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Q5PQT2 (MTMR3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Myotubularin-related protein 3
EC=3.1.3.48
Gene names
Name:Mtmr3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length1194 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

Contains 1 FYVE-type zinc finger.

Contains 1 myotubularin phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11941194Myotubularin-related protein 3
PRO_0000304808

Regions

Domain151 – 572422Myotubularin phosphatase
Zinc finger1115 – 117561FYVE-type
Region322 – 3254Substrate binding By similarity
Region347 – 3482Substrate binding By similarity
Region409 – 4157Substrate binding By similarity
Coiled coil1025 – 105834 Potential

Sites

Active site4091Phosphocysteine intermediate By similarity
Binding site4551Substrate By similarity

Amino acid modifications

Modified residue6091Phosphoserine By similarity
Modified residue6291Phosphoserine By similarity
Modified residue6431Phosphoserine By similarity
Modified residue7251Phosphothreonine By similarity
Modified residue11771Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5PQT2 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: D0F4497AD70D5EE4

FASTA1,194133,500
        10         20         30         40         50         60 
MRHSLECIQA NQIFPRKQLI REDENLQVPF LELHGESTEY VGRAEDAIIA LSNYRLHIKF 

        70         80         90        100        110        120 
KESLVNVPLQ LIESVECRDI FQLHLTCKDC KVIRCQFPTF EQCQDWLKRL NNAIRPPGKI 

       130        140        150        160        170        180 
EDLFSFAYHA WCMEVYASEK EQHGDLCRPG EHVTSRFKNE VERMGFDMNN AWRISNINEK 

       190        200        210        220        230        240 
YKLCGSYPQE LIVPAWITDK ELESVAGFRS WKRIPAVIYR HQSNGAVIAR CGQPEVSWWG 

       250        260        270        280        290        300 
WRNADDEHLV QSVAKACASD SQSSVGKVST RNSCRGFPNA GDLSDVEFDA SLSNASGTES 

       310        320        330        340        350        360 
LALQPQKLLI LDARSYAAAV ANRAKGGGCE CPEYYPNCEV VFMGMANIHS IRRSFQSLRL 

       370        380        390        400        410        420 
LCTQMPDPGN WLSALESTKW LHHLSVLLKS ALLVVHAVDR DQRPVLVHCS DGWDRTPQIV 

       430        440        450        460        470        480 
ALAKLLLDPY YRTVEGFQVL VEMEWLDFGH KFADRCGHGE NSDDLNERCP VFLQWLDCVH 

       490        500        510        520        530        540 
QLQRQFPCSF EFNEAFLVKL VQHTYSCLFG TFLCNNAKER GEKQTQERTC SVWSLLRAGN 

       550        560        570        580        590        600 
KAFKNLLYSS QSEAVLYPVC HVRNLMLWSA VYLPCPSPST PTDDSCAPYP APGTSPDEPP 

       610        620        630        640        650        660 
LSRLPKTRSF DNLTTTCDNM VPLASRRSSD PSLNEKWQEH GRSLELSSFA GSGEEVPAID 

       670        680        690        700        710        720 
SLRRPSRLLG GAELSVAAGV AEGQMENILQ EATKEESGVE EPTHREHTEV PEVKEEAPLA 

       730        740        750        760        770        780 
KESRTAAQGS GVLYQEPQLD DATLRSHLGP SLSSFSQGIP EHREVGHSVL SSSLPASLRG 

       790        800        810        820        830        840 
EDSQEVPVEQ PQVENIAEDR ENVVPAVPVD VKIGLGTSES SPLLPSQVPF ETRGPHMNNS 

       850        860        870        880        890        900 
VHMLLEDKVK SESGPQLHHR PCLASSGRFS GKDMLPIAPE PRSAERPQWD SVLHRTSSPG 

       910        920        930        940        950        960 
NTLSLMMQAP CALPLDKCRQ RIVCNGALET ENKASEQPAG FDTLQKYPTP NGHCANGETG 

       970        980        990       1000       1010       1020 
RSKDSLSHQL SATSYSSAHS CSRNLHHKWL NSHSGRPSTT NSPEQPSRSH LDDDGMPVYT 

      1030       1040       1050       1060       1070       1080 
DTIQQRLRQI ESGHQQEVET LKKQVQELKS RLESQYLTSS LRFNGDFGDE VTSIPDSESN 

      1090       1100       1110       1120       1130       1140 
LDQNCLSRCS TEIFSEASWE QVDKQDTEMT RWLPDHLAAH CYACDSAFWL ASRKHHCRNC 

      1150       1160       1170       1180       1190 
GNVFCSSCCN QKVPVPSQQL FEPSRVCKSC YSSLHPTSSS IDLELDKPIA ATSN

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References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC087045 mRNA. Translation: AAH87045.1.
IPIIPI00734566.
RefSeqNP_001012038.1. NM_001012038.1.
UniGeneRn.8338.

3D structure databases

HSSPHSSP built from PDB template 1VFY based on UniProtKB P40343.
ProteinModelPortalQ5PQT2.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000054309.

PTM databases

PhosphoSiteQ5PQT2.

Proteomic databases

PaxDbQ5PQT2.
PRIDEQ5PQT2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000057501; ENSRNOP00000054309; ENSRNOG00000007120.
GeneID305482.
KEGGrno:305482.
UCSCRGD:1310972. rat.

Organism-specific databases

CTD8897.
RGD1310972. Mtmr3.

Phylogenomic databases

eggNOGNOG322789.
GeneTreeENSGT00670000097670.
HOGENOMHOG000004861.
HOVERGENHBG052526.
InParanoidQ5PQT2.
KOK01104.
OMATDTIQQR.
OrthoDBEOG4H19V0.

Gene expression databases

ArrayExpressQ5PQT2.
GenevestigatorQ5PQT2.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR010569. Myotub-related.
IPR017906. Myotubularin_phosphatase_dom.
IPR016130. Tyr_Pase_AS.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF01363. FYVE. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMSSF57903. FYVE_PHD_ZnF. 1 hit.
PROSITEPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. False negative.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio654690.

Entry information

Entry nameMTMR3_RAT
AccessionPrimary (citable) accession number: Q5PQT2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 4, 2005
Last modified: April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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