Q5QD10 (TAA7D_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trace amine-associated receptor 7d
Short name=TaR-7d
Short name=Trace amine receptor 7d

Gene names

Name:

Taar7d

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Trace amine-associated receptor 7d		PRO_0000070167
Regions
	Topological domain	1 – 47	47	Extracellular Potential
	Transmembrane	48 – 68	21	Helical; Name=1; Potential
	Topological domain	69 – 83	15	Cytoplasmic Potential
	Transmembrane	84 – 104	21	Helical; Name=2; Potential
	Topological domain	105 – 121	17	Extracellular Potential
	Transmembrane	122 – 143	22	Helical; Name=3; Potential
	Topological domain	144 – 166	23	Cytoplasmic Potential
	Transmembrane	167 – 187	21	Helical; Name=4; Potential
	Topological domain	188 – 212	25	Extracellular Potential
	Transmembrane	213 – 233	21	Helical; Name=5; Potential
	Topological domain	234 – 274	41	Cytoplasmic Potential
	Transmembrane	275 – 295	21	Helical; Name=6; Potential
	Topological domain	296 – 309	14	Extracellular Potential
	Transmembrane	310 – 333	24	Helical; Name=7; Potential
	Topological domain	334 – 358	25	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	34	1	N-linked (GlcNAc...) Potential
	Glycosylation	210	1	N-linked (GlcNAc...) Potential
	Disulfide bond	120 ↔ 205		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5QD10 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: 36BED1D7EEFA354C	FASTA	358	40,305
	10 20 30 40 50 60 MATGDDSFPW DQDSILSRDL FSATSTELCY ENLNRSCVRS PYSPGPRLIL YAVFGFGAVL 70 80 90 100 110 120 AVCGNLLVMT SILHFRQLHS PANFLVASLA CADFLVGVMV MPFSMVRSVE GCWYFGESYC 130 140 150 160 170 180 KFHSCFEGSF CYSSLFHLCF ISVDRYIAVS DPLTYPTRFT ASVSGKCITF SWLLSIIYSF 190 200 210 220 230 240 SLLYTGANDA GLEDLVSALT CVGGCQIAVN QTWVFINFLL FLIPTLVMIT VYSKIFLIAK 250 260 270 280 290 300 QQAQNIEKMS KQTARASESY KDRVTKRERK AAKTLGIAVA AFLLSWLPYF IDSIIDAFLG 310 320 330 340 350 FITPTYVYEI LVWIVYYNSA MNPLIYAFFY SWFRKAIKLI VSGKILRENS STTNLFPE

References

[1]	"Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors." Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K., Hoener M.C. Genomics 85:372-385(2005) [PubMed: 15718104] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C57BL/6.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY702334 Genomic DNA. Translation: AAV70143.1.
IPI	IPI00408035.
RefSeq	NP_001010838.1. NM_001010838.1.
UniGene	Mm.377965.
3D structure databases
ProteinModelPortal	Q5QD10.
SMR	Q5QD10. Positions 43-342.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q5QD10.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000092657; ENSMUSP00000090327; ENSMUSG00000069704.
GeneID	435206.
KEGG	mmu:435206.
Organism-specific databases
CTD	435206.
MGI	MGI:3527443. Taar7d.
Phylogenomic databases
eggNOG	roNOG08437.
GeneTree	ENSGT00550000074214.
HOGENOM	HBG445348.
HOVERGEN	HBG106962.
InParanoid	Q5QD10.
OMA	DDSFPWD.
OrthoDB	EOG4V439J.
PhylomeDB	Q5QD10.
Gene expression databases
Bgee	Q5QD10.
CleanEx	MM_TAAR7D.
Genevestigator	Q5QD10.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR009132. Trace_amine_rcpt. [Graphical view]
KO	K05051.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01830. TRACEAMINER.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	409977.
SOURCE	Search...

Entry information

Entry name

TAA7D_MOUSE

Accession

Primary (citable) accession number: Q5QD10

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	January 4, 2005
Last modified:	November 16, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program