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Protein

Structure-specific endonuclease subunit SLX1

Gene

Slx1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri182 – 234SLX1-typeUniRule annotationAdd BLAST53

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA recombination, DNA repair
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-RNO-6783310 Fanconi Anemia Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Structure-specific endonuclease subunit SLX1UniRule annotation (EC:3.1.-.-UniRule annotation)
Alternative name(s):
GIY-YIG domain-containing protein 1UniRule annotation
Gene namesi
Name:Slx1b
Synonyms:Giyd1, Giyd2, Slx1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1311568 Slx1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003321221 – 271Structure-specific endonuclease subunit SLX1Add BLAST271

Proteomic databases

PaxDbiQ5PQP5

PTM databases

PhosphoSitePlusiQ5PQP5

Expressioni

Gene expression databases

BgeeiENSRNOG00000019369
ExpressionAtlasiQ5PQP5 baseline and differential
GenevisibleiQ5PQP5 RN

Interactioni

Subunit structurei

Forms a heterodimer with SLX4.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026231

Structurei

3D structure databases

ProteinModelPortaliQ5PQP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 94GIY-YIGUniRule annotationAdd BLAST86

Sequence similaritiesi

Belongs to the SLX1 family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri182 – 234SLX1-typeUniRule annotationAdd BLAST53

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3005 Eukaryota
ENOG411266C LUCA
GeneTreeiENSGT00390000013368
HOGENOMiHOG000008012
InParanoidiQ5PQP5
KOiK15078
OMAiCHMLCLA
OrthoDBiEOG091G0J09
PhylomeDBiQ5PQP5
TreeFamiTF352344

Family and domain databases

Gene3Di3.30.40.10, 1 hit
3.40.1440.10, 1 hit
HAMAPiMF_03100 Endonuc_su_Slx1, 1 hit
InterProiView protein in InterPro
IPR000305 GIY-YIG_endonuc
IPR035901 GIY-YIG_endonuc_sf
IPR027520 Slx1
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01541 GIY-YIG, 1 hit
SMARTiView protein in SMART
SM00465 GIYc, 1 hit
SUPFAMiSSF82771 SSF82771, 1 hit
PROSITEiView protein in PROSITE
PS50164 GIY_YIG, 1 hit

Sequencei

Sequence statusi: Complete.

Q5PQP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHAARPGRF FGVYLLYCQN PRHRGRVYVG FTVNPARRVR QHNAGRKKGG
60 70 80 90 100
AWRTSGRGPW DMVLILHGFP SAVAALRFEW AWQHPQASRR LTHVGPRLRS
110 120 130 140 150
EASFTFHLRV LAHMLRVPPW VRLPLTVRWL RPDFRHELCP APPPHMPIAF
160 170 180 190 200
GPPPPQPLVP KRPAASEADS ERRLDLGAKA SCTLCARMLQ DEEGPLCCPH
210 220 230 240 250
PGCPLRAHII CLAEEFLQEE PGQLLPLEGH CPSCKKSLLW GNLVGQCHED
260 270
TEEEEVDLEL EEEHWTDLLE T
Length:271
Mass (Da):30,746
Last modified:January 4, 2005 - v1
Checksum:iA6B6F5BB87969433
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087090 mRNA Translation: AAH87090.1
RefSeqiNP_001009292.1, NM_001009292.1
UniGeneiRn.30339

Genome annotation databases

EnsembliENSRNOT00000026231; ENSRNOP00000026231; ENSRNOG00000019369
GeneIDi293489
KEGGirno:293489
UCSCiRGD:1311568 rat

Similar proteinsi

Entry informationi

Entry nameiSLX1_RAT
AccessioniPrimary (citable) accession number: Q5PQP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 4, 2005
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health