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Q5PSW7

- Q5PSW7_KLEPN

UniProt

Q5PSW7 - Q5PSW7_KLEPN

Protein

Beta-lactamase

Gene

blaSHV-1

Organism
Klebsiella pneumoniae
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. beta-lactamase activity Source: InterPro

    GO - Biological processi

    1. beta-lactam antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    HydrolaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Antibiotic resistanceUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamaseUniRule annotation (EC:3.5.2.6UniRule annotation)
    Gene namesi
    Name:blaSHV-1Imported
    Synonyms:blaCTX-MImported, blaSHVImported, blaSHV-11Imported, blaSHV1Imported, SHVImported, SHV-1Imported, shv-1Imported, SHV-1b-aImported
    Encoded oniPlasmid pKP308Imported
    Plasmid unnamedImported
    OrganismiKlebsiella pneumoniaeImported
    Taxonomic identifieri573 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

    Structurei

    3D structure databases

    SMRiQ5PSW7. Positions 22-286.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5PSW7.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-A beta-lactamase family.UniRule annotation

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    IPR023650. Beta-lactam_class-A_AS.
    [Graphical view]
    PRINTSiPR00118. BLACTAMASEA.
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5PSW7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRYIRLCIIS LLATLPLAVH ASPQPLEQIK LSESQLSGRV GMIEMDLASG    50
    RTLTAWRADE RFPMMSTFKV VLCGAVLARV DAGDEQLERK IHYRQQDLVD 100
    YSPVSEKHLA DGMTVGELCA AAITMSDNSA ANLLLATVGG PAGLTAFLRQ 150
    IGDNVTRLDR WETELNEALP GDARDTTTPA SMAATLRKLL TSQRLSARSQ 200
    RQLLQWMVDD RVAGPLIRSV LPAGWFIADK TGAGERGARG IVALLGPNNK 250
    AERIVVIYLR DTPASMAERN QQIAGIGAAL IEHWQR 286
    Length:286
    Mass (Da):31,224
    Last modified:May 10, 2005 - v1
    Checksum:iC78F42667E698E6C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY826416 Genomic DNA. Translation: AAV83794.1.
    DQ166781 Genomic DNA. Translation: AAZ98826.1.
    DQ219474 Genomic DNA. Translation: ABB01159.1.
    DQ355784 Genomic DNA. Translation: ABC88472.1.
    DQ478720 Genomic DNA. Translation: ABF29674.1.
    EF035564 Genomic DNA. Translation: ABM89165.1.
    EF035565 Genomic DNA. Translation: ABM89166.1.
    EF035566 Genomic DNA. Translation: ABM89167.1.
    EF035567 Genomic DNA. Translation: ABM89168.1.
    EU280315 Genomic DNA. Translation: ABX76424.1.
    EU418908 Genomic DNA. Translation: ACM04454.1.
    FJ685657 Genomic DNA. Translation: ACO07069.1.
    FJ668799 Genomic DNA. Translation: ACR66308.1.
    FJ668800 Genomic DNA. Translation: ACR66309.1.
    FJ668804 Genomic DNA. Translation: ACR66313.1.
    FJ668811 Genomic DNA. Translation: ACR66320.1.
    FJ668813 Genomic DNA. Translation: ACR66322.1.
    FJ668814 Genomic DNA. Translation: ACR66323.1.
    FJ668818 Genomic DNA. Translation: ACR66327.1.
    GQ380692 Genomic DNA. Translation: ACU57153.1.
    GQ389701 Genomic DNA. Translation: ACV32617.1.
    GQ407112 Genomic DNA. Translation: ACV33199.1.
    GQ407113 Genomic DNA. Translation: ACV33200.1.
    GQ407119 Genomic DNA. Translation: ACV33206.1.
    GQ407121 Genomic DNA. Translation: ACV33208.1.
    GQ407122 Genomic DNA. Translation: ACV33209.1.
    GQ407123 Genomic DNA. Translation: ACV33210.1.
    GQ407127 Genomic DNA. Translation: ACV33214.1.
    GQ407128 Genomic DNA. Translation: ACV33215.1.
    GQ407129 Genomic DNA. Translation: ACV33216.1.
    GQ407131 Genomic DNA. Translation: ACV33218.1.
    GQ407132 Genomic DNA. Translation: ACV33219.1.
    GQ407133 Genomic DNA. Translation: ACV33220.1.
    GQ407136 Genomic DNA. Translation: ACV33223.1.
    GQ407137 Genomic DNA. Translation: ACV33224.1.
    GQ407138 Genomic DNA. Translation: ACV33225.1.
    GQ407140 Genomic DNA. Translation: ACV33227.1.
    GQ407142 Genomic DNA. Translation: ACV33229.1.
    GQ407144 Genomic DNA. Translation: ACV33231.1.
    GQ407145 Genomic DNA. Translation: ACV33232.1.
    GU083598 Genomic DNA. Translation: ACY35991.1.
    GU083599 Genomic DNA. Translation: ACY35992.1.
    GU064389 Genomic DNA. Translation: ACY68236.1.
    HM751097 Genomic DNA. Translation: ADR80603.1.
    HM751099 Genomic DNA. Translation: ADR80605.1.
    HM751102 Genomic DNA. Translation: ADR80608.1.
    JX268740 Genomic DNA. Translation: AFN82169.1.
    KF585134 Genomic DNA. Translation: AHB36952.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY826416 Genomic DNA. Translation: AAV83794.1 .
    DQ166781 Genomic DNA. Translation: AAZ98826.1 .
    DQ219474 Genomic DNA. Translation: ABB01159.1 .
    DQ355784 Genomic DNA. Translation: ABC88472.1 .
    DQ478720 Genomic DNA. Translation: ABF29674.1 .
    EF035564 Genomic DNA. Translation: ABM89165.1 .
    EF035565 Genomic DNA. Translation: ABM89166.1 .
    EF035566 Genomic DNA. Translation: ABM89167.1 .
    EF035567 Genomic DNA. Translation: ABM89168.1 .
    EU280315 Genomic DNA. Translation: ABX76424.1 .
    EU418908 Genomic DNA. Translation: ACM04454.1 .
    FJ685657 Genomic DNA. Translation: ACO07069.1 .
    FJ668799 Genomic DNA. Translation: ACR66308.1 .
    FJ668800 Genomic DNA. Translation: ACR66309.1 .
    FJ668804 Genomic DNA. Translation: ACR66313.1 .
    FJ668811 Genomic DNA. Translation: ACR66320.1 .
    FJ668813 Genomic DNA. Translation: ACR66322.1 .
    FJ668814 Genomic DNA. Translation: ACR66323.1 .
    FJ668818 Genomic DNA. Translation: ACR66327.1 .
    GQ380692 Genomic DNA. Translation: ACU57153.1 .
    GQ389701 Genomic DNA. Translation: ACV32617.1 .
    GQ407112 Genomic DNA. Translation: ACV33199.1 .
    GQ407113 Genomic DNA. Translation: ACV33200.1 .
    GQ407119 Genomic DNA. Translation: ACV33206.1 .
    GQ407121 Genomic DNA. Translation: ACV33208.1 .
    GQ407122 Genomic DNA. Translation: ACV33209.1 .
    GQ407123 Genomic DNA. Translation: ACV33210.1 .
    GQ407127 Genomic DNA. Translation: ACV33214.1 .
    GQ407128 Genomic DNA. Translation: ACV33215.1 .
    GQ407129 Genomic DNA. Translation: ACV33216.1 .
    GQ407131 Genomic DNA. Translation: ACV33218.1 .
    GQ407132 Genomic DNA. Translation: ACV33219.1 .
    GQ407133 Genomic DNA. Translation: ACV33220.1 .
    GQ407136 Genomic DNA. Translation: ACV33223.1 .
    GQ407137 Genomic DNA. Translation: ACV33224.1 .
    GQ407138 Genomic DNA. Translation: ACV33225.1 .
    GQ407140 Genomic DNA. Translation: ACV33227.1 .
    GQ407142 Genomic DNA. Translation: ACV33229.1 .
    GQ407144 Genomic DNA. Translation: ACV33231.1 .
    GQ407145 Genomic DNA. Translation: ACV33232.1 .
    GU083598 Genomic DNA. Translation: ACY35991.1 .
    GU083599 Genomic DNA. Translation: ACY35992.1 .
    GU064389 Genomic DNA. Translation: ACY68236.1 .
    HM751097 Genomic DNA. Translation: ADR80603.1 .
    HM751099 Genomic DNA. Translation: ADR80605.1 .
    HM751102 Genomic DNA. Translation: ADR80608.1 .
    JX268740 Genomic DNA. Translation: AFN82169.1 .
    KF585134 Genomic DNA. Translation: AHB36952.1 .

    3D structure databases

    SMRi Q5PSW7. Positions 22-286.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q5PSW7.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    IPR023650. Beta-lactam_class-A_AS.
    [Graphical view ]
    PRINTSi PR00118. BLACTAMASEA.
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A study on a novel SHV type extended spectrum beta-lactamase."
      Li J., Cheng J., Li H., Wang Y.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: KPn308Imported.
      Plasmid: pKP308
    2. "Molecular epidemiology of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit."
      Bagattini M., Crivaro V., Di Popolo A., Gentile F., Scarcella A., Triassi M., Villari P., Zarrilli R.
      J. Antimicrob. Chemother. 57:979-982(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Kp 403Imported.
      Plasmid: unnamed
    3. "Genetic Diversity of bla-SHV in Brazilian Klesiella pneumoniae isolates."
      Nogueira M.C.L., Pacca C.C., Almeida M.T.G., Nogueira M.L.
      Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    4. "Occurrence and molecular analysis of extended-spectrum and AmpC beta-lactamases in Enterobacteriaceae in China."
      Zhu L.-X., Zhang Z.-W., Jiang D., Wang C., Du N., Zhang Q., Cheng J.
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: TT-18Imported.
      Plasmid: unnamed
    5. "SHV beta lactamase gene produced by Gram-negative bacteria isolated from AIIMS hospital, India."
      Lal P., Kapil A., Das B.K.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Kp297Imported, Kp311Imported, Kp344Imported and Kp734Imported.
    6. "Differential expression of bla(SHV) related to susceptibility to ampicillin in Klebsiella pneumoniae."
      Fu Y., Zhang F., Zhang W., Chen X., Zhao Y., Ma J., Bao L., Song W., Ohsugi T., Urano T., Liu S.
      Int. J. Antimicrob. Agents 29:344-347(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 753Imported.
    7. "Detection of blaSHV in clinical strain Klebsiella pneumoniae."
      Ben Achour N., Mercuri P., Chouchani C., Belhadj C., Ben Moussa M., Frere J.-M., Galleni M., Belhadj O.
      Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ML3296Imported.
    8. "Dominance of blaCTX-M within an Australian extended-spectrum beta-lactamase gene pool."
      Zong Z., Partridge S.R., Thomas L., Iredell J.R.
      Antimicrob. Agents Chemother. 52:4198-4202(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: JIE092Imported.
    9. "Diversity of TEM-, SHV-, and CTX-M- Type beta-Lactamases Present in Clinical Isolates of Klebsiella pneumoniae from a Brazilian Hospital."
      Tolentino F.M., Polotto M., Remeli G.A., Nogueira M.L., Nogueira M.C.L.
      Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: HB 100Imported, HB 28Imported, HB 29Imported, HB 68Imported, HB 71Imported, HB 74Imported, HB 76Imported, HB 80Imported, HB 81Imported, HB 82Imported, HB 84Imported, HB 85Imported, HB 86Imported, HB 89Imported, HB 90Imported, HB 91Imported, HB 94Imported, HB 97Imported and HB 99Imported.
    10. "Diversity of TEM-, SHV-, and CTX-M- type beta-lactamases present in clinical isolates of Klebsiella pneumoniae from a Brazilian hospital."
      Tolentino F.M., Polotto M., Remeli G.A., Nogueira M.L., Nogueira M.C.L.
      Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: HB 2Imported.
    11. "Diversity of TEM-, SHV-, CTX-M-Type Beta-Lactamases Present in Clinical Isolates of Klebsiella pneumoniae from a Brazilian Hospital."
      Tolentino F.M., Polotto M., Remeli G.A., Nogueira M.L., Nogueira M.C.L.
      Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: HB 12Imported.
    12. "Diversity of TEM-, SHV-, and CTX-M- type beta-lactamases present in clinical isolates of Klebsiella pneumoniae from a Brazilian hospital."
      Tolentino F.M., Polotto M., Remeli G.A., Nogueira M.L., Nogueira M.C.L.
      Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: HB 65Imported.
    13. "Diversity of TEM-, SHV-, and CTX-M-type beta-lactamases present in clinical isolates of Klebsiella pneumoniae from a Brazilian hospital."
      Tolentino F.M., Polotto M., Remeli G.A., Nogueira M.L., Nogueira M.C.L.
      Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: HB 43Imported and HB 48Imported.
    14. "Integrated detection of extended-spectrum-beta-lactam resistance by DNA microarray-based genotyping of TEM, SHV, and CTX-M genes."
      Leinberger D.M., Grimm V., Rubtsova M., Weile J., Schroppel K., Wichelhaus T.A., Knabbe C., Schmid R.D., Bachmann T.T.
      J. Clin. Microbiol. 48:460-471(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 10Imported, 16Imported, 35Imported, 37Imported, 42Imported, 62Imported and 7Imported.
      Plasmid: unnamed
    15. "Prevalence of the bla (SHV) gene in Klebsiella pneumoniae isolates obtained from hospital and community infections and from the microbiota of healthy individuals in Recife, Brazil."
      Veras D.L., Alves L.C., Brayner F.A., Guedes D.R., Maciel M.A., Rocha C.R., de Souza Lopes A.C.
      Curr. Microbiol. 62:1610-1616(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: K13RImported, K16RImported and K3CMImported.
    16. "Phenotypic and genotypic characterization of ?-lactam resistance in Klebsiella pneumoniae isolated from swine."
      Zou L.K., Wang H.N., Zeng B., Zhang A.Y., Li J.N., Li X.T., Tian G.B., Wei K., Zhou Y.S., Xu C.W., Yang Z.R.
      Vet. Microbiol. 149:139-146(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DY-x-XImported.
    17. "Emergence of several beta-lactamases in Austria."
      Barisic I., Mitteregger D., Goekler D., Hirschl A., Noehammer C., Wiesinger-Mayr H.
      Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: AKH11/46Imported.
    18. "Comparative genomics of an IncA/C multidrug resistance plasmid from Escherichia coli and Klebsiella species isolated from ICU patients."
      Hazen T.H., Zhao L., Boutin M.A., Stancil A., Robinson G.L., Harris A.D., Rasko D.A., Johnson J.K.
      Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 1830-2Imported.

    Entry informationi

    Entry nameiQ5PSW7_KLEPN
    AccessioniPrimary (citable) accession number: Q5PSW7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    PlasmidImported

    External Data

    Dasty 3