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Protein

Cdc42 effector protein 2

Gene

Cdc42ep2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell shape

Enzyme and pathway databases

ReactomeiR-RNO-5687128 MAPK6/MAPK4 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Cdc42 effector protein 2
Alternative name(s):
Binder of Rho GTPases 1
Gene namesi
Name:Cdc42ep2
Synonyms:Borg1, Cep2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi1310253 Cdc42ep2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002126502 – 214Cdc42 effector protein 2Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei31PhosphoserineBy similarity1
Modified residuei101PhosphoserineCombined sources1
Modified residuei137PhosphoserineCombined sources1
Modified residuei141PhosphoserineCombined sources1
Modified residuei145PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5PQP4

PTM databases

iPTMnetiQ5PQP4
PhosphoSitePlusiQ5PQP4

Expressioni

Gene expression databases

BgeeiENSRNOG00000020904
GenevisibleiQ5PQP4 RN

Interactioni

Subunit structurei

Interacts with CDC42 and RHOQ, in a GTP-dependent manner, and with SEPT7.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028379

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 44CRIBPROSITE-ProRule annotationAdd BLAST15

Domaini

The CRIB domain mediates interaction with CDC42.By similarity

Sequence similaritiesi

Belongs to the BORG/CEP family.Curated

Phylogenomic databases

eggNOGiENOG410IZS0 Eukaryota
ENOG4111X3X LUCA
GeneTreeiENSGT00730000110928
HOGENOMiHOG000233908
HOVERGENiHBG052803
InParanoidiQ5PQP4
OMAiIMDQDLG
OrthoDBiEOG091G0GMP
PhylomeDBiQ5PQP4
TreeFamiTF331725

Family and domain databases

InterProiView protein in InterPro
IPR029273 Cdc42_effect
IPR017363 Cdc42_effector_prot_2
IPR000095 CRIB_dom
PfamiView protein in Pfam
PF14957 BORG_CEP, 1 hit
PF00786 PBD, 1 hit
PIRSFiPIRSF038036 Cdc42_effector_p2, 1 hit
SMARTiView protein in SMART
SM00285 PBD, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5PQP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKVPIYLK RGSRKGKKEK LRDLLSSDMI SPPLGDFRHT IHIGSGGGDD
60 70 80 90 100
MFGDISFLQG KFHLLPGTAV EEAEEDGSFD LPFQFTRTTT VCGRELPGGL
110 120 130 140 150
SPLLKNAISL PVIGGPQALT LPTTQAPPKP PRLHLESPQP SPKSSPQEAG
160 170 180 190 200
NVDIWRVPEA GLPHNGMSPE PEAEEPFLSH ASSLLSLHVD LGPSILDDVL
210
QIMDQDLGRV QIPT
Length:214
Mass (Da):23,048
Last modified:January 4, 2005 - v1
Checksum:i93BCAF80D7D2C903
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087091 mRNA Translation: AAH87091.1
RefSeqiNP_001009689.1, NM_001009689.1
XP_006230868.1, XM_006230806.3
XP_006230869.1, XM_006230807.3
XP_017444741.1, XM_017589252.1
XP_017444742.1, XM_017589253.1
XP_017444743.1, XM_017589254.1
XP_017444744.1, XM_017589255.1
UniGeneiRn.17464

Genome annotation databases

EnsembliENSRNOT00000028379; ENSRNOP00000028379; ENSRNOG00000020904
GeneIDi309175
KEGGirno:309175
UCSCiRGD:1310253 rat

Similar proteinsi

Entry informationi

Entry nameiBORG1_RAT
AccessioniPrimary (citable) accession number: Q5PQP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 4, 2005
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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