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Protein

Trace amine-associated receptor 9

Gene

Taar9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan olfactory receptor specific for trace amines.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 9
Short name:
TaR-9
Short name:
Trace amine receptor 9
Short name:
mTaar9
Gene namesi
Name:Taar9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:3527454. Taar9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 68CytoplasmicSequence analysisAdd BLAST14
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini90 – 107ExtracellularSequence analysisAdd BLAST18
Transmembranei108 – 128Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini129 – 147CytoplasmicSequence analysisAdd BLAST19
Transmembranei148 – 168Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini169 – 197ExtracellularSequence analysisAdd BLAST29
Transmembranei198 – 218Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini219 – 259CytoplasmicSequence analysisAdd BLAST41
Transmembranei260 – 280Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini281 – 294ExtracellularSequence analysisAdd BLAST14
Transmembranei295 – 315Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini316 – 348CytoplasmicSequence analysisAdd BLAST33

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6, Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and Taar9 show no visible phenotype or behavioral deficits. They however show an absence of aversion to low concentrations of amines such as 2-phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701821 – 348Trace amine-associated receptor 9Add BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi105 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5QD04.
PRIDEiQ5QD04.

PTM databases

PhosphoSitePlusiQ5QD04.

Expressioni

Tissue specificityi

Specifically expressed in neurons of the olfactory epithelium.1 Publication

Gene expression databases

CleanExiMM_TAAR9.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043552.

Structurei

3D structure databases

ProteinModelPortaliQ5QD04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ5QD04.
KOiK05051.
OMAiCIALSWF.
OrthoDBiEOG091G0BXO.
PhylomeDBiQ5QD04.
TreeFamiTF343107.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5QD04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSDFSPEPP MELCYENVNG SCIKSSYAPW PRAILYGVLG LGALLAVFGN
60 70 80 90 100
LLVIIAILHF KQLHTPTNFL VASLACADFL VGVTVMPFST VRSVESCWYF
110 120 130 140 150
GESYCKFHTC FDTSFCFASL FHLCCISIDR YIAVTDPLTY PTKFTVSVSG
160 170 180 190 200
LCIALSWFFS VTYSFSIFYT GANEEGIEEL VVALTCVGGC QAPLNQNWVL
210 220 230 240 250
LCFLLFFLPT VVMVFLYGRI FLVAKYQARK IEGTANQAQA SSESYKERVA
260 270 280 290 300
KRERKAAKTL GIAMAAFLVS WLPYIIDAVI DAYMNFITPA YVYEILVWCV
310 320 330 340
YYNSAMNPLI YAFFYPWFRK AIKLIVSGKV FRADSSTTNL FSEEAGAG
Length:348
Mass (Da):38,901
Last modified:January 4, 2005 - v1
Checksum:i0164AAF9C5474BA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702340 Genomic DNA. Translation: AAV70149.1.
BC139084 mRNA. Translation: AAI39085.1.
BC139085 mRNA. Translation: AAI39086.1.
CCDSiCCDS23748.1.
RefSeqiNP_001010831.1. NM_001010831.1.
UniGeneiMm.300923.

Genome annotation databases

EnsembliENSMUST00000041180; ENSMUSP00000043552; ENSMUSG00000037424.
GeneIDi503558.
KEGGimmu:503558.
UCSCiuc007eqr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY702340 Genomic DNA. Translation: AAV70149.1.
BC139084 mRNA. Translation: AAI39085.1.
BC139085 mRNA. Translation: AAI39086.1.
CCDSiCCDS23748.1.
RefSeqiNP_001010831.1. NM_001010831.1.
UniGeneiMm.300923.

3D structure databases

ProteinModelPortaliQ5QD04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043552.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ5QD04.

Proteomic databases

PaxDbiQ5QD04.
PRIDEiQ5QD04.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041180; ENSMUSP00000043552; ENSMUSG00000037424.
GeneIDi503558.
KEGGimmu:503558.
UCSCiuc007eqr.1. mouse.

Organism-specific databases

CTDi134860.
MGIiMGI:3527454. Taar9.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239243.
HOVERGENiHBG106962.
InParanoidiQ5QD04.
KOiK05051.
OMAiCIALSWF.
OrthoDBiEOG091G0BXO.
PhylomeDBiQ5QD04.
TreeFamiTF343107.

Miscellaneous databases

PROiQ5QD04.
SOURCEiSearch...

Gene expression databases

CleanExiMM_TAAR9.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR009132. TAAR_fam.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAAR9_MOUSE
AccessioniPrimary (citable) accession number: Q5QD04
Secondary accession number(s): B2RT07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 4, 2005
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.