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Protein

Sodium/bile acid cotransporter 5

Gene

SLC10A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciZFISH:G66-33022-MONOMER.

Protein family/group databases

TCDBi2.A.28.1.6. the bile acid:na(+) symporter (bass) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/bile acid cotransporter 5
Alternative name(s):
Na(+)/bile acid cotransporter 5
Solute carrier family 10 member 5
Gene namesi
Name:SLC10A5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:22981. SLC10A5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 142ExtracellularSequence analysisAdd BLAST123
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 174CytoplasmicSequence analysisAdd BLAST11
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 206ExtracellularSequence analysisAdd BLAST11
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Topological domaini228 – 231CytoplasmicSequence analysis4
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 270ExtracellularSequence analysisAdd BLAST18
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 308CytoplasmicSequence analysisAdd BLAST17
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21
Topological domaini330 – 333ExtracellularSequence analysis4
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Topological domaini355 – 367CytoplasmicSequence analysisAdd BLAST13
Transmembranei368 – 388HelicalSequence analysisAdd BLAST21
Topological domaini389 – 397ExtracellularSequence analysis9
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 438CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000253598.
PharmGKBiPA134933839.

Polymorphism and mutation databases

BioMutaiSLC10A5.
DMDMi74708105.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000026374520 – 438Sodium/bile acid cotransporter 5Add BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...)Sequence analysis1
Glycosylationi85N-linked (GlcNAc...)Sequence analysis1
Glycosylationi99N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ5PT55.
PaxDbiQ5PT55.
PeptideAtlasiQ5PT55.
PRIDEiQ5PT55.

PTM databases

iPTMnetiQ5PT55.
PhosphoSitePlusiQ5PT55.

Expressioni

Gene expression databases

BgeeiENSG00000253598.
CleanExiHS_SLC10A5.

Organism-specific databases

HPAiHPA025966.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000428612.

Structurei

3D structure databases

ProteinModelPortaliQ5PT55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2718. Eukaryota.
COG0385. LUCA.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000037944.
HOVERGENiHBG002872.
InParanoidiQ5PT55.
KOiK14343.
OMAiCAFGCKI.
OrthoDBiEOG091G0HEJ.
PhylomeDBiQ5PT55.
TreeFamiTF315811.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
IPR030209. SLC10A5.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PTHR10361:SF29. PTHR10361:SF29. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5PT55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRKLFIVLL LLLVTIEEAR MSSLSFLNIE KTEILFFTKT EETILVSSSY
60 70 80 90 100
ENKRPNSSHL FVKIEDPKIL QMVNVAKKIS SDATNFTINL VTDEEGETNV
110 120 130 140 150
TIQLWDSEGR QERLIEEIKN VKVKVLKQKD SLLQAPMHID RNILMLILPL
160 170 180 190 200
ILLNKCAFGC KIELQLFQTV WKRPLPVILG AVTQFFLMPF CGFLLSQIVA
210 220 230 240 250
LPEAQAFGVV MTCTCPGGGG GYLFALLLDG DFTLAILMTC TSTLLALIMM
260 270 280 290 300
PVNSYIYSRI LGLSGTFHIP VSKIVSTLLF ILVPVSIGIV IKHRIPEKAS
310 320 330 340 350
FLERIIRPLS FILMFVGIYL TFTVGLVFLK TDNLEVILLG LLVPALGLLF
360 370 380 390 400
GYSFAKVCTL PLPVCKTVAI ESGMLNSFLA LAVIQLSFPQ SKANLASVAP
410 420 430
FTVAMCSGCE MLLIILVYKA KKRCIFFLQD KRKRNFLI
Length:438
Mass (Da):48,871
Last modified:January 4, 2005 - v1
Checksum:iC275CD022408DAF3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050230287I → T.Corresponds to variant rs7012758dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY825924 mRNA. Translation: AAV80707.1.
AK095808 mRNA. Translation: BAG53134.1.
BC136625 mRNA. Translation: AAI36626.1.
BC136631 mRNA. Translation: AAI36632.1.
CCDSiCCDS34915.1.
RefSeqiNP_001010893.1. NM_001010893.2.
UniGeneiHs.683849.

Genome annotation databases

EnsembliENST00000518568; ENSP00000428612; ENSG00000253598.
GeneIDi347051.
KEGGihsa:347051.
UCSCiuc011lfs.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY825924 mRNA. Translation: AAV80707.1.
AK095808 mRNA. Translation: BAG53134.1.
BC136625 mRNA. Translation: AAI36626.1.
BC136631 mRNA. Translation: AAI36632.1.
CCDSiCCDS34915.1.
RefSeqiNP_001010893.1. NM_001010893.2.
UniGeneiHs.683849.

3D structure databases

ProteinModelPortaliQ5PT55.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000428612.

Protein family/group databases

TCDBi2.A.28.1.6. the bile acid:na(+) symporter (bass) family.

PTM databases

iPTMnetiQ5PT55.
PhosphoSitePlusiQ5PT55.

Polymorphism and mutation databases

BioMutaiSLC10A5.
DMDMi74708105.

Proteomic databases

EPDiQ5PT55.
PaxDbiQ5PT55.
PeptideAtlasiQ5PT55.
PRIDEiQ5PT55.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000518568; ENSP00000428612; ENSG00000253598.
GeneIDi347051.
KEGGihsa:347051.
UCSCiuc011lfs.3. human.

Organism-specific databases

CTDi347051.
GeneCardsiSLC10A5.
HGNCiHGNC:22981. SLC10A5.
HPAiHPA025966.
neXtProtiNX_Q5PT55.
OpenTargetsiENSG00000253598.
PharmGKBiPA134933839.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2718. Eukaryota.
COG0385. LUCA.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000037944.
HOVERGENiHBG002872.
InParanoidiQ5PT55.
KOiK14343.
OMAiCAFGCKI.
OrthoDBiEOG091G0HEJ.
PhylomeDBiQ5PT55.
TreeFamiTF315811.

Enzyme and pathway databases

BioCyciZFISH:G66-33022-MONOMER.

Miscellaneous databases

GenomeRNAii347051.
PROiQ5PT55.

Gene expression databases

BgeeiENSG00000253598.
CleanExiHS_SLC10A5.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
IPR030209. SLC10A5.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PTHR10361:SF29. PTHR10361:SF29. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNTCP5_HUMAN
AccessioniPrimary (citable) accession number: Q5PT55
Secondary accession number(s): B2RN26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 4, 2005
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.