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Protein

UDP-glucuronic acid decarboxylase 1

Gene

Uxs1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.1 Publication

Catalytic activityi

UDP-D-glucuronate = UDP-D-xylose + CO2.

Cofactori

Pathwayi: UDP-alpha-D-xylose biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes UDP-alpha-D-xylose from UDP-alpha-D-glucuronate.
Proteins known to be involved in this subpathway in this organism are:
  1. UDP-glucuronic acid decarboxylase 1 (Uxs1)
This subpathway is part of the pathway UDP-alpha-D-xylose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP-alpha-D-xylose from UDP-alpha-D-glucuronate, the pathway UDP-alpha-D-xylose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei228SubstrateBy similarity1
Active sitei231Proton acceptorBy similarity1
Binding sitei260SubstrateBy similarity1
Binding sitei272NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi119 – 144NADBy similarityAdd BLAST26
Nucleotide bindingi231 – 235NADBy similarity5
Nucleotide bindingi273 – 277SubstrateBy similarity5
Nucleotide bindingi290 – 297SubstrateBy similarity8
Nucleotide bindingi357 – 361SubstrateBy similarity5

GO - Molecular functioni

  • NAD+ binding Source: GO_Central
  • UDP-glucuronate decarboxylase activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
LigandNAD

Enzyme and pathway databases

BRENDAi4.1.1.35 5301
UniPathwayiUPA00796; UER00771

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronic acid decarboxylase 1 (EC:4.1.1.35)
Alternative name(s):
UDP-glucuronate decarboxylase 1
Short name:
UGD
Short name:
UXS-1
Gene namesi
Name:Uxs1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi628680 Uxs1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini41 – 420LumenalSequence analysisAdd BLAST380

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001832721 – 420UDP-glucuronic acid decarboxylase 1Add BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei94PhosphothreonineBy similarity1
Glycosylationi316N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ5PQX0
PRIDEiQ5PQX0

Expressioni

Tissue specificityi

Ubiquitous. Detected in heart, brain, spleen, lung, testis, liver, skeletal muscle and kidney.1 Publication

Gene expression databases

BgeeiENSRNOG00000045605
GenevisibleiQ5PQX0 RN

Interactioni

Subunit structurei

Interacts with AKT1.1 Publication

Protein-protein interaction databases

BioGridi251537, 1 interactor
STRINGi10116.ENSRNOP00000066044

Structurei

3D structure databases

ProteinModelPortaliQ5PQX0
SMRiQ5PQX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1429 Eukaryota
COG0451 LUCA
GeneTreeiENSGT00530000063128
HOVERGENiHBG094144
InParanoidiQ5PQX0
KOiK08678
OMAiHWLGHEN
OrthoDBiEOG091G0BV7
PhylomeDBiQ5PQX0

Family and domain databases

InterProiView protein in InterPro
IPR016040 NAD(P)-bd_dom
IPR036291 NAD(P)-bd_dom_sf
IPR021761 UXS1_N
PfamiView protein in Pfam
PF16363 GDP_Man_Dehyd, 1 hit
PF11803 UXS1_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Q5PQX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSKGLLRLV SSVNRRKMKL LLGIALFAYA ASVWGNFVNM RSIQENGELK
60 70 80 90 100
IESKIEEIIE PLREKIRDLE KSFTQKYPPV KFLSEKDRKR ILITGGAGFV
110 120 130 140 150
GSHLTDKLMM DGHEVTVVDN FFTGRKRNVE HWIGHENFEL INHDVVEPLY
160 170 180 190 200
IEVDQIYHLA SPASPPNYMY NPIKTLKTNT IGTLNMLGLA KRVGARLLLA
210 220 230 240 250
STSEVYGDPE VHPQSEDYWG HVNPIGPRAC YDEGKRVAET MCYAYMKQEG
260 270 280 290 300
VEVRVARIFN TFGPRMHMND GRVVSNFILQ ALQGEPLTVY GSGSQTRAFQ
310 320 330 340 350
YVSDLVNGLV ALMNSNVSSP VNLGNPEEHT ILEFAQLIKN LVGSGSEIQF
360 370 380 390 400
LSEAQDDPQK RKPDIKKAKL MLGWEPVVPL EEGLNKAIHY FRKELEYQAN
410 420
NQYIPKPKPA RVKKGRTRHS
Length:420
Mass (Da):47,539
Last modified:January 4, 2005 - v1
Checksum:i1F0CF93BAF78C65B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55I → T in AAM45939 (PubMed:11877387).Curated1
Sequence conflicti114 – 116EVT → DVS in AAM45939 (PubMed:11877387).Curated3
Sequence conflicti336Q → E in AAM45939 (PubMed:11877387).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF482705 mRNA Translation: AAM45939.1
BC086988 mRNA Translation: AAH86988.1
RefSeqiNP_647552.1, NM_139336.1
UniGeneiRn.3037

Genome annotation databases

EnsembliENSRNOT00000070920; ENSRNOP00000066044; ENSRNOG00000045605
ENSRNOT00000082837; ENSRNOP00000070855; ENSRNOG00000045605
GeneIDi246232
KEGGirno:246232

Similar proteinsi

Entry informationi

Entry nameiUXS1_RAT
AccessioniPrimary (citable) accession number: Q5PQX0
Secondary accession number(s): Q8K464
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 4, 2005
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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