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Protein

Protein SMG9

Gene

Smg9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (By similarity). Plays a role in brain, heart, and eye development.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processNonsense-mediated mRNA decay

Enzyme and pathway databases

ReactomeiR-RNO-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SMG9By similarity
Gene namesi
Name:Smg9Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1309888 Smg9

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002891652 – 520Protein SMG9Add BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei4PhosphoserineCombined sources1
Modified residuei7PhosphoserineCombined sources1
Modified residuei32PhosphoserineCombined sources1
Modified residuei53PhosphoserineBy similarity1
Modified residuei451PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by SMG1.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5PQS6
PRIDEiQ5PQS6

PTM databases

iPTMnetiQ5PQS6
PhosphoSitePlusiQ5PQS6

Expressioni

Gene expression databases

BgeeiENSRNOG00000019596
GenevisibleiQ5PQS6 RN

Interactioni

Subunit structurei

Component of the SMG1C complex composed of SMG1, SMG8 and SMG9. Self-associates to form homodimers and forms heterodimers with SMG8; these assembly forms may represent SMG1C intermediate forms (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026669

Structurei

3D structure databases

ProteinModelPortaliQ5PQS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi71 – 133Pro-richAdd BLAST63

Sequence similaritiesi

Belongs to the SMG9 family.Curated

Phylogenomic databases

eggNOGiKOG4181 Eukaryota
ENOG410XSTF LUCA
GeneTreeiENSGT00390000003568
HOGENOMiHOG000006915
InParanoidiQ5PQS6
KOiK18735
OMAiGAEYYPH
OrthoDBiEOG091G0F37
PhylomeDBiQ5PQS6

Family and domain databases

InterProiView protein in InterPro
IPR019354 Smg8/Smg9
PfamiView protein in Pfam
PF10220 Smg8_Smg9, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5PQS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESGHSQPG LYGIERRRRW KEPGSSGPQN LSGPGGRERD YIAPWERERR
60 70 80 90 100
DGSEDPSTNV MQKTPIILSK PPAERSKQPP PSTAPAAPPA PAPLEKPIVL
110 120 130 140 150
MKPREEGKGP VAATGASTPE GTAPPPPTAP APPKGEKEGQ RPTQPVYQIQ
160 170 180 190 200
NRGMGTAAPT AMDPVVGQAK LLPPERMKHS IKLVDDQMNW CDSAIEYLLD
210 220 230 240 250
QTDVLVVGVL GLQGTGKSMV MSLLSANTPE EDQRAYVFRA QSAEMKERGG
260 270 280 290 300
NQTSGIDFFI TQERIVFLDT QPILSPSILD HLINNDRKLP PEYNLPHTYV
310 320 330 340 350
EMQSLQIAAF LFTVCHVVIV VQDWFTDLSL YRFLQTAEMV KPSTPSPSHE
360 370 380 390 400
SSSAAGSDEG TEYYPHLVFL QNKARREDFC PRKLRQMHLM IDQLMAHSHL
410 420 430 440 450
RYKGTLSMLQ CNIFPGLPPD FLDAEVNLFL VPFMDSEAEN ENPPRAGPGS
460 470 480 490 500
SPLFSLLPGY RGHPSFQSLV SKLRSQVMSM ARPQLSHTIL TEKNWFHYAA
510 520
RIWDGVKKSS ALAEYSRLLA
Length:520
Mass (Da):57,633
Last modified:January 4, 2005 - v1
Checksum:i7ED417FAF2B0257C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087051 mRNA Translation: AAH87051.1
RefSeqiNP_001014265.1, NM_001014243.1
XP_006228512.1, XM_006228450.3
UniGeneiRn.32677

Genome annotation databases

EnsembliENSRNOT00000026669; ENSRNOP00000026669; ENSRNOG00000019596
GeneIDi365215
KEGGirno:365215
UCSCiRGD:1309888 rat

Similar proteinsi

Entry informationi

Entry nameiSMG9_RAT
AccessioniPrimary (citable) accession number: Q5PQS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 4, 2005
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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