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Protein

Pleckstrin homology-like domain family A member 3

Gene

Phlda3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology-like domain family A member 3
Alternative name(s):
TDAG51/Ipl homolog 1
Gene namesi
Name:Phlda3
Synonyms:Tih1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1310502 Phlda3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000539041 – 125Pleckstrin homology-like domain family A member 3Add BLAST125

Proteomic databases

PaxDbiQ5PQT7
PRIDEiQ5PQT7

PTM databases

iPTMnetiQ5PQT7
PhosphoSitePlusiQ5PQT7

Expressioni

Gene expression databases

BgeeiENSRNOG00000009068
GenevisibleiQ5PQT7 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011999

Structurei

3D structure databases

ProteinModelPortaliQ5PQT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 125PHAdd BLAST120

Domaini

The PH domain binds phosphoinositides with a broad specificity. It competes with the PH domain of AKT1 and directly interferes with AKT1 binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3), preventing AKT1 association to membrane lipids and subsequent activation of AKT1 signaling (By similarity).By similarity

Sequence similaritiesi

Belongs to the PHLDA3 family.Curated

Phylogenomic databases

eggNOGiENOG410IXIC Eukaryota
ENOG410YMWS LUCA
GeneTreeiENSGT00440000039564
HOGENOMiHOG000115528
HOVERGENiHBG052730
InParanoidiQ5PQT7
OMAiWNAEIAL
OrthoDBiEOG091G0TXC
PhylomeDBiQ5PQT7
TreeFamiTF332320

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
SMARTiView protein in SMART
SM00233 PH, 1 hit

Sequencei

Sequence statusi: Complete.

Q5PQT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAAATVLKE GVLEKRSGGL LQLWKRKRCV LTERGLQLFE AKGTGGRPKE
60 70 80 90 100
LSFSRIKAVE CVESTGRHIY FTLVTEGGGE IDFRCPLEDP GWNAQITLGL
110 120
VKFKNQQAIQ TVRARQSLGT GTLVS
Length:125
Mass (Da):13,735
Last modified:January 4, 2005 - v1
Checksum:i1F3E58A6F3C036BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087038 mRNA Translation: AAH87038.1
RefSeqiNP_001012206.1, NM_001012206.2
UniGeneiRn.17905

Genome annotation databases

EnsembliENSRNOT00000011999; ENSRNOP00000011999; ENSRNOG00000009068
GeneIDi363989
KEGGirno:363989
UCSCiRGD:1310502 rat

Similar proteinsi

Entry informationi

Entry nameiPHLA3_RAT
AccessioniPrimary (citable) accession number: Q5PQT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 4, 2005
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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