SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5PRF9

- SMAG2_HUMAN

UniProt

Q5PRF9 - SMAG2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein Smaug homolog 2

Gene
SAMD4B, SMAUG2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A.1 Publication

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Smaug homolog 2
Short name:
Smaug 2
Short name:
hSmaug2
Alternative name(s):
Sterile alpha motif domain-containing protein 4B
Short name:
SAM domain-containing protein 4B
Gene namesi
Name:SAMD4B
Synonyms:SMAUG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:25492. SAMD4B.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485607.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 694694Protein Smaug homolog 2PRO_0000260080Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei271 – 2711Phosphoserine1 Publication
Modified residuei407 – 4071Phosphothreonine1 Publication
Modified residuei555 – 5551Phosphoserine1 Publication
Modified residuei557 – 5571Phosphoserine1 Publication
Modified residuei563 – 5631Phosphoserine1 Publication
Modified residuei592 – 5921Phosphoserine3 Publications
Modified residuei600 – 6001Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5PRF9.
PaxDbiQ5PRF9.
PRIDEiQ5PRF9.

PTM databases

PhosphoSiteiQ5PRF9.

Expressioni

Tissue specificityi

Widely expressed in embryonic and adult tissues.1 Publication

Gene expression databases

ArrayExpressiQ5PRF9.
BgeeiQ5PRF9.
CleanExiHS_SAMD4B.
GenevestigatoriQ5PRF9.

Organism-specific databases

HPAiHPA016800.

Interactioni

Protein-protein interaction databases

BioGridi120407. 8 interactions.
IntActiQ5PRF9. 2 interactions.
MINTiMINT-3307444.
STRINGi9606.ENSP00000317224.

Structurei

3D structure databases

ProteinModelPortaliQ5PRF9.
SMRiQ5PRF9. Positions 300-392.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini299 – 37274SAMAdd
BLAST

Sequence similaritiesi

Belongs to the SMAUG family.

Phylogenomic databases

eggNOGiNOG300236.
HOGENOMiHOG000290216.
InParanoidiQ5PRF9.
OMAiQTEEQGS.
PhylomeDBiQ5PRF9.
TreeFamiTF324165.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.25.40.170. 2 hits.
InterProiIPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR015327. Smaug_PHAT.
[Graphical view]
PfamiPF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5PRF9-1 [UniParc]FASTAAdd to Basket

« Hide

MMFRDQVGIL AGWFKGWNEC EQTVALLSLL KRVTRTQARF LQLCLEHSLA    50
DCNDIHLLES EANSAAIVSQ WQQESKEKVV SLLLSHLPLL QPGNTEAKSE 100
YMRLLQKVLA YSIESNAFIE ESRQLLSYAL IHPATTLEDR NALALWLSHL 150
EERLASGFRS RPEPSYHSRQ GSDEWGGPAE LGPGEAGPGW QDKPPRENGH 200
VPFHPSSSVP PAINSIGSNA NTGLPCQIHP SPLKRSMSLI PTSPQVPGEW 250
PSPEELGARA AFTTPDHAPL SPQSSVASSG SEQTEEQGSS RNTFQEDGSG 300
MKDVPSWLKS LRLHKYAALF SQMSYEEMMT LTEQHLESQN VTKGARHKIA 350
LSIQKLRERQ SVLKSLEKDV LEGGNLRNAL QELQQIIITP IKAYSVLQAT 400
VAAATTTPTA KDGAPGEPPL PGAEPPLAHP GTDKGTEAKD PPAVENYPPP 450
PAPAPTDGSE PAPAPVADGD IPSQFTRVMG KVCTQLLVSR PDEENITSYL 500
QLIEKCLTHE AFTETQKKRL LSWKQQVLKL LRTFPRKAAL EMQNYRQQKG 550
WAFGSNSLPI AGSVGMGVAR RTQRQFPMPP RALPPGRMGL LSPSGIGGVS 600
PRHALTSPSL GGQGRQNLWF ANPGGSNSMP SQSRSSVQRT HSLPVHSSPQ 650
AILMFPPDCP VPGPDLEINP TLESLCLSMT EHALGDGTDK TSTI 694
Length:694
Mass (Da):75,483
Last modified:January 4, 2005 - v1
Checksum:i4AA4769F38494E56
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF601121 mRNA. Translation: ABQ85549.1.
CH471126 Genomic DNA. Translation: EAW56877.1.
BC054518 mRNA. Translation: AAH54518.1.
BC065211 mRNA. Translation: AAH65211.1.
CCDSiCCDS33020.1.
RefSeqiNP_060498.2. NM_018028.2.
XP_005259085.1. XM_005259028.2.
XP_005259086.1. XM_005259029.1.
XP_006723319.1. XM_006723256.1.
UniGeneiHs.612332.
Hs.707137.

Genome annotation databases

EnsembliENST00000314471; ENSP00000317224; ENSG00000179134.
GeneIDi55095.
KEGGihsa:55095.
UCSCiuc002ola.3. human.

Polymorphism databases

DMDMi74736136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF601121 mRNA. Translation: ABQ85549.1 .
CH471126 Genomic DNA. Translation: EAW56877.1 .
BC054518 mRNA. Translation: AAH54518.1 .
BC065211 mRNA. Translation: AAH65211.1 .
CCDSi CCDS33020.1.
RefSeqi NP_060498.2. NM_018028.2.
XP_005259085.1. XM_005259028.2.
XP_005259086.1. XM_005259029.1.
XP_006723319.1. XM_006723256.1.
UniGenei Hs.612332.
Hs.707137.

3D structure databases

ProteinModelPortali Q5PRF9.
SMRi Q5PRF9. Positions 300-392.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120407. 8 interactions.
IntActi Q5PRF9. 2 interactions.
MINTi MINT-3307444.
STRINGi 9606.ENSP00000317224.

PTM databases

PhosphoSitei Q5PRF9.

Polymorphism databases

DMDMi 74736136.

Proteomic databases

MaxQBi Q5PRF9.
PaxDbi Q5PRF9.
PRIDEi Q5PRF9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000314471 ; ENSP00000317224 ; ENSG00000179134 .
GeneIDi 55095.
KEGGi hsa:55095.
UCSCi uc002ola.3. human.

Organism-specific databases

CTDi 55095.
GeneCardsi GC19P039833.
H-InvDB HIX0015115.
HGNCi HGNC:25492. SAMD4B.
HPAi HPA016800.
neXtProti NX_Q5PRF9.
PharmGKBi PA143485607.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG300236.
HOGENOMi HOG000290216.
InParanoidi Q5PRF9.
OMAi QTEEQGS.
PhylomeDBi Q5PRF9.
TreeFami TF324165.

Miscellaneous databases

ChiTaRSi SAMD4B. human.
GenomeRNAii 55095.
NextBioi 58681.
PROi Q5PRF9.

Gene expression databases

ArrayExpressi Q5PRF9.
Bgeei Q5PRF9.
CleanExi HS_SAMD4B.
Genevestigatori Q5PRF9.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
1.25.40.170. 2 hits.
InterProi IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR015327. Smaug_PHAT.
[Graphical view ]
Pfami PF00536. SAM_1. 1 hit.
[Graphical view ]
SMARTi SM00454. SAM. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "SAMD4B, a novel SAM-containing protein, inhibits AP-1-, p53- and p21-mediated transcriptional activity."
    Luo N., Li G., Li Y., Fan X., Wang Y., Ye X., Mo X., Zhou J., Yuan W., Tan M., Xie H., Ocorr K., Bodmer R., Deng Y., Wu X.
    BMB Rep. 43:355-361(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Heart.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary and Uterus.
  4. "Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules."
    Baez M.V., Boccaccio G.L.
    J. Biol. Chem. 280:43131-43140(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  5. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-407, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-271; SER-592 AND SER-600, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-592, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-555; SER-557; SER-563; SER-592 AND SER-600, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSMAG2_HUMAN
AccessioniPrimary (citable) accession number: Q5PRF9
Secondary accession number(s): A5Z0M6, Q6P194
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: January 4, 2005
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi