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Protein

Myotubularin-related protein 3

Gene

Mtmr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotationBy similarity
1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.By similarity
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei409Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei455SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1115 – 1175FYVE-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Lipid metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-1632852. Macroautophagy.
R-RNO-1660499. Synthesis of PIPs at the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 3 (EC:3.1.3.48)
Alternative name(s):
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC:3.1.3.95By similarity)
Phosphatidylinositol-3-phosphate phosphatase (EC:3.1.3.64By similarity)
Gene namesi
Name:Mtmr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1310972. Mtmr3.

Subcellular locationi

  • Cytoplasm By similarity
  • Membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003048081 – 1194Myotubularin-related protein 3Add BLAST1194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Modified residuei609PhosphoserineCombined sources1
Modified residuei629PhosphoserineBy similarity1
Modified residuei643PhosphoserineBy similarity1
Modified residuei647PhosphoserineBy similarity1
Modified residuei725PhosphothreonineBy similarity1
Modified residuei904PhosphoserineBy similarity1
Modified residuei1060PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5PQT2.
PRIDEiQ5PQT2.

PTM databases

iPTMnetiQ5PQT2.
PhosphoSitePlusiQ5PQT2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007120.
ExpressionAtlasiQ5PQT2. baseline and differential.
GenevisibleiQ5PQT2. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054309.

Structurei

3D structure databases

ProteinModelPortaliQ5PQT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini151 – 572Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST422

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni322 – 325Substrate bindingBy similarity4
Regioni347 – 348Substrate bindingBy similarity2
Regioni409 – 415Substrate bindingBy similarity7

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1025 – 1058Sequence analysisAdd BLAST34

Sequence similaritiesi

Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1115 – 1175FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG4471. Eukaryota.
ENOG410XPTU. LUCA.
GeneTreeiENSGT00760000118832.
HOGENOMiHOG000004861.
HOVERGENiHBG052526.
InParanoidiQ5PQT2.
KOiK18082.
PhylomeDBiQ5PQT2.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.40.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 2 hits.
PfamiPF01363. FYVE. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 2 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PQT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHSLECIQA NQIFPRKQLI REDENLQVPF LELHGESTEY VGRAEDAIIA
60 70 80 90 100
LSNYRLHIKF KESLVNVPLQ LIESVECRDI FQLHLTCKDC KVIRCQFPTF
110 120 130 140 150
EQCQDWLKRL NNAIRPPGKI EDLFSFAYHA WCMEVYASEK EQHGDLCRPG
160 170 180 190 200
EHVTSRFKNE VERMGFDMNN AWRISNINEK YKLCGSYPQE LIVPAWITDK
210 220 230 240 250
ELESVAGFRS WKRIPAVIYR HQSNGAVIAR CGQPEVSWWG WRNADDEHLV
260 270 280 290 300
QSVAKACASD SQSSVGKVST RNSCRGFPNA GDLSDVEFDA SLSNASGTES
310 320 330 340 350
LALQPQKLLI LDARSYAAAV ANRAKGGGCE CPEYYPNCEV VFMGMANIHS
360 370 380 390 400
IRRSFQSLRL LCTQMPDPGN WLSALESTKW LHHLSVLLKS ALLVVHAVDR
410 420 430 440 450
DQRPVLVHCS DGWDRTPQIV ALAKLLLDPY YRTVEGFQVL VEMEWLDFGH
460 470 480 490 500
KFADRCGHGE NSDDLNERCP VFLQWLDCVH QLQRQFPCSF EFNEAFLVKL
510 520 530 540 550
VQHTYSCLFG TFLCNNAKER GEKQTQERTC SVWSLLRAGN KAFKNLLYSS
560 570 580 590 600
QSEAVLYPVC HVRNLMLWSA VYLPCPSPST PTDDSCAPYP APGTSPDEPP
610 620 630 640 650
LSRLPKTRSF DNLTTTCDNM VPLASRRSSD PSLNEKWQEH GRSLELSSFA
660 670 680 690 700
GSGEEVPAID SLRRPSRLLG GAELSVAAGV AEGQMENILQ EATKEESGVE
710 720 730 740 750
EPTHREHTEV PEVKEEAPLA KESRTAAQGS GVLYQEPQLD DATLRSHLGP
760 770 780 790 800
SLSSFSQGIP EHREVGHSVL SSSLPASLRG EDSQEVPVEQ PQVENIAEDR
810 820 830 840 850
ENVVPAVPVD VKIGLGTSES SPLLPSQVPF ETRGPHMNNS VHMLLEDKVK
860 870 880 890 900
SESGPQLHHR PCLASSGRFS GKDMLPIAPE PRSAERPQWD SVLHRTSSPG
910 920 930 940 950
NTLSLMMQAP CALPLDKCRQ RIVCNGALET ENKASEQPAG FDTLQKYPTP
960 970 980 990 1000
NGHCANGETG RSKDSLSHQL SATSYSSAHS CSRNLHHKWL NSHSGRPSTT
1010 1020 1030 1040 1050
NSPEQPSRSH LDDDGMPVYT DTIQQRLRQI ESGHQQEVET LKKQVQELKS
1060 1070 1080 1090 1100
RLESQYLTSS LRFNGDFGDE VTSIPDSESN LDQNCLSRCS TEIFSEASWE
1110 1120 1130 1140 1150
QVDKQDTEMT RWLPDHLAAH CYACDSAFWL ASRKHHCRNC GNVFCSSCCN
1160 1170 1180 1190
QKVPVPSQQL FEPSRVCKSC YSSLHPTSSS IDLELDKPIA ATSN
Length:1,194
Mass (Da):133,500
Last modified:January 4, 2005 - v1
Checksum:iD0F4497AD70D5EE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087045 mRNA. Translation: AAH87045.1.
RefSeqiNP_001012038.1. NM_001012038.1.
UniGeneiRn.8338.

Genome annotation databases

EnsembliENSRNOT00000057501; ENSRNOP00000054309; ENSRNOG00000007120.
GeneIDi305482.
KEGGirno:305482.
UCSCiRGD:1310972. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087045 mRNA. Translation: AAH87045.1.
RefSeqiNP_001012038.1. NM_001012038.1.
UniGeneiRn.8338.

3D structure databases

ProteinModelPortaliQ5PQT2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054309.

PTM databases

iPTMnetiQ5PQT2.
PhosphoSitePlusiQ5PQT2.

Proteomic databases

PaxDbiQ5PQT2.
PRIDEiQ5PQT2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000057501; ENSRNOP00000054309; ENSRNOG00000007120.
GeneIDi305482.
KEGGirno:305482.
UCSCiRGD:1310972. rat.

Organism-specific databases

CTDi8897.
RGDi1310972. Mtmr3.

Phylogenomic databases

eggNOGiKOG4471. Eukaryota.
ENOG410XPTU. LUCA.
GeneTreeiENSGT00760000118832.
HOGENOMiHOG000004861.
HOVERGENiHBG052526.
InParanoidiQ5PQT2.
KOiK18082.
PhylomeDBiQ5PQT2.

Enzyme and pathway databases

ReactomeiR-RNO-1632852. Macroautophagy.
R-RNO-1660499. Synthesis of PIPs at the plasma membrane.

Miscellaneous databases

PROiQ5PQT2.

Gene expression databases

BgeeiENSRNOG00000007120.
ExpressionAtlasiQ5PQT2. baseline and differential.
GenevisibleiQ5PQT2. RN.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.40.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 2 hits.
PfamiPF01363. FYVE. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 2 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTMR3_RAT
AccessioniPrimary (citable) accession number: Q5PQT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 4, 2005
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.