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Q5QD04

- TAAR9_MOUSE

UniProt

Q5QD04 - TAAR9_MOUSE

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Protein
Trace amine-associated receptor 9
Gene
Taar9
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Orphan olfactory receptor specific for trace amines By similarity.

GO - Molecular functioni

  1. trace-amine receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trace amine-associated receptor 9
    Short name:
    TaR-9
    Short name:
    Trace amine receptor 9
    Short name:
    mTaar9
    Gene namesi
    Name:Taar9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:3527454. Taar9.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei34 – 5421Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini55 – 6814Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei69 – 8921Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini90 – 10718Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei108 – 12821Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini129 – 14719Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei148 – 16821Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini169 – 19729Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei198 – 21821Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini219 – 25941Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei260 – 28021Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini281 – 29414Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei295 – 31521Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini316 – 34833Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6, Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and Taar9 show no visible phenotype or behavioral deficits. They however show an absence of aversion to low concentrations of amines such as 2-phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 348348Trace amine-associated receptor 9
    PRO_0000070182Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi19 – 191N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi105 ↔ 190 By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ5QD04.

    Expressioni

    Tissue specificityi

    Specifically expressed in neurons of the olfactory epithelium.1 Publication

    Gene expression databases

    CleanExiMM_TAAR9.
    GenevestigatoriQ5QD04.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5QD04.
    SMRiQ5QD04. Positions 8-329.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG262944.
    GeneTreeiENSGT00750000117380.
    HOGENOMiHOG000239243.
    HOVERGENiHBG106962.
    InParanoidiB2RT07.
    KOiK05051.
    OMAiCIALSWF.
    OrthoDBiEOG7966GS.
    PhylomeDBiQ5QD04.
    TreeFamiTF343107.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR009132. TAAR_fam.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01830. TRACEAMINER.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5QD04-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSDFSPEPP MELCYENVNG SCIKSSYAPW PRAILYGVLG LGALLAVFGN    50
    LLVIIAILHF KQLHTPTNFL VASLACADFL VGVTVMPFST VRSVESCWYF 100
    GESYCKFHTC FDTSFCFASL FHLCCISIDR YIAVTDPLTY PTKFTVSVSG 150
    LCIALSWFFS VTYSFSIFYT GANEEGIEEL VVALTCVGGC QAPLNQNWVL 200
    LCFLLFFLPT VVMVFLYGRI FLVAKYQARK IEGTANQAQA SSESYKERVA 250
    KRERKAAKTL GIAMAAFLVS WLPYIIDAVI DAYMNFITPA YVYEILVWCV 300
    YYNSAMNPLI YAFFYPWFRK AIKLIVSGKV FRADSSTTNL FSEEAGAG 348
    Length:348
    Mass (Da):38,901
    Last modified:January 4, 2005 - v1
    Checksum:i0164AAF9C5474BA8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY702340 Genomic DNA. Translation: AAV70149.1.
    BC139084 mRNA. Translation: AAI39085.1.
    BC139085 mRNA. Translation: AAI39086.1.
    CCDSiCCDS23748.1.
    RefSeqiNP_001010831.1. NM_001010831.1.
    UniGeneiMm.300923.

    Genome annotation databases

    EnsembliENSMUST00000041180; ENSMUSP00000043552; ENSMUSG00000037424.
    GeneIDi503558.
    KEGGimmu:503558.
    UCSCiuc007eqr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY702340 Genomic DNA. Translation: AAV70149.1 .
    BC139084 mRNA. Translation: AAI39085.1 .
    BC139085 mRNA. Translation: AAI39086.1 .
    CCDSi CCDS23748.1.
    RefSeqi NP_001010831.1. NM_001010831.1.
    UniGenei Mm.300923.

    3D structure databases

    ProteinModelPortali Q5QD04.
    SMRi Q5QD04. Positions 8-329.
    ModBasei Search...

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi Q5QD04.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041180 ; ENSMUSP00000043552 ; ENSMUSG00000037424 .
    GeneIDi 503558.
    KEGGi mmu:503558.
    UCSCi uc007eqr.1. mouse.

    Organism-specific databases

    CTDi 134860.
    MGIi MGI:3527454. Taar9.

    Phylogenomic databases

    eggNOGi NOG262944.
    GeneTreei ENSGT00750000117380.
    HOGENOMi HOG000239243.
    HOVERGENi HBG106962.
    InParanoidi B2RT07.
    KOi K05051.
    OMAi CIALSWF.
    OrthoDBi EOG7966GS.
    PhylomeDBi Q5QD04.
    TreeFami TF343107.

    Miscellaneous databases

    NextBioi 411844.
    PROi Q5QD04.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_TAAR9.
    Genevestigatori Q5QD04.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR009132. TAAR_fam.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01830. TRACEAMINER.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors."
      Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K., Hoener M.C.
      Genomics 85:372-385(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "A second class of chemosensory receptors in the olfactory epithelium."
      Liberles S.D., Buck L.B.
      Nature 442:645-650(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    4. "Non-redundant coding of aversive odours in the main olfactory pathway."
      Dewan A., Pacifico R., Zhan R., Rinberg D., Bozza T.
      Nature 497:486-489(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiTAAR9_MOUSE
    AccessioniPrimary (citable) accession number: Q5QD04
    Secondary accession number(s): B2RT07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: January 4, 2005
    Last modified: July 9, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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