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Protein

Integrin beta-like protein 1

Gene

Itgbl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-like protein 1
Gene namesi
Name:Itgbl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1560635. Itgbl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000032302424 – 494Integrin beta-like protein 1Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi405N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5PQQ8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004516.
GenevisibleiQ5PQQ8. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006264.

Structurei

3D structure databases

ProteinModelPortaliQ5PQQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati51 – 95IAdd BLAST45
Repeati96 – 142IIAdd BLAST47
Repeati143 – 184IIIAdd BLAST42
Repeati185 – 230IVAdd BLAST46
Repeati231 – 275VAdd BLAST45
Repeati276 – 326VIAdd BLAST51
Repeati327 – 367VIIAdd BLAST41
Repeati368 – 414VIIIAdd BLAST47
Repeati415 – 454IXAdd BLAST40
Repeati455 – 494XAdd BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 494Cysteine-rich tandem repeatsAdd BLAST444

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 476Cys-richAdd BLAST414

Domaini

Contains ten tandem EGF-like repeats strikingly similar to those found in the cysteine rich 'stalk-like' structure of integrin beta-subunits.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000113115.
HOVERGENiHBG052797.
InParanoidiQ5PQQ8.
OMAiLCQHPRK.
OrthoDBiEOG091G05SQ.
PhylomeDBiQ5PQQ8.
TreeFamiTF332636.

Family and domain databases

InterProiIPR000742. EGF-like_dom.
IPR013111. EGF_extracell.
IPR027070. Integrin_b-like_p1.
IPR015812. Integrin_bsu.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF3. PTHR10082:SF3. 1 hit.
PfamiPF07974. EGF_2. 4 hits.
[Graphical view]
SMARTiSM00181. EGF. 6 hits.
[Graphical view]
PROSITEiPS00022. EGF_1. 5 hits.
PS01186. EGF_2. 5 hits.
PS00243. INTEGRIN_BETA. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5PQQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPPGFKNFL LLVSSLFFIG LSAAPQSFSP SLRSLSGAPC RLSRAESERR
60 70 80 90 100
CRAPGQPPGS ALCHDRGRCE CGVCICHVTE PGTYFGPLCE CHDWVCETYD
110 120 130 140 150
GKTCAGHGTC DCGKCKCDVG WSGEACQYPT KCDLTKKISN QMCKNSQDVI
160 170 180 190 200
CSNAGTCHCG RCKCDNSDGH GLIYGKFCEC DDRECIDDET EEICGGHGKC
210 220 230 240 250
YCGNCYCEAG WHGDKCEFQC DITPWESKRR CTSPDGKVCS NRGTCVCGEC
260 270 280 290 300
SCHDVDPTGD WGDIHGDTCE CDERDCRAVY DRYSDDFCSG HGQCNCGRCD
310 320 330 340 350
CRAGWYGKKC EHPKNCPLSA EESTRKCQGS SDLPCSGRGR CECGRCTCYP
360 370 380 390 400
PGDSRVYGKT CECDDRRCED LDGVVCGGRG TCSCGRCVCE KGWFGKLCQH
410 420 430 440 450
PRKCNMTEEQ SRSLCESADG TLCSGKGSCH CGKCICSGEE WYISGEFCDC
460 470 480 490
DDRDCDKHDG LICTGNGICS CGNCECWDGW NGNACEIWLG TEYP
Length:494
Mass (Da):53,904
Last modified:January 4, 2005 - v1
Checksum:i8A60A8CA4FADD366
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087076 mRNA. Translation: AAH87076.1.
RefSeqiNP_001017505.1. NM_001017505.1.
UniGeneiRn.12893.

Genome annotation databases

EnsembliENSRNOT00000006264; ENSRNOP00000006264; ENSRNOG00000004516.
GeneIDi498564.
KEGGirno:498564.
UCSCiRGD:1560635. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087076 mRNA. Translation: AAH87076.1.
RefSeqiNP_001017505.1. NM_001017505.1.
UniGeneiRn.12893.

3D structure databases

ProteinModelPortaliQ5PQQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006264.

Proteomic databases

PaxDbiQ5PQQ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006264; ENSRNOP00000006264; ENSRNOG00000004516.
GeneIDi498564.
KEGGirno:498564.
UCSCiRGD:1560635. rat.

Organism-specific databases

CTDi9358.
RGDi1560635. Itgbl1.

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000113115.
HOVERGENiHBG052797.
InParanoidiQ5PQQ8.
OMAiLCQHPRK.
OrthoDBiEOG091G05SQ.
PhylomeDBiQ5PQQ8.
TreeFamiTF332636.

Miscellaneous databases

PROiQ5PQQ8.

Gene expression databases

BgeeiENSRNOG00000004516.
GenevisibleiQ5PQQ8. RN.

Family and domain databases

InterProiIPR000742. EGF-like_dom.
IPR013111. EGF_extracell.
IPR027070. Integrin_b-like_p1.
IPR015812. Integrin_bsu.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF3. PTHR10082:SF3. 1 hit.
PfamiPF07974. EGF_2. 4 hits.
[Graphical view]
SMARTiSM00181. EGF. 6 hits.
[Graphical view]
PROSITEiPS00022. EGF_1. 5 hits.
PS01186. EGF_2. 5 hits.
PS00243. INTEGRIN_BETA. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITGBL_RAT
AccessioniPrimary (citable) accession number: Q5PQQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 4, 2005
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.