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Protein

Trace amine-associated receptor 5

Gene

Taar5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Olfactory receptor specific for trimethylamine, a trace amine enriched in the urine of male mice, playing a role in social behavior. Trimethylamine is present at high concentration in the urine of male mice after puberty and acts as an attractant. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase.2 Publications

Miscellaneous

Trimethylamine is a bacterial metabolite found in some animal odors, and is a repulsive odor associated with bad breath and spoiled food for most organisms, except for M.musculus, where it acts as an attractant (PubMed:16878137, PubMed:23177478).2 Publications

GO - Molecular functioni

  • trimethylamine receptor activity Source: UniProtKB

GO - Biological processi

  • cell surface receptor signaling pathway Source: InterPro
  • mating behavior Source: UniProtKB
  • sensory perception of chemical stimulus Source: UniProtKB
  • social behavior Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processBehavior

Enzyme and pathway databases

ReactomeiR-MMU-375280 Amine ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 5
Short name:
TaR-5
Short name:
Trace amine receptor 5
Short name:
mTaar5
Alternative name(s):
Trimethylamine receptor
Gene namesi
Name:Taar5
Synonyms:Gm227
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2685073 Taar5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 59Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini60 – 70CytoplasmicSequence analysisAdd BLAST11
Transmembranei71 – 91Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini92 – 109ExtracellularSequence analysisAdd BLAST18
Transmembranei110 – 130Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini131 – 154CytoplasmicSequence analysisAdd BLAST24
Transmembranei155 – 175Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini176 – 204ExtracellularSequence analysisAdd BLAST29
Transmembranei205 – 225Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini226 – 253CytoplasmicSequence analysisAdd BLAST28
Transmembranei254 – 274Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini275 – 284ExtracellularSequence analysis10
Transmembranei285 – 307Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini308 – 337CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6, Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and Taar9 show no visible phenotype or behavioral deficits. They however show an absence of aversion to low concentrations of amines such as 2-phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine.1 Publication

Chemistry databases

ChEMBLiCHEMBL3784908
GuidetoPHARMACOLOGYi170

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701551 – 337Trace amine-associated receptor 5Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5QD14
PRIDEiQ5QD14

PTM databases

iPTMnetiQ5QD14
PhosphoSitePlusiQ5QD14

Expressioni

Tissue specificityi

Specifically expressed in neurons of the olfactory epithelium, to discrete glomeruli predominantly localized to a confined bulb region. Present in the dorsal area of the main olfactory epithelium.2 Publications

Gene expression databases

BgeeiENSMUSG00000069706
CleanExiMM_TAAR5
ExpressionAtlasiQ5QD14 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090329

Structurei

3D structure databases

ProteinModelPortaliQ5QD14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139340
HOGENOMiHOG000239243
HOVERGENiHBG106962
InParanoidiQ5QD14
KOiK05051
OMAiHCAICDP
OrthoDBiEOG091G06VI
PhylomeDBiQ5QD14
TreeFamiTF343107

Family and domain databases

InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR009132 TAAR_fam
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01830 TRACEAMINER
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5QD14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAVLLPGSG EQPTAFCYQV NGSCPRTVHP LAIQVVIYLA CAVGVLITVL
60 70 80 90 100
GNLFVVFAVS YFKVLHTPTN FLLLSLALAD MLLGLLVLPL STVRSVESCW
110 120 130 140 150
FFGDFLCRLH TYLDTLFCLT SIFHLCFISI DRHCAICDPL LYPSKFTVRT
160 170 180 190 200
ALRYIVAGWG IPAAYTAFFL YTDVVERALS QWLEEMPCVG SCQLLFNKFW
210 220 230 240 250
GWLNFPAFFV PCLIMISLYL KIFVVATRQA QQIRTLSQSL AGAVKRERKA
260 270 280 290 300
AKTLGIAVGI YLVCWLPFTV DTLVDSLLNF ITPPLVFDIF IWFAYFNSAC
310 320 330
NPIIYVFSYR WFRKALKLLL SREIFSPRTP TVDLYHD
Length:337
Mass (Da):38,220
Last modified:January 4, 2005 - v1
Checksum:i25B14CDEE31CB915
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702329 Genomic DNA Translation: AAV70139.1
CCDSiCCDS23738.1
RefSeqiNP_001009574.1, NM_001009574.1
UniGeneiMm.377236

Genome annotation databases

EnsembliENSMUST00000092659; ENSMUSP00000090329; ENSMUSG00000069706
GeneIDi215854
KEGGimmu:215854
UCSCiuc007eqh.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTAAR5_MOUSE
AccessioniPrimary (citable) accession number: Q5QD14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 4, 2005
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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