Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Trophoblast glycoprotein

Gene

Tpbg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Trophoblast glycoprotein
Alternative name(s):
5T4 oncofetal trophoblast glycoprotein
Short name:
5T4 oncotrophoblast glycoprotein
Wnt-activated inhibitory factor 1
Short name:
WAIF1
Gene namesi
Name:Tpbg
Synonyms:5t4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi621453. Tpbg.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 361330ExtracellularSequence analysisAdd
BLAST
Transmembranei362 – 38221HelicalSequence analysisAdd
BLAST
Topological domaini383 – 42644CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence analysisAdd
BLAST
Chaini32 – 426395Trophoblast glycoproteinPRO_0000019594Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi62 ↔ 68By similarity
Disulfide bondi66 ↔ 77By similarity
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence analysis
Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence analysis
Disulfide bondi304 ↔ 329By similarity
Disulfide bondi306 ↔ 350By similarity
Modified residuei424 – 4241PhosphoserineCombined sources

Post-translational modificationi

Highly glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ5PQV5.
PRIDEiQ5PQV5.

PTM databases

iPTMnetiQ5PQV5.
PhosphoSiteiQ5PQV5.
UniCarbKBiQ5PQV5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000010694.
GenevisibleiQ5PQV5. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014326.

Structurei

3D structure databases

ProteinModelPortaliQ5PQV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 9139LRRNTAdd
BLAST
Repeati92 – 11322LRR 1Add
BLAST
Repeati116 – 13924LRR 2Add
BLAST
Repeati141 – 16323LRR 3Add
BLAST
Repeati172 – 21039LRR 4Add
BLAST
Repeati215 – 23824LRR 5Add
BLAST
Repeati239 – 26123LRR 6Add
BLAST
Repeati262 – 28120LRR 7Add
BLAST
Domaini289 – 35264LRRCTAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi32 – 5322Ser-richAdd
BLAST

Domaini

The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway.By similarity

Sequence similaritiesi

Contains 7 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129720.
HOGENOMiHOG000013090.
HOVERGENiHBG053843.
InParanoidiQ5PQV5.
OMAiTYVSFRN.
PhylomeDBiQ5PQV5.
TreeFamiTF351115.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 6 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5PQV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGAGSRGPS AGDGRLRLAR LALVLLGWVS ASAPSSSLPS SSTSPAAFLA
60 70 80 90 100
SGSAQPPPAE RCPAACECSE AARTVKCVNR NLLEVPADLP PYVRNLFLTG
110 120 130 140 150
NQMTVLPAGA FARQPPLADL AVLNLSGNHL KEVGAGAFEH LPGLRRLDLS
160 170 180 190 200
HNPLTNLSAF TFAGSNVSVS TPSPLLELIL NHIVPPEDQR QNGSFEGMVA
210 220 230 240 250
FEGMVAAALR SGLALRGLHH LELASNHFLY LPRDLLDQLP SLKHLDLRNN
260 270 280 290 300
SLVSLTYASF RNLTHLESLH LEDNALKVLH NSTLAEWQGL AHVRVFLDNN
310 320 330 340 350
PWVCDCYMAD MVSWLKETEV VPDKARLTCA FPEKMRNRGL LDLTSSDLDC
360 370 380 390 400
DATLPQSLQT SYVFLGIVLA LIGAIFLLVL YLNRKGIKKW MHNIRDACRD
410 420
HMEGYHYRYE INADPRLTNL SSNSDV
Length:426
Mass (Da):46,508
Last modified:January 4, 2005 - v1
Checksum:i4EEFF69F86B545B0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti416 – 4161R → S in AAF21770 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063939 mRNA. Translation: AAF21770.1.
BC087011 mRNA. Translation: AAH87011.1.
RefSeqiNP_113995.1. NM_031807.1.
XP_006243561.1. XM_006243499.2.
XP_008764679.1. XM_008766457.1.
UniGeneiRn.43122.

Genome annotation databases

EnsembliENSRNOT00000014326; ENSRNOP00000014326; ENSRNOG00000010694.
ENSRNOT00000089491; ENSRNOP00000075124; ENSRNOG00000010694.
GeneIDi83684.
KEGGirno:83684.
UCSCiRGD:621453. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063939 mRNA. Translation: AAF21770.1.
BC087011 mRNA. Translation: AAH87011.1.
RefSeqiNP_113995.1. NM_031807.1.
XP_006243561.1. XM_006243499.2.
XP_008764679.1. XM_008766457.1.
UniGeneiRn.43122.

3D structure databases

ProteinModelPortaliQ5PQV5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014326.

PTM databases

iPTMnetiQ5PQV5.
PhosphoSiteiQ5PQV5.
UniCarbKBiQ5PQV5.

Proteomic databases

PaxDbiQ5PQV5.
PRIDEiQ5PQV5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014326; ENSRNOP00000014326; ENSRNOG00000010694.
ENSRNOT00000089491; ENSRNOP00000075124; ENSRNOG00000010694.
GeneIDi83684.
KEGGirno:83684.
UCSCiRGD:621453. rat.

Organism-specific databases

CTDi7162.
RGDi621453. Tpbg.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129720.
HOGENOMiHOG000013090.
HOVERGENiHBG053843.
InParanoidiQ5PQV5.
OMAiTYVSFRN.
PhylomeDBiQ5PQV5.
TreeFamiTF351115.

Miscellaneous databases

PROiQ5PQV5.

Gene expression databases

BgeeiENSRNOG00000010694.
GenevisibleiQ5PQV5. RN.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 6 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPBG_RAT
AccessioniPrimary (citable) accession number: Q5PQV5
Secondary accession number(s): Q9QYD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: January 4, 2005
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.