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Q5PQT3

- GLYAT_RAT

UniProt

Q5PQT3 - GLYAT_RAT

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Protein

Glycine N-acyltransferase

Gene

Glyat

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate a multitude of substrates to form a variety of N-acylglycines, thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid (By similarity).By similarity

Catalytic activityi

Acyl-CoA + glycine = CoA + N-acylglycine.
Benzoyl-CoA + glycine = CoA + hippurate.

GO - Molecular functioni

  1. glycine N-acyltransferase activity Source: UniProtKB-EC
  2. glycine N-benzoyltransferase activity Source: UniProtKB

GO - Biological processi

  1. glycine metabolic process Source: UniProtKB
  2. monocarboxylic acid metabolic process Source: UniProtKB
  3. response to toxic substance Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Detoxification

Enzyme and pathway databases

ReactomeiREACT_239809. Conjugation of salicylate with glycine.
REACT_243458. Conjugation of benzoate with glycine.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine N-acyltransferase (EC:2.3.1.13, EC:2.3.1.71)
Alternative name(s):
Acyl-CoA:glycine N-acyltransferase
Short name:
AAc
Aralkyl acyl-CoA N-acyltransferase
Aralkyl acyl-CoA:amino acid N-acyltransferase
Benzoyl-coenzyme A:glycine N-acyltransferase
Glycine N-benzoyltransferase
Liver regeneration-related protein LRRG067
Gene namesi
Name:Glyat
ORF Names:Ab2-132
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi1307163. Glyat.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Glycine N-acyltransferasePRO_0000281872Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161N6-acetyllysine; alternateBy similarity
Modified residuei16 – 161N6-succinyllysine; alternateBy similarity
Modified residuei113 – 1131N6-acetyllysineBy similarity
Modified residuei127 – 1271N6-acetyllysine; alternateBy similarity
Modified residuei127 – 1271N6-succinyllysine; alternateBy similarity
Modified residuei142 – 1421N6-acetyllysine; alternateBy similarity
Modified residuei142 – 1421N6-succinyllysine; alternateBy similarity
Modified residuei159 – 1591N6-acetyllysineBy similarity
Modified residuei169 – 1691N6-succinyllysineBy similarity
Modified residuei183 – 1831N6-acetyllysine; alternateBy similarity
Modified residuei183 – 1831N6-succinyllysine; alternateBy similarity
Modified residuei256 – 2561N6-acetyllysine; alternateBy similarity
Modified residuei256 – 2561N6-succinyllysine; alternateBy similarity
Modified residuei267 – 2671N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5PQT3.
PRIDEiQ5PQT3.

PTM databases

PhosphoSiteiQ5PQT3.

Expressioni

Gene expression databases

ExpressionAtlasiQ5PQT3. baseline.
GenevestigatoriQ5PQT3.

Structurei

3D structure databases

ProteinModelPortaliQ5PQT3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycine N-acyltransferase family.Curated

Phylogenomic databases

eggNOGiNOG48018.
GeneTreeiENSGT00390000004997.
HOGENOMiHOG000263599.
HOVERGENiHBG107953.
InParanoidiQ5PQT3.
KOiK00628.
OMAiFPVYSHV.
OrthoDBiEOG7MKW6X.
PhylomeDBiQ5PQT3.
TreeFamiTF353258.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR010313. Glycine_N-acyltransferase.
IPR013652. Glycine_N-acyltransferase_C.
IPR015938. Glycine_N-acyltransferase_N.
[Graphical view]
PANTHERiPTHR15298. PTHR15298. 1 hit.
PfamiPF08444. Gly_acyl_tr_C. 1 hit.
PF06021. Gly_acyl_tr_N. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5PQT3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIVPLQGAQM LQMLEKSLKK YLPESLKVYG TIYHVNHGNP FNLKALVDKW
60 70 80 90 100
PDFNTVVVRP QEQEMKDDLD FYTNTYQIYS KDPENCQEFL GSSEVINWKQ
110 120 130 140 150
HLQIQSSQSH LNKAIQNLAS IHSLQVKHSE NILYVVSETV RKLFPSLLDT
160 170 180 190 200
KNLSPGSGKP KAINQEMFKL SSLDVTHAAL VNKFWLFGGN ERSQRFIERC
210 220 230 240 250
IKNFPSSCVL GPEGTPASWT LMDQTGEMRM GGTVPQYRAQ GLVSFVIYSQ
260 270 280 290
DQIMKKRGFP VYSHTDKSNT VMQKMSYSLQ HLPMPCAWNQ WICVPM
Length:296
Mass (Da):33,899
Last modified:January 4, 2005 - v1
Checksum:iA559056779671ABB
GO

Sequence cautioni

The sequence AAP92593.1 differs from that shown. Reason: Intron retention.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325192 mRNA. Translation: AAP92593.1. Sequence problems.
BC087043 mRNA. Translation: AAH87043.1.
RefSeqiNP_001009648.1. NM_001009648.2.
XP_006231183.1. XM_006231121.2.
XP_006231184.1. XM_006231122.2.
XP_006231185.1. XM_006231123.2.
XP_008758479.1. XM_008760257.1.
UniGeneiRn.21872.

Genome annotation databases

EnsembliENSRNOT00000016454; ENSRNOP00000016454; ENSRNOG00000012142.
GeneIDi293779.
KEGGirno:293779.
UCSCiRGD:1307163. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325192 mRNA. Translation: AAP92593.1 . Sequence problems.
BC087043 mRNA. Translation: AAH87043.1 .
RefSeqi NP_001009648.1. NM_001009648.2.
XP_006231183.1. XM_006231121.2.
XP_006231184.1. XM_006231122.2.
XP_006231185.1. XM_006231123.2.
XP_008758479.1. XM_008760257.1.
UniGenei Rn.21872.

3D structure databases

ProteinModelPortali Q5PQT3.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q5PQT3.

Proteomic databases

PaxDbi Q5PQT3.
PRIDEi Q5PQT3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000016454 ; ENSRNOP00000016454 ; ENSRNOG00000012142 .
GeneIDi 293779.
KEGGi rno:293779.
UCSCi RGD:1307163. rat.

Organism-specific databases

CTDi 10249.
RGDi 1307163. Glyat.

Phylogenomic databases

eggNOGi NOG48018.
GeneTreei ENSGT00390000004997.
HOGENOMi HOG000263599.
HOVERGENi HBG107953.
InParanoidi Q5PQT3.
KOi K00628.
OMAi FPVYSHV.
OrthoDBi EOG7MKW6X.
PhylomeDBi Q5PQT3.
TreeFami TF353258.

Enzyme and pathway databases

Reactomei REACT_239809. Conjugation of salicylate with glycine.
REACT_243458. Conjugation of benzoate with glycine.

Miscellaneous databases

NextBioi 636988.
PROi Q5PQT3.

Gene expression databases

ExpressionAtlasi Q5PQT3. baseline.
Genevestigatori Q5PQT3.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR010313. Glycine_N-acyltransferase.
IPR013652. Glycine_N-acyltransferase_C.
IPR015938. Glycine_N-acyltransferase_N.
[Graphical view ]
PANTHERi PTHR15298. PTHR15298. 1 hit.
Pfami PF08444. Gly_acyl_tr_C. 1 hit.
PF06021. Gly_acyl_tr_N. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Liver regeneration after PH."
    Xu C.S., Chang C.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J., Zhao L.F., Ma H., Wang L., Wang S.F., Xing X.K., Shen G.M., Shi J.B., Rahman S., Wang Q.N., Zhang J.B.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiGLYAT_RAT
AccessioniPrimary (citable) accession number: Q5PQT3
Secondary accession number(s): Q7TP56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: January 4, 2005
Last modified: November 26, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3