Q5PSV4 (BRM1L_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 53.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Breast cancer metastasis-suppressor 1-like protein Alternative name(s): BRMS1-homolog protein p40 BRMS1-like protein p40 | ||
| Gene names |
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| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 323 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth. Ref.1 |
| Subunit structure | Component of the Sin3/HDAC1 corepressor complex at least composed of BRMS1, BRMS1L and ING2/ING1L. Interacts with HDAC and SIN3A. Ref.1 |
| Subcellular location | Nucleus Probable. |
| Sequence similarities | Belongs to the BRMS1 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Growth regulation Transcription Transcription regulation |
| Cellular component | Nucleus |
| Domain | Coiled coil |
| Molecular function | Repressor |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | regulation of growth Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependentInferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependentInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 323 | 323 | Breast cancer metastasis-suppressor 1-like protein | PRO_0000305309 | |||||
Regions | |||||||||
| Coiled coil | 52 – 84 | 33 | Potential | ||||||
| Coiled coil | 149 – 180 | 32 | Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 206 | 1 | V → G in AAV83797. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex." Nikolaev A.Y., Papanikolaou N.A., Li M., Qin J., Gu W. Biochem. Biophys. Res. Commun. 323:1216-1222(2004) [PubMed: 15451426] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, IDENTIFICATION IN THE SIN3/HDAC1 COMPLEX, INTERACTION WITH HDAC AND SIN3A. |
| [2] | "The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. Weissenbach J.Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AY827074 mRNA. Translation: AAV83797.1. AL162311 Genomic DNA. No translation available. BC006250 mRNA. Translation: AAH06250.2. |
| IPI | IPI00031653. |
| RefSeq | NP_115728.2. NM_032352.3. |
| UniGene | Hs.525299. |
3D structure databases | |
| ProteinModelPortal | Q5PSV4. |
| SMR | Q5PSV4. Positions 55-94. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q5PSV4. |
PTM databases | |
| PhosphoSite | Q5PSV4. |
Polymorphism databases | |
| DMDM | 158706476. |
Proteomic databases | |
| PRIDE | Q5PSV4. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000216807; ENSP00000216807; ENSG00000100916. |
| GeneID | 84312. |
| KEGG | hsa:84312. |
| UCSC | uc001wtl.1. human. |
Organism-specific databases | |
| CTD | 84312. |
| GeneCards | GC14P036295. |
| H-InvDB | HIX0011601. |
| HGNC | HGNC:20512. BRMS1L. |
| neXtProt | NX_Q5PSV4. |
| PharmGKB | PA134968356. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG14044. |
| GeneTree | ENSGT00530000063177. |
| HOGENOM | HBG446857. |
| HOVERGEN | HBG050734. |
| InParanoid | Q5PSV4. |
| OMA | MPVHSRE. |
| OrthoDB | EOG4C5CK5. |
| PhylomeDB | Q5PSV4. |
Gene expression databases | |
| ArrayExpress | Q5PSV4. |
| Bgee | Q5PSV4. |
| CleanEx | HS_BRMS1L. |
| Genevestigator | Q5PSV4. |
Family and domain databases | |
| InterPro | IPR013907. Sds3. [Graphical view] |
| Pfam | PF08598. Sds3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 74010. |
Entry information
| Entry name | BRM1L_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q5PSV4 Secondary accession number(s): A6NFW5, A6NH45, Q9BRI4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 14 Human chromosome 14: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

Clusters with