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Protein

Receptor-binding cancer antigen expressed on SiSo cells

Gene

Ebag9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.By similarity

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-binding cancer antigen expressed on SiSo cells
Alternative name(s):
Estrogen receptor-binding fragment-associated gene 9 protein
Gene namesi
Name:Ebag9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1307293 Ebag9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6ExtracellularSequence analysis6
Transmembranei7 – 27Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini28 – 213CytoplasmicSequence analysisAdd BLAST186

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000971971 – 213Receptor-binding cancer antigen expressed on SiSo cellsAdd BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36PhosphoserineCombined sources1
Modified residuei41PhosphothreonineBy similarity1
Modified residuei94PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5PQP2
PRIDEiQ5PQP2

PTM databases

iPTMnetiQ5PQP2
PhosphoSitePlusiQ5PQP2
SwissPalmiQ5PQP2

Expressioni

Gene expression databases

BgeeiENSRNOG00000004220
GenevisibleiQ5PQP2 RN

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005705

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili168 – 209Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi160 – 163Poly-Glu4

Domaini

The coiled coil domain is necessary for the homodimerization.By similarity

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE57 Eukaryota
ENOG41101KS LUCA
GeneTreeiENSGT00390000004040
HOGENOMiHOG000073537
HOVERGENiHBG059707
InParanoidiQ5PQP2
KOiK22455
OMAiFRLFKIC
OrthoDBiEOG091G0L0F
PhylomeDBiQ5PQP2
TreeFamiTF326584

Family and domain databases

InterProiView protein in InterPro
IPR017025 Cancer-assoc_antigen_RCAS1
PANTHERiPTHR15208 PTHR15208, 1 hit
PIRSFiPIRSF034247 RCAS1, 1 hit

Sequencei

Sequence statusi: Complete.

Q5PQP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAITQFRLFK VCTCLATVLS FLKRLICRSG RGRKLSGDQI TLPTTVDYSS
60 70 80 90 100
VPKQTDVEEW TSWDEDAPTS VKIEGGTGNA AAQQNSLEQL EPDYFKDMTP
110 120 130 140 150
TIRKTQKIVI KKREPLSFGV PDGSTGFSSR LAATQDMPFI HQSSELGDLD
160 170 180 190 200
TWQENSNAWE EEEDAAWQAE EVLRQQKIAD REKRAAEQQR KKMEKEAQRL
210
LKKEQNKMGV KLS
Length:213
Mass (Da):24,187
Last modified:January 4, 2005 - v1
Checksum:iB151945039179878
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087093 mRNA Translation: AAH87093.1
RefSeqiNP_001009665.1, NM_001009665.1
XP_006241675.1, XM_006241613.3
UniGeneiRn.64132

Genome annotation databases

EnsembliENSRNOT00000005705; ENSRNOP00000005705; ENSRNOG00000004220
GeneIDi299864
KEGGirno:299864
UCSCiRGD:1307293 rat

Similar proteinsi

Entry informationi

Entry nameiRCAS1_RAT
AccessioniPrimary (citable) accession number: Q5PQP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: January 4, 2005
Last modified: April 25, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health