Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cdc42 effector protein 2

Gene

Cdc42ep2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell shape

Enzyme and pathway databases

ReactomeiR-RNO-5687128. MAPK6/MAPK4 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Cdc42 effector protein 2
Alternative name(s):
Binder of Rho GTPases 1
Gene namesi
Name:Cdc42ep2
Synonyms:Borg1, Cep2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1310253. Cdc42ep2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 214213Cdc42 effector protein 2PRO_0000212650Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei31 – 311PhosphoserineBy similarity
Modified residuei101 – 1011PhosphoserineCombined sources
Modified residuei137 – 1371PhosphoserineCombined sources
Modified residuei141 – 1411PhosphoserineCombined sources
Modified residuei145 – 1451PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5PQP4.

Expressioni

Gene expression databases

GenevisibleiQ5PQP4. RN.

Interactioni

Subunit structurei

Interacts with CDC42 and RHOQ, in a GTP-dependent manner, and with SEPT7.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028379.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 4415CRIBPROSITE-ProRule annotationAdd
BLAST

Domaini

The CRIB domain mediates interaction with CDC42.By similarity

Sequence similaritiesi

Belongs to the BORG/CEP family.Curated
Contains 1 CRIB domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IZS0. Eukaryota.
ENOG4111X3X. LUCA.
GeneTreeiENSGT00730000110928.
HOGENOMiHOG000233908.
HOVERGENiHBG052803.
InParanoidiQ5PQP4.
OMAiIMDQDLG.
OrthoDBiEOG7V1FSH.
PhylomeDBiQ5PQP4.
TreeFamiTF331725.

Family and domain databases

InterProiIPR029273. Cdc42_effect.
IPR017363. Cdc42_effector_prot_2.
IPR000095. CRIB_dom.
[Graphical view]
PANTHERiPTHR15344:SF4. PTHR15344:SF4. 1 hit.
PfamiPF14957. BORG_CEP. 1 hit.
PF00786. PBD. 1 hit.
[Graphical view]
PIRSFiPIRSF038036. Cdc42_effector_p2. 1 hit.
SMARTiSM00285. PBD. 1 hit.
[Graphical view]
PROSITEiPS50108. CRIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5PQP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKVPIYLK RGSRKGKKEK LRDLLSSDMI SPPLGDFRHT IHIGSGGGDD
60 70 80 90 100
MFGDISFLQG KFHLLPGTAV EEAEEDGSFD LPFQFTRTTT VCGRELPGGL
110 120 130 140 150
SPLLKNAISL PVIGGPQALT LPTTQAPPKP PRLHLESPQP SPKSSPQEAG
160 170 180 190 200
NVDIWRVPEA GLPHNGMSPE PEAEEPFLSH ASSLLSLHVD LGPSILDDVL
210
QIMDQDLGRV QIPT
Length:214
Mass (Da):23,048
Last modified:January 4, 2005 - v1
Checksum:i93BCAF80D7D2C903
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087091 mRNA. Translation: AAH87091.1.
RefSeqiNP_001009689.1. NM_001009689.1.
XP_006230868.1. XM_006230806.2.
XP_006230869.1. XM_006230807.2.
XP_006230871.1. XM_006230809.1.
XP_008758362.1. XM_008760140.1.
XP_008758363.1. XM_008760141.1.
XP_008758364.1. XM_008760142.1.
UniGeneiRn.17464.

Genome annotation databases

EnsembliENSRNOT00000028379; ENSRNOP00000028379; ENSRNOG00000020904.
GeneIDi309175.
KEGGirno:309175.
UCSCiRGD:1310253. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087091 mRNA. Translation: AAH87091.1.
RefSeqiNP_001009689.1. NM_001009689.1.
XP_006230868.1. XM_006230806.2.
XP_006230869.1. XM_006230807.2.
XP_006230871.1. XM_006230809.1.
XP_008758362.1. XM_008760140.1.
XP_008758363.1. XM_008760141.1.
XP_008758364.1. XM_008760142.1.
UniGeneiRn.17464.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028379.

Proteomic databases

PaxDbiQ5PQP4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028379; ENSRNOP00000028379; ENSRNOG00000020904.
GeneIDi309175.
KEGGirno:309175.
UCSCiRGD:1310253. rat.

Organism-specific databases

CTDi10435.
RGDi1310253. Cdc42ep2.

Phylogenomic databases

eggNOGiENOG410IZS0. Eukaryota.
ENOG4111X3X. LUCA.
GeneTreeiENSGT00730000110928.
HOGENOMiHOG000233908.
HOVERGENiHBG052803.
InParanoidiQ5PQP4.
OMAiIMDQDLG.
OrthoDBiEOG7V1FSH.
PhylomeDBiQ5PQP4.
TreeFamiTF331725.

Enzyme and pathway databases

ReactomeiR-RNO-5687128. MAPK6/MAPK4 signaling.

Miscellaneous databases

NextBioi660346.
PROiQ5PQP4.

Gene expression databases

GenevisibleiQ5PQP4. RN.

Family and domain databases

InterProiIPR029273. Cdc42_effect.
IPR017363. Cdc42_effector_prot_2.
IPR000095. CRIB_dom.
[Graphical view]
PANTHERiPTHR15344:SF4. PTHR15344:SF4. 1 hit.
PfamiPF14957. BORG_CEP. 1 hit.
PF00786. PBD. 1 hit.
[Graphical view]
PIRSFiPIRSF038036. Cdc42_effector_p2. 1 hit.
SMARTiSM00285. PBD. 1 hit.
[Graphical view]
PROSITEiPS50108. CRIB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101; SER-137 AND SER-141, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBORG1_RAT
AccessioniPrimary (citable) accession number: Q5PQP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 4, 2005
Last modified: May 11, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.