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Protein

Inositol-pentakisphosphate 2-kinase

Gene

Ippk

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.1 Publication

Catalytic activityi

ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.158. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-pentakisphosphate 2-kinase (EC:2.7.1.158)
Alternative name(s):
Inositol-1,3,4,5,6-pentakisphosphate 2-kinase
Ins(1,3,4,5,6)P5 2-kinase
Short name:
InsP5 2-kinase
Short name:
rIPK1
Gene namesi
Name:Ippk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1311271. Ippk.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001105311 – 489Inositol-pentakisphosphate 2-kinaseAdd BLAST489

Proteomic databases

PaxDbiQ5PXE9.
PRIDEiQ5PXE9.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021022.

Structurei

3D structure databases

SMRiQ5PXE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi136 – 140EXKPK motif5

Domaini

The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

Sequence similaritiesi

Belongs to the IPK1 type 2 family.Curated

Phylogenomic databases

eggNOGiKOG4749. Eukaryota.
ENOG410XSF2. LUCA.
HOGENOMiHOG000113092.
HOVERGENiHBG079461.
InParanoidiQ5PXE9.
KOiK10572.
PhylomeDBiQ5PXE9.

Family and domain databases

InterProiView protein in InterPro
IPR009286. Ins_P5_2-kin.
PANTHERiPTHR14456. PTHR14456. 1 hit.
PfamiView protein in Pfam
PF06090. Ins_P5_2-kin. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5PXE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEGKMDENE WSYHGEGNKS LVVAHAQRCV VLRFLKFPPN KKKTSEEILQ
60 70 80 90 100
HLQNIVDFGK NVMKDFLGEN YVHCGEVVQL PLEFVKQLCL KIQCERPESR
110 120 130 140 150
CDKDLDTLSG YAMCLPNLTR LQTFPFAEHR PILCVEIKPK CGFIPFSNGV
160 170 180 190 200
THEMKHKVCR YCMHQHLKVA TGKWKKISKY CPLDLYSGNK QRMHFALKSL
210 220 230 240 250
LQEAQNNLRI FKNGELIYGC ADARSPVADL KALAHHLKPF FFPSNGLASG
260 270 280 290 300
PQCTRAVIRE LVHVITRVLL STSDKGRAGA LRLGLQGARV CEASPFSRSL
310 320 330 340 350
HHQGKNTPEH SGLPKGCLLY KTLQVQMLDQ LDIEGLYPLY NRVEQYLEEF
360 370 380 390 400
PEERKTLQID GPYDEVFYQK LLDLSTEDDG TVAFALTKVQ QYRVAMTAKD
410 420 430 440 450
CSIMIALSPC LQGASSDQRP VIPSSRSRLA FSVSVLDLDL KPYESIPHQY
460 470 480
KLDSKIVSYY SKTVHAKDDT VRSTRFKEHE DCTLVLHKV
Length:489
Mass (Da):55,634
Last modified:January 4, 2005 - v1
Checksum:i4C710CBA57BFA215
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY823319 mRNA. Translation: AAV76010.1.
RefSeqiNP_001008556.1. NM_001008556.1.
UniGeneiRn.211702.
Rn.73677.

Genome annotation databases

GeneIDi306808.
KEGGirno:306808.

Similar proteinsi

Entry informationi

Entry nameiIPPK_RAT
AccessioniPrimary (citable) accession number: Q5PXE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: January 4, 2005
Last modified: November 22, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families