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Q5PQW8

- Q5PQW8_RAT

UniProt

Q5PQW8 - Q5PQW8_RAT

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Protein
Submitted name:

Guanylate binding protein 2

Gene

Gbp2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: InterPro

GO - Biological processi

  1. adhesion of symbiont to host Source: Ensembl
  2. cellular response to interferon-beta Source: Ensembl
  3. cellular response to interferon-gamma Source: Ensembl
  4. cellular response to lipopolysaccharide Source: Ensembl
  5. defense response to Gram-positive bacterium Source: Ensembl
  6. defense response to protozoan Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Guanylate binding protein 2Imported
Submitted name:
Guanylate nucleotide binding protein 2Imported
Submitted name:
Interferon-induced guanylate-binding protein 2Imported
Gene namesi
Name:Gbp2Imported
ORF Names:rCG_28968Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi621810. Gbp2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic vesicle Source: Ensembl
  2. symbiont-containing vacuole membrane Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ5PQW8.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00550000074475.
HOVERGENiHBG001979.
OMAiMAREFNE.
OrthoDBiEOG7BW0J3.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003191. Guanylate-bd_C.
IPR015894. Guanylate-bd_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02263. GBP. 1 hit.
PF02841. GBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF48340. SSF48340. 1 hit.
SSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5PQW8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDMASEIHML QPMCLIENTE AHLVINQEAL RILSAINQPV VVVAIVGLYR
60 70 80 90 100
TGKSYLMNKL AGKRTGFSLG STVQSHTKGI WMWCVPHPKK AGQTLVLLDT
110 120 130 140 150
EGLEDVEKGD NQNDCWIFAL AVLLSSTFVY NSMGTINQQA MDQLHYVTEL
160 170 180 190 200
TDLIKSKSSP DQSGIDDSAN FVGFFPTFVW ALRDFSLELE VNGKLVTPDE
210 220 230 240 250
YLEHSLTLKK GADKKTKSFN EPRLCIRKFF PKRKCFIFDR PALRKQLCKL
260 270 280 290 300
ETLGEEELCS EFVEQVAEFT SYIFSYSAVK TLSGGIIVNG PRLKSLVQTY
310 320 330 340 350
VGAISSGSLP CMESAVLTLA QIENSAAVQK AITHYEEQMN QKIQMPTETL
360 370 380 390 400
QELLDLHRLI EREAIEIFLK NSFKDVDQKF QTELGNLLIS KRDAFIKKNS
410 420 430 440 450
DVSSAHCSDL IEDIFGPLEE EVKQGTFSKP GGYFLFLQMR QELEKKYNQA
460 470 480 490 500
PGKGLEAEAV LKKYFESKED IVETLLKTDQ SLTEAAKEIE VERIKAETAE
510 520 530 540 550
AANRELAEKQ EKFELMMQQK EESYQEHVRQ LTEKMKEEQK KLIEEQDNII
560 570 580 590
ALKLREQEKF LREGYENESK KLLREIENMK RRQSPGKCTI L
Length:591
Mass (Da):67,355
Last modified:January 4, 2005 - v1
Checksum:i3249C0EB57217176
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06021159 Genomic DNA. No translation available.
AABR06021160 Genomic DNA. No translation available.
BC086991 mRNA. Translation: AAH86991.1.
CH473952 Genomic DNA. Translation: EDL82354.1.
RefSeqiNP_598308.1. NM_133624.2.
UniGeneiRn.25736.

Genome annotation databases

EnsembliENSRNOT00000068683; ENSRNOP00000061437; ENSRNOG00000031743.
GeneIDi171164.
KEGGirno:171164.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06021159 Genomic DNA. No translation available.
AABR06021160 Genomic DNA. No translation available.
BC086991 mRNA. Translation: AAH86991.1 .
CH473952 Genomic DNA. Translation: EDL82354.1 .
RefSeqi NP_598308.1. NM_133624.2.
UniGenei Rn.25736.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000068683 ; ENSRNOP00000061437 ; ENSRNOG00000031743 .
GeneIDi 171164.
KEGGi rno:171164.

Organism-specific databases

CTDi 2634.
RGDi 621810. Gbp2.

Phylogenomic databases

GeneTreei ENSGT00550000074475.
HOVERGENi HBG001979.
OMAi MAREFNE.
OrthoDBi EOG7BW0J3.

Miscellaneous databases

NextBioi 622019.

Gene expression databases

Genevestigatori Q5PQW8.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003191. Guanylate-bd_C.
IPR015894. Guanylate-bd_N.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF02263. GBP. 1 hit.
PF02841. GBP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48340. SSF48340. 1 hit.
SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: HeartImported.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ5PQW8_RAT
AccessioniPrimary (citable) accession number: Q5PQW8
Secondary accession number(s): D4A6I2
Entry historyi
Integrated into UniProtKB/TrEMBL: January 4, 2005
Last sequence update: January 4, 2005
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3