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Protein

tRNA modification GTPase GTPBP3, mitochondrial

Gene

Gtpbp3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GTPase involved in the 5-carboxymethylaminomethyl modification (mnm5s2U34) of the wobble uridine base in mitochondrial tRNAs.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi256 – 263GTPSequence analysis8
Nucleotide bindingi303 – 307GTPSequence analysis5
Nucleotide bindingi374 – 377GTPSequence analysis4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processtRNA processing
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA modification GTPase GTPBP3, mitochondrial
Alternative name(s):
GTP-binding protein 3
Gene namesi
Name:Gtpbp3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1305367 Gtpbp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 81MitochondrionSequence analysisAdd BLAST81
ChainiPRO_000028026782 – 492tRNA modification GTPase GTPBP3, mitochondrialAdd BLAST411

Proteomic databases

PaxDbiQ5PQQ1
PRIDEiQ5PQQ1

PTM databases

PhosphoSitePlusiQ5PQQ1

Expressioni

Gene expression databases

BgeeiENSRNOG00000023403
GenevisibleiQ5PQQ1 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000057102

Structurei

3D structure databases

ProteinModelPortaliQ5PQQ1
SMRiQ5PQQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini249 – 416TrmE-type GAdd BLAST168

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1191 Eukaryota
COG0486 LUCA
GeneTreeiENSGT00390000016851
HOGENOMiHOG000200714
HOVERGENiHBG081577
InParanoidiQ5PQQ1
KOiK03650
OMAiEFTQRAF
OrthoDBiEOG091G07VM
PhylomeDBiQ5PQQ1
TreeFamiTF313153

Family and domain databases

CDDicd04164 trmE, 1 hit
Gene3Di1.20.120.430, 2 hits
3.30.1360.120, 1 hit
HAMAPiMF_00379 GTPase_MnmE, 1 hit
InterProiView protein in InterPro
IPR031168 G_TrmE
IPR018948 GTP-bd_TrmE_N
IPR006073 GTP_binding_domain
IPR004520 GTPase_MnmE
IPR027368 MnmE_dom2
IPR025867 MnmE_helical
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR027266 TrmE/GcvT_dom1
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
PF12631 MnmE_helical, 1 hit
PF10396 TrmE_N, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR00450 mnmE_trmE_thdF, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51709 G_TRME, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5PQQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRGLSALVT RPASAPLRLC ARCSTGAESL VPGSTIFALS SGQGRCAIAV
60 70 80 90 100
IRTSGPASGL ALRSLTALRE PPPARSACLR LLRHPCSGEP LDRSLVLWFP
110 120 130 140 150
GPQSFTGEDC MELHVHGGPA VVSGVLQALG SVPGLRPAKA GEFTRRAFAH
160 170 180 190 200
GKLSLTEVEG LADLIHAETE AQRRQALRQL DGELSQLCQG WAKTLTKALA
210 220 230 240 250
HVEAYIDFGE DDNLEEGVLE QVDRDVRALE VALSSHLRDA RRGQRLRSGA
260 270 280 290 300
NVVVAGPPNA GKSSLVNLLS QKPVSIVSPE PGTTRDILET PVDLAGFPVL
310 320 330 340 350
LSDTAGLREG AGAVEQEGVR RARQRLEQAD IILGMLDASD LASSSSCSFL
360 370 380 390 400
DTVVAPLVAQ SHDSGRQRLL LLLNKSDLLS ANAPASSTAL PPHLLLSCHT
410 420 430 440 450
GAGMDALLQA LKTELAAVCG DPSTGPPLLT RARHQYHLQG CLDALGRFQL
460 470 480 490
TTDLALAAEA LRQARRQLSH LTGGGGTEEI LDLIFQDFCV GK
Length:492
Mass (Da):52,017
Last modified:January 4, 2005 - v1
Checksum:i5749762D7E3FBA61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087083 mRNA Translation: AAH87083.1
RefSeqiNP_001011919.1, NM_001011919.1
UniGeneiRn.109111

Genome annotation databases

EnsembliENSRNOT00000060355; ENSRNOP00000057102; ENSRNOG00000023403
GeneIDi290633
KEGGirno:290633
UCSCiRGD:1305367 rat

Similar proteinsi

Entry informationi

Entry nameiGTPB3_RAT
AccessioniPrimary (citable) accession number: Q5PQQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: January 4, 2005
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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