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Q5PQT2

- MTMR3_RAT

UniProt

Q5PQT2 - MTMR3_RAT

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Protein

Myotubularin-related protein 3

Gene

Mtmr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.By similarityPROSITE-ProRule annotation
1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.By similarity
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei409 – 4091Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei455 – 4551SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1115 – 117561FYVE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity Source: UniProtKB
  3. phosphatidylinositol-3-phosphatase activity Source: UniProtKB
  4. protein serine/threonine phosphatase activity Source: Ensembl
  5. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. phosphatidylinositol dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Lipid metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_198600. Synthesis of PIPs at the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 3 (EC:3.1.3.48)
Alternative name(s):
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC:3.1.3.95By similarity)
Phosphatidylinositol-3-phosphate phosphatase (EC:3.1.3.64By similarity)
Gene namesi
Name:Mtmr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 14

Organism-specific databases

RGDi1310972. Mtmr3.

Subcellular locationi

Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extrinsic component of membrane Source: UniProtKB
  3. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11941194Myotubularin-related protein 3PRO_0000304808Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei629 – 6291PhosphoserineBy similarity
Modified residuei643 – 6431PhosphoserineBy similarity
Modified residuei725 – 7251PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5PQT2.
PRIDEiQ5PQT2.

PTM databases

PhosphoSiteiQ5PQT2.

Expressioni

Gene expression databases

GenevestigatoriQ5PQT2.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054309.

Structurei

3D structure databases

ProteinModelPortaliQ5PQT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini151 – 572422Myotubularin phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni322 – 3254Substrate bindingBy similarity
Regioni347 – 3482Substrate bindingBy similarity
Regioni409 – 4157Substrate bindingBy similarity

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1025 – 105834Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1115 – 117561FYVE-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG322789.
GeneTreeiENSGT00760000118832.
HOGENOMiHOG000004861.
HOVERGENiHBG052526.
InParanoidiQ5PQT2.
KOiK18082.
OMAiTDTIQQR.
OrthoDBiEOG7PVWNJ.
PhylomeDBiQ5PQT2.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR010569. Myotubularin-like_Pase_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PQT2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRHSLECIQA NQIFPRKQLI REDENLQVPF LELHGESTEY VGRAEDAIIA
60 70 80 90 100
LSNYRLHIKF KESLVNVPLQ LIESVECRDI FQLHLTCKDC KVIRCQFPTF
110 120 130 140 150
EQCQDWLKRL NNAIRPPGKI EDLFSFAYHA WCMEVYASEK EQHGDLCRPG
160 170 180 190 200
EHVTSRFKNE VERMGFDMNN AWRISNINEK YKLCGSYPQE LIVPAWITDK
210 220 230 240 250
ELESVAGFRS WKRIPAVIYR HQSNGAVIAR CGQPEVSWWG WRNADDEHLV
260 270 280 290 300
QSVAKACASD SQSSVGKVST RNSCRGFPNA GDLSDVEFDA SLSNASGTES
310 320 330 340 350
LALQPQKLLI LDARSYAAAV ANRAKGGGCE CPEYYPNCEV VFMGMANIHS
360 370 380 390 400
IRRSFQSLRL LCTQMPDPGN WLSALESTKW LHHLSVLLKS ALLVVHAVDR
410 420 430 440 450
DQRPVLVHCS DGWDRTPQIV ALAKLLLDPY YRTVEGFQVL VEMEWLDFGH
460 470 480 490 500
KFADRCGHGE NSDDLNERCP VFLQWLDCVH QLQRQFPCSF EFNEAFLVKL
510 520 530 540 550
VQHTYSCLFG TFLCNNAKER GEKQTQERTC SVWSLLRAGN KAFKNLLYSS
560 570 580 590 600
QSEAVLYPVC HVRNLMLWSA VYLPCPSPST PTDDSCAPYP APGTSPDEPP
610 620 630 640 650
LSRLPKTRSF DNLTTTCDNM VPLASRRSSD PSLNEKWQEH GRSLELSSFA
660 670 680 690 700
GSGEEVPAID SLRRPSRLLG GAELSVAAGV AEGQMENILQ EATKEESGVE
710 720 730 740 750
EPTHREHTEV PEVKEEAPLA KESRTAAQGS GVLYQEPQLD DATLRSHLGP
760 770 780 790 800
SLSSFSQGIP EHREVGHSVL SSSLPASLRG EDSQEVPVEQ PQVENIAEDR
810 820 830 840 850
ENVVPAVPVD VKIGLGTSES SPLLPSQVPF ETRGPHMNNS VHMLLEDKVK
860 870 880 890 900
SESGPQLHHR PCLASSGRFS GKDMLPIAPE PRSAERPQWD SVLHRTSSPG
910 920 930 940 950
NTLSLMMQAP CALPLDKCRQ RIVCNGALET ENKASEQPAG FDTLQKYPTP
960 970 980 990 1000
NGHCANGETG RSKDSLSHQL SATSYSSAHS CSRNLHHKWL NSHSGRPSTT
1010 1020 1030 1040 1050
NSPEQPSRSH LDDDGMPVYT DTIQQRLRQI ESGHQQEVET LKKQVQELKS
1060 1070 1080 1090 1100
RLESQYLTSS LRFNGDFGDE VTSIPDSESN LDQNCLSRCS TEIFSEASWE
1110 1120 1130 1140 1150
QVDKQDTEMT RWLPDHLAAH CYACDSAFWL ASRKHHCRNC GNVFCSSCCN
1160 1170 1180 1190
QKVPVPSQQL FEPSRVCKSC YSSLHPTSSS IDLELDKPIA ATSN
Length:1,194
Mass (Da):133,500
Last modified:January 4, 2005 - v1
Checksum:iD0F4497AD70D5EE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087045 mRNA. Translation: AAH87045.1.
RefSeqiNP_001012038.1. NM_001012038.1.
UniGeneiRn.8338.

Genome annotation databases

EnsembliENSRNOT00000057501; ENSRNOP00000054309; ENSRNOG00000007120.
GeneIDi305482.
KEGGirno:305482.
UCSCiRGD:1310972. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087045 mRNA. Translation: AAH87045.1 .
RefSeqi NP_001012038.1. NM_001012038.1.
UniGenei Rn.8338.

3D structure databases

ProteinModelPortali Q5PQT2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000054309.

PTM databases

PhosphoSitei Q5PQT2.

Proteomic databases

PaxDbi Q5PQT2.
PRIDEi Q5PQT2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000057501 ; ENSRNOP00000054309 ; ENSRNOG00000007120 .
GeneIDi 305482.
KEGGi rno:305482.
UCSCi RGD:1310972. rat.

Organism-specific databases

CTDi 8897.
RGDi 1310972. Mtmr3.

Phylogenomic databases

eggNOGi NOG322789.
GeneTreei ENSGT00760000118832.
HOGENOMi HOG000004861.
HOVERGENi HBG052526.
InParanoidi Q5PQT2.
KOi K18082.
OMAi TDTIQQR.
OrthoDBi EOG7PVWNJ.
PhylomeDBi Q5PQT2.

Enzyme and pathway databases

Reactomei REACT_198600. Synthesis of PIPs at the plasma membrane.

Miscellaneous databases

NextBioi 654690.
PROi Q5PQT2.

Gene expression databases

Genevestigatori Q5PQT2.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR010569. Myotubularin-like_Pase_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF01363. FYVE. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view ]
SMARTi SM00064. FYVE. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 2 hits.
SSF57903. SSF57903. 1 hit.
PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiMTMR3_RAT
AccessioniPrimary (citable) accession number: Q5PQT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 4, 2005
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3