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Protein

Phosphatidylinositol N-acetylglucosaminyltransferase subunit C

Gene

Pigc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.By similarity

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processGPI-anchor biosynthesis

Enzyme and pathway databases

ReactomeiR-RNO-162710 Synthesis of glycosylphosphatidylinositol (GPI)
UniPathwayiUPA00196

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C (EC:2.4.1.198)
Alternative name(s):
Phosphatidylinositol-glycan biosynthesis class C protein
Short name:
PIG-C
Gene namesi
Name:Pigc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1311337 Pigc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000584331 – 297Phosphatidylinositol N-acetylglucosaminyltransferase subunit CAdd BLAST297

Proteomic databases

PaxDbiQ5PQQ4
PRIDEiQ5PQQ4

Expressioni

Gene expression databases

BgeeiENSRNOG00000026497
ExpressionAtlasiQ5PQQ4 baseline and differential
GenevisibleiQ5PQQ4 RN

Interactioni

Subunit structurei

Associates with PIGA, PIGH, PIGP, PIGQ and DPM2. The latter is not essential for activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035922

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3059 Eukaryota
ENOG41112YY LUCA
GeneTreeiENSGT00390000005496
HOGENOMiHOG000194668
HOVERGENiHBG009071
InParanoidiQ5PQQ4
KOiK03859
OMAiSYHAFVL
OrthoDBiEOG091G0M0J
PhylomeDBiQ5PQQ4
TreeFamiTF314325

Family and domain databases

InterProiView protein in InterPro
IPR009450 Plno_GlcNAc_GPI2
PANTHERiPTHR12982 PTHR12982, 1 hit
PfamiView protein in Pfam
PF06432 GPI2, 1 hit
PIRSFiPIRSF016104 GPI2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5PQQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCAQHVADTS EVKWQKVLYE RQPFPDNYVD QRFLEELRKN IYARKYQYWA
60 70 80 90 100
VVFESSVVIQ QLCSVCVFVV IWWYMDEGLL APQWLFGTGL ASSLVGYVLF
110 120 130 140 150
DLIDGGDGRK KSGRTRWADL KSTLVFITFT YGFSPVLKTL TESVSTDTIY
160 170 180 190 200
AMSVFMLLGH LIFFDYGANA AIVSSTLSLN MAIFASVCLA SRLPRSLHAF
210 220 230 240 250
IMVTFAIQIF ALWPMLQKKL KAYTPRSYVG VTLLFAFSAF GGLLSISGVG
260 270 280 290
AILFALLLFS ISCLCPYYLI HLQLFKENIH GPWDEAEIKE DLSRFLS
Length:297
Mass (Da):33,666
Last modified:January 4, 2005 - v1
Checksum:iFE914EE878ED8597
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087080 mRNA Translation: AAH87080.1
RefSeqiNP_001012207.1, NM_001012207.1
XP_006250244.1, XM_006250182.2
XP_006250245.1, XM_006250183.2
XP_008767887.1, XM_008769665.2
UniGeneiRn.3171

Genome annotation databases

EnsembliENSRNOT00000035558; ENSRNOP00000035922; ENSRNOG00000026497
GeneIDi364032
KEGGirno:364032
UCSCiRGD:1311337 rat

Similar proteinsi

Entry informationi

Entry nameiPIGC_RAT
AccessioniPrimary (citable) accession number: Q5PQQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: January 4, 2005
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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