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Protein

Sodium/bile acid cotransporter 5

Gene

SLC10A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. bile acid:sodium symporter activity Source: GO_Central

GO - Biological processi

  1. bile acid and bile salt transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Protein family/group databases

TCDBi2.A.28.1.6. the bile acid:na(+) symporter (bass) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/bile acid cotransporter 5
Alternative name(s):
Na(+)/bile acid cotransporter 5
Solute carrier family 10 member 5
Gene namesi
Name:SLC10A5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:22981. SLC10A5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 142123ExtracellularSequence AnalysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence AnalysisAdd
BLAST
Topological domaini164 – 17411CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei175 – 19521HelicalSequence AnalysisAdd
BLAST
Topological domaini196 – 20611ExtracellularSequence AnalysisAdd
BLAST
Transmembranei207 – 22721HelicalSequence AnalysisAdd
BLAST
Topological domaini228 – 2314CytoplasmicSequence Analysis
Transmembranei232 – 25221HelicalSequence AnalysisAdd
BLAST
Topological domaini253 – 27018ExtracellularSequence AnalysisAdd
BLAST
Transmembranei271 – 29121HelicalSequence AnalysisAdd
BLAST
Topological domaini292 – 30817CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei309 – 32921HelicalSequence AnalysisAdd
BLAST
Topological domaini330 – 3334ExtracellularSequence Analysis
Transmembranei334 – 35421HelicalSequence AnalysisAdd
BLAST
Topological domaini355 – 36713CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei368 – 38821HelicalSequence AnalysisAdd
BLAST
Topological domaini389 – 3979ExtracellularSequence Analysis
Transmembranei398 – 41821HelicalSequence AnalysisAdd
BLAST
Topological domaini419 – 43820CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134933839.

Polymorphism and mutation databases

BioMutaiSLC10A5.
DMDMi74708105.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 438419Sodium/bile acid cotransporter 5PRO_0000263745Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5PT55.
PeptideAtlasiQ5PT55.
PRIDEiQ5PT55.

PTM databases

PhosphoSiteiQ5PT55.

Expressioni

Gene expression databases

BgeeiQ5PT55.
CleanExiHS_SLC10A5.
GenevestigatoriQ5PT55.

Organism-specific databases

HPAiHPA025966.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000368353.

Structurei

3D structure databases

ProteinModelPortaliQ5PT55.
SMRiQ5PT55. Positions 146-420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0385.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000037944.
HOVERGENiHBG002872.
InParanoidiQ5PT55.
KOiK14343.
OMAiCAFGCKI.
OrthoDBiEOG70ZZNM.
PhylomeDBiQ5PT55.
TreeFamiTF315811.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
IPR030209. SLC10A5.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PTHR10361:SF29. PTHR10361:SF29. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5PT55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRKLFIVLL LLLVTIEEAR MSSLSFLNIE KTEILFFTKT EETILVSSSY
60 70 80 90 100
ENKRPNSSHL FVKIEDPKIL QMVNVAKKIS SDATNFTINL VTDEEGETNV
110 120 130 140 150
TIQLWDSEGR QERLIEEIKN VKVKVLKQKD SLLQAPMHID RNILMLILPL
160 170 180 190 200
ILLNKCAFGC KIELQLFQTV WKRPLPVILG AVTQFFLMPF CGFLLSQIVA
210 220 230 240 250
LPEAQAFGVV MTCTCPGGGG GYLFALLLDG DFTLAILMTC TSTLLALIMM
260 270 280 290 300
PVNSYIYSRI LGLSGTFHIP VSKIVSTLLF ILVPVSIGIV IKHRIPEKAS
310 320 330 340 350
FLERIIRPLS FILMFVGIYL TFTVGLVFLK TDNLEVILLG LLVPALGLLF
360 370 380 390 400
GYSFAKVCTL PLPVCKTVAI ESGMLNSFLA LAVIQLSFPQ SKANLASVAP
410 420 430
FTVAMCSGCE MLLIILVYKA KKRCIFFLQD KRKRNFLI
Length:438
Mass (Da):48,871
Last modified:January 4, 2005 - v1
Checksum:iC275CD022408DAF3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti287 – 2871I → T.
Corresponds to variant rs7012758 [ dbSNP | Ensembl ].
VAR_050230

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY825924 mRNA. Translation: AAV80707.1.
AK095808 mRNA. Translation: BAG53134.1.
BC136625 mRNA. Translation: AAI36626.1.
BC136631 mRNA. Translation: AAI36632.1.
CCDSiCCDS34915.1.
RefSeqiNP_001010893.1. NM_001010893.2.
UniGeneiHs.683849.

Genome annotation databases

EnsembliENST00000518568; ENSP00000428612; ENSG00000253598.
GeneIDi347051.
KEGGihsa:347051.
UCSCiuc011lfs.2. human.

Polymorphism and mutation databases

BioMutaiSLC10A5.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY825924 mRNA. Translation: AAV80707.1.
AK095808 mRNA. Translation: BAG53134.1.
BC136625 mRNA. Translation: AAI36626.1.
BC136631 mRNA. Translation: AAI36632.1.
CCDSiCCDS34915.1.
RefSeqiNP_001010893.1. NM_001010893.2.
UniGeneiHs.683849.

3D structure databases

ProteinModelPortaliQ5PT55.
SMRiQ5PT55. Positions 146-420.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000368353.

Protein family/group databases

TCDBi2.A.28.1.6. the bile acid:na(+) symporter (bass) family.

PTM databases

PhosphoSiteiQ5PT55.

Polymorphism and mutation databases

BioMutaiSLC10A5.
DMDMi74708105.

Proteomic databases

PaxDbiQ5PT55.
PeptideAtlasiQ5PT55.
PRIDEiQ5PT55.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000518568; ENSP00000428612; ENSG00000253598.
GeneIDi347051.
KEGGihsa:347051.
UCSCiuc011lfs.2. human.

Organism-specific databases

CTDi347051.
GeneCardsiGC08M082605.
HGNCiHGNC:22981. SLC10A5.
HPAiHPA025966.
neXtProtiNX_Q5PT55.
PharmGKBiPA134933839.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0385.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000037944.
HOVERGENiHBG002872.
InParanoidiQ5PT55.
KOiK14343.
OMAiCAFGCKI.
OrthoDBiEOG70ZZNM.
PhylomeDBiQ5PT55.
TreeFamiTF315811.

Miscellaneous databases

GenomeRNAii347051.
NextBioi99030.
PROiQ5PT55.

Gene expression databases

BgeeiQ5PT55.
CleanExiHS_SLC10A5.
GenevestigatoriQ5PT55.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
IPR030209. SLC10A5.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PTHR10361:SF29. PTHR10361:SF29. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Geyer J., Fernandes C., Petzinger E.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiNTCP5_HUMAN
AccessioniPrimary (citable) accession number: Q5PT55
Secondary accession number(s): B2RN26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 4, 2005
Last modified: April 29, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.