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Q5PT55 (NTCP5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium/bile acid cotransporter 5
Alternative name(s):
Na(+)/bile acid cotransporter 5
Solute carrier family 10 member 5
Gene names
Name:SLC10A5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length438 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. [View classification]

Ontologies

Keywords
   Biological processIon transport
Sodium transport
Symport
Transport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   LigandSodium
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbile acid:sodium symporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 438419Sodium/bile acid cotransporter 5
PRO_0000263745

Regions

Topological domain20 – 142123Extracellular Potential
Transmembrane143 – 16321Helical; Potential
Topological domain164 – 17411Cytoplasmic Potential
Transmembrane175 – 19521Helical; Potential
Topological domain196 – 20611Extracellular Potential
Transmembrane207 – 22721Helical; Potential
Topological domain228 – 2314Cytoplasmic Potential
Transmembrane232 – 25221Helical; Potential
Topological domain253 – 27018Extracellular Potential
Transmembrane271 – 29121Helical; Potential
Topological domain292 – 30817Cytoplasmic Potential
Transmembrane309 – 32921Helical; Potential
Topological domain330 – 3334Extracellular Potential
Transmembrane334 – 35421Helical; Potential
Topological domain355 – 36713Cytoplasmic Potential
Transmembrane368 – 38821Helical; Potential
Topological domain389 – 3979Extracellular Potential
Transmembrane398 – 41821Helical; Potential
Topological domain419 – 43820Cytoplasmic Potential

Amino acid modifications

Glycosylation561N-linked (GlcNAc...) Potential
Glycosylation851N-linked (GlcNAc...) Potential
Glycosylation991N-linked (GlcNAc...) Potential

Natural variations

Natural variant2871I → T.
Corresponds to variant rs7012758 [ dbSNP | Ensembl ].
VAR_050230

Sequences

Sequence LengthMass (Da)Tools
Q5PT55 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: C275CD022408DAF3

FASTA43848,871
        10         20         30         40         50         60 
MIRKLFIVLL LLLVTIEEAR MSSLSFLNIE KTEILFFTKT EETILVSSSY ENKRPNSSHL 

        70         80         90        100        110        120 
FVKIEDPKIL QMVNVAKKIS SDATNFTINL VTDEEGETNV TIQLWDSEGR QERLIEEIKN 

       130        140        150        160        170        180 
VKVKVLKQKD SLLQAPMHID RNILMLILPL ILLNKCAFGC KIELQLFQTV WKRPLPVILG 

       190        200        210        220        230        240 
AVTQFFLMPF CGFLLSQIVA LPEAQAFGVV MTCTCPGGGG GYLFALLLDG DFTLAILMTC 

       250        260        270        280        290        300 
TSTLLALIMM PVNSYIYSRI LGLSGTFHIP VSKIVSTLLF ILVPVSIGIV IKHRIPEKAS 

       310        320        330        340        350        360 
FLERIIRPLS FILMFVGIYL TFTVGLVFLK TDNLEVILLG LLVPALGLLF GYSFAKVCTL 

       370        380        390        400        410        420 
PLPVCKTVAI ESGMLNSFLA LAVIQLSFPQ SKANLASVAP FTVAMCSGCE MLLIILVYKA 

       430 
KKRCIFFLQD KRKRNFLI 

« Hide

References

« Hide 'large scale' references
[1]Geyer J., Fernandes C., Petzinger E.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY825924 mRNA. Translation: AAV80707.1.
AK095808 mRNA. Translation: BAG53134.1.
BC136625 mRNA. Translation: AAI36626.1.
BC136631 mRNA. Translation: AAI36632.1.
CCDSCCDS34915.1.
RefSeqNP_001010893.1. NM_001010893.2.
UniGeneHs.683849.

3D structure databases

ProteinModelPortalQ5PT55.
SMRQ5PT55. Positions 145-419.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000368353.

Protein family/group databases

TCDB2.A.28.1.6. the bile acid:na(+) symporter (bass) family.

PTM databases

PhosphoSiteQ5PT55.

Polymorphism databases

DMDM74708105.

Proteomic databases

PaxDbQ5PT55.
PeptideAtlasQ5PT55.
PRIDEQ5PT55.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000518568; ENSP00000428612; ENSG00000253598.
GeneID347051.
KEGGhsa:347051.
UCSCuc011lfs.2. human.

Organism-specific databases

CTD347051.
GeneCardsGC08M082605.
HGNCHGNC:22981. SLC10A5.
HPAHPA025966.
neXtProtNX_Q5PT55.
PharmGKBPA134933839.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0385.
HOGENOMHOG000037944.
HOVERGENHBG002872.
InParanoidQ5PT55.
KOK14343.
OMACAFGCKI.
OrthoDBEOG70ZZNM.
PhylomeDBQ5PT55.
TreeFamTF315811.

Gene expression databases

BgeeQ5PT55.
CleanExHS_SLC10A5.
GenevestigatorQ5PT55.

Family and domain databases

InterProIPR002657. BilAc/Na_symport.
[Graphical view]
PANTHERPTHR10361. PTHR10361. 1 hit.
PfamPF01758. SBF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi347051.
NextBio99030.
PROQ5PT55.

Entry information

Entry nameNTCP5_HUMAN
AccessionPrimary (citable) accession number: Q5PT55
Secondary accession number(s): B2RN26
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 4, 2005
Last modified: July 9, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM