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Q5PQX1

- TOIP1_RAT

UniProt

Q5PQX1 - TOIP1_RAT

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Protein

Torsin-1A-interacting protein 1

Gene

Tor1aip1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina.

GO - Molecular functioni

  1. ATPase activator activity Source: UniProtKB
  2. lamin binding Source: RGD

GO - Biological processi

  1. nuclear membrane organization Source: Ensembl
  2. positive regulation of ATPase activity Source: UniProtKB
  3. protein localization to nucleus Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Torsin-1A-interacting protein 1
Alternative name(s):
Lamina-associated polypeptide 1B
Short name:
LAP1B
Lamina-associated polypeptide 1C
Short name:
LAP1C
Gene namesi
Name:Tor1aip1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi628851. Tor1aip1.

Subcellular locationi

Nucleus inner membrane 2 Publications; Single-pass membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 339339Nuclear1 PublicationSequence AnalysisAdd
BLAST
Transmembranei340 – 36021HelicalSequence AnalysisAdd
BLAST
Topological domaini361 – 583223Perinuclear spaceSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. nuclear envelope Source: RGD
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 583583Torsin-1A-interacting protein 1PRO_0000084355Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei134 – 1341PhosphoserineBy similarity
Modified residuei142 – 1421PhosphoserineBy similarity
Modified residuei155 – 1551PhosphoserineBy similarity
Modified residuei189 – 1891PhosphoserineBy similarity
Modified residuei222 – 2221PhosphothreonineBy similarity
Modified residuei228 – 2281PhosphoserineBy similarity
Modified residuei316 – 3161PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5PQX1.
PRIDEiQ5PQX1.

PTM databases

PhosphoSiteiQ5PQX1.

Expressioni

Gene expression databases

ExpressionAtlasiQ5PQX1. baseline.
GenevestigatoriQ5PQX1.

Interactioni

Subunit structurei

Interacts with ATP1B4. Interacts with TOR1A (ATP-bound). Interacts with TOR1B, TOR2A and TOR3A. Interacts with VIM.1 Publication

Protein-protein interaction databases

DIPiDIP-60963N.
MINTiMINT-4997163.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni356 – 583228Interaction with TOR1ABy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili360 – 38829Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the TOR1AIP family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40503.
GeneTreeiENSGT00390000012166.
HOGENOMiHOG000015293.
HOVERGENiHBG083152.
InParanoidiQ5PQX1.
OMAiNSYKHMD.
OrthoDBiEOG7G7KQH.

Family and domain databases

InterProiIPR008662. Lamina-ass_polypeptide_CLAP1C.
[Graphical view]
PfamiPF05609. LAP1C. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5PQX1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGERWRAEG LGEGWAIYVT PRAPIREGRR RLATQNGDGS DAPAYETHPS
60 70 80 90 100
RHGRREVRFS EEPPEVYGDF EPRAAKERSP GERRTPPEKF RSDSAKEEVR
110 120 130 140 150
ESAYNLRSRQ RRQRGPQEAE EMKTRRSTRL EQHSQQAQQQ LSPATSGRGL
160 170 180 190 200
RDAQSLSEDR GEDEPSSQPV TSQTVSKKTV RTPETSVMSE DPISNLCRPP
210 220 230 240 250
LRSPRPDASI VQHINPFEEG ETEDDLESSY SDVTIRIRSR DSVESRDEAA
260 270 280 290 300
VAAGHHPDSL WGLPHSRGDF TAHENQPSLL PTGCQKNPQE WVEQAVRMRT
310 320 330 340 350
RMAYNNIQKS DFGNQSPSTS RQQAAVQPPD ESSVKIKWWL LILVAALAMG
360 370 380 390 400
IYWFFHTPVV ETTAVQEFQN QMKQLQSKYQ SQDEKLWKRG TTFLEKHLNS
410 420 430 440 450
SLPRPQPAIL LLTAAQDAAE VLKCLSEQIA DAYSSFRSVR AIRIDGAGKA
460 470 480 490 500
AQDSDLVKHE VDQELTDGFR NGQNAAVVHR FESLPAGSTL IFYKYCDHEN
510 520 530 540 550
AAFKDVALVL TVLLEEQTLE ASLGLKEIEE KVRDFLKVKF TSSDTANSYN
560 570 580
HMDPDKLNGL WSRISHLVLP VQPENALKAG SCL
Length:583
Mass (Da):65,649
Last modified:January 4, 2005 - v1
Checksum:i827FC3FA8CBDE3D8
GO
Isoform 21 Publication (identifier: Q5PQX1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-246: Missing.
     362-412: TTAVQEFQNQMKQLQSKYQSQDEKLWKRGTTFLEKHLNSSLPRPQPAILLL → I

Show »
Length:506
Mass (Da):56,696
Checksum:i1A59296053E0A243
GO
Isoform 31 Publication (identifier: Q5PQX1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: Missing.

Show »
Length:462
Mass (Da):51,690
Checksum:iD65027BF8EAC42B9
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 121121Missing in isoform 3. 1 PublicationVSP_051776Add
BLAST
Alternative sequencei220 – 24627Missing in isoform 2. 1 PublicationVSP_051777Add
BLAST
Alternative sequencei362 – 41251TTAVQ…AILLL → I in isoform 2. 1 PublicationVSP_051778Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19614 mRNA. Translation: AAA69914.1.
U20286 mRNA. Translation: AAA69915.1.
BC086987 mRNA. Translation: AAH86987.1.
PIRiA56391.
I61730.
RefSeqiNP_659560.2. NM_145092.2. [Q5PQX1-1]
UniGeneiRn.11373.

Genome annotation databases

EnsembliENSRNOT00000005280; ENSRNOP00000005280; ENSRNOG00000003946. [Q5PQX1-1]
GeneIDi246314.
KEGGirno:246314.
UCSCiRGD:628851. rat. [Q5PQX1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19614 mRNA. Translation: AAA69914.1 .
U20286 mRNA. Translation: AAA69915.1 .
BC086987 mRNA. Translation: AAH86987.1 .
PIRi A56391.
I61730.
RefSeqi NP_659560.2. NM_145092.2. [Q5PQX1-1 ]
UniGenei Rn.11373.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60963N.
MINTi MINT-4997163.

PTM databases

PhosphoSitei Q5PQX1.

Proteomic databases

PaxDbi Q5PQX1.
PRIDEi Q5PQX1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000005280 ; ENSRNOP00000005280 ; ENSRNOG00000003946 . [Q5PQX1-1 ]
GeneIDi 246314.
KEGGi rno:246314.
UCSCi RGD:628851. rat. [Q5PQX1-1 ]

Organism-specific databases

CTDi 26092.
RGDi 628851. Tor1aip1.

Phylogenomic databases

eggNOGi NOG40503.
GeneTreei ENSGT00390000012166.
HOGENOMi HOG000015293.
HOVERGENi HBG083152.
InParanoidi Q5PQX1.
OMAi NSYKHMD.
OrthoDBi EOG7G7KQH.

Miscellaneous databases

NextBioi 623740.
PROi Q5PQX1.

Gene expression databases

ExpressionAtlasi Q5PQX1. baseline.
Genevestigatori Q5PQX1.

Family and domain databases

InterProi IPR008662. Lamina-ass_polypeptide_CLAP1C.
[Graphical view ]
Pfami PF05609. LAP1C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and characterization of lamina-associated polypeptide 1C (LAP1C), an integral protein of the inner nuclear membrane."
    Martin L., Crimaudo C., Gerace L.
    J. Biol. Chem. 270:8822-8828(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), SUBCELLULAR LOCATION.
    Strain: Sprague-DawleyImported.
    Tissue: LiverImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  3. "Proteome analysis of a rat liver nuclear insoluble protein fraction and localization of a novel protein, ISP36, to compartments in the interchromatin space."
    Segawa M., Niino K., Mineki R., Kaga N., Murayama K., Sugimoto K., Watanabe Y., Furukawa K., Horigome T.
    FEBS J. 272:4327-4338(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 32-39 AND 152-160, SUBCELLULAR LOCATION.
    Tissue: Liver.
  4. "Accumulation of beta (m), a structural member of X,K-ATPase beta-subunit family, in nuclear envelopes of perinatal myocytes."
    Zhao H., Pestov N.B., Korneenko T.V., Shakhparonov M.I., Modyanov N.N.
    Am. J. Physiol. 286:C757-C767(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATP1B4.

Entry informationi

Entry nameiTOIP1_RAT
AccessioniPrimary (citable) accession number: Q5PQX1
Secondary accession number(s): Q62741, Q62754
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: January 4, 2005
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3