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Protein

Protein Smaug homolog 2

Gene

SAMD4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A.1 Publication

GO - Molecular functioni

  • mRNA binding Source: GO_Central
  • poly(A) RNA binding Source: UniProtKB
  • translation repressor activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Smaug homolog 2
Short name:
Smaug 2
Short name:
hSmaug2
Alternative name(s):
Sterile alpha motif domain-containing protein 4B
Short name:
SAM domain-containing protein 4B
Gene namesi
Name:SAMD4B
Synonyms:SMAUG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25492. SAMD4B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485607.

Polymorphism and mutation databases

BioMutaiSAMD4B.
DMDMi74736136.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 694694Protein Smaug homolog 2PRO_0000260080Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei172 – 1721PhosphoserineCombined sources
Modified residuei271 – 2711PhosphoserineCombined sources
Modified residuei278 – 2781PhosphoserineBy similarity
Modified residuei279 – 2791PhosphoserineBy similarity
Modified residuei281 – 2811PhosphoserineBy similarity
Modified residuei407 – 4071PhosphothreonineCombined sources
Modified residuei555 – 5551PhosphoserineCombined sources
Modified residuei557 – 5571PhosphoserineCombined sources
Modified residuei563 – 5631PhosphoserineCombined sources
Modified residuei592 – 5921PhosphoserineCombined sources
Modified residuei600 – 6001PhosphoserineCombined sources
Modified residuei628 – 6281PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5PRF9.
MaxQBiQ5PRF9.
PaxDbiQ5PRF9.
PeptideAtlasiQ5PRF9.
PRIDEiQ5PRF9.

PTM databases

iPTMnetiQ5PRF9.
PhosphoSiteiQ5PRF9.

Expressioni

Tissue specificityi

Widely expressed in embryonic and adult tissues.1 Publication

Gene expression databases

BgeeiENSG00000179134.
CleanExiHS_SAMD4B.
ExpressionAtlasiQ5PRF9. baseline and differential.
GenevisibleiQ5PRF9. HS.

Organism-specific databases

HPAiHPA016800.
HPA059385.

Interactioni

Protein-protein interaction databases

BioGridi120407. 19 interactions.
IntActiQ5PRF9. 9 interactions.
MINTiMINT-3307444.
STRINGi9606.ENSP00000317224.

Structurei

3D structure databases

ProteinModelPortaliQ5PRF9.
SMRiQ5PRF9. Positions 300-392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini299 – 37274SAMAdd
BLAST

Sequence similaritiesi

Belongs to the SMAUG family.Curated

Phylogenomic databases

eggNOGiKOG3791. Eukaryota.
ENOG410XSUP. LUCA.
GeneTreeiENSGT00390000015877.
HOGENOMiHOG000290216.
InParanoidiQ5PRF9.
OMAiMFPPDCP.
OrthoDBiEOG091G0A44.
PhylomeDBiQ5PRF9.
TreeFamiTF324165.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.25.40.170. 2 hits.
InterProiIPR015327. PHAT_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5PRF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFRDQVGIL AGWFKGWNEC EQTVALLSLL KRVTRTQARF LQLCLEHSLA
60 70 80 90 100
DCNDIHLLES EANSAAIVSQ WQQESKEKVV SLLLSHLPLL QPGNTEAKSE
110 120 130 140 150
YMRLLQKVLA YSIESNAFIE ESRQLLSYAL IHPATTLEDR NALALWLSHL
160 170 180 190 200
EERLASGFRS RPEPSYHSRQ GSDEWGGPAE LGPGEAGPGW QDKPPRENGH
210 220 230 240 250
VPFHPSSSVP PAINSIGSNA NTGLPCQIHP SPLKRSMSLI PTSPQVPGEW
260 270 280 290 300
PSPEELGARA AFTTPDHAPL SPQSSVASSG SEQTEEQGSS RNTFQEDGSG
310 320 330 340 350
MKDVPSWLKS LRLHKYAALF SQMSYEEMMT LTEQHLESQN VTKGARHKIA
360 370 380 390 400
LSIQKLRERQ SVLKSLEKDV LEGGNLRNAL QELQQIIITP IKAYSVLQAT
410 420 430 440 450
VAAATTTPTA KDGAPGEPPL PGAEPPLAHP GTDKGTEAKD PPAVENYPPP
460 470 480 490 500
PAPAPTDGSE PAPAPVADGD IPSQFTRVMG KVCTQLLVSR PDEENITSYL
510 520 530 540 550
QLIEKCLTHE AFTETQKKRL LSWKQQVLKL LRTFPRKAAL EMQNYRQQKG
560 570 580 590 600
WAFGSNSLPI AGSVGMGVAR RTQRQFPMPP RALPPGRMGL LSPSGIGGVS
610 620 630 640 650
PRHALTSPSL GGQGRQNLWF ANPGGSNSMP SQSRSSVQRT HSLPVHSSPQ
660 670 680 690
AILMFPPDCP VPGPDLEINP TLESLCLSMT EHALGDGTDK TSTI
Length:694
Mass (Da):75,483
Last modified:January 4, 2005 - v1
Checksum:i4AA4769F38494E56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF601121 mRNA. Translation: ABQ85549.1.
CH471126 Genomic DNA. Translation: EAW56877.1.
BC054518 mRNA. Translation: AAH54518.1.
BC065211 mRNA. Translation: AAH65211.1.
CCDSiCCDS33020.1.
RefSeqiNP_001290543.1. NM_001303614.1.
NP_060498.2. NM_018028.3.
XP_011525365.1. XM_011527063.2.
UniGeneiHs.612332.
Hs.707137.

Genome annotation databases

EnsembliENST00000314471; ENSP00000317224; ENSG00000179134.
ENST00000610417; ENSP00000484229; ENSG00000179134.
GeneIDi55095.
KEGGihsa:55095.
UCSCiuc002olb.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF601121 mRNA. Translation: ABQ85549.1.
CH471126 Genomic DNA. Translation: EAW56877.1.
BC054518 mRNA. Translation: AAH54518.1.
BC065211 mRNA. Translation: AAH65211.1.
CCDSiCCDS33020.1.
RefSeqiNP_001290543.1. NM_001303614.1.
NP_060498.2. NM_018028.3.
XP_011525365.1. XM_011527063.2.
UniGeneiHs.612332.
Hs.707137.

3D structure databases

ProteinModelPortaliQ5PRF9.
SMRiQ5PRF9. Positions 300-392.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120407. 19 interactions.
IntActiQ5PRF9. 9 interactions.
MINTiMINT-3307444.
STRINGi9606.ENSP00000317224.

PTM databases

iPTMnetiQ5PRF9.
PhosphoSiteiQ5PRF9.

Polymorphism and mutation databases

BioMutaiSAMD4B.
DMDMi74736136.

Proteomic databases

EPDiQ5PRF9.
MaxQBiQ5PRF9.
PaxDbiQ5PRF9.
PeptideAtlasiQ5PRF9.
PRIDEiQ5PRF9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314471; ENSP00000317224; ENSG00000179134.
ENST00000610417; ENSP00000484229; ENSG00000179134.
GeneIDi55095.
KEGGihsa:55095.
UCSCiuc002olb.4. human.

Organism-specific databases

CTDi55095.
GeneCardsiSAMD4B.
H-InvDBHIX0015115.
HGNCiHGNC:25492. SAMD4B.
HPAiHPA016800.
HPA059385.
neXtProtiNX_Q5PRF9.
PharmGKBiPA143485607.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3791. Eukaryota.
ENOG410XSUP. LUCA.
GeneTreeiENSGT00390000015877.
HOGENOMiHOG000290216.
InParanoidiQ5PRF9.
OMAiMFPPDCP.
OrthoDBiEOG091G0A44.
PhylomeDBiQ5PRF9.
TreeFamiTF324165.

Miscellaneous databases

ChiTaRSiSAMD4B. human.
GenomeRNAii55095.
PROiQ5PRF9.

Gene expression databases

BgeeiENSG00000179134.
CleanExiHS_SAMD4B.
ExpressionAtlasiQ5PRF9. baseline and differential.
GenevisibleiQ5PRF9. HS.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.25.40.170. 2 hits.
InterProiIPR015327. PHAT_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSMAG2_HUMAN
AccessioniPrimary (citable) accession number: Q5PRF9
Secondary accession number(s): A5Z0M6, Q6P194
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: January 4, 2005
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.