Q5PRD0 (143BA_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
14-3-3 protein beta/alpha-A

Gene names

Name:	ywhaba
Synonyms:	ywhab1
ORF Names:	wu:fb80c08

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner By similarity.
Subunit structure	Homodimer, and heterodimer with other family members By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the 14-3-3 family.
Sequence caution	The sequence AAH86710.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Cytoplasm
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein domain specific binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 244	244	14-3-3 protein beta/alpha-A		PRO_0000058602
Sites
	Site	56	1	Interaction with phosphoserine on interacting protein By similarity
	Site	127	1	Interaction with phosphoserine on interacting protein By similarity
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5PRD0 [UniParc]. Last modified November 22, 2005. Version 2. Checksum: D8421934B4BF17EA	FASTA	244	27,647
	10 20 30 40 50 60 MDKSDLVQKA KLAEQAERYD DMAASMKAVT EGGVELSNEE RNLLSVAYKN VVGARRSSWR 70 80 90 100 110 120 VISSIEQKTE GNEKKQQMAR EYREKIEAEL QEICNDVLGL LEKYLIPNAS QAESKVFYLK 130 140 150 160 170 180 MKGDYYRYLS EVASGDSKRT TVENSQKAYQ DAFEISKKEM QPTHPIRLGL ALNFSVFYYE 190 200 210 220 230 240 ILNTPEQACS LAKTAFDEAI AELDTLNEDS YKDSTLIMQL LRDNLTLWTS ENQGDEGDAG EGEN

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo and Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC086710 mRNA. Translation: AAH86710.1. Different initiation. BC133863 mRNA. Translation: AAI33864.1.
IPI	IPI00509301.
RefSeq	NP_001076267.1. NM_001082798.1.
UniGene	Dr.77005.
3D structure databases
ProteinModelPortal	Q5PRD0.
SMR	Q5PRD0. Positions 1-231.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5PRD0.
Proteomic databases
PRIDE	Q5PRD0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000025940; ENSDARP00000027118; ENSDARG00000013078.
GeneID	323055.
KEGG	dre:323055.
NMPDR	fig|7955.3.peg.29744.
Organism-specific databases
CTD	323055.
ZFIN	ZDB-GENE-030131-6583. ywhaba.
Phylogenomic databases
GeneTree	ENSGT00550000074221.
HOGENOM	HBG611720.
HOVERGEN	HBG050423.
InParanoid	Q5PRD0.
OrthoDB	EOG4N30PR.
PhylomeDB	Q5PRD0.
Gene expression databases
Bgee	Q5PRD0.
Family and domain databases
InterPro	IPR000308. 14-3-3. IPR023409. 14-3-3_CS. IPR023410. 14-3-3_domain. [Graphical view]
Gene3D	G3DSA:1.20.190.20. 14-3-3. 1 hit.
KO	K06630.
PANTHER	PTHR18860. 14-3-3. 1 hit.
Pfam	PF00244. 14-3-3. 1 hit. [Graphical view]
PIRSF	PIRSF000868. 14-3-3. 1 hit.
PRINTS	PR00305. 1433ZETA.
SMART	SM00101. 14_3_3. 1 hit. [Graphical view]
SUPFAM	SSF48445. 14-3-3. 1 hit.
PROSITE	PS00796. 1433_1. 1 hit. PS00797. 1433_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

143BA_DANRE

Accession

Primary (citable) accession number: Q5PRD0
Secondary accession number(s): A3KNI9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	November 22, 2005
Last modified:	November 16, 2011
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program