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Protein

Breast cancer metastasis-suppressor 1-like protein

Gene

BRMS1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth.1 Publication

Caution

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processGrowth regulation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Breast cancer metastasis-suppressor 1-like protein
Alternative name(s):
BRMS1-homolog protein p40
BRMS1-like protein p40
Gene namesi
Name:BRMS1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100916.13
HGNCiHGNC:20512 BRMS1L
neXtProtiNX_Q5PSV4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84312
OpenTargetsiENSG00000100916
PharmGKBiPA134968356

Polymorphism and mutation databases

BioMutaiBRMS1L
DMDMi158706476

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003053091 – 323Breast cancer metastasis-suppressor 1-like proteinAdd BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei197PhosphoserineCombined sources1
Cross-linki240Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki246Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5PSV4
MaxQBiQ5PSV4
PaxDbiQ5PSV4
PeptideAtlasiQ5PSV4
PRIDEiQ5PSV4

PTM databases

iPTMnetiQ5PSV4
PhosphoSitePlusiQ5PSV4

Expressioni

Gene expression databases

BgeeiENSG00000100916
CleanExiHS_BRMS1L
ExpressionAtlasiQ5PSV4 baseline and differential
GenevisibleiQ5PSV4 HS

Organism-specific databases

HPAiHPA046623

Interactioni

Subunit structurei

Component of the Sin3/HDAC1 corepressor complex at least composed of BRMS1, BRMS1L and ING2/ING1L. Interacts with HDAC and SIN3A.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi12403828 interactors.
CORUMiQ5PSV4
IntActiQ5PSV4 18 interactors.
MINTiQ5PSV4
STRINGi9606.ENSP00000216807

Structurei

3D structure databases

ProteinModelPortaliQ5PSV4
SMRiQ5PSV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili52 – 84Sequence analysisAdd BLAST33
Coiled coili149 – 180Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the BRMS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4466 Eukaryota
ENOG410Y9N9 LUCA
GeneTreeiENSGT00910000144178
HOGENOMiHOG000007483
HOVERGENiHBG050734
InParanoidiQ5PSV4
KOiK19196
OMAiEWYGRGQ
OrthoDBiEOG091G0UCP
PhylomeDBiQ5PSV4
TreeFamiTF323740

Family and domain databases

InterProiView protein in InterPro
IPR013907 Sds3
PANTHERiPTHR21964 PTHR21964, 1 hit
PfamiView protein in Pfam
PF08598 Sds3, 1 hit
SMARTiView protein in SMART
SM01401 Sds3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5PSV4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVHSRGDKK ETNHHDEMEV DYAENEGSSS EDEDTESSSV SEDGDSSEMD
60 70 80 90 100
DEDCERRRME CLDEMSNLEK QFTDLKDQLY KERLSQVDAK LQEVIAGKAP
110 120 130 140 150
EYLEPLATLQ ENMQIRTKVA GIYRELCLES VKNKYECEIQ ASRQHCESEK
160 170 180 190 200
LLLYDTVQSE LEEKIRRLEE DRHSIDITSE LWNDELQSRK KRKDPFSPDK
210 220 230 240 250
KKPVVVSGPY IVYMLQDLDI LEDWTTIRKA MATLGPHRVK TEPPVKLEKH
260 270 280 290 300
LHSARSEEGR LYYDGEWYIR GQTICIDKKD ECPTSAVITT INHDEVWFKR
310 320
PDGSKSKLYI SQLQKGKYSI KHS
Length:323
Mass (Da):37,629
Last modified:October 2, 2007 - v2
Checksum:i35908ACFD439A117
GO
Isoform 2 (identifier: Q5PSV4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.

Note: No experimental confirmation available.
Show »
Length:275
Mass (Da):32,345
Checksum:i8EB074B3F841B4E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti206V → G in AAV83797 (PubMed:15451426).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0555471 – 48Missing in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY827074 mRNA Translation: AAV83797.1
AK315424 mRNA Translation: BAG37812.1
AL162311 Genomic DNA No translation available.
BC006250 mRNA Translation: AAH06250.2
CCDSiCCDS32066.1 [Q5PSV4-1]
RefSeqiNP_115728.2, NM_032352.3 [Q5PSV4-1]
XP_006720338.1, XM_006720275.2 [Q5PSV4-2]
XP_016877193.1, XM_017021704.1 [Q5PSV4-2]
XP_016877194.1, XM_017021705.1 [Q5PSV4-2]
UniGeneiHs.525299

Genome annotation databases

EnsembliENST00000216807; ENSP00000216807; ENSG00000100916 [Q5PSV4-1]
GeneIDi84312
KEGGihsa:84312
UCSCiuc001wtl.4 human [Q5PSV4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBRM1L_HUMAN
AccessioniPrimary (citable) accession number: Q5PSV4
Secondary accession number(s): A6NFW5
, A6NH45, B2RD65, Q9BRI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: March 28, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome