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Protein

tRNA modification GTPase GTPBP3, mitochondrial

Gene

Gtpbp3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GTPase involved in the 5-carboxymethylaminomethyl modification (mnm5s2U34) of the wobble uridine base in mitochondrial tRNAs.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi256 – 2638GTPSequence analysis
Nucleotide bindingi303 – 3075GTPSequence analysis
Nucleotide bindingi374 – 3774GTPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA modification GTPase GTPBP3, mitochondrial
Alternative name(s):
GTP-binding protein 3
Gene namesi
Name:Gtpbp3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1305367. Gtpbp3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 8181MitochondrionSequence analysisAdd
BLAST
Chaini82 – 492411tRNA modification GTPase GTPBP3, mitochondrialPRO_0000280267Add
BLAST

Proteomic databases

PaxDbiQ5PQQ1.
PRIDEiQ5PQQ1.

PTM databases

PhosphoSiteiQ5PQQ1.

Expressioni

Gene expression databases

GenevisibleiQ5PQQ1. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000057102.

Structurei

3D structure databases

ProteinModelPortaliQ5PQQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini249 – 416168TrmE-type GAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1191. Eukaryota.
COG0486. LUCA.
GeneTreeiENSGT00390000016851.
HOGENOMiHOG000200714.
HOVERGENiHBG081577.
InParanoidiQ5PQQ1.
KOiK03650.
OMAiDIPLDMC.
OrthoDBiEOG7PS1FF.
PhylomeDBiQ5PQQ1.
TreeFamiTF313153.

Family and domain databases

Gene3Di1.20.120.430. 3 hits.
3.30.1360.120. 1 hit.
3.40.50.300. 2 hits.
HAMAPiMF_00379. GTPase_MnmE.
InterProiIPR031168. G_TrmE.
IPR018948. GTP-bd_TrmE_N.
IPR006073. GTP_binding_domain.
IPR004520. GTPase_MnmE.
IPR027368. MnmE_dom2.
IPR025867. MnmE_helical.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
PF12631. MnmE_helical. 1 hit.
PF10396. TrmE_N. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00450. mnmE_trmE_thdF. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51709. G_TRME. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5PQQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRGLSALVT RPASAPLRLC ARCSTGAESL VPGSTIFALS SGQGRCAIAV
60 70 80 90 100
IRTSGPASGL ALRSLTALRE PPPARSACLR LLRHPCSGEP LDRSLVLWFP
110 120 130 140 150
GPQSFTGEDC MELHVHGGPA VVSGVLQALG SVPGLRPAKA GEFTRRAFAH
160 170 180 190 200
GKLSLTEVEG LADLIHAETE AQRRQALRQL DGELSQLCQG WAKTLTKALA
210 220 230 240 250
HVEAYIDFGE DDNLEEGVLE QVDRDVRALE VALSSHLRDA RRGQRLRSGA
260 270 280 290 300
NVVVAGPPNA GKSSLVNLLS QKPVSIVSPE PGTTRDILET PVDLAGFPVL
310 320 330 340 350
LSDTAGLREG AGAVEQEGVR RARQRLEQAD IILGMLDASD LASSSSCSFL
360 370 380 390 400
DTVVAPLVAQ SHDSGRQRLL LLLNKSDLLS ANAPASSTAL PPHLLLSCHT
410 420 430 440 450
GAGMDALLQA LKTELAAVCG DPSTGPPLLT RARHQYHLQG CLDALGRFQL
460 470 480 490
TTDLALAAEA LRQARRQLSH LTGGGGTEEI LDLIFQDFCV GK
Length:492
Mass (Da):52,017
Last modified:January 4, 2005 - v1
Checksum:i5749762D7E3FBA61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087083 mRNA. Translation: AAH87083.1.
RefSeqiNP_001011919.1. NM_001011919.1.
UniGeneiRn.109111.

Genome annotation databases

EnsembliENSRNOT00000060355; ENSRNOP00000057102; ENSRNOG00000023403.
GeneIDi290633.
KEGGirno:290633.
UCSCiRGD:1305367. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087083 mRNA. Translation: AAH87083.1.
RefSeqiNP_001011919.1. NM_001011919.1.
UniGeneiRn.109111.

3D structure databases

ProteinModelPortaliQ5PQQ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000057102.

PTM databases

PhosphoSiteiQ5PQQ1.

Proteomic databases

PaxDbiQ5PQQ1.
PRIDEiQ5PQQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000060355; ENSRNOP00000057102; ENSRNOG00000023403.
GeneIDi290633.
KEGGirno:290633.
UCSCiRGD:1305367. rat.

Organism-specific databases

CTDi84705.
RGDi1305367. Gtpbp3.

Phylogenomic databases

eggNOGiKOG1191. Eukaryota.
COG0486. LUCA.
GeneTreeiENSGT00390000016851.
HOGENOMiHOG000200714.
HOVERGENiHBG081577.
InParanoidiQ5PQQ1.
KOiK03650.
OMAiDIPLDMC.
OrthoDBiEOG7PS1FF.
PhylomeDBiQ5PQQ1.
TreeFamiTF313153.

Miscellaneous databases

PROiQ5PQQ1.

Gene expression databases

GenevisibleiQ5PQQ1. RN.

Family and domain databases

Gene3Di1.20.120.430. 3 hits.
3.30.1360.120. 1 hit.
3.40.50.300. 2 hits.
HAMAPiMF_00379. GTPase_MnmE.
InterProiIPR031168. G_TrmE.
IPR018948. GTP-bd_TrmE_N.
IPR006073. GTP_binding_domain.
IPR004520. GTPase_MnmE.
IPR027368. MnmE_dom2.
IPR025867. MnmE_helical.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
PF12631. MnmE_helical. 1 hit.
PF10396. TrmE_N. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00450. mnmE_trmE_thdF. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51709. G_TRME. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiGTPB3_RAT
AccessioniPrimary (citable) accession number: Q5PQQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: January 4, 2005
Last modified: June 8, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.