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Q5PQW8

- Q5PQW8_RAT

UniProt

Q5PQW8 - Q5PQW8_RAT

Protein
Submitted name:

Guanylate binding protein 2

Gene

Gbp2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: InterPro

    GO - Biological processi

    1. cellular response to interferon-beta Source: Ensembl
    2. cellular response to interferon-gamma Source: Ensembl
    3. cellular response to lipopolysaccharide Source: Ensembl
    4. defense response to Gram-positive bacterium Source: Ensembl
    5. defense response to protozoan Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Guanylate binding protein 2Imported
    Submitted name:
    Guanylate nucleotide binding protein 2Imported
    Submitted name:
    Interferon-induced guanylate-binding protein 2Imported
    Gene namesi
    Name:Gbp2Imported
    ORF Names:rCG_28968Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi621810. Gbp2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic vesicle Source: Ensembl
    2. symbiont-containing vacuole membrane Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriQ5PQW8.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00550000074475.
    HOVERGENiHBG001979.
    OMAiMAREFNE.
    OrthoDBiEOG7BW0J3.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003191. Guanylate-bd_C.
    IPR015894. Guanylate-bd_N.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF02263. GBP. 1 hit.
    PF02841. GBP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48340. SSF48340. 1 hit.
    SSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5PQW8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDMASEIHML QPMCLIENTE AHLVINQEAL RILSAINQPV VVVAIVGLYR    50
    TGKSYLMNKL AGKRTGFSLG STVQSHTKGI WMWCVPHPKK AGQTLVLLDT 100
    EGLEDVEKGD NQNDCWIFAL AVLLSSTFVY NSMGTINQQA MDQLHYVTEL 150
    TDLIKSKSSP DQSGIDDSAN FVGFFPTFVW ALRDFSLELE VNGKLVTPDE 200
    YLEHSLTLKK GADKKTKSFN EPRLCIRKFF PKRKCFIFDR PALRKQLCKL 250
    ETLGEEELCS EFVEQVAEFT SYIFSYSAVK TLSGGIIVNG PRLKSLVQTY 300
    VGAISSGSLP CMESAVLTLA QIENSAAVQK AITHYEEQMN QKIQMPTETL 350
    QELLDLHRLI EREAIEIFLK NSFKDVDQKF QTELGNLLIS KRDAFIKKNS 400
    DVSSAHCSDL IEDIFGPLEE EVKQGTFSKP GGYFLFLQMR QELEKKYNQA 450
    PGKGLEAEAV LKKYFESKED IVETLLKTDQ SLTEAAKEIE VERIKAETAE 500
    AANRELAEKQ EKFELMMQQK EESYQEHVRQ LTEKMKEEQK KLIEEQDNII 550
    ALKLREQEKF LREGYENESK KLLREIENMK RRQSPGKCTI L 591
    Length:591
    Mass (Da):67,355
    Last modified:January 4, 2005 - v1
    Checksum:i3249C0EB57217176
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06021159 Genomic DNA. No translation available.
    AABR06021160 Genomic DNA. No translation available.
    BC086991 mRNA. Translation: AAH86991.1.
    CH473952 Genomic DNA. Translation: EDL82354.1.
    RefSeqiNP_598308.1. NM_133624.2.
    UniGeneiRn.25736.

    Genome annotation databases

    EnsembliENSRNOT00000068683; ENSRNOP00000061437; ENSRNOG00000031743.
    GeneIDi171164.
    KEGGirno:171164.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06021159 Genomic DNA. No translation available.
    AABR06021160 Genomic DNA. No translation available.
    BC086991 mRNA. Translation: AAH86991.1 .
    CH473952 Genomic DNA. Translation: EDL82354.1 .
    RefSeqi NP_598308.1. NM_133624.2.
    UniGenei Rn.25736.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000068683 ; ENSRNOP00000061437 ; ENSRNOG00000031743 .
    GeneIDi 171164.
    KEGGi rno:171164.

    Organism-specific databases

    CTDi 2634.
    RGDi 621810. Gbp2.

    Phylogenomic databases

    GeneTreei ENSGT00550000074475.
    HOVERGENi HBG001979.
    OMAi MAREFNE.
    OrthoDBi EOG7BW0J3.

    Miscellaneous databases

    NextBioi 622019.

    Gene expression databases

    Genevestigatori Q5PQW8.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003191. Guanylate-bd_C.
    IPR015894. Guanylate-bd_N.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF02263. GBP. 1 hit.
    PF02841. GBP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48340. SSF48340. 1 hit.
    SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: HeartImported.
    2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    5. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ5PQW8_RAT
    AccessioniPrimary (citable) accession number: Q5PQW8
    Secondary accession number(s): D4A6I2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 4, 2005
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3