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Protein

14-3-3 protein beta/alpha-A

Gene

ywhaba

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity).By similarity

GO - Biological processi

  • phagocytosis, engulfment Source: ZFIN
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DRE-111447. Activation of BAD and translocation to mitochondria.
R-DRE-1445148. Translocation of GLUT4 to the plasma membrane.
R-DRE-165159. mTOR signalling.
R-DRE-166208. mTORC1-mediated signalling.
R-DRE-2028269. Signaling by Hippo.
R-DRE-392517. Rap1 signalling.
R-DRE-450385. Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
R-DRE-5628897. TP53 Regulates Metabolic Genes.
R-DRE-5673000. RAF activation.
R-DRE-5674135. MAP2K and MAPK activation.
R-DRE-5675221. Negative regulation of MAPK pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
14-3-3 protein beta/alpha-A
Gene namesi
Name:ywhaba
Synonyms:ywhab1
ORF Names:wu:fb80c08
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 6

Organism-specific databases

ZFINiZDB-GENE-030131-6583. ywhaba.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 24424414-3-3 protein beta/alpha-APRO_0000058602Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5PRD0.
PRIDEiQ5PRD0.

Expressioni

Gene expression databases

BgeeiQ5PRD0.

Interactioni

Subunit structurei

Homodimer, and heterodimer with other family members.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei56 – 561Interaction with phosphoserine on interacting proteinBy similarity
Sitei127 – 1271Interaction with phosphoserine on interacting proteinBy similarity

Protein-protein interaction databases

IntActiQ5PRD0. 1 interaction.
MINTiMINT-8283610.
STRINGi7955.ENSDARP00000027118.

Structurei

3D structure databases

ProteinModelPortaliQ5PRD0.
SMRiQ5PRD0. Positions 1-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

eggNOGiKOG0841. Eukaryota.
COG5040. LUCA.
GeneTreeiENSGT00760000119116.
HOGENOMiHOG000240379.
HOVERGENiHBG050423.
InParanoidiQ5PRD0.
KOiK16197.
OMAiMGREYRE.
OrthoDBiEOG7HHWT3.
PhylomeDBiQ5PRD0.
TreeFamiTF102003.

Family and domain databases

InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFiPIRSF000868. 14-3-3. 1 hit.
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PRD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKSDLVQKA KLAEQAERYD DMAASMKAVT EGGVELSNEE RNLLSVAYKN
60 70 80 90 100
VVGARRSSWR VISSIEQKTE GNEKKQQMAR EYREKIEAEL QEICNDVLGL
110 120 130 140 150
LEKYLIPNAS QAESKVFYLK MKGDYYRYLS EVASGDSKRT TVENSQKAYQ
160 170 180 190 200
DAFEISKKEM QPTHPIRLGL ALNFSVFYYE ILNTPEQACS LAKTAFDEAI
210 220 230 240
AELDTLNEDS YKDSTLIMQL LRDNLTLWTS ENQGDEGDAG EGEN
Length:244
Mass (Da):27,647
Last modified:November 22, 2005 - v2
Checksum:iD8421934B4BF17EA
GO

Sequence cautioni

The sequence AAH86710.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086710 mRNA. Translation: AAH86710.1. Different initiation.
BC133863 mRNA. Translation: AAI33864.1.
RefSeqiNP_001076267.1. NM_001082798.1.
UniGeneiDr.77005.

Genome annotation databases

EnsembliENSDART00000025940; ENSDARP00000027118; ENSDARG00000013078.
GeneIDi323055.
KEGGidre:323055.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086710 mRNA. Translation: AAH86710.1. Different initiation.
BC133863 mRNA. Translation: AAI33864.1.
RefSeqiNP_001076267.1. NM_001082798.1.
UniGeneiDr.77005.

3D structure databases

ProteinModelPortaliQ5PRD0.
SMRiQ5PRD0. Positions 1-231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5PRD0. 1 interaction.
MINTiMINT-8283610.
STRINGi7955.ENSDARP00000027118.

Proteomic databases

PaxDbiQ5PRD0.
PRIDEiQ5PRD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000025940; ENSDARP00000027118; ENSDARG00000013078.
GeneIDi323055.
KEGGidre:323055.

Organism-specific databases

CTDi323055.
ZFINiZDB-GENE-030131-6583. ywhaba.

Phylogenomic databases

eggNOGiKOG0841. Eukaryota.
COG5040. LUCA.
GeneTreeiENSGT00760000119116.
HOGENOMiHOG000240379.
HOVERGENiHBG050423.
InParanoidiQ5PRD0.
KOiK16197.
OMAiMGREYRE.
OrthoDBiEOG7HHWT3.
PhylomeDBiQ5PRD0.
TreeFamiTF102003.

Enzyme and pathway databases

ReactomeiR-DRE-111447. Activation of BAD and translocation to mitochondria.
R-DRE-1445148. Translocation of GLUT4 to the plasma membrane.
R-DRE-165159. mTOR signalling.
R-DRE-166208. mTORC1-mediated signalling.
R-DRE-2028269. Signaling by Hippo.
R-DRE-392517. Rap1 signalling.
R-DRE-450385. Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
R-DRE-5628897. TP53 Regulates Metabolic Genes.
R-DRE-5673000. RAF activation.
R-DRE-5674135. MAP2K and MAPK activation.
R-DRE-5675221. Negative regulation of MAPK pathway.

Miscellaneous databases

PROiQ5PRD0.

Gene expression databases

BgeeiQ5PRD0.

Family and domain databases

InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFiPIRSF000868. 14-3-3. 1 hit.
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo and Testis.

Entry informationi

Entry namei143BA_DANRE
AccessioniPrimary (citable) accession number: Q5PRD0
Secondary accession number(s): A3KNI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: June 8, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.