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Protein

Meteorin

Gene

Metrn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Meteorin
Alternative name(s):
Hypoxia/reoxygenation regulatory factor
Gene namesi
Name:Metrn
Synonyms:Hyrac
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1306222 Metrn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000028910322 – 291MeteorinAdd BLAST270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 49PROSITE-ProRule annotation
Disulfide bondi80 ↔ 116PROSITE-ProRule annotation
Disulfide bondi169 ↔ 240PROSITE-ProRule annotation
Disulfide bondi172 ↔ 264PROSITE-ProRule annotation
Disulfide bondi182 ↔ 286PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ5Q0T9
PRIDEiQ5Q0T9

Expressioni

Gene expression databases

BgeeiENSRNOG00000019692
GenevisibleiQ5Q0T9 RN

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026676

Structurei

3D structure databases

SMRiQ5Q0T9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the meteorin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKV7 Eukaryota
ENOG4111FCI LUCA
GeneTreeiENSGT00390000001390
HOGENOMiHOG000236301
HOVERGENiHBG052461
InParanoidiQ5Q0T9
OMAiYSEDQCS
OrthoDBiEOG091G0FAE
PhylomeDBiQ5Q0T9
TreeFamiTF330918

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5Q0T9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVAALLCAL CCGLLAASAR AGYSEDRCSW RGSGLTQEPG SVGQLTLDCT
60 70 80 90 100
EGAIEWLYPA GALRLTLGGS DPGTRPSIVC LRPTRPFAGA QVFAERMAGN
110 120 130 140 150
LELLLAEGQG LAGGRCMRWG PRERRALFLQ ATPHRDISRR VAAFQFELHE
160 170 180 190 200
DQRAEMSPQA QGFGVDGACR PCSDAELLLT ACTSDFVIHG TIHGVVHDME
210 220 230 240 250
LQESVITVVA TRVIRQTLPL FQEGSSEGRG QASVRTLLRC GVRPGPGSFL
260 270 280 290
FMGWSRFGEA WLGCAPRFQE FSRVYSAALA AHLNPCEVAL D
Length:291
Mass (Da):31,353
Last modified:January 4, 2005 - v1
Checksum:iE50F49FFB5824A11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY800384 mRNA Translation: AAV74418.1
RefSeqiNP_001009962.1, NM_001009962.1
UniGeneiRn.50391

Genome annotation databases

EnsembliENSRNOT00000026676; ENSRNOP00000026676; ENSRNOG00000019692
GeneIDi287151
KEGGirno:287151
UCSCiRGD:1306222 rat

Similar proteinsi

Entry informationi

Entry nameiMETRN_RAT
AccessioniPrimary (citable) accession number: Q5Q0T9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 4, 2005
Last modified: March 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health