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Protein

Trace amine-associated receptor 8b

Gene

Taar8b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan olfactory receptor specific for trace amines.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 8b
Short name:
TaR-8b
Short name:
Trace amine receptor 8b
Short name:
mTaar8b
Gene namesi
Name:Taar8b
Synonyms:Gm1149
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2685995. Taar8b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31ExtracellularSequence analysisAdd BLAST31
Transmembranei32 – 52Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini53 – 67CytoplasmicSequence analysisAdd BLAST15
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini89 – 111ExtracellularSequence analysisAdd BLAST23
Transmembranei112 – 132Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini133 – 146CytoplasmicSequence analysisAdd BLAST14
Transmembranei147 – 167Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini168 – 195ExtracellularSequence analysisAdd BLAST28
Transmembranei196 – 216Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini217 – 260CytoplasmicSequence analysisAdd BLAST44
Transmembranei261 – 281Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini282ExtracellularSequence analysis1
Transmembranei283 – 303Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini304 – 344CytoplasmicSequence analysisAdd BLAST41

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6, Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and Taar9 show no visible phenotype or behavioral deficits. They however show an absence of aversion to low concentrations of amines such as 2-phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701771 – 344Trace amine-associated receptor 8bAdd BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi18N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi104 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5QD06.
PRIDEiQ5QD06.

Expressioni

Tissue specificityi

Specifically expressed in neurons of the olfactory epithelium.1 Publication

Gene expression databases

CleanExiMM_TAAR8B.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090324.

Structurei

3D structure databases

ProteinModelPortaliQ5QD06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ5QD06.
KOiK05051.
OMAiAYCNSAI.
OrthoDBiEOG091G0BXO.
PhylomeDBiQ5QD06.
TreeFamiTF343107.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5QD06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSNFSQPAL QLCYENTNGS CIKTPYSPGP RVILYMVFGF GAVLAVCGNL
60 70 80 90 100
LVVISVLHFK QLHSPANFLI ASLASADFLV GISVMPFSMV RSIESCWYFG
110 120 130 140 150
DAFCSLHSCC DVAFCYSSAL HLCFISVDRY IAVTDPLVYP TKFTVSVSGI
160 170 180 190 200
CISISWILPL VYSSAVFYTG ISAKGIESLV SALNCVGGCQ IVVNQDWVLI
210 220 230 240 250
DFLLFFIPTL VMIILYSKIF LVAKQQAVKI ETSVSDNRGE SSSESHKARV
260 270 280 290 300
AKRERKAAKT LGVTVVAFMV SWLPYTIDSL VDAFVGFITP AYVYEICCWS
310 320 330 340
AYYNSAMNPL IYAFFYPWFR KAIKLILSGE ILKSHSSTMS LFSE
Length:344
Mass (Da):38,006
Last modified:January 4, 2005 - v1
Checksum:i4BAAF8838AB136D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702338 Genomic DNA. Translation: AAV70147.1.
BC139105 mRNA. Translation: AAI39106.1.
BC139106 mRNA. Translation: AAI39107.1.
CCDSiCCDS23746.1.
RefSeqiNP_001010837.1. NM_001010837.1.
UniGeneiMm.377897.

Genome annotation databases

EnsembliENSMUST00000092654; ENSMUSP00000090324; ENSMUSG00000100186.
GeneIDi382348.
KEGGimmu:382348.
UCSCiuc007eqp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702338 Genomic DNA. Translation: AAV70147.1.
BC139105 mRNA. Translation: AAI39106.1.
BC139106 mRNA. Translation: AAI39107.1.
CCDSiCCDS23746.1.
RefSeqiNP_001010837.1. NM_001010837.1.
UniGeneiMm.377897.

3D structure databases

ProteinModelPortaliQ5QD06.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090324.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ5QD06.
PRIDEiQ5QD06.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000092654; ENSMUSP00000090324; ENSMUSG00000100186.
GeneIDi382348.
KEGGimmu:382348.
UCSCiuc007eqp.1. mouse.

Organism-specific databases

CTDi382348.
MGIiMGI:2685995. Taar8b.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ5QD06.
KOiK05051.
OMAiAYCNSAI.
OrthoDBiEOG091G0BXO.
PhylomeDBiQ5QD06.
TreeFamiTF343107.

Miscellaneous databases

PROiQ5QD06.
SOURCEiSearch...

Gene expression databases

CleanExiMM_TAAR8B.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAA8B_MOUSE
AccessioniPrimary (citable) accession number: Q5QD06
Secondary accession number(s): B2RT24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 4, 2005
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.