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Protein

LETM1 domain-containing protein LETM2, mitochondrial

Gene

Letm2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
LETM1 domain-containing protein LETM2, mitochondrial
Alternative name(s):
LETM1 and EF-hand domain-containing protein 2
Leucine zipper-EF-hand-containing transmembrane protein 1-like
Gene namesi
Name:Letm2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1311220. Letm2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 176151Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei177 – 19721HelicalSequence analysisAdd
BLAST
Topological domaini198 – 459262Mitochondrial matrixSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2525MitochondrionSequence analysisAdd
BLAST
Chaini26 – 459434LETM1 domain-containing protein LETM2, mitochondrialPRO_0000307139Add
BLAST

Proteomic databases

PaxDbiQ5PQQ5.
PRIDEiQ5PQQ5.

Expressioni

Tissue specificityi

Testis and sperm.1 Publication

Developmental stagei

Expressed in the developmental stages from spermatocyte to spermatozoon.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062009.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini220 – 440221Letm1 RBDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Letm1 RBD (ribosome-binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1043. Eukaryota.
ENOG410XRSP. LUCA.
HOGENOMiHOG000113315.
HOVERGENiHBG108085.
InParanoidiQ5PQQ5.
PhylomeDBiQ5PQQ5.

Family and domain databases

InterProiIPR011685. LETM1.
IPR033122. LETM1_RBD.
[Graphical view]
PfamiPF07766. LETM1. 1 hit.
[Graphical view]
PROSITEiPS51758. LETM1_RBD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5PQQ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFYSYNSFL AIFWTRLPGH SVHPPCSHFP PLAFFHLPDS HLRTAYMKNC
60 70 80 90 100
GSRKYSYPGL TGNNKVHPLR TRLPQKLHTT CWLQNHPGKP QPEQIPEEPK
110 120 130 140 150
ATDPQPTKDD QTEVAEGKWS LRQKIIDEVK YYYNGFSLLW IDTKVAARIV
160 170 180 190 200
WRLLHGQVLT RRERRRLLRT CADVFRLVPF VVFIIVPFME FLIPVFLKLF
210 220 230 240 250
PDMLPSTFES ESKKEEKQKK MMGAKLEIAK FLQETMTEMA KRNRAKLDDD
260 270 280 290 300
SSDSSQLSSY VKQVQTGHKP STKEIVRFSK LFEDQLALEH LRRPQLVALC
310 320 330 340 350
KLLELQAFGT NNLLRFQLLM TLRSIKADDE VIAKEGVKAL SVSELQAACR
360 370 380 390 400
ARGMRSLGLT EEQLRQQLTE WLDLHLKENV PPSLLLLSRT FYLIDVKPKP
410 420 430 440 450
IELPPSIETP KTNLGIPSSP PPESKEDITD PAPQLNGTKI LQAKSQETSQ

NSKANSKGA
Length:459
Mass (Da):52,524
Last modified:January 4, 2005 - v1
Checksum:i065886C1EAF9707A
GO
Isoform 2 (identifier: Q5PQQ5-2) [UniParc]FASTAAdd to basket

Also known as: LETM2S

The sequence of this isoform differs from the canonical sequence as follows:
     167-214: Missing.

Show »
Length:411
Mass (Da):46,920
Checksum:iF22E3D5E60AE306A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei167 – 21448Missing in isoform 2. CuratedVSP_037817Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB296367 Genomic DNA. Translation: BAF79864.1.
AB296368 Genomic DNA. Translation: BAF79865.1.
BC087079 mRNA. Translation: AAH87079.1.
RefSeqiNP_001012158.1. NM_001012158.1. [Q5PQQ5-1]
UniGeneiRn.203805.

Genome annotation databases

GeneIDi361169.
KEGGirno:361169.
UCSCiRGD:1311220. rat. [Q5PQQ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB296367 Genomic DNA. Translation: BAF79864.1.
AB296368 Genomic DNA. Translation: BAF79865.1.
BC087079 mRNA. Translation: AAH87079.1.
RefSeqiNP_001012158.1. NM_001012158.1. [Q5PQQ5-1]
UniGeneiRn.203805.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062009.

Proteomic databases

PaxDbiQ5PQQ5.
PRIDEiQ5PQQ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi361169.
KEGGirno:361169.
UCSCiRGD:1311220. rat. [Q5PQQ5-1]

Organism-specific databases

CTDi137994.
RGDi1311220. Letm2.

Phylogenomic databases

eggNOGiKOG1043. Eukaryota.
ENOG410XRSP. LUCA.
HOGENOMiHOG000113315.
HOVERGENiHBG108085.
InParanoidiQ5PQQ5.
PhylomeDBiQ5PQQ5.

Miscellaneous databases

PROiQ5PQQ5.

Family and domain databases

InterProiIPR011685. LETM1.
IPR033122. LETM1_RBD.
[Graphical view]
PfamiPF07766. LETM1. 1 hit.
[Graphical view]
PROSITEiPS51758. LETM1_RBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L."
    Tamai S., Iida H., Yokota S., Sayano T., Kiguchiya S., Ishihara N., Hayashi J., Mihara K., Oka T.
    J. Cell Sci. 121:2588-2600(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiLETM2_RAT
AccessioniPrimary (citable) accession number: Q5PQQ5
Secondary accession number(s): A7VL16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: January 4, 2005
Last modified: June 8, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Despite its name, it does not contain any EF-hand domains.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.