Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5PQT3

- GLYAT_RAT

UniProt

Q5PQT3 - GLYAT_RAT

Protein

Glycine N-acyltransferase

Gene

Glyat

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (04 Jan 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate a multitude of substrates to form a variety of N-acylglycines, thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid By similarity.By similarity

    Catalytic activityi

    Acyl-CoA + glycine = CoA + N-acylglycine.
    Benzoyl-CoA + glycine = CoA + hippurate.

    GO - Molecular functioni

    1. glycine N-acyltransferase activity Source: UniProtKB-EC
    2. glycine N-benzoyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. glycine metabolic process Source: UniProtKB
    2. monocarboxylic acid metabolic process Source: UniProtKB
    3. response to toxic substance Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Detoxification

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine N-acyltransferase (EC:2.3.1.13, EC:2.3.1.71)
    Alternative name(s):
    Acyl-CoA:glycine N-acyltransferase
    Short name:
    AAc
    Aralkyl acyl-CoA N-acyltransferase
    Aralkyl acyl-CoA:amino acid N-acyltransferase
    Benzoyl-coenzyme A:glycine N-acyltransferase
    Glycine N-benzoyltransferase
    Liver regeneration-related protein LRRG067
    Gene namesi
    Name:Glyat
    ORF Names:Ab2-132
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi1307163. Glyat.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296Glycine N-acyltransferasePRO_0000281872Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei16 – 161N6-acetyllysine; alternateBy similarity
    Modified residuei16 – 161N6-succinyllysine; alternateBy similarity
    Modified residuei113 – 1131N6-acetyllysineBy similarity
    Modified residuei127 – 1271N6-acetyllysine; alternateBy similarity
    Modified residuei127 – 1271N6-succinyllysine; alternateBy similarity
    Modified residuei142 – 1421N6-acetyllysine; alternateBy similarity
    Modified residuei142 – 1421N6-succinyllysine; alternateBy similarity
    Modified residuei159 – 1591N6-acetyllysineBy similarity
    Modified residuei169 – 1691N6-succinyllysineBy similarity
    Modified residuei183 – 1831N6-acetyllysine; alternateBy similarity
    Modified residuei183 – 1831N6-succinyllysine; alternateBy similarity
    Modified residuei256 – 2561N6-acetyllysine; alternateBy similarity
    Modified residuei256 – 2561N6-succinyllysine; alternateBy similarity
    Modified residuei267 – 2671N6-succinyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ5PQT3.
    PRIDEiQ5PQT3.

    PTM databases

    PhosphoSiteiQ5PQT3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5PQT3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5PQT3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycine N-acyltransferase family.Curated

    Phylogenomic databases

    eggNOGiNOG48018.
    GeneTreeiENSGT00390000004997.
    HOGENOMiHOG000263599.
    HOVERGENiHBG107953.
    KOiK00628.
    OMAiFPVYSHV.
    OrthoDBiEOG7MKW6X.
    PhylomeDBiQ5PQT3.
    TreeFamiTF353258.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR010313. Glycine_N-acyltransferase.
    IPR013652. Glycine_N-acyltransferase_C.
    IPR015938. Glycine_N-acyltransferase_N.
    [Graphical view]
    PANTHERiPTHR15298. PTHR15298. 1 hit.
    PfamiPF08444. Gly_acyl_tr_C. 1 hit.
    PF06021. Gly_acyl_tr_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5PQT3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIVPLQGAQM LQMLEKSLKK YLPESLKVYG TIYHVNHGNP FNLKALVDKW    50
    PDFNTVVVRP QEQEMKDDLD FYTNTYQIYS KDPENCQEFL GSSEVINWKQ 100
    HLQIQSSQSH LNKAIQNLAS IHSLQVKHSE NILYVVSETV RKLFPSLLDT 150
    KNLSPGSGKP KAINQEMFKL SSLDVTHAAL VNKFWLFGGN ERSQRFIERC 200
    IKNFPSSCVL GPEGTPASWT LMDQTGEMRM GGTVPQYRAQ GLVSFVIYSQ 250
    DQIMKKRGFP VYSHTDKSNT VMQKMSYSLQ HLPMPCAWNQ WICVPM 296
    Length:296
    Mass (Da):33,899
    Last modified:January 4, 2005 - v1
    Checksum:iA559056779671ABB
    GO

    Sequence cautioni

    The sequence AAP92593.1 differs from that shown. Reason: Intron retention.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY325192 mRNA. Translation: AAP92593.1. Sequence problems.
    BC087043 mRNA. Translation: AAH87043.1.
    RefSeqiNP_001009648.1. NM_001009648.2.
    XP_006231183.1. XM_006231121.1.
    XP_006231184.1. XM_006231122.1.
    XP_006231185.1. XM_006231123.1.
    UniGeneiRn.21872.

    Genome annotation databases

    EnsembliENSRNOT00000016454; ENSRNOP00000016454; ENSRNOG00000012142.
    GeneIDi293779.
    KEGGirno:293779.
    UCSCiRGD:1307163. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY325192 mRNA. Translation: AAP92593.1 . Sequence problems.
    BC087043 mRNA. Translation: AAH87043.1 .
    RefSeqi NP_001009648.1. NM_001009648.2.
    XP_006231183.1. XM_006231121.1.
    XP_006231184.1. XM_006231122.1.
    XP_006231185.1. XM_006231123.1.
    UniGenei Rn.21872.

    3D structure databases

    ProteinModelPortali Q5PQT3.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q5PQT3.

    Proteomic databases

    PaxDbi Q5PQT3.
    PRIDEi Q5PQT3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000016454 ; ENSRNOP00000016454 ; ENSRNOG00000012142 .
    GeneIDi 293779.
    KEGGi rno:293779.
    UCSCi RGD:1307163. rat.

    Organism-specific databases

    CTDi 10249.
    RGDi 1307163. Glyat.

    Phylogenomic databases

    eggNOGi NOG48018.
    GeneTreei ENSGT00390000004997.
    HOGENOMi HOG000263599.
    HOVERGENi HBG107953.
    KOi K00628.
    OMAi FPVYSHV.
    OrthoDBi EOG7MKW6X.
    PhylomeDBi Q5PQT3.
    TreeFami TF353258.

    Miscellaneous databases

    NextBioi 636988.
    PROi Q5PQT3.

    Gene expression databases

    Genevestigatori Q5PQT3.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR010313. Glycine_N-acyltransferase.
    IPR013652. Glycine_N-acyltransferase_C.
    IPR015938. Glycine_N-acyltransferase_N.
    [Graphical view ]
    PANTHERi PTHR15298. PTHR15298. 1 hit.
    Pfami PF08444. Gly_acyl_tr_C. 1 hit.
    PF06021. Gly_acyl_tr_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Liver regeneration after PH."
      Xu C.S., Chang C.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J., Zhao L.F., Ma H., Wang L., Wang S.F., Xing X.K., Shen G.M., Shi J.B., Rahman S., Wang Q.N., Zhang J.B.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiGLYAT_RAT
    AccessioniPrimary (citable) accession number: Q5PQT3
    Secondary accession number(s): Q7TP56
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3