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Protein

Meteorin

Gene

Metrn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Meteorin
Alternative name(s):
Hypoxia/reoxygenation regulatory factor
Gene namesi
Name:Metrn
Synonyms:Hyrac
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1306222. Metrn.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 291270MeteorinPRO_0000289103Add
BLAST

Post-translational modificationi

Contains five disulfide bridges.By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ5Q0T9.
PRIDEiQ5Q0T9.

Expressioni

Gene expression databases

GenevisibleiQ5Q0T9. RN.

Interactioni

Subunit structurei

Monomer.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the meteorin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKV7. Eukaryota.
ENOG4111FCI. LUCA.
GeneTreeiENSGT00390000001390.
HOGENOMiHOG000236301.
HOVERGENiHBG052461.
InParanoidiQ5Q0T9.
OMAiIEWLYPA.
OrthoDBiEOG77DJ6J.
PhylomeDBiQ5Q0T9.
TreeFamiTF330918.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5Q0T9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVAALLCAL CCGLLAASAR AGYSEDRCSW RGSGLTQEPG SVGQLTLDCT
60 70 80 90 100
EGAIEWLYPA GALRLTLGGS DPGTRPSIVC LRPTRPFAGA QVFAERMAGN
110 120 130 140 150
LELLLAEGQG LAGGRCMRWG PRERRALFLQ ATPHRDISRR VAAFQFELHE
160 170 180 190 200
DQRAEMSPQA QGFGVDGACR PCSDAELLLT ACTSDFVIHG TIHGVVHDME
210 220 230 240 250
LQESVITVVA TRVIRQTLPL FQEGSSEGRG QASVRTLLRC GVRPGPGSFL
260 270 280 290
FMGWSRFGEA WLGCAPRFQE FSRVYSAALA AHLNPCEVAL D
Length:291
Mass (Da):31,353
Last modified:January 4, 2005 - v1
Checksum:iE50F49FFB5824A11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY800384 mRNA. Translation: AAV74418.1.
RefSeqiNP_001009962.1. NM_001009962.1.
UniGeneiRn.50391.

Genome annotation databases

EnsembliENSRNOT00000026676; ENSRNOP00000026676; ENSRNOG00000019692.
GeneIDi287151.
KEGGirno:287151.
UCSCiRGD:1306222. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY800384 mRNA. Translation: AAV74418.1.
RefSeqiNP_001009962.1. NM_001009962.1.
UniGeneiRn.50391.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ5Q0T9.
PRIDEiQ5Q0T9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026676; ENSRNOP00000026676; ENSRNOG00000019692.
GeneIDi287151.
KEGGirno:287151.
UCSCiRGD:1306222. rat.

Organism-specific databases

CTDi79006.
RGDi1306222. Metrn.

Phylogenomic databases

eggNOGiENOG410IKV7. Eukaryota.
ENOG4111FCI. LUCA.
GeneTreeiENSGT00390000001390.
HOGENOMiHOG000236301.
HOVERGENiHBG052461.
InParanoidiQ5Q0T9.
OMAiIEWLYPA.
OrthoDBiEOG77DJ6J.
PhylomeDBiQ5Q0T9.
TreeFamiTF330918.

Miscellaneous databases

NextBioi625627.
PROiQ5Q0T9.

Gene expression databases

GenevisibleiQ5Q0T9. RN.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. Park J.A., Song H.S., Kim K.-W.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiMETRN_RAT
AccessioniPrimary (citable) accession number: Q5Q0T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 4, 2005
Last modified: November 11, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.