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Protein

U3 small nucleolar ribonucleoprotein protein IMP4

Gene

Imp4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

ReactomeiR-RNO-6791226. Major pathway of rRNA processing in the nucleolus.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar ribonucleoprotein protein IMP4
Short name:
U3 snoRNP protein IMP4
Gene namesi
Name:Imp4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1308463. Imp4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291U3 small nucleolar ribonucleoprotein protein IMP4PRO_0000120239Add
BLAST

Proteomic databases

PaxDbiQ5PQR5.
PRIDEiQ5PQR5.

PTM databases

iPTMnetiQ5PQR5.

Expressioni

Gene expression databases

GenevisibleiQ5PQR5. RN.

Interactioni

Subunit structurei

Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062237.

Structurei

3D structure databases

ProteinModelPortaliQ5PQR5.
SMRiQ5PQR5. Positions 84-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 264182BrixPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 4846Arg/Glu/Lys-richAdd
BLAST

Sequence similaritiesi

Contains 1 Brix domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2781. Eukaryota.
COG2136. LUCA.
GeneTreeiENSGT00550000074987.
HOGENOMiHOG000172063.
HOVERGENiHBG056795.
InParanoidiQ5PQR5.
KOiK14561.
OMAiGTMSEQY.
OrthoDBiEOG7QG44B.
PhylomeDBiQ5PQR5.

Family and domain databases

Gene3Di3.40.50.10480. 1 hit.
InterProiIPR004154. Anticodon-bd.
IPR007109. Brix.
[Graphical view]
PfamiPF04427. Brix. 1 hit.
[Graphical view]
SMARTiSM00879. Brix. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
PROSITEiPS50833. BRIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PQR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRREARLRR EYLYRKAREE AQRSVQEKKE RVKRALEENQ LIPTELRREA
60 70 80 90 100
LALQGSLEFD DAGGEGVTSH VDDEYRWAGV EDPKVMITTS RDPSSRLKMF
110 120 130 140 150
AKELKLVFPG AQRMNRGRHE VGALVRACKA NGVTDLLVVH EHRGTPVGLI
160 170 180 190 200
VSHLPFGPTA YFTLCNVVMR HDIPDLGTMS EAKPHLITHG FSSRLGKRVS
210 220 230 240 250
DILRYLFPVP KDDSHRVITF ANQDDYISFR HHVYKKTDHR NVELTEVGPR
260 270 280 290
FELKLYMIRL GTLEQEATAD VEWRWHPYTN TARKRVFLSA E
Length:291
Mass (Da):33,656
Last modified:January 4, 2005 - v1
Checksum:i5AFF74AA16E0C7BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087066 mRNA. Translation: AAH87066.1.
RefSeqiNP_001009700.1. NM_001009700.1.
UniGeneiRn.6698.

Genome annotation databases

EnsembliENSRNOT00000066913; ENSRNOP00000062237; ENSRNOG00000013285.
GeneIDi316317.
KEGGirno:316317.
UCSCiRGD:1308463. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087066 mRNA. Translation: AAH87066.1.
RefSeqiNP_001009700.1. NM_001009700.1.
UniGeneiRn.6698.

3D structure databases

ProteinModelPortaliQ5PQR5.
SMRiQ5PQR5. Positions 84-158.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062237.

PTM databases

iPTMnetiQ5PQR5.

Proteomic databases

PaxDbiQ5PQR5.
PRIDEiQ5PQR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000066913; ENSRNOP00000062237; ENSRNOG00000013285.
GeneIDi316317.
KEGGirno:316317.
UCSCiRGD:1308463. rat.

Organism-specific databases

CTDi92856.
RGDi1308463. Imp4.

Phylogenomic databases

eggNOGiKOG2781. Eukaryota.
COG2136. LUCA.
GeneTreeiENSGT00550000074987.
HOGENOMiHOG000172063.
HOVERGENiHBG056795.
InParanoidiQ5PQR5.
KOiK14561.
OMAiGTMSEQY.
OrthoDBiEOG7QG44B.
PhylomeDBiQ5PQR5.

Enzyme and pathway databases

ReactomeiR-RNO-6791226. Major pathway of rRNA processing in the nucleolus.

Miscellaneous databases

PROiQ5PQR5.

Gene expression databases

GenevisibleiQ5PQR5. RN.

Family and domain databases

Gene3Di3.40.50.10480. 1 hit.
InterProiIPR004154. Anticodon-bd.
IPR007109. Brix.
[Graphical view]
PfamiPF04427. Brix. 1 hit.
[Graphical view]
SMARTiSM00879. Brix. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
PROSITEiPS50833. BRIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiIMP4_RAT
AccessioniPrimary (citable) accession number: Q5PQR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: January 4, 2005
Last modified: July 6, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.