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Protein

Pleckstrin homology-like domain family A member 3

Gene

Phlda3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology-like domain family A member 3
Alternative name(s):
TDAG51/Ipl homolog 1
Gene namesi
Name:Phlda3
Synonyms:Tih1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1310502. Phlda3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 125125Pleckstrin homology-like domain family A member 3PRO_0000053904Add
BLAST

Proteomic databases

PaxDbiQ5PQT7.

PTM databases

iPTMnetiQ5PQT7.

Expressioni

Gene expression databases

GenevisibleiQ5PQT7. RN.

Structurei

3D structure databases

ProteinModelPortaliQ5PQT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 125120PHAdd
BLAST

Domaini

The PH domain binds phosphoinositides with a broad specificity. It competes with the PH domain of AKT1 and directly interferes with AKT1 binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3), preventing AKT1 association to membrane lipids and subsequent activation of AKT1 signaling (By similarity).By similarity

Sequence similaritiesi

Belongs to the PHLDA3 family.Curated
Contains 1 PH domain.Curated

Phylogenomic databases

eggNOGiENOG410IXIC. Eukaryota.
ENOG410YMWS. LUCA.
GeneTreeiENSGT00440000039564.
HOGENOMiHOG000115528.
HOVERGENiHBG052730.
InParanoidiQ5PQT7.
OMAiVRARHSC.
OrthoDBiEOG7NKKM7.
PhylomeDBiQ5PQT7.
TreeFamiTF332320.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5PQT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAAATVLKE GVLEKRSGGL LQLWKRKRCV LTERGLQLFE AKGTGGRPKE
60 70 80 90 100
LSFSRIKAVE CVESTGRHIY FTLVTEGGGE IDFRCPLEDP GWNAQITLGL
110 120
VKFKNQQAIQ TVRARQSLGT GTLVS
Length:125
Mass (Da):13,735
Last modified:January 4, 2005 - v1
Checksum:i1F3E58A6F3C036BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087038 mRNA. Translation: AAH87038.1.
RefSeqiNP_001012206.1. NM_001012206.2.
UniGeneiRn.17905.

Genome annotation databases

EnsembliENSRNOT00000011999; ENSRNOP00000011999; ENSRNOG00000009068.
GeneIDi363989.
KEGGirno:363989.
UCSCiRGD:1310502. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087038 mRNA. Translation: AAH87038.1.
RefSeqiNP_001012206.1. NM_001012206.2.
UniGeneiRn.17905.

3D structure databases

ProteinModelPortaliQ5PQT7.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ5PQT7.

Proteomic databases

PaxDbiQ5PQT7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011999; ENSRNOP00000011999; ENSRNOG00000009068.
GeneIDi363989.
KEGGirno:363989.
UCSCiRGD:1310502. rat.

Organism-specific databases

CTDi23612.
RGDi1310502. Phlda3.

Phylogenomic databases

eggNOGiENOG410IXIC. Eukaryota.
ENOG410YMWS. LUCA.
GeneTreeiENSGT00440000039564.
HOGENOMiHOG000115528.
HOVERGENiHBG052730.
InParanoidiQ5PQT7.
OMAiVRARHSC.
OrthoDBiEOG7NKKM7.
PhylomeDBiQ5PQT7.
TreeFamiTF332320.

Miscellaneous databases

PROiQ5PQT7.

Gene expression databases

GenevisibleiQ5PQT7. RN.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiPHLA3_RAT
AccessioniPrimary (citable) accession number: Q5PQT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 4, 2005
Last modified: June 8, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.