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Q5PT55

- NTCP5_HUMAN

UniProt

Q5PT55 - NTCP5_HUMAN

Protein

Sodium/bile acid cotransporter 5

Gene

SLC10A5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. bile acid:sodium symporter activity Source: InterPro

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Protein family/group databases

    TCDBi2.A.28.1.6. the bile acid:na(+) symporter (bass) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/bile acid cotransporter 5
    Alternative name(s):
    Na(+)/bile acid cotransporter 5
    Solute carrier family 10 member 5
    Gene namesi
    Name:SLC10A5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:22981. SLC10A5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134933839.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 438419Sodium/bile acid cotransporter 5PRO_0000263745Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ5PT55.
    PeptideAtlasiQ5PT55.
    PRIDEiQ5PT55.

    PTM databases

    PhosphoSiteiQ5PT55.

    Expressioni

    Gene expression databases

    BgeeiQ5PT55.
    CleanExiHS_SLC10A5.
    GenevestigatoriQ5PT55.

    Organism-specific databases

    HPAiHPA025966.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000368353.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5PT55.
    SMRiQ5PT55. Positions 145-419.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 142123ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini164 – 17411CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini196 – 20611ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini228 – 2314CytoplasmicSequence Analysis
    Topological domaini253 – 27018ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 30817CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini330 – 3334ExtracellularSequence Analysis
    Topological domaini355 – 36713CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini389 – 3979ExtracellularSequence Analysis
    Topological domaini419 – 43820CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei175 – 19521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei207 – 22721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei232 – 25221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei271 – 29121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei309 – 32921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei334 – 35421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei368 – 38821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei398 – 41821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0385.
    HOGENOMiHOG000037944.
    HOVERGENiHBG002872.
    InParanoidiQ5PT55.
    KOiK14343.
    OMAiCAFGCKI.
    OrthoDBiEOG70ZZNM.
    PhylomeDBiQ5PT55.
    TreeFamiTF315811.

    Family and domain databases

    InterProiIPR002657. BilAc/Na_symport.
    [Graphical view]
    PANTHERiPTHR10361. PTHR10361. 1 hit.
    PfamiPF01758. SBF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5PT55-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIRKLFIVLL LLLVTIEEAR MSSLSFLNIE KTEILFFTKT EETILVSSSY    50
    ENKRPNSSHL FVKIEDPKIL QMVNVAKKIS SDATNFTINL VTDEEGETNV 100
    TIQLWDSEGR QERLIEEIKN VKVKVLKQKD SLLQAPMHID RNILMLILPL 150
    ILLNKCAFGC KIELQLFQTV WKRPLPVILG AVTQFFLMPF CGFLLSQIVA 200
    LPEAQAFGVV MTCTCPGGGG GYLFALLLDG DFTLAILMTC TSTLLALIMM 250
    PVNSYIYSRI LGLSGTFHIP VSKIVSTLLF ILVPVSIGIV IKHRIPEKAS 300
    FLERIIRPLS FILMFVGIYL TFTVGLVFLK TDNLEVILLG LLVPALGLLF 350
    GYSFAKVCTL PLPVCKTVAI ESGMLNSFLA LAVIQLSFPQ SKANLASVAP 400
    FTVAMCSGCE MLLIILVYKA KKRCIFFLQD KRKRNFLI 438
    Length:438
    Mass (Da):48,871
    Last modified:January 4, 2005 - v1
    Checksum:iC275CD022408DAF3
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti287 – 2871I → T.
    Corresponds to variant rs7012758 [ dbSNP | Ensembl ].
    VAR_050230

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY825924 mRNA. Translation: AAV80707.1.
    AK095808 mRNA. Translation: BAG53134.1.
    BC136625 mRNA. Translation: AAI36626.1.
    BC136631 mRNA. Translation: AAI36632.1.
    CCDSiCCDS34915.1.
    RefSeqiNP_001010893.1. NM_001010893.2.
    UniGeneiHs.683849.

    Genome annotation databases

    EnsembliENST00000518568; ENSP00000428612; ENSG00000253598.
    GeneIDi347051.
    KEGGihsa:347051.
    UCSCiuc011lfs.2. human.

    Polymorphism databases

    DMDMi74708105.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY825924 mRNA. Translation: AAV80707.1 .
    AK095808 mRNA. Translation: BAG53134.1 .
    BC136625 mRNA. Translation: AAI36626.1 .
    BC136631 mRNA. Translation: AAI36632.1 .
    CCDSi CCDS34915.1.
    RefSeqi NP_001010893.1. NM_001010893.2.
    UniGenei Hs.683849.

    3D structure databases

    ProteinModelPortali Q5PT55.
    SMRi Q5PT55. Positions 145-419.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000368353.

    Protein family/group databases

    TCDBi 2.A.28.1.6. the bile acid:na(+) symporter (bass) family.

    PTM databases

    PhosphoSitei Q5PT55.

    Polymorphism databases

    DMDMi 74708105.

    Proteomic databases

    PaxDbi Q5PT55.
    PeptideAtlasi Q5PT55.
    PRIDEi Q5PT55.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000518568 ; ENSP00000428612 ; ENSG00000253598 .
    GeneIDi 347051.
    KEGGi hsa:347051.
    UCSCi uc011lfs.2. human.

    Organism-specific databases

    CTDi 347051.
    GeneCardsi GC08M082605.
    HGNCi HGNC:22981. SLC10A5.
    HPAi HPA025966.
    neXtProti NX_Q5PT55.
    PharmGKBi PA134933839.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0385.
    HOGENOMi HOG000037944.
    HOVERGENi HBG002872.
    InParanoidi Q5PT55.
    KOi K14343.
    OMAi CAFGCKI.
    OrthoDBi EOG70ZZNM.
    PhylomeDBi Q5PT55.
    TreeFami TF315811.

    Miscellaneous databases

    GenomeRNAii 347051.
    NextBioi 99030.
    PROi Q5PT55.

    Gene expression databases

    Bgeei Q5PT55.
    CleanExi HS_SLC10A5.
    Genevestigatori Q5PT55.

    Family and domain databases

    InterProi IPR002657. BilAc/Na_symport.
    [Graphical view ]
    PANTHERi PTHR10361. PTHR10361. 1 hit.
    Pfami PF01758. SBF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Geyer J., Fernandes C., Petzinger E.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiNTCP5_HUMAN
    AccessioniPrimary (citable) accession number: Q5PT55
    Secondary accession number(s): B2RN26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3