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Protein

Beta-lactamase

Gene

blaSHV-1

Organism
Klebsiella pneumoniae
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Antibiotic resistanceUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamaseUniRule annotationSAAS annotation (EC:3.5.2.6UniRule annotationSAAS annotation)
Gene namesi
Name:blaSHV-1Imported
Synonyms:blaCTX-MImported, blaSHVImported, blaSHV-11Imported, blaSHV1Imported, SHVImported, SHV-1Imported, shv-1Imported, SHV-1b-aImported
Encoded oniPlasmid pKP308Imported
Plasmid unnamedImported
OrganismiKlebsiella pneumoniaeImported
Taxonomic identifieri573 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500878149022 – 286Beta-lactamaseSequence analysisAdd BLAST265

Interactioni

Protein-protein interaction databases

STRINGi272620.KPN_01607.

Family & Domainsi

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG4108J4B. Bacteria.
COG2367. LUCA.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PSW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYIRLCIIS LLATLPLAVH ASPQPLEQIK LSESQLSGRV GMIEMDLASG
60 70 80 90 100
RTLTAWRADE RFPMMSTFKV VLCGAVLARV DAGDEQLERK IHYRQQDLVD
110 120 130 140 150
YSPVSEKHLA DGMTVGELCA AAITMSDNSA ANLLLATVGG PAGLTAFLRQ
160 170 180 190 200
IGDNVTRLDR WETELNEALP GDARDTTTPA SMAATLRKLL TSQRLSARSQ
210 220 230 240 250
RQLLQWMVDD RVAGPLIRSV LPAGWFIADK TGAGERGARG IVALLGPNNK
260 270 280
AERIVVIYLR DTPASMAERN QQIAGIGAAL IEHWQR
Length:286
Mass (Da):31,224
Last modified:May 10, 2005 - v1
Checksum:iC78F42667E698E6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY826416 Genomic DNA. Translation: AAV83794.1.
DQ166781 Genomic DNA. Translation: AAZ98826.1.
DQ219474 Genomic DNA. Translation: ABB01159.1.
DQ355784 Genomic DNA. Translation: ABC88472.1.
DQ478720 Genomic DNA. Translation: ABF29674.1.
EF035564 Genomic DNA. Translation: ABM89165.1.
EF035565 Genomic DNA. Translation: ABM89166.1.
EF035566 Genomic DNA. Translation: ABM89167.1.
EF035567 Genomic DNA. Translation: ABM89168.1.
EU280315 Genomic DNA. Translation: ABX76424.1.
EU418908 Genomic DNA. Translation: ACM04454.1.
FJ685657 Genomic DNA. Translation: ACO07069.1.
FJ668799 Genomic DNA. Translation: ACR66308.1.
FJ668800 Genomic DNA. Translation: ACR66309.1.
FJ668804 Genomic DNA. Translation: ACR66313.1.
FJ668811 Genomic DNA. Translation: ACR66320.1.
FJ668813 Genomic DNA. Translation: ACR66322.1.
FJ668814 Genomic DNA. Translation: ACR66323.1.
FJ668818 Genomic DNA. Translation: ACR66327.1.
GQ380692 Genomic DNA. Translation: ACU57153.1.
GQ389701 Genomic DNA. Translation: ACV32617.1.
GQ407112 Genomic DNA. Translation: ACV33199.1.
GQ407113 Genomic DNA. Translation: ACV33200.1.
GQ407119 Genomic DNA. Translation: ACV33206.1.
GQ407121 Genomic DNA. Translation: ACV33208.1.
GQ407122 Genomic DNA. Translation: ACV33209.1.
GQ407123 Genomic DNA. Translation: ACV33210.1.
GQ407127 Genomic DNA. Translation: ACV33214.1.
GQ407128 Genomic DNA. Translation: ACV33215.1.
GQ407129 Genomic DNA. Translation: ACV33216.1.
GQ407131 Genomic DNA. Translation: ACV33218.1.
GQ407132 Genomic DNA. Translation: ACV33219.1.
GQ407133 Genomic DNA. Translation: ACV33220.1.
GQ407136 Genomic DNA. Translation: ACV33223.1.
GQ407137 Genomic DNA. Translation: ACV33224.1.
GQ407138 Genomic DNA. Translation: ACV33225.1.
GQ407140 Genomic DNA. Translation: ACV33227.1.
GQ407142 Genomic DNA. Translation: ACV33229.1.
GQ407144 Genomic DNA. Translation: ACV33231.1.
GQ407145 Genomic DNA. Translation: ACV33232.1.
GU083598 Genomic DNA. Translation: ACY35991.1.
GU083599 Genomic DNA. Translation: ACY35992.1.
GU064389 Genomic DNA. Translation: ACY68236.1.
HM751097 Genomic DNA. Translation: ADR80603.1.
HM751099 Genomic DNA. Translation: ADR80605.1.
HM751102 Genomic DNA. Translation: ADR80608.1.
JX268740 Genomic DNA. Translation: AFN82169.1.
KF585134 Genomic DNA. Translation: AHB36952.1.
RefSeqiWP_001620095.1. NZ_LZCT01000013.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY826416 Genomic DNA. Translation: AAV83794.1.
DQ166781 Genomic DNA. Translation: AAZ98826.1.
DQ219474 Genomic DNA. Translation: ABB01159.1.
DQ355784 Genomic DNA. Translation: ABC88472.1.
DQ478720 Genomic DNA. Translation: ABF29674.1.
EF035564 Genomic DNA. Translation: ABM89165.1.
EF035565 Genomic DNA. Translation: ABM89166.1.
EF035566 Genomic DNA. Translation: ABM89167.1.
EF035567 Genomic DNA. Translation: ABM89168.1.
EU280315 Genomic DNA. Translation: ABX76424.1.
EU418908 Genomic DNA. Translation: ACM04454.1.
FJ685657 Genomic DNA. Translation: ACO07069.1.
FJ668799 Genomic DNA. Translation: ACR66308.1.
FJ668800 Genomic DNA. Translation: ACR66309.1.
FJ668804 Genomic DNA. Translation: ACR66313.1.
FJ668811 Genomic DNA. Translation: ACR66320.1.
FJ668813 Genomic DNA. Translation: ACR66322.1.
FJ668814 Genomic DNA. Translation: ACR66323.1.
FJ668818 Genomic DNA. Translation: ACR66327.1.
GQ380692 Genomic DNA. Translation: ACU57153.1.
GQ389701 Genomic DNA. Translation: ACV32617.1.
GQ407112 Genomic DNA. Translation: ACV33199.1.
GQ407113 Genomic DNA. Translation: ACV33200.1.
GQ407119 Genomic DNA. Translation: ACV33206.1.
GQ407121 Genomic DNA. Translation: ACV33208.1.
GQ407122 Genomic DNA. Translation: ACV33209.1.
GQ407123 Genomic DNA. Translation: ACV33210.1.
GQ407127 Genomic DNA. Translation: ACV33214.1.
GQ407128 Genomic DNA. Translation: ACV33215.1.
GQ407129 Genomic DNA. Translation: ACV33216.1.
GQ407131 Genomic DNA. Translation: ACV33218.1.
GQ407132 Genomic DNA. Translation: ACV33219.1.
GQ407133 Genomic DNA. Translation: ACV33220.1.
GQ407136 Genomic DNA. Translation: ACV33223.1.
GQ407137 Genomic DNA. Translation: ACV33224.1.
GQ407138 Genomic DNA. Translation: ACV33225.1.
GQ407140 Genomic DNA. Translation: ACV33227.1.
GQ407142 Genomic DNA. Translation: ACV33229.1.
GQ407144 Genomic DNA. Translation: ACV33231.1.
GQ407145 Genomic DNA. Translation: ACV33232.1.
GU083598 Genomic DNA. Translation: ACY35991.1.
GU083599 Genomic DNA. Translation: ACY35992.1.
GU064389 Genomic DNA. Translation: ACY68236.1.
HM751097 Genomic DNA. Translation: ADR80603.1.
HM751099 Genomic DNA. Translation: ADR80605.1.
HM751102 Genomic DNA. Translation: ADR80608.1.
JX268740 Genomic DNA. Translation: AFN82169.1.
KF585134 Genomic DNA. Translation: AHB36952.1.
RefSeqiWP_001620095.1. NZ_LZCT01000013.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272620.KPN_01607.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4108J4B. Bacteria.
COG2367. LUCA.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5PSW7_KLEPN
AccessioniPrimary (citable) accession number: Q5PSW7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 30, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

PlasmidImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.