFHLCFISI DRHCAICDPL LYPSKFTVRT ALRYIVAGWG IPAAYTAFFL YTDVVERALS 190 200 210 220 230 240 QWLEEMPCVG SCQLLFNKFW GWLNFPAFFV PCLIMISLYL KIFVVATRQA QQIRTLSQSL 250 260 270 280 290 300 AGAVKRERKA AKTLGIAVGI YLVCWLPFTV DTLVDSLLNF ITPPLVFDIF IWFAYFNSAC 310 320 330 NPIIYVFSYR WFRKALKLLL SREIFSPRTP TVDLYHD

References

[1]	"Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors." Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K., Hoener M.C. Genomics 85:372-385(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C57BL/6.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY702329 Genomic DNA. Translation: AAV70139.1.
IPI	IPI00340310.
RefSeq	NP_001009574.1. NM_001009574.1.
UniGene	Mm.377236.
3D structure databases
ProteinModelPortal	Q5QD14.
SMR	Q5QD14. Positions 39-321.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	Q5QD14.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000092659; ENSMUSP00000090329; ENSMUSG00000069706.
GeneID	215854.
KEGG	mmu:215854.
Organism-specific databases
CTD	9038.
MGI	MGI:2685073. Taar5.
Phylogenomic databases
eggNOG	NOG242261.
GeneTree	ENSGT00700000104062.
HOGENOM	HOG000239243.
HOVERGEN	HBG106962.
InParanoid	Q5QD14.
KO	K05051.
OMA	DIFIWFA.
OrthoDB	EOG495ZS8.
Gene expression databases
ArrayExpress	Q5QD14.
Bgee	Q5QD14.
CleanEx	MM_TAAR5.
Genevestigator	Q5QD14.
Family and domain databases
InterPro	IPR017981. GPCR_2-like. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR009132. Trace_amine_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01830. TRACEAMINER.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	374869.
SOURCE	Search...

Entry information

Entry name

TAAR5_MOUSE

Accession

Primary (citable) accession number: Q5QD14

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	January 4, 2005
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program