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Protein

Intraflagellar transport protein 56

Gene

ttc26

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly.1 Publication1 Publication

GO - Biological processi

  • cilium assembly Source: UniProtKB
  • intraciliary transport Source: UniProtKB
  • photoreceptor cell differentiation Source: MGI
  • photoreceptor cell morphogenesis Source: MGI
  • photoreceptor cell outer segment organization Source: ZFIN
  • pronephric duct morphogenesis Source: ZFIN
  • smoothened signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-DRE-5620924. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 561 Publication
Alternative name(s):
Tetratricopeptide repeat protein 26
Short name:
TPR repeat protein 26
Gene namesi
Name:ttc26
Synonyms:ift561 Publication
ORF Names:zgc:103412
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 6

Organism-specific databases

ZFINiZDB-GENE-041212-41. ttc26.

Subcellular locationi

  • Cell projectioncilium By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Disruption phenotypei

Defective cilia (PubMed:22718903, PubMed:24596149). Morpholino knockdown of the protein results in cilia defects in the pronephric kidney at 27 hpf and distension/dilation of pronephros at 5 dpf. In the eyes, the outer segments of photoreceptor cells appear shortened or absent, whereas cellular lamination seems normal in retinas at 5 dpf (PubMed:22718903). Left-right asymmetry defects with abnormal heart looping, hydrocephalus, pronephric cysts, abnormal ear otolith formation and curly body axis (PubMed:24596149).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002890861 – 557Intraflagellar transport protein 56Add BLAST557

Proteomic databases

PaxDbiQ5PR66.

Expressioni

Gene expression databases

BgeeiENSDARG00000012039.

Interactioni

Subunit structurei

Component of the IFT complex B.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000032176.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati60 – 93TPR 1Add BLAST34
Repeati95 – 128TPR 2Add BLAST34
Repeati154 – 187TPR 3Add BLAST34
Repeati471 – 504TPR 4Add BLAST34

Sequence similaritiesi

Belongs to the IFT56 family.Curated
Contains 4 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG3785. Eukaryota.
ENOG410XRMP. LUCA.
GeneTreeiENSGT00390000000159.
HOGENOMiHOG000258854.
HOVERGENiHBG108610.
InParanoidiQ5PR66.
KOiK19685.
OMAiVEYMIRI.
OrthoDBiEOG091G04RS.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR030511. TTC26.
[Graphical view]
PANTHERiPTHR14781:SF0. PTHR14781:SF0. 1 hit.
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 4 hits.
PROSITEiPS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PR66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLSRMKPAV GGEASTSSNE KKRKNKSKKI PRLEDYLNQR DYLGALTLLE
60 70 80 90 100
FQRNSGVSVE HADLWTGFCA FHVGDHKRAM EEYKALTLRP DCPVDVWVYL
110 120 130 140 150
GCALFFLGLY KEAEEAALKG SKTQLQNRLL FHLAHKFNDE KKLMGFHQNL
160 170 180 190 200
EDVTEDQLSL ASIHYMRSHY QEAIDIYKRI LLQNREFLAL NVYVALCYYK
210 220 230 240 250
LDYYDVSQEV LAVYLQSIPD STIALNLKAC NHFRLYNGKA AETELKNLID
260 270 280 290 300
ISSSSFQFAK ELIQHNLVVF RGGEGALQVL PPLIDVISEA RLNLVIYYLR
310 320 330 340 350
QDDIQEAYKL IKDLEPTTPQ EYILKGVVNA ALGQEIGSRD HLKIAQQFFQ
360 370 380 390 400
LVGGSASECD TIPGRQCMAS CFFLLKQFED VLIYLNSVKS YFYNDDTFSF
410 420 430 440 450
NYAQAKAALG NYREAEELFL LIQNEKIKSD YVFQSWLARC YIMNQKPRQA
460 470 480 490 500
WELYLRMETS SDPFSLLQLI ANDCYKMGQF YYAAKAFDAL ERLDPNPEYW
510 520 530 540 550
EGKRGACVGI FQLILAGRES REILKEVLPM LRSTGNPQVE YIIRIMKKWA

KDNRVAL
Length:557
Mass (Da):64,186
Last modified:January 7, 2015 - v2
Checksum:iDCED6622EFF8BFBE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti274E → G in AAH86810 (Ref. 2) 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954384 Genomic DNA. No translation available.
BC086810 mRNA. Translation: AAH86810.1.
RefSeqiNP_001008617.1. NM_001008617.1.
UniGeneiDr.14525.

Genome annotation databases

EnsembliENSDART00000032494; ENSDARP00000032176; ENSDARG00000012039.
GeneIDi494074.
KEGGidre:494074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954384 Genomic DNA. No translation available.
BC086810 mRNA. Translation: AAH86810.1.
RefSeqiNP_001008617.1. NM_001008617.1.
UniGeneiDr.14525.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000032176.

Proteomic databases

PaxDbiQ5PR66.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000032494; ENSDARP00000032176; ENSDARG00000012039.
GeneIDi494074.
KEGGidre:494074.

Organism-specific databases

CTDi79989.
ZFINiZDB-GENE-041212-41. ttc26.

Phylogenomic databases

eggNOGiKOG3785. Eukaryota.
ENOG410XRMP. LUCA.
GeneTreeiENSGT00390000000159.
HOGENOMiHOG000258854.
HOVERGENiHBG108610.
InParanoidiQ5PR66.
KOiK19685.
OMAiVEYMIRI.
OrthoDBiEOG091G04RS.

Enzyme and pathway databases

ReactomeiR-DRE-5620924. Intraflagellar transport.

Miscellaneous databases

PROiQ5PR66.

Gene expression databases

BgeeiENSDARG00000012039.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR030511. TTC26.
[Graphical view]
PANTHERiPTHR14781:SF0. PTHR14781:SF0. 1 hit.
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 4 hits.
PROSITEiPS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIFT56_DANRE
AccessioniPrimary (citable) accession number: Q5PR66
Secondary accession number(s): F1QZ19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 7, 2015
Last modified: September 7, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.