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Protein

Trace amine-associated receptor 8b

Gene

Taar8b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan olfactory receptor specific for trace amines.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375280 Amine ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 8b
Short name:
TaR-8b
Short name:
Trace amine receptor 8b
Short name:
mTaar8b
Gene namesi
Name:Taar8b
Synonyms:Gm1149
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2685995 Taar8b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31ExtracellularSequence analysisAdd BLAST31
Transmembranei32 – 52Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini53 – 67CytoplasmicSequence analysisAdd BLAST15
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini89 – 111ExtracellularSequence analysisAdd BLAST23
Transmembranei112 – 132Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini133 – 146CytoplasmicSequence analysisAdd BLAST14
Transmembranei147 – 167Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini168 – 195ExtracellularSequence analysisAdd BLAST28
Transmembranei196 – 216Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini217 – 260CytoplasmicSequence analysisAdd BLAST44
Transmembranei261 – 281Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini282ExtracellularSequence analysis1
Transmembranei283 – 303Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini304 – 344CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6, Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and Taar9 show no visible phenotype or behavioral deficits. They however show an absence of aversion to low concentrations of amines such as 2-phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701771 – 344Trace amine-associated receptor 8bAdd BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi104 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5QD06
PRIDEiQ5QD06

Expressioni

Tissue specificityi

Specifically expressed in neurons of the olfactory epithelium.1 Publication

Gene expression databases

BgeeiENSMUSG00000100186
CleanExiMM_TAAR8B

Structurei

3D structure databases

ProteinModelPortaliQ5QD06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139340
HOGENOMiHOG000239243
HOVERGENiHBG106962
InParanoidiQ5QD06
KOiK05051
OMAiFGARFCT
OrthoDBiEOG091G0BXO
PhylomeDBiQ5QD06
TreeFamiTF343107

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR009132 TAAR_fam
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01830 TRACEAMINER
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5QD06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSNFSQPAL QLCYENTNGS CIKTPYSPGP RVILYMVFGF GAVLAVCGNL
60 70 80 90 100
LVVISVLHFK QLHSPANFLI ASLASADFLV GISVMPFSMV RSIESCWYFG
110 120 130 140 150
DAFCSLHSCC DVAFCYSSAL HLCFISVDRY IAVTDPLVYP TKFTVSVSGI
160 170 180 190 200
CISISWILPL VYSSAVFYTG ISAKGIESLV SALNCVGGCQ IVVNQDWVLI
210 220 230 240 250
DFLLFFIPTL VMIILYSKIF LVAKQQAVKI ETSVSDNRGE SSSESHKARV
260 270 280 290 300
AKRERKAAKT LGVTVVAFMV SWLPYTIDSL VDAFVGFITP AYVYEICCWS
310 320 330 340
AYYNSAMNPL IYAFFYPWFR KAIKLILSGE ILKSHSSTMS LFSE
Length:344
Mass (Da):38,006
Last modified:January 4, 2005 - v1
Checksum:i4BAAF8838AB136D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702338 Genomic DNA Translation: AAV70147.1
BC139105 mRNA Translation: AAI39106.1
BC139106 mRNA Translation: AAI39107.1
CCDSiCCDS23746.1
RefSeqiNP_001010837.1, NM_001010837.1
UniGeneiMm.377897

Genome annotation databases

EnsembliENSMUST00000092654; ENSMUSP00000090324; ENSMUSG00000100186
GeneIDi382348
KEGGimmu:382348
UCSCiuc007eqp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTAA8B_MOUSE
AccessioniPrimary (citable) accession number: Q5QD06
Secondary accession number(s): B2RT24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 4, 2005
Last modified: February 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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