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Q5PRA2

- DHTK1_DANRE

UniProt

Q5PRA2 - DHTK1_DANRE

Protein

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

Gene

dhtkd1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Thiamine pyrophosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial (EC:1.2.4.2)
    Alternative name(s):
    Dehydrogenase E1 and transketolase domain-containing protein 1
    Gene namesi
    Name:dhtkd1
    ORF Names:zgc:101818
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-041212-44. dhtkd1.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 920Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrialPRO_0000307940
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000025776.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5PRA2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0567.
    HOGENOMiHOG000259586.
    HOVERGENiHBG001892.
    InParanoidiQ5PRA2.
    KOiK15791.
    PhylomeDBiQ5PRA2.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5PRA2-1 [UniParc]FASTAAdd to Basket

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    MLIHLPRLLH RSFGARRSFL ASLYHTQRGV YGFRPRDGPE RRAELTQISA    50
    LNRDHGLARL VEAYRAHGHK VAKINPLLPQ SPVLESVPEI SLLNGAVRGV 100
    LNTTGLRHFG KAEATAEEVV AYLESTYCGG ISVETSQLQT LEEREWFADR 150
    FEELKKEAFS PEERRMLAKL MLESQEFDHF LATKFATVKR YGGEGAESMM 200
    GFFYELFRSS VYSGVTDVVM GMPHRGRLNL LTGLLQFPPE LMFRKMRGLS 250
    EFPEHSPSIG DVLSHLTSTV ELDFGAGHPL HVTMLPNPSH LEAINPVTQG 300
    KTRGRQQVKQ DGDYSTDPHS RPGDKVICLQ VHGDASFSGQ GIVPETFTLS 350
    NLPHYRVGGS IHLIVNNQVG YTTPSERGRS SLYCSDVGKM VGCAIIHVNG 400
    DDAEEVLRAT RLAVEYQRRF RKDVIVDLLC YRQWGHNELD EPFFTNPAMY 450
    KIIRSRKSIP DSYADQLISE GLMTDEERSQ IKTSYYATLN NQLTNMTLYS 500
    PPPTNLQGRW GDLVEPQNRV SCWDTGVAQP LLQFVGAKSV DIPEEIILHS 550
    HLRKTHVQAR LQKLEEGTKL DWSTAEALAF GTLLCQGFNI RISGQDVGRG 600
    TFSQRHAMVV CQETNDMFIP LNHISSEQKG HLEVCNSALS EEAVLGFEYG 650
    MSIAQPRLLP IWEAQFGDFF NGAQIIFDTF LSGGEAKWLL QSGLVILLPH 700
    GYDGAGPEHS SCRIERFLQL CDSKEEGVDG DTVNMAVVNP TLPAQYFHLL 750
    RRQMIRNFRK PLIVASPKTL LRFSGAVSGL SDMGPGTSFK PIIGDSSVNP 800
    ASVQRVLFCS GKHYYALLKH RETIPEAEKN TALVRVEELC PFPTEALQQE 850
    LNKYTNAKEF IWSQEEPQNM GCWSFVSPRF EKQLACKLRL VSRPALPAPA 900
    VGIGTLHHQQ HEAILTSSFS 920
    Length:920
    Mass (Da):102,964
    Last modified:October 23, 2007 - v2
    Checksum:i7753F5D8CB29A2A7
    GO

    Sequence cautioni

    The sequence AAH86742.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC086742 mRNA. Translation: AAH86742.1. Different initiation.
    RefSeqiNP_001008619.1. NM_001008619.1.
    UniGeneiDr.81849.

    Genome annotation databases

    GeneIDi494076.
    KEGGidre:494076.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC086742 mRNA. Translation: AAH86742.1 . Different initiation.
    RefSeqi NP_001008619.1. NM_001008619.1.
    UniGenei Dr.81849.

    3D structure databases

    ProteinModelPortali Q5PRA2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000025776.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 494076.
    KEGGi dre:494076.

    Organism-specific databases

    CTDi 55526.
    ZFINi ZDB-GENE-041212-44. dhtkd1.

    Phylogenomic databases

    eggNOGi COG0567.
    HOGENOMi HOG000259586.
    HOVERGENi HBG001892.
    InParanoidi Q5PRA2.
    KOi K15791.
    PhylomeDBi Q5PRA2.

    Miscellaneous databases

    NextBioi 20865584.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.

    Entry informationi

    Entry nameiDHTK1_DANRE
    AccessioniPrimary (citable) accession number: Q5PRA2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3