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Protein

Protein ZNF365

Gene

Znf365

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth (PubMed:24481677). Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis. Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (By similarity). Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth. Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand breaks (DSBs) by HR. Is required for recovery of stalled replication forks, and directly contributes to genomic stability. Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery. Contributes to genomic stability by preventing telomere dysfunction (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri26 – 51C2H2-type; degeneratePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processNeurogenesis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ZNF365
Alternative name(s):
DISC1-binding zinc-finger protein1 Publication
Gene namesi
Name:Znf365
Synonyms:DBZ1 Publication, Zfp365
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1565986. Zfp365.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000763771 – 408Protein ZNF365Add BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineBy similarity1
Modified residuei139PhosphoserineBy similarity1
Modified residuei146PhosphoserineBy similarity1
Modified residuei176PhosphothreonineCombined sources1
Modified residuei370PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5PQS2.
PRIDEiQ5PQS2.

PTM databases

iPTMnetiQ5PQS2.
PhosphoSitePlusiQ5PQS2.

Expressioni

Tissue specificityi

Expressed in cerebral cortex, hippocampus, olfactory tubercle and striatum.1 Publication

Gene expression databases

BgeeiENSRNOG00000000638.
GenevisibleiQ5PQS2. RN.

Interactioni

Subunit structurei

Homodimers. Interacts with NDE1 and NDEL1 (By similarity). Interacts with DISC1 (PubMed:17389905). Interacts with PARP1 (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054802.

Structurei

3D structure databases

SMRiQ5PQS2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili170 – 298Sequence analysisAdd BLAST129

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri26 – 51C2H2-type; degeneratePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IH1N. Eukaryota.
ENOG4111IHT. LUCA.
GeneTreeiENSGT00530000063713.
HOGENOMiHOG000155791.
HOVERGENiHBG094181.
InParanoidiQ5PQS2.
KOiK16737.
OMAiTHFHPKG.
OrthoDBiEOG091G0BHK.
PhylomeDBiQ5PQS2.

Sequencei

Sequence statusi: Complete.

Q5PQS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQTTFEESR YRWQDSLENV AVCLPFRCPR CGDHTRFRSL SSLRAHLEFS
60 70 80 90 100
HSYEERTLLT KCSLLPSLKD TDLLRSSELP KQGKLLRGHA KVTKQKPSYV
110 120 130 140 150
NLYSISHGHS KDPKPFEMVA ERPVSYVQTY TAVDIRADSL DAPRSSSGLP
160 170 180 190 200
TQDTKAAFEA HVREKFNRMV EAVDRTIEKR IDKLTKELAQ KTAELLEVRA
210 220 230 240 250
AFVQLTQKKQ EVQRRERALH KQVDVAVEMI AVLKQRLTES EEELLRKEEE
260 270 280 290 300
VVTFNHFLEA AAEKEVQGKA RLQDFIENLL QRVELAEKQL EYYQSQQASG
310 320 330 340 350
FSHDTSEHML TDISSSRKSR CLSRGHQHSV CNHPELKAHF HLKGRSYLKK
360 370 380 390 400
AKDERAGMQP AKAIHEQAES PREFFRPAKK GEHLGLSRKG NFRPKMAKKK

PTAIVNII
Length:408
Mass (Da):46,968
Last modified:January 4, 2005 - v1
Checksum:i6756159816AE504D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087056 mRNA. Translation: AAH87056.1.
RefSeqiNP_001020316.1. NM_001025145.1.
UniGeneiRn.24356.

Genome annotation databases

EnsembliENSRNOT00000057992; ENSRNOP00000054802; ENSRNOG00000000638.
GeneIDi499425.
KEGGirno:499425.
UCSCiRGD:1565986. rat.

Similar proteinsi

Entry informationi

Entry nameiZN365_RAT
AccessioniPrimary (citable) accession number: Q5PQS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 4, 2005
Last modified: December 20, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome