Reviewed, UniProtKB/Swiss-Prot Q5PSV4 (BRM1L_HUMAN)

Names and origin

Protein names

Recommended name:
    Breast cancer metastasis-suppressor 1-like protein
Alternative name(s):
    BRMS1-homolog protein p40
    BRMS1-like protein p40

Gene names

Name:

BRMS1L

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth.
Subunit structure	Component of the Sin3/HDAC1 corepressor complex at least composed of BRMS1, BRMS1L and ING2/ING1L. Interacts with HDAC and SIN3A.
Subcellular location	NucleusProbable.
Sequence similarities	Belongs to the BRMS1 family.

Ontologies

Keywords
Biological process	Growth regulation Transcription Transcription regulation
Cellular component	Nucleus
Domain	Coiled coil
Molecular function	Repressor
Gene Ontology (GO)
Biological process	regulation of cell growth Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Breast cancer metastasis-suppressor 1-like protein		PRO_0000305309
Regions
	Coiled coil	52 – 84	33	Potential
	Coiled coil	149 – 180	32	Potential
Experimental info
	Sequence conflict	206	1	V → G in AAV83797. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q5PSV4-1 [UniParc]. Last modified October 2, 2007. Version 2. Checksum: 35908ACFD439A117	FASTA	323	37,629
	10 20 30 40 50 60 MPVHSRGDKK ETNHHDEMEV DYAENEGSSS EDEDTESSSV SEDGDSSEMD DEDCERRRME 70 80 90 100 110 120 CLDEMSNLEK QFTDLKDQLY KERLSQVDAK LQEVIAGKAP EYLEPLATLQ ENMQIRTKVA 130 140 150 160 170 180 GIYRELCLES VKNKYECEIQ ASRQHCESEK LLLYDTVQSE LEEKIRRLEE DRHSIDITSE 190 200 210 220 230 240 LWNDELQSRK KRKDPFSPDK KKPVVVSGPY IVYMLQDLDI LEDWTTIRKA MATLGPHRVK 250 260 270 280 290 300 TEPPVKLEKH LHSARSEEGR LYYDGEWYIR GQTICIDKKD ECPTSAVITT INHDEVWFKR 310 320 PDGSKSKLYI SQLQKGKYSI KHS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex." Nikolaev A.Y., Papanikolaou N.A., Li M., Qin J., Gu W. Biochem. Biophys. Res. Commun. 323:1216-1222(2004) [PubMed: 15451426] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, IDENTIFICATION IN THE SIN3/HDAC1 COMPLEX, INTERACTION WITH HDAC AND SIN3A.
[2]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY827074 mRNA. Translation: AAV83797.1. AL162311 Genomic DNA. No translation available. BC006250 mRNA. Translation: AAH06250.2.
RefSeq	NP_115728.2.
UniGene	Hs.525299
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q5PSV4.
Genome annotation databases
Ensembl	ENSG00000100916. Homo sapiens. [Contig view]
GeneID	84312.
KEGG	hsa:84312.
Organism-specific databases
HGNC	HGNC:20512. BRMS1L.
PharmGKB	PA134968356.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q5PSV4.
Gene expression databases
ArrayExpress	Q5PSV4.
CleanEx	HS_BRMS1L.
Family and domain databases
InterPro	IPR013907. Sds3. [Graphical view]
Pfam	PF08598. Sds3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	74010.

Entry information

Entry name

BRM1L_HUMAN

Accession

Primary (citable) accession number: Q5PSV4
Secondary accession number(s): A6NFW5, A6NH45, Q9BRI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	October 2, 2007
Last modified:	November 25, 2008
This is version 25 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)