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Q5PRA2

- DHTK1_DANRE

UniProt

Q5PRA2 - DHTK1_DANRE

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Protein

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

Gene

dhtkd1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial (EC:1.2.4.2)
Alternative name(s):
Dehydrogenase E1 and transketolase domain-containing protein 1
Gene namesi
Name:dhtkd1
ORF Names:zgc:101818
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-041212-44. dhtkd1.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 920Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrialPRO_0000307940
Transit peptidei1 – ?MitochondrionSequence Analysis

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000025776.

Structurei

3D structure databases

ProteinModelPortaliQ5PRA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259586.
HOVERGENiHBG001892.
InParanoidiQ5PRA2.
KOiK15791.
PhylomeDBiQ5PRA2.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5PRA2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLIHLPRLLH RSFGARRSFL ASLYHTQRGV YGFRPRDGPE RRAELTQISA
60 70 80 90 100
LNRDHGLARL VEAYRAHGHK VAKINPLLPQ SPVLESVPEI SLLNGAVRGV
110 120 130 140 150
LNTTGLRHFG KAEATAEEVV AYLESTYCGG ISVETSQLQT LEEREWFADR
160 170 180 190 200
FEELKKEAFS PEERRMLAKL MLESQEFDHF LATKFATVKR YGGEGAESMM
210 220 230 240 250
GFFYELFRSS VYSGVTDVVM GMPHRGRLNL LTGLLQFPPE LMFRKMRGLS
260 270 280 290 300
EFPEHSPSIG DVLSHLTSTV ELDFGAGHPL HVTMLPNPSH LEAINPVTQG
310 320 330 340 350
KTRGRQQVKQ DGDYSTDPHS RPGDKVICLQ VHGDASFSGQ GIVPETFTLS
360 370 380 390 400
NLPHYRVGGS IHLIVNNQVG YTTPSERGRS SLYCSDVGKM VGCAIIHVNG
410 420 430 440 450
DDAEEVLRAT RLAVEYQRRF RKDVIVDLLC YRQWGHNELD EPFFTNPAMY
460 470 480 490 500
KIIRSRKSIP DSYADQLISE GLMTDEERSQ IKTSYYATLN NQLTNMTLYS
510 520 530 540 550
PPPTNLQGRW GDLVEPQNRV SCWDTGVAQP LLQFVGAKSV DIPEEIILHS
560 570 580 590 600
HLRKTHVQAR LQKLEEGTKL DWSTAEALAF GTLLCQGFNI RISGQDVGRG
610 620 630 640 650
TFSQRHAMVV CQETNDMFIP LNHISSEQKG HLEVCNSALS EEAVLGFEYG
660 670 680 690 700
MSIAQPRLLP IWEAQFGDFF NGAQIIFDTF LSGGEAKWLL QSGLVILLPH
710 720 730 740 750
GYDGAGPEHS SCRIERFLQL CDSKEEGVDG DTVNMAVVNP TLPAQYFHLL
760 770 780 790 800
RRQMIRNFRK PLIVASPKTL LRFSGAVSGL SDMGPGTSFK PIIGDSSVNP
810 820 830 840 850
ASVQRVLFCS GKHYYALLKH RETIPEAEKN TALVRVEELC PFPTEALQQE
860 870 880 890 900
LNKYTNAKEF IWSQEEPQNM GCWSFVSPRF EKQLACKLRL VSRPALPAPA
910 920
VGIGTLHHQQ HEAILTSSFS
Length:920
Mass (Da):102,964
Last modified:October 23, 2007 - v2
Checksum:i7753F5D8CB29A2A7
GO

Sequence cautioni

The sequence AAH86742.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086742 mRNA. Translation: AAH86742.1. Different initiation.
RefSeqiNP_001008619.1. NM_001008619.1.
UniGeneiDr.81849.

Genome annotation databases

GeneIDi494076.
KEGGidre:494076.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086742 mRNA. Translation: AAH86742.1 . Different initiation.
RefSeqi NP_001008619.1. NM_001008619.1.
UniGenei Dr.81849.

3D structure databases

ProteinModelPortali Q5PRA2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000025776.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 494076.
KEGGi dre:494076.

Organism-specific databases

CTDi 55526.
ZFINi ZDB-GENE-041212-44. dhtkd1.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259586.
HOVERGENi HBG001892.
InParanoidi Q5PRA2.
KOi K15791.
PhylomeDBi Q5PRA2.

Miscellaneous databases

NextBioi 20865584.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiDHTK1_DANRE
AccessioniPrimary (citable) accession number: Q5PRA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 26, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3