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Q5PQT2

- MTMR3_RAT

UniProt

Q5PQT2 - MTMR3_RAT

Protein

Myotubularin-related protein 3

Gene

Mtmr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei409 – 4091Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei455 – 4551SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1115 – 117561FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphatidylinositol-3-phosphatase activity Source: UniProtKB
    3. protein serine/threonine phosphatase activity Source: Ensembl
    4. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. phosphatidylinositol dephosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_198600. Synthesis of PIPs at the plasma membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myotubularin-related protein 3 (EC:3.1.3.48)
    Gene namesi
    Name:Mtmr3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 14

    Organism-specific databases

    RGDi1310972. Mtmr3.

    Subcellular locationi

    Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB-SubCell
    3. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11941194Myotubularin-related protein 3PRO_0000304808Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei629 – 6291PhosphoserineBy similarity
    Modified residuei643 – 6431PhosphoserineBy similarity
    Modified residuei725 – 7251PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ5PQT2.
    PRIDEiQ5PQT2.

    PTM databases

    PhosphoSiteiQ5PQT2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5PQT2.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000054309.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5PQT2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini151 – 572422Myotubularin phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni322 – 3254Substrate bindingBy similarity
    Regioni347 – 3482Substrate bindingBy similarity
    Regioni409 – 4157Substrate bindingBy similarity

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1025 – 105834Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
    Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1115 – 117561FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG322789.
    GeneTreeiENSGT00670000097670.
    HOGENOMiHOG000004861.
    HOVERGENiHBG052526.
    InParanoidiQ5PQT2.
    KOiK18082.
    OMAiTDTIQQR.
    OrthoDBiEOG7PVWNJ.
    PhylomeDBiQ5PQT2.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR010569. Myotubularin-like_Pase_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR016130. Tyr_Pase_AS.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF01363. FYVE. 1 hit.
    PF06602. Myotub-related. 1 hit.
    [Graphical view]
    SMARTiSM00064. FYVE. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 2 hits.
    SSF57903. SSF57903. 1 hit.
    PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50178. ZF_FYVE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5PQT2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRHSLECIQA NQIFPRKQLI REDENLQVPF LELHGESTEY VGRAEDAIIA     50
    LSNYRLHIKF KESLVNVPLQ LIESVECRDI FQLHLTCKDC KVIRCQFPTF 100
    EQCQDWLKRL NNAIRPPGKI EDLFSFAYHA WCMEVYASEK EQHGDLCRPG 150
    EHVTSRFKNE VERMGFDMNN AWRISNINEK YKLCGSYPQE LIVPAWITDK 200
    ELESVAGFRS WKRIPAVIYR HQSNGAVIAR CGQPEVSWWG WRNADDEHLV 250
    QSVAKACASD SQSSVGKVST RNSCRGFPNA GDLSDVEFDA SLSNASGTES 300
    LALQPQKLLI LDARSYAAAV ANRAKGGGCE CPEYYPNCEV VFMGMANIHS 350
    IRRSFQSLRL LCTQMPDPGN WLSALESTKW LHHLSVLLKS ALLVVHAVDR 400
    DQRPVLVHCS DGWDRTPQIV ALAKLLLDPY YRTVEGFQVL VEMEWLDFGH 450
    KFADRCGHGE NSDDLNERCP VFLQWLDCVH QLQRQFPCSF EFNEAFLVKL 500
    VQHTYSCLFG TFLCNNAKER GEKQTQERTC SVWSLLRAGN KAFKNLLYSS 550
    QSEAVLYPVC HVRNLMLWSA VYLPCPSPST PTDDSCAPYP APGTSPDEPP 600
    LSRLPKTRSF DNLTTTCDNM VPLASRRSSD PSLNEKWQEH GRSLELSSFA 650
    GSGEEVPAID SLRRPSRLLG GAELSVAAGV AEGQMENILQ EATKEESGVE 700
    EPTHREHTEV PEVKEEAPLA KESRTAAQGS GVLYQEPQLD DATLRSHLGP 750
    SLSSFSQGIP EHREVGHSVL SSSLPASLRG EDSQEVPVEQ PQVENIAEDR 800
    ENVVPAVPVD VKIGLGTSES SPLLPSQVPF ETRGPHMNNS VHMLLEDKVK 850
    SESGPQLHHR PCLASSGRFS GKDMLPIAPE PRSAERPQWD SVLHRTSSPG 900
    NTLSLMMQAP CALPLDKCRQ RIVCNGALET ENKASEQPAG FDTLQKYPTP 950
    NGHCANGETG RSKDSLSHQL SATSYSSAHS CSRNLHHKWL NSHSGRPSTT 1000
    NSPEQPSRSH LDDDGMPVYT DTIQQRLRQI ESGHQQEVET LKKQVQELKS 1050
    RLESQYLTSS LRFNGDFGDE VTSIPDSESN LDQNCLSRCS TEIFSEASWE 1100
    QVDKQDTEMT RWLPDHLAAH CYACDSAFWL ASRKHHCRNC GNVFCSSCCN 1150
    QKVPVPSQQL FEPSRVCKSC YSSLHPTSSS IDLELDKPIA ATSN 1194
    Length:1,194
    Mass (Da):133,500
    Last modified:January 4, 2005 - v1
    Checksum:iD0F4497AD70D5EE4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC087045 mRNA. Translation: AAH87045.1.
    RefSeqiNP_001012038.1. NM_001012038.1.
    UniGeneiRn.8338.

    Genome annotation databases

    EnsembliENSRNOT00000057501; ENSRNOP00000054309; ENSRNOG00000007120.
    GeneIDi305482.
    KEGGirno:305482.
    UCSCiRGD:1310972. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC087045 mRNA. Translation: AAH87045.1 .
    RefSeqi NP_001012038.1. NM_001012038.1.
    UniGenei Rn.8338.

    3D structure databases

    ProteinModelPortali Q5PQT2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000054309.

    PTM databases

    PhosphoSitei Q5PQT2.

    Proteomic databases

    PaxDbi Q5PQT2.
    PRIDEi Q5PQT2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000057501 ; ENSRNOP00000054309 ; ENSRNOG00000007120 .
    GeneIDi 305482.
    KEGGi rno:305482.
    UCSCi RGD:1310972. rat.

    Organism-specific databases

    CTDi 8897.
    RGDi 1310972. Mtmr3.

    Phylogenomic databases

    eggNOGi NOG322789.
    GeneTreei ENSGT00670000097670.
    HOGENOMi HOG000004861.
    HOVERGENi HBG052526.
    InParanoidi Q5PQT2.
    KOi K18082.
    OMAi TDTIQQR.
    OrthoDBi EOG7PVWNJ.
    PhylomeDBi Q5PQT2.

    Enzyme and pathway databases

    Reactomei REACT_198600. Synthesis of PIPs at the plasma membrane.

    Miscellaneous databases

    NextBioi 654690.
    PROi Q5PQT2.

    Gene expression databases

    Genevestigatori Q5PQT2.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR010569. Myotubularin-like_Pase_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR016130. Tyr_Pase_AS.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF01363. FYVE. 1 hit.
    PF06602. Myotub-related. 1 hit.
    [Graphical view ]
    SMARTi SM00064. FYVE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 2 hits.
    SSF57903. SSF57903. 1 hit.
    PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50178. ZF_FYVE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiMTMR3_RAT
    AccessioniPrimary (citable) accession number: Q5PQT2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3