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Protein

Trace amine-associated receptor 6

Gene

Taar6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan olfactory receptor specific for trace amines.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 6
Short name:
TaR-6
Short name:
Trace amine receptor 6
Short name:
mTaar6
Gene namesi
Name:Taar6
Synonyms:Gm228
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2685074. Taar6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence analysisAdd
BLAST
Transmembranei33 – 5321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini54 – 6815CytoplasmicSequence analysisAdd
BLAST
Transmembranei69 – 8921Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini90 – 10718ExtracellularSequence analysisAdd
BLAST
Transmembranei108 – 12821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini129 – 14719CytoplasmicSequence analysisAdd
BLAST
Transmembranei148 – 16821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini169 – 20234ExtracellularSequence analysisAdd
BLAST
Transmembranei203 – 22321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini224 – 25936CytoplasmicSequence analysisAdd
BLAST
Transmembranei260 – 27617Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini277 – 2826ExtracellularSequence analysis
Transmembranei283 – 30220Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini303 – 34543CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6, Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and Taar9 show no visible phenotype or behavioral deficits. They however show an absence of aversion to low concentrations of amines such as 2-phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Trace amine-associated receptor 6PRO_0000070159Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence analysis
Disulfide bondi105 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5QD13.
PRIDEiQ5QD13.

PTM databases

PhosphoSiteiQ5QD13.

Expressioni

Tissue specificityi

Specifically expressed in neurons of the olfactory epithelium, to discrete glomeruli predominantly localized to a confined bulb region. Present in a ventral area of the main olfactory epithelium.2 Publications

Gene expression databases

BgeeiQ5QD13.
CleanExiMM_TAAR6.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097603.

Structurei

3D structure databases

ProteinModelPortaliQ5QD13.
SMRiQ5QD13. Positions 28-326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ5QD13.
KOiK05051.
OMAiCIGGCQT.
OrthoDBiEOG7966GS.
PhylomeDBiQ5QD13.
TreeFamiTF343107.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5QD13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSNSSPPTV LQLCYENVTG SCVKTPYSPG SRVILYAVFG FGAVLAVFGN
60 70 80 90 100
LMVMISILHF KQLHSPTNFL IASLACADFG VGISVMPFSM VRSIESCWYF
110 120 130 140 150
GRSFCTFHTC CDVAFCYSSL FHLSFISIDR YIAVTDPLVY PTKFTVSVSG
160 170 180 190 200
ICIGVSWILP LVYSGAVFYT GVYDDGLEEL SSALNCVGGC QVVVNQNWVL
210 220 230 240 250
IDFLSFLIPT LVMIILYGNI FLVARQQAKK IENIGSKTES SSESYKARVA
260 270 280 290 300
RRERKAAKTL GITVVAFMIS WLPYSIDSLV DAFMGFITPA YIYEICVWCA
310 320 330 340
YYNSAMNPLI YALFYPWFKK AIKVIMSGQV FKNSSATMNL FSEQI
Length:345
Mass (Da):38,279
Last modified:January 4, 2005 - v1
Checksum:iEFF2226F4B92F9C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702330 Genomic DNA. Translation: AAV70140.1.
CCDSiCCDS23739.1.
RefSeqiNP_001010828.1. NM_001010828.1.
UniGeneiMm.377237.

Genome annotation databases

EnsembliENSMUST00000057080; ENSMUSP00000097603; ENSMUSG00000045111.
GeneIDi215855.
KEGGimmu:215855.
UCSCiuc007eqi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702330 Genomic DNA. Translation: AAV70140.1.
CCDSiCCDS23739.1.
RefSeqiNP_001010828.1. NM_001010828.1.
UniGeneiMm.377237.

3D structure databases

ProteinModelPortaliQ5QD13.
SMRiQ5QD13. Positions 28-326.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097603.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ5QD13.

Proteomic databases

PaxDbiQ5QD13.
PRIDEiQ5QD13.

Protocols and materials databases

DNASUi215855.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057080; ENSMUSP00000097603; ENSMUSG00000045111.
GeneIDi215855.
KEGGimmu:215855.
UCSCiuc007eqi.1. mouse.

Organism-specific databases

CTDi319100.
MGIiMGI:2685074. Taar6.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ5QD13.
KOiK05051.
OMAiCIGGCQT.
OrthoDBiEOG7966GS.
PhylomeDBiQ5QD13.
TreeFamiTF343107.

Miscellaneous databases

NextBioi374873.
PROiQ5QD13.
SOURCEiSearch...

Gene expression databases

BgeeiQ5QD13.
CleanExiMM_TAAR6.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors."
    Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K., Hoener M.C.
    Genomics 85:372-385(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6J.
  2. "A second class of chemosensory receptors in the olfactory epithelium."
    Liberles S.D., Buck L.B.
    Nature 442:645-650(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  3. "Neurons expressing trace amine-associated receptors project to discrete glomeruli and constitute an olfactory subsystem."
    Johnson M.A., Tsai L., Roy D.S., Valenzuela D.H., Mosley C., Magklara A., Lomvardas S., Liberles S.D., Barnea G.
    Proc. Natl. Acad. Sci. U.S.A. 109:13410-13415(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "Non-redundant coding of aversive odours in the main olfactory pathway."
    Dewan A., Pacifico R., Zhan R., Rinberg D., Bozza T.
    Nature 497:486-489(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiTAAR6_MOUSE
AccessioniPrimary (citable) accession number: Q5QD13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 4, 2005
Last modified: May 11, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.