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Protein

Trophoblast glycoprotein

Gene

Tpbg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Trophoblast glycoprotein
Alternative name(s):
5T4 oncofetal trophoblast glycoprotein
Short name:
5T4 oncotrophoblast glycoprotein
Wnt-activated inhibitory factor 1
Short name:
WAIF1
Gene namesi
Name:Tpbg
Synonyms:5t4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi621453 Tpbg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 361ExtracellularSequence analysisAdd BLAST330
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Topological domaini383 – 426CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000001959432 – 426Trophoblast glycoproteinAdd BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi62 ↔ 68By similarity
Disulfide bondi66 ↔ 77By similarity
Glycosylationi124N-linked (HexNAc...) asparagineCombined sources1
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi281N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi304 ↔ 329By similarity
Disulfide bondi306 ↔ 350By similarity
Modified residuei424PhosphoserineCombined sources1

Post-translational modificationi

Highly glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ5PQV5
PRIDEiQ5PQV5

PTM databases

iPTMnetiQ5PQV5
PhosphoSitePlusiQ5PQV5
UniCarbKBiQ5PQV5

Expressioni

Gene expression databases

BgeeiENSRNOG00000010694
GenevisibleiQ5PQV5 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014326

Structurei

3D structure databases

ProteinModelPortaliQ5PQV5
SMRiQ5PQV5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 91LRRNTAdd BLAST39
Repeati92 – 113LRR 1Add BLAST22
Repeati116 – 139LRR 2Add BLAST24
Repeati141 – 163LRR 3Add BLAST23
Repeati172 – 210LRR 4Add BLAST39
Repeati215 – 238LRR 5Add BLAST24
Repeati239 – 261LRR 6Add BLAST23
Repeati262 – 281LRR 7Add BLAST20
Domaini289 – 352LRRCTAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 53Ser-richAdd BLAST22

Domaini

The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway.By similarity

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00880000138002
HOGENOMiHOG000013090
HOVERGENiHBG053843
InParanoidiQ5PQV5
OMAiTYVSFRN
PhylomeDBiQ5PQV5
TreeFamiTF351115

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 6 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 5 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5PQV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGAGSRGPS AGDGRLRLAR LALVLLGWVS ASAPSSSLPS SSTSPAAFLA
60 70 80 90 100
SGSAQPPPAE RCPAACECSE AARTVKCVNR NLLEVPADLP PYVRNLFLTG
110 120 130 140 150
NQMTVLPAGA FARQPPLADL AVLNLSGNHL KEVGAGAFEH LPGLRRLDLS
160 170 180 190 200
HNPLTNLSAF TFAGSNVSVS TPSPLLELIL NHIVPPEDQR QNGSFEGMVA
210 220 230 240 250
FEGMVAAALR SGLALRGLHH LELASNHFLY LPRDLLDQLP SLKHLDLRNN
260 270 280 290 300
SLVSLTYASF RNLTHLESLH LEDNALKVLH NSTLAEWQGL AHVRVFLDNN
310 320 330 340 350
PWVCDCYMAD MVSWLKETEV VPDKARLTCA FPEKMRNRGL LDLTSSDLDC
360 370 380 390 400
DATLPQSLQT SYVFLGIVLA LIGAIFLLVL YLNRKGIKKW MHNIRDACRD
410 420
HMEGYHYRYE INADPRLTNL SSNSDV
Length:426
Mass (Da):46,508
Last modified:January 4, 2005 - v1
Checksum:i4EEFF69F86B545B0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti416R → S in AAF21770 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063939 mRNA Translation: AAF21770.1
BC087011 mRNA Translation: AAH87011.1
RefSeqiNP_113995.1, NM_031807.1
XP_006243561.1, XM_006243499.3
XP_008764679.1, XM_008766457.2
XP_017451424.1, XM_017595935.1
UniGeneiRn.43122

Genome annotation databases

EnsembliENSRNOT00000014326; ENSRNOP00000014326; ENSRNOG00000010694
ENSRNOT00000089491; ENSRNOP00000075124; ENSRNOG00000010694
GeneIDi83684
KEGGirno:83684
UCSCiRGD:621453 rat

Similar proteinsi

Entry informationi

Entry nameiTPBG_RAT
AccessioniPrimary (citable) accession number: Q5PQV5
Secondary accession number(s): Q9QYD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: January 4, 2005
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health