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Protein

Myotubularin-related protein 3

Gene

Mtmr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotationBy similarity
1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.By similarity
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei409Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei455SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1115 – 1175FYVE-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processLipid metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-1632852 Macroautophagy
R-RNO-1660499 Synthesis of PIPs at the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 3 (EC:3.1.3.48)
Alternative name(s):
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC:3.1.3.95By similarity)
Phosphatidylinositol-3-phosphate phosphatase (EC:3.1.3.64By similarity)
Gene namesi
Name:Mtmr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi1310972 Mtmr3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003048081 – 1194Myotubularin-related protein 3Add BLAST1194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Modified residuei609PhosphoserineCombined sources1
Modified residuei629PhosphoserineBy similarity1
Modified residuei643PhosphoserineBy similarity1
Modified residuei647PhosphoserineBy similarity1
Modified residuei725PhosphothreonineBy similarity1
Modified residuei904PhosphoserineBy similarity1
Modified residuei1060PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5PQT2
PRIDEiQ5PQT2

PTM databases

iPTMnetiQ5PQT2
PhosphoSitePlusiQ5PQT2

Expressioni

Gene expression databases

BgeeiENSRNOG00000007120
ExpressionAtlasiQ5PQT2 baseline and differential
GenevisibleiQ5PQT2 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054309

Structurei

3D structure databases

ProteinModelPortaliQ5PQT2
SMRiQ5PQT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini151 – 572Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST422

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni322 – 325Substrate bindingBy similarity4
Regioni347 – 348Substrate bindingBy similarity2
Regioni409 – 415Substrate bindingBy similarity7

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1025 – 1058Sequence analysisAdd BLAST34

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1115 – 1175FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG4471 Eukaryota
ENOG410XPTU LUCA
GeneTreeiENSGT00760000118832
HOGENOMiHOG000004861
HOVERGENiHBG052526
InParanoidiQ5PQT2
KOiK18082
PhylomeDBiQ5PQT2

Family and domain databases

CDDicd13341 PH-GRAM_MTMR3, 1 hit
Gene3Di3.30.40.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR035888 MTMR3_PH-GRAM
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10807 PTHR10807, 1 hit
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF06602 Myotub-related, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 2 hits
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51339 PPASE_MYOTUBULARIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50178 ZF_FYVE, 1 hit

Sequencei

Sequence statusi: Complete.

Q5PQT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHSLECIQA NQIFPRKQLI REDENLQVPF LELHGESTEY VGRAEDAIIA
60 70 80 90 100
LSNYRLHIKF KESLVNVPLQ LIESVECRDI FQLHLTCKDC KVIRCQFPTF
110 120 130 140 150
EQCQDWLKRL NNAIRPPGKI EDLFSFAYHA WCMEVYASEK EQHGDLCRPG
160 170 180 190 200
EHVTSRFKNE VERMGFDMNN AWRISNINEK YKLCGSYPQE LIVPAWITDK
210 220 230 240 250
ELESVAGFRS WKRIPAVIYR HQSNGAVIAR CGQPEVSWWG WRNADDEHLV
260 270 280 290 300
QSVAKACASD SQSSVGKVST RNSCRGFPNA GDLSDVEFDA SLSNASGTES
310 320 330 340 350
LALQPQKLLI LDARSYAAAV ANRAKGGGCE CPEYYPNCEV VFMGMANIHS
360 370 380 390 400
IRRSFQSLRL LCTQMPDPGN WLSALESTKW LHHLSVLLKS ALLVVHAVDR
410 420 430 440 450
DQRPVLVHCS DGWDRTPQIV ALAKLLLDPY YRTVEGFQVL VEMEWLDFGH
460 470 480 490 500
KFADRCGHGE NSDDLNERCP VFLQWLDCVH QLQRQFPCSF EFNEAFLVKL
510 520 530 540 550
VQHTYSCLFG TFLCNNAKER GEKQTQERTC SVWSLLRAGN KAFKNLLYSS
560 570 580 590 600
QSEAVLYPVC HVRNLMLWSA VYLPCPSPST PTDDSCAPYP APGTSPDEPP
610 620 630 640 650
LSRLPKTRSF DNLTTTCDNM VPLASRRSSD PSLNEKWQEH GRSLELSSFA
660 670 680 690 700
GSGEEVPAID SLRRPSRLLG GAELSVAAGV AEGQMENILQ EATKEESGVE
710 720 730 740 750
EPTHREHTEV PEVKEEAPLA KESRTAAQGS GVLYQEPQLD DATLRSHLGP
760 770 780 790 800
SLSSFSQGIP EHREVGHSVL SSSLPASLRG EDSQEVPVEQ PQVENIAEDR
810 820 830 840 850
ENVVPAVPVD VKIGLGTSES SPLLPSQVPF ETRGPHMNNS VHMLLEDKVK
860 870 880 890 900
SESGPQLHHR PCLASSGRFS GKDMLPIAPE PRSAERPQWD SVLHRTSSPG
910 920 930 940 950
NTLSLMMQAP CALPLDKCRQ RIVCNGALET ENKASEQPAG FDTLQKYPTP
960 970 980 990 1000
NGHCANGETG RSKDSLSHQL SATSYSSAHS CSRNLHHKWL NSHSGRPSTT
1010 1020 1030 1040 1050
NSPEQPSRSH LDDDGMPVYT DTIQQRLRQI ESGHQQEVET LKKQVQELKS
1060 1070 1080 1090 1100
RLESQYLTSS LRFNGDFGDE VTSIPDSESN LDQNCLSRCS TEIFSEASWE
1110 1120 1130 1140 1150
QVDKQDTEMT RWLPDHLAAH CYACDSAFWL ASRKHHCRNC GNVFCSSCCN
1160 1170 1180 1190
QKVPVPSQQL FEPSRVCKSC YSSLHPTSSS IDLELDKPIA ATSN
Length:1,194
Mass (Da):133,500
Last modified:January 4, 2005 - v1
Checksum:iD0F4497AD70D5EE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087045 mRNA Translation: AAH87045.1
RefSeqiNP_001012038.1, NM_001012038.1
UniGeneiRn.8338

Genome annotation databases

EnsembliENSRNOT00000057501; ENSRNOP00000054309; ENSRNOG00000007120
GeneIDi305482
KEGGirno:305482
UCSCiRGD:1310972 rat

Entry informationi

Entry nameiMTMR3_RAT
AccessioniPrimary (citable) accession number: Q5PQT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 4, 2005
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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