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Protein

14-3-3 protein beta/alpha-A

Gene

ywhaba

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • phagocytosis, engulfment Source: ZFIN

Enzyme and pathway databases

ReactomeiR-DRE-111447 Activation of BAD and translocation to mitochondria
R-DRE-1445148 Translocation of GLUT4 to the plasma membrane
R-DRE-165159 mTOR signalling
R-DRE-166208 mTORC1-mediated signalling
R-DRE-2028269 Signaling by Hippo
R-DRE-392517 Rap1 signalling
R-DRE-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-DRE-5625740 RHO GTPases activate PKNs
R-DRE-5628897 TP53 Regulates Metabolic Genes
R-DRE-5673000 RAF activation
R-DRE-5674135 MAP2K and MAPK activation
R-DRE-5675221 Negative regulation of MAPK pathway
R-DRE-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Names & Taxonomyi

Protein namesi
Recommended name:
14-3-3 protein beta/alpha-A
Gene namesi
Name:ywhaba
Synonyms:ywhab1
ORF Names:wu:fb80c08
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi

Organism-specific databases

ZFINiZDB-GENE-030131-6583 ywhaba

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000586021 – 24414-3-3 protein beta/alpha-AAdd BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5PRD0
PRIDEiQ5PRD0

Expressioni

Gene expression databases

BgeeiENSDARG00000013078
ExpressionAtlasiQ5PRD0 baseline

Interactioni

Subunit structurei

Homodimer, and heterodimer with other family members.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei56Interaction with phosphoserine on interacting proteinBy similarity1
Sitei127Interaction with phosphoserine on interacting proteinBy similarity1

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ5PRD0, 1 interactor
MINTiQ5PRD0
STRINGi7955.ENSDARP00000027118

Structurei

3D structure databases

ProteinModelPortaliQ5PRD0
SMRiQ5PRD0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

eggNOGiKOG0841 Eukaryota
COG5040 LUCA
GeneTreeiENSGT00760000119116
HOGENOMiHOG000240379
HOVERGENiHBG050423
InParanoidiQ5PRD0
KOiK16197
OrthoDBiEOG091G0VKY
PhylomeDBiQ5PRD0
TreeFamiTF102003

Family and domain databases

Gene3Di1.20.190.20, 1 hit
InterProiView protein in InterPro
IPR000308 14-3-3
IPR023409 14-3-3_CS
IPR036815 14-3-3_dom_sf
IPR023410 14-3-3_domain
PANTHERiPTHR18860 PTHR18860, 1 hit
PfamiView protein in Pfam
PF00244 14-3-3, 1 hit
PIRSFiPIRSF000868 14-3-3, 1 hit
PRINTSiPR00305 1433ZETA
SMARTiView protein in SMART
SM00101 14_3_3, 1 hit
SUPFAMiSSF48445 SSF48445, 1 hit
PROSITEiView protein in PROSITE
PS00796 1433_1, 1 hit
PS00797 1433_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5PRD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKSDLVQKA KLAEQAERYD DMAASMKAVT EGGVELSNEE RNLLSVAYKN
60 70 80 90 100
VVGARRSSWR VISSIEQKTE GNEKKQQMAR EYREKIEAEL QEICNDVLGL
110 120 130 140 150
LEKYLIPNAS QAESKVFYLK MKGDYYRYLS EVASGDSKRT TVENSQKAYQ
160 170 180 190 200
DAFEISKKEM QPTHPIRLGL ALNFSVFYYE ILNTPEQACS LAKTAFDEAI
210 220 230 240
AELDTLNEDS YKDSTLIMQL LRDNLTLWTS ENQGDEGDAG EGEN
Length:244
Mass (Da):27,647
Last modified:November 22, 2005 - v2
Checksum:iD8421934B4BF17EA
GO

Sequence cautioni

The sequence AAH86710 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086710 mRNA Translation: AAH86710.1 Different initiation.
BC133863 mRNA Translation: AAI33864.1
RefSeqiNP_001076267.1, NM_001082798.1
UniGeneiDr.77005

Genome annotation databases

EnsembliENSDART00000025940; ENSDARP00000027118; ENSDARG00000013078
GeneIDi323055
KEGGidre:323055

Similar proteinsi

Entry informationi

Entry namei143BA_DANRE
AccessioniPrimary (citable) accession number: Q5PRD0
Secondary accession number(s): A3KNI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: May 23, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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