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Protein

Trophoblast glycoprotein

Gene

Tpbg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Trophoblast glycoprotein
Alternative name(s):
5T4 oncofetal trophoblast glycoprotein
Short name:
5T4 oncotrophoblast glycoprotein
Wnt-activated inhibitory factor 1
Short name:
WAIF1
Gene namesi
Name:Tpbg
Synonyms:5t4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi621453. Tpbg.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 361ExtracellularSequence analysisAdd BLAST330
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Topological domaini383 – 426CytoplasmicSequence analysisAdd BLAST44

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000001959432 – 426Trophoblast glycoproteinAdd BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi62 ↔ 68By similarity
Disulfide bondi66 ↔ 77By similarity
Glycosylationi166N-linked (GlcNAc...)Sequence analysis1
Glycosylationi281N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi304 ↔ 329By similarity
Disulfide bondi306 ↔ 350By similarity
Modified residuei424PhosphoserineCombined sources1

Post-translational modificationi

Highly glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ5PQV5.
PRIDEiQ5PQV5.

PTM databases

iPTMnetiQ5PQV5.
PhosphoSitePlusiQ5PQV5.
UniCarbKBiQ5PQV5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000010694.
GenevisibleiQ5PQV5. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014326.

Structurei

3D structure databases

ProteinModelPortaliQ5PQV5.
SMRiQ5PQV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 91LRRNTAdd BLAST39
Repeati92 – 113LRR 1Add BLAST22
Repeati116 – 139LRR 2Add BLAST24
Repeati141 – 163LRR 3Add BLAST23
Repeati172 – 210LRR 4Add BLAST39
Repeati215 – 238LRR 5Add BLAST24
Repeati239 – 261LRR 6Add BLAST23
Repeati262 – 281LRR 7Add BLAST20
Domaini289 – 352LRRCTAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 53Ser-richAdd BLAST22

Domaini

The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway.By similarity

Sequence similaritiesi

Contains 7 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00850000132353.
HOGENOMiHOG000013090.
HOVERGENiHBG053843.
InParanoidiQ5PQV5.
OMAiTYVSFRN.
PhylomeDBiQ5PQV5.
TreeFamiTF351115.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 6 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5PQV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGAGSRGPS AGDGRLRLAR LALVLLGWVS ASAPSSSLPS SSTSPAAFLA
60 70 80 90 100
SGSAQPPPAE RCPAACECSE AARTVKCVNR NLLEVPADLP PYVRNLFLTG
110 120 130 140 150
NQMTVLPAGA FARQPPLADL AVLNLSGNHL KEVGAGAFEH LPGLRRLDLS
160 170 180 190 200
HNPLTNLSAF TFAGSNVSVS TPSPLLELIL NHIVPPEDQR QNGSFEGMVA
210 220 230 240 250
FEGMVAAALR SGLALRGLHH LELASNHFLY LPRDLLDQLP SLKHLDLRNN
260 270 280 290 300
SLVSLTYASF RNLTHLESLH LEDNALKVLH NSTLAEWQGL AHVRVFLDNN
310 320 330 340 350
PWVCDCYMAD MVSWLKETEV VPDKARLTCA FPEKMRNRGL LDLTSSDLDC
360 370 380 390 400
DATLPQSLQT SYVFLGIVLA LIGAIFLLVL YLNRKGIKKW MHNIRDACRD
410 420
HMEGYHYRYE INADPRLTNL SSNSDV
Length:426
Mass (Da):46,508
Last modified:January 4, 2005 - v1
Checksum:i4EEFF69F86B545B0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti416R → S in AAF21770 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063939 mRNA. Translation: AAF21770.1.
BC087011 mRNA. Translation: AAH87011.1.
RefSeqiNP_113995.1. NM_031807.1.
XP_006243561.1. XM_006243499.3.
XP_008764679.1. XM_008766457.2.
XP_017451424.1. XM_017595935.1.
UniGeneiRn.43122.

Genome annotation databases

EnsembliENSRNOT00000014326; ENSRNOP00000014326; ENSRNOG00000010694.
ENSRNOT00000089491; ENSRNOP00000075124; ENSRNOG00000010694.
GeneIDi83684.
KEGGirno:83684.
UCSCiRGD:621453. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063939 mRNA. Translation: AAF21770.1.
BC087011 mRNA. Translation: AAH87011.1.
RefSeqiNP_113995.1. NM_031807.1.
XP_006243561.1. XM_006243499.3.
XP_008764679.1. XM_008766457.2.
XP_017451424.1. XM_017595935.1.
UniGeneiRn.43122.

3D structure databases

ProteinModelPortaliQ5PQV5.
SMRiQ5PQV5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014326.

PTM databases

iPTMnetiQ5PQV5.
PhosphoSitePlusiQ5PQV5.
UniCarbKBiQ5PQV5.

Proteomic databases

PaxDbiQ5PQV5.
PRIDEiQ5PQV5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014326; ENSRNOP00000014326; ENSRNOG00000010694.
ENSRNOT00000089491; ENSRNOP00000075124; ENSRNOG00000010694.
GeneIDi83684.
KEGGirno:83684.
UCSCiRGD:621453. rat.

Organism-specific databases

CTDi7162.
RGDi621453. Tpbg.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00850000132353.
HOGENOMiHOG000013090.
HOVERGENiHBG053843.
InParanoidiQ5PQV5.
OMAiTYVSFRN.
PhylomeDBiQ5PQV5.
TreeFamiTF351115.

Miscellaneous databases

PROiQ5PQV5.

Gene expression databases

BgeeiENSRNOG00000010694.
GenevisibleiQ5PQV5. RN.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 6 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPBG_RAT
AccessioniPrimary (citable) accession number: Q5PQV5
Secondary accession number(s): Q9QYD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: January 4, 2005
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.