Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTP-binding protein Di-Ras2

Gene

Diras2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Displays low GTPase activity and exist predominantly in the GTP-bound form.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 218GTPBy similarity
Nucleotide bindingi33 – 397GTPBy similarity
Nucleotide bindingi61 – 655GTPBy similarity
Nucleotide bindingi121 – 1244GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein Di-Ras2
Alternative name(s):
Distinct subgroup of the Ras family member 2
Gene namesi
Name:Diras2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1915453. Diras2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196GTP-binding protein Di-Ras2PRO_0000191652Add
BLAST
Propeptidei197 – 1993Removed in mature formSequence analysisPRO_0000370779

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351PhosphoserineCombined sources
Modified residuei126 – 1261PhosphoserineCombined sources
Modified residuei196 – 1961Cysteine methyl esterSequence analysis
Lipidationi196 – 1961S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ5PR73.
MaxQBiQ5PR73.
PaxDbiQ5PR73.
PRIDEiQ5PR73.

PTM databases

iPTMnetiQ5PR73.
PhosphoSiteiQ5PR73.

Expressioni

Gene expression databases

BgeeiQ5PR73.
CleanExiMM_DIRAS2.
ExpressionAtlasiQ5PR73. baseline and differential.
GenevisibleiQ5PR73. MM.

Interactioni

Protein-protein interaction databases

BioGridi212726. 2 interactions.
IntActiQ5PR73. 2 interactions.
STRINGi10090.ENSMUSP00000055416.

Structurei

3D structure databases

ProteinModelPortaliQ5PR73.
SMRiQ5PR73. Positions 6-176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 449Effector regionSequence analysis

Sequence similaritiesi

Belongs to the small GTPase superfamily. Di-Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121857.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ5PR73.
KOiK07841.
OMAiWGVSFME.
OrthoDBiEOG7SBNQ3.
PhylomeDBiQ5PR73.
TreeFamiTF313014.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5PR73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEQSNDYRV AVFGAGGVGK SSLVLRFVKG TFRESYIPTV EDTYRQVISC
60 70 80 90 100
DKSICTLQIT DTTGSHQFPA MQRLSISKGH AFILVYSITS RQSLEELKPI
110 120 130 140 150
YEQICEIKGD VESIPIMLVG NKCDESPNRE VQSSEAEALA RTWKCAFMET
160 170 180 190
SAKLNHNVKE LFQELLNLEK RRTVSLQIDG KKSKQQKRKE KLKGKCVVM
Length:199
Mass (Da):22,498
Last modified:January 4, 2005 - v1
Checksum:iC1A69D3145C3EACD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086799 mRNA. Translation: AAH86799.1.
CCDSiCCDS26516.1.
RefSeqiNP_001019645.1. NM_001024474.2.
XP_006517013.1. XM_006516950.2.
UniGeneiMm.29362.

Genome annotation databases

EnsembliENSMUST00000057442; ENSMUSP00000055416; ENSMUSG00000047842.
GeneIDi68203.
KEGGimmu:68203.
UCSCiuc007qmv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC086799 mRNA. Translation: AAH86799.1.
CCDSiCCDS26516.1.
RefSeqiNP_001019645.1. NM_001024474.2.
XP_006517013.1. XM_006516950.2.
UniGeneiMm.29362.

3D structure databases

ProteinModelPortaliQ5PR73.
SMRiQ5PR73. Positions 6-176.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212726. 2 interactions.
IntActiQ5PR73. 2 interactions.
STRINGi10090.ENSMUSP00000055416.

PTM databases

iPTMnetiQ5PR73.
PhosphoSiteiQ5PR73.

Proteomic databases

EPDiQ5PR73.
MaxQBiQ5PR73.
PaxDbiQ5PR73.
PRIDEiQ5PR73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057442; ENSMUSP00000055416; ENSMUSG00000047842.
GeneIDi68203.
KEGGimmu:68203.
UCSCiuc007qmv.1. mouse.

Organism-specific databases

CTDi54769.
MGIiMGI:1915453. Diras2.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121857.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ5PR73.
KOiK07841.
OMAiWGVSFME.
OrthoDBiEOG7SBNQ3.
PhylomeDBiQ5PR73.
TreeFamiTF313014.

Miscellaneous databases

ChiTaRSiDiras2. mouse.
PROiQ5PR73.
SOURCEiSearch...

Gene expression databases

BgeeiQ5PR73.
CleanExiMM_DIRAS2.
ExpressionAtlasiQ5PR73. baseline and differential.
GenevisibleiQ5PR73. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35 AND SER-126, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiDIRA2_MOUSE
AccessioniPrimary (citable) accession number: Q5PR73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: January 4, 2005
Last modified: July 6, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.