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Protein

Inositol-pentakisphosphate 2-kinase

Gene

Ippk

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.1 Publication

Catalytic activityi

ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.158. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-pentakisphosphate 2-kinase (EC:2.7.1.158)
Alternative name(s):
Inositol-1,3,4,5,6-pentakisphosphate 2-kinase
Ins(1,3,4,5,6)P5 2-kinase
Short name:
InsP5 2-kinase
Short name:
rIPK1
Gene namesi
Name:Ippk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1311271. Ippk.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489Inositol-pentakisphosphate 2-kinasePRO_0000110531Add
BLAST

Proteomic databases

PaxDbiQ5PXE9.
PRIDEiQ5PXE9.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021022.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi136 – 1405EXKPK motif

Domaini

The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

Sequence similaritiesi

Belongs to the IPK1 type 2 family.Curated

Phylogenomic databases

eggNOGiKOG4749. Eukaryota.
ENOG410XSF2. LUCA.
HOGENOMiHOG000113092.
HOVERGENiHBG079461.
InParanoidiQ5PXE9.
KOiK10572.
PhylomeDBiQ5PXE9.

Family and domain databases

InterProiIPR009286. Ins_P5_2-kin.
[Graphical view]
PANTHERiPTHR14456. PTHR14456. 2 hits.
PfamiPF06090. Ins_P5_2-kin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PXE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEGKMDENE WSYHGEGNKS LVVAHAQRCV VLRFLKFPPN KKKTSEEILQ
60 70 80 90 100
HLQNIVDFGK NVMKDFLGEN YVHCGEVVQL PLEFVKQLCL KIQCERPESR
110 120 130 140 150
CDKDLDTLSG YAMCLPNLTR LQTFPFAEHR PILCVEIKPK CGFIPFSNGV
160 170 180 190 200
THEMKHKVCR YCMHQHLKVA TGKWKKISKY CPLDLYSGNK QRMHFALKSL
210 220 230 240 250
LQEAQNNLRI FKNGELIYGC ADARSPVADL KALAHHLKPF FFPSNGLASG
260 270 280 290 300
PQCTRAVIRE LVHVITRVLL STSDKGRAGA LRLGLQGARV CEASPFSRSL
310 320 330 340 350
HHQGKNTPEH SGLPKGCLLY KTLQVQMLDQ LDIEGLYPLY NRVEQYLEEF
360 370 380 390 400
PEERKTLQID GPYDEVFYQK LLDLSTEDDG TVAFALTKVQ QYRVAMTAKD
410 420 430 440 450
CSIMIALSPC LQGASSDQRP VIPSSRSRLA FSVSVLDLDL KPYESIPHQY
460 470 480
KLDSKIVSYY SKTVHAKDDT VRSTRFKEHE DCTLVLHKV
Length:489
Mass (Da):55,634
Last modified:January 4, 2005 - v1
Checksum:i4C710CBA57BFA215
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY823319 mRNA. Translation: AAV76010.1.
RefSeqiNP_001008556.1. NM_001008556.1.
UniGeneiRn.211702.
Rn.73677.

Genome annotation databases

GeneIDi306808.
KEGGirno:306808.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY823319 mRNA. Translation: AAV76010.1.
RefSeqiNP_001008556.1. NM_001008556.1.
UniGeneiRn.211702.
Rn.73677.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021022.

Proteomic databases

PaxDbiQ5PXE9.
PRIDEiQ5PXE9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi306808.
KEGGirno:306808.

Organism-specific databases

CTDi64768.
RGDi1311271. Ippk.

Phylogenomic databases

eggNOGiKOG4749. Eukaryota.
ENOG410XSF2. LUCA.
HOGENOMiHOG000113092.
HOVERGENiHBG079461.
InParanoidiQ5PXE9.
KOiK10572.
PhylomeDBiQ5PXE9.

Enzyme and pathway databases

BRENDAi2.7.1.158. 5301.

Miscellaneous databases

PROiQ5PXE9.

Family and domain databases

InterProiIPR009286. Ins_P5_2-kin.
[Graphical view]
PANTHERiPTHR14456. PTHR14456. 2 hits.
PfamiPF06090. Ins_P5_2-kin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIPPK_RAT
AccessioniPrimary (citable) accession number: Q5PXE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: January 4, 2005
Last modified: September 7, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.