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Protein

Beta-lactamase

Gene

blaSHV-1

Organism
Klebsiella pneumoniae
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Antibiotic resistanceUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamaseUniRule annotationSAAS annotation (EC:3.5.2.6UniRule annotationSAAS annotation)
Gene namesi
Name:blaSHV-1Imported
Synonyms:bla_1Imported, blaCTX-MImported, blaSHVImported, blaSHV-11Imported, blaSHV1Imported, SHVImported, SHV-1Imported, shv-1Imported, SHV-1b-aImported
ORF Names:KPOL2_02800Imported
Encoded oniPlasmid pKP308Imported
Plasmid unnamedImported
OrganismiKlebsiella pneumoniaeImported
Taxonomic identifieri573 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

Interactioni

Protein-protein interaction databases

STRINGi272620.KPN_01607.

Structurei

3D structure databases

ProteinModelPortaliQ5PSW7.
SMRiQ5PSW7. Positions 22-286.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.UniRule annotation

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PSW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYIRLCIIS LLATLPLAVH ASPQPLEQIK LSESQLSGRV GMIEMDLASG
60 70 80 90 100
RTLTAWRADE RFPMMSTFKV VLCGAVLARV DAGDEQLERK IHYRQQDLVD
110 120 130 140 150
YSPVSEKHLA DGMTVGELCA AAITMSDNSA ANLLLATVGG PAGLTAFLRQ
160 170 180 190 200
IGDNVTRLDR WETELNEALP GDARDTTTPA SMAATLRKLL TSQRLSARSQ
210 220 230 240 250
RQLLQWMVDD RVAGPLIRSV LPAGWFIADK TGAGERGARG IVALLGPNNK
260 270 280
AERIVVIYLR DTPASMAERN QQIAGIGAAL IEHWQR
Length:286
Mass (Da):31,224
Last modified:May 10, 2005 - v1
Checksum:iC78F42667E698E6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY826416 Genomic DNA. Translation: AAV83794.1.
DQ166781 Genomic DNA. Translation: AAZ98826.1.
DQ219474 Genomic DNA. Translation: ABB01159.1.
DQ355784 Genomic DNA. Translation: ABC88472.1.
DQ478720 Genomic DNA. Translation: ABF29674.1.
EF035564 Genomic DNA. Translation: ABM89165.1.
EF035565 Genomic DNA. Translation: ABM89166.1.
EF035566 Genomic DNA. Translation: ABM89167.1.
EF035567 Genomic DNA. Translation: ABM89168.1.
EU280315 Genomic DNA. Translation: ABX76424.1.
EU418908 Genomic DNA. Translation: ACM04454.1.
FJ685657 Genomic DNA. Translation: ACO07069.1.
FJ668799 Genomic DNA. Translation: ACR66308.1.
FJ668800 Genomic DNA. Translation: ACR66309.1.
FJ668804 Genomic DNA. Translation: ACR66313.1.
FJ668811 Genomic DNA. Translation: ACR66320.1.
FJ668813 Genomic DNA. Translation: ACR66322.1.
FJ668814 Genomic DNA. Translation: ACR66323.1.
FJ668818 Genomic DNA. Translation: ACR66327.1.
GQ380692 Genomic DNA. Translation: ACU57153.1.
GQ389701 Genomic DNA. Translation: ACV32617.1.
GQ407112 Genomic DNA. Translation: ACV33199.1.
GQ407113 Genomic DNA. Translation: ACV33200.1.
GQ407119 Genomic DNA. Translation: ACV33206.1.
GQ407121 Genomic DNA. Translation: ACV33208.1.
GQ407122 Genomic DNA. Translation: ACV33209.1.
GQ407123 Genomic DNA. Translation: ACV33210.1.
GQ407127 Genomic DNA. Translation: ACV33214.1.
GQ407128 Genomic DNA. Translation: ACV33215.1.
GQ407129 Genomic DNA. Translation: ACV33216.1.
GQ407131 Genomic DNA. Translation: ACV33218.1.
GQ407132 Genomic DNA. Translation: ACV33219.1.
GQ407133 Genomic DNA. Translation: ACV33220.1.
GQ407136 Genomic DNA. Translation: ACV33223.1.
GQ407137 Genomic DNA. Translation: ACV33224.1.
GQ407138 Genomic DNA. Translation: ACV33225.1.
GQ407140 Genomic DNA. Translation: ACV33227.1.
GQ407142 Genomic DNA. Translation: ACV33229.1.
GQ407144 Genomic DNA. Translation: ACV33231.1.
GQ407145 Genomic DNA. Translation: ACV33232.1.
GU083598 Genomic DNA. Translation: ACY35991.1.
GU083599 Genomic DNA. Translation: ACY35992.1.
GU064389 Genomic DNA. Translation: ACY68236.1.
HM751097 Genomic DNA. Translation: ADR80603.1.
HM751099 Genomic DNA. Translation: ADR80605.1.
HM751102 Genomic DNA. Translation: ADR80608.1.
JX268740 Genomic DNA. Translation: AFN82169.1.
KF585134 Genomic DNA. Translation: AHB36952.1.
CDPE01000060 Genomic DNA. Translation: CEN67343.1.
RefSeqiWP_001620095.1. NG_039559.1.
YP_009079584.1. NG_036025.1.
YP_009086336.1. NG_039544.1.
YP_009086337.1. NG_039545.1.
YP_009086341.1. NG_039549.1.
YP_009086348.1. NG_039556.1.
YP_009086350.1. NG_039558.1.
YP_009086351.1. NG_039559.1.
YP_009091661.1. NG_036755.1.

Genome annotation databases

EnsemblBacteriaiKFJ77022; KFJ77022; DR88_3745.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY826416 Genomic DNA. Translation: AAV83794.1.
DQ166781 Genomic DNA. Translation: AAZ98826.1.
DQ219474 Genomic DNA. Translation: ABB01159.1.
DQ355784 Genomic DNA. Translation: ABC88472.1.
DQ478720 Genomic DNA. Translation: ABF29674.1.
EF035564 Genomic DNA. Translation: ABM89165.1.
EF035565 Genomic DNA. Translation: ABM89166.1.
EF035566 Genomic DNA. Translation: ABM89167.1.
EF035567 Genomic DNA. Translation: ABM89168.1.
EU280315 Genomic DNA. Translation: ABX76424.1.
EU418908 Genomic DNA. Translation: ACM04454.1.
FJ685657 Genomic DNA. Translation: ACO07069.1.
FJ668799 Genomic DNA. Translation: ACR66308.1.
FJ668800 Genomic DNA. Translation: ACR66309.1.
FJ668804 Genomic DNA. Translation: ACR66313.1.
FJ668811 Genomic DNA. Translation: ACR66320.1.
FJ668813 Genomic DNA. Translation: ACR66322.1.
FJ668814 Genomic DNA. Translation: ACR66323.1.
FJ668818 Genomic DNA. Translation: ACR66327.1.
GQ380692 Genomic DNA. Translation: ACU57153.1.
GQ389701 Genomic DNA. Translation: ACV32617.1.
GQ407112 Genomic DNA. Translation: ACV33199.1.
GQ407113 Genomic DNA. Translation: ACV33200.1.
GQ407119 Genomic DNA. Translation: ACV33206.1.
GQ407121 Genomic DNA. Translation: ACV33208.1.
GQ407122 Genomic DNA. Translation: ACV33209.1.
GQ407123 Genomic DNA. Translation: ACV33210.1.
GQ407127 Genomic DNA. Translation: ACV33214.1.
GQ407128 Genomic DNA. Translation: ACV33215.1.
GQ407129 Genomic DNA. Translation: ACV33216.1.
GQ407131 Genomic DNA. Translation: ACV33218.1.
GQ407132 Genomic DNA. Translation: ACV33219.1.
GQ407133 Genomic DNA. Translation: ACV33220.1.
GQ407136 Genomic DNA. Translation: ACV33223.1.
GQ407137 Genomic DNA. Translation: ACV33224.1.
GQ407138 Genomic DNA. Translation: ACV33225.1.
GQ407140 Genomic DNA. Translation: ACV33227.1.
GQ407142 Genomic DNA. Translation: ACV33229.1.
GQ407144 Genomic DNA. Translation: ACV33231.1.
GQ407145 Genomic DNA. Translation: ACV33232.1.
GU083598 Genomic DNA. Translation: ACY35991.1.
GU083599 Genomic DNA. Translation: ACY35992.1.
GU064389 Genomic DNA. Translation: ACY68236.1.
HM751097 Genomic DNA. Translation: ADR80603.1.
HM751099 Genomic DNA. Translation: ADR80605.1.
HM751102 Genomic DNA. Translation: ADR80608.1.
JX268740 Genomic DNA. Translation: AFN82169.1.
KF585134 Genomic DNA. Translation: AHB36952.1.
CDPE01000060 Genomic DNA. Translation: CEN67343.1.
RefSeqiWP_001620095.1. NG_039559.1.
YP_009079584.1. NG_036025.1.
YP_009086336.1. NG_039544.1.
YP_009086337.1. NG_039545.1.
YP_009086341.1. NG_039549.1.
YP_009086348.1. NG_039556.1.
YP_009086350.1. NG_039558.1.
YP_009086351.1. NG_039559.1.
YP_009091661.1. NG_036755.1.

3D structure databases

ProteinModelPortaliQ5PSW7.
SMRiQ5PSW7. Positions 22-286.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272620.KPN_01607.

Chemistry

BindingDBiQ5PSW7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiKFJ77022; KFJ77022; DR88_3745.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A study on a novel SHV type extended spectrum beta-lactamase."
    Li J., Cheng J., Li H., Wang Y.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: KPn308Imported.
    Plasmid: pKP308
  2. "Molecular epidemiology of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit."
    Bagattini M., Crivaro V., Di Popolo A., Gentile F., Scarcella A., Triassi M., Villari P., Zarrilli R.
    J. Antimicrob. Chemother. 57:979-982(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Kp 403Imported.
    Plasmid: unnamed
  3. "Genetic Diversity of bla-SHV in Brazilian Klesiella pneumoniae isolates."
    Nogueira M.C.L., Pacca C.C., Almeida M.T.G., Nogueira M.L.
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "Occurrence and molecular analysis of extended-spectrum and AmpC beta-lactamases in Enterobacteriaceae in China."
    Zhu L.-X., Zhang Z.-W., Jiang D., Wang C., Du N., Zhang Q., Cheng J.
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: TT-18Imported.
    Plasmid: unnamed
  5. "SHV beta lactamase gene produced by Gram-negative bacteria isolated from AIIMS hospital, India."
    Lal P., Kapil A., Das B.K.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Kp297Imported, Kp311Imported, Kp344Imported and Kp734Imported.
  6. "Differential expression of bla(SHV) related to susceptibility to ampicillin in Klebsiella pneumoniae."
    Fu Y., Zhang F., Zhang W., Chen X., Zhao Y., Ma J., Bao L., Song W., Ohsugi T., Urano T., Liu S.
    Int. J. Antimicrob. Agents 29:344-347(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 753Imported.
  7. "Detection of blaSHV in clinical strain Klebsiella pneumoniae."
    Ben Achour N., Mercuri P., Chouchani C., Belhadj C., Ben Moussa M., Frere J.-M., Galleni M., Belhadj O.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ML3296Imported.
  8. "Dominance of blaCTX-M within an Australian extended-spectrum beta-lactamase gene pool."
    Zong Z., Partridge S.R., Thomas L., Iredell J.R.
    Antimicrob. Agents Chemother. 52:4198-4202(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: JIE092Imported.
  9. "Diversity of TEM-, SHV-, and CTX-M- type beta-lactamases present in clinical isolates of Klebsiella pneumoniae from a Brazilian hospital."
    Tolentino F.M., Polotto M., Remeli G.A., Nogueira M.L., Nogueira M.C.L.
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HB 2Imported.
  10. "Diversity of TEM-, SHV-, and CTX-M- Type beta-Lactamases Present in Clinical Isolates of Klebsiella pneumoniae from a Brazilian Hospital."
    Tolentino F.M., Polotto M., Remeli G.A., Nogueira M.L., Nogueira M.C.L.
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HB 100Imported, HB 28Imported, HB 29Imported, HB 68Imported, HB 71Imported, HB 74Imported, HB 76Imported, HB 80Imported, HB 81Imported, HB 82Imported, HB 84Imported, HB 85Imported, HB 86Imported, HB 89Imported, HB 90Imported, HB 91Imported, HB 94Imported, HB 97Imported and HB 99Imported.
  11. "Diversity of TEM-, SHV-, CTX-M-Type Beta-Lactamases Present in Clinical Isolates of Klebsiella pneumoniae from a Brazilian Hospital."
    Tolentino F.M., Polotto M., Remeli G.A., Nogueira M.L., Nogueira M.C.L.
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HB 12Imported.
  12. "Diversity of TEM-, SHV-, and CTX-M- type beta-lactamases present in clinical isolates of Klebsiella pneumoniae from a Brazilian hospital."
    Tolentino F.M., Polotto M., Remeli G.A., Nogueira M.L., Nogueira M.C.L.
    Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HB 65Imported.
  13. "Diversity of TEM-, SHV-, and CTX-M-type beta-lactamases present in clinical isolates of Klebsiella pneumoniae from a Brazilian hospital."
    Tolentino F.M., Polotto M., Remeli G.A., Nogueira M.L., Nogueira M.C.L.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HB 43Imported and HB 48Imported.
  14. "Integrated detection of extended-spectrum-beta-lactam resistance by DNA microarray-based genotyping of TEM, SHV, and CTX-M genes."
    Leinberger D.M., Grimm V., Rubtsova M., Weile J., Schroppel K., Wichelhaus T.A., Knabbe C., Schmid R.D., Bachmann T.T.
    J. Clin. Microbiol. 48:460-471(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 10Imported, 16Imported, 35Imported, 37Imported, 42Imported, 62Imported and 7Imported.
    Plasmid: unnamed
  15. "Prevalence of the bla (SHV) gene in Klebsiella pneumoniae isolates obtained from hospital and community infections and from the microbiota of healthy individuals in Recife, Brazil."
    Veras D.L., Alves L.C., Brayner F.A., Guedes D.R., Maciel M.A., Rocha C.R., de Souza Lopes A.C.
    Curr. Microbiol. 62:1610-1616(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: K13RImported, K16RImported and K3CMImported.
  16. "Phenotypic and genotypic characterization of ?-lactam resistance in Klebsiella pneumoniae isolated from swine."
    Zou L.K., Wang H.N., Zeng B., Zhang A.Y., Li J.N., Li X.T., Tian G.B., Wei K., Zhou Y.S., Xu C.W., Yang Z.R.
    Vet. Microbiol. 149:139-146(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DY-x-XImported.
  17. "Emergence of several beta-lactamases in Austria."
    Barisic I., Mitteregger D., Goekler D., Hirschl A., Noehammer C., Wiesinger-Mayr H.
    Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: AKH11/46Imported.
  18. "Comparative Genomics of an IncA/C Multidrug Resistance Plasmid from Escherichia coli and Klebsiella Isolates from Intensive Care Unit Patients and the Utility of Whole-Genome Sequencing in Health Care Settings."
    Hazen T.H., Zhao L., Boutin M.A., Stancil A., Robinson G., Harris A.D., Rasko D.A., Johnson J.K.
    Antimicrob. Agents Chemother. 58:4814-4825(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 1830-2Imported.
  19. Aslett A.Martin., De Silva Nishadi
    Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Novel ST outbreak lineage 2Imported.

Entry informationi

Entry nameiQ5PSW7_KLEPN
AccessioniPrimary (citable) accession number: Q5PSW7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: June 24, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

PlasmidImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.