Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Receptor-binding cancer antigen expressed on SiSo cells

Gene

Ebag9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-binding cancer antigen expressed on SiSo cells
Alternative name(s):
Estrogen receptor-binding fragment-associated gene 9 protein
Gene namesi
Name:Ebag9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1307293. Ebag9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66ExtracellularSequence analysis
Transmembranei7 – 2721Helical; Signal-anchor for type III membrane proteinSequence analysisAdd
BLAST
Topological domaini28 – 213186CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • secretory granule Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213Receptor-binding cancer antigen expressed on SiSo cellsPRO_0000097197Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei36 – 361PhosphoserineCombined sources
Modified residuei41 – 411PhosphothreonineBy similarity
Modified residuei94 – 941PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5PQP2.
PRIDEiQ5PQP2.

PTM databases

iPTMnetiQ5PQP2.
PhosphoSiteiQ5PQP2.
SwissPalmiQ5PQP2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004220.
GenevisibleiQ5PQP2. RN.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

MINTiMINT-4580499.
STRINGi10116.ENSRNOP00000005705.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili168 – 20942Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi160 – 1634Poly-Glu

Domaini

The coiled coil domain is necessary for the homodimerization.By similarity

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE57. Eukaryota.
ENOG41101KS. LUCA.
GeneTreeiENSGT00390000004040.
HOGENOMiHOG000073537.
HOVERGENiHBG059707.
InParanoidiQ5PQP2.
OMAiFRLFKIC.
OrthoDBiEOG091G0L0F.
PhylomeDBiQ5PQP2.
TreeFamiTF326584.

Family and domain databases

InterProiIPR017025. Cancer-assoc_antigen_RCAS1.
[Graphical view]
PANTHERiPTHR15208. PTHR15208. 1 hit.
PIRSFiPIRSF034247. RCAS1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5PQP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAITQFRLFK VCTCLATVLS FLKRLICRSG RGRKLSGDQI TLPTTVDYSS
60 70 80 90 100
VPKQTDVEEW TSWDEDAPTS VKIEGGTGNA AAQQNSLEQL EPDYFKDMTP
110 120 130 140 150
TIRKTQKIVI KKREPLSFGV PDGSTGFSSR LAATQDMPFI HQSSELGDLD
160 170 180 190 200
TWQENSNAWE EEEDAAWQAE EVLRQQKIAD REKRAAEQQR KKMEKEAQRL
210
LKKEQNKMGV KLS
Length:213
Mass (Da):24,187
Last modified:January 4, 2005 - v1
Checksum:iB151945039179878
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087093 mRNA. Translation: AAH87093.1.
RefSeqiNP_001009665.1. NM_001009665.1.
XP_006241675.1. XM_006241613.2.
XP_008763674.1. XM_008765452.1.
UniGeneiRn.64132.

Genome annotation databases

EnsembliENSRNOT00000005705; ENSRNOP00000005705; ENSRNOG00000004220.
GeneIDi299864.
KEGGirno:299864.
UCSCiRGD:1307293. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087093 mRNA. Translation: AAH87093.1.
RefSeqiNP_001009665.1. NM_001009665.1.
XP_006241675.1. XM_006241613.2.
XP_008763674.1. XM_008765452.1.
UniGeneiRn.64132.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4580499.
STRINGi10116.ENSRNOP00000005705.

PTM databases

iPTMnetiQ5PQP2.
PhosphoSiteiQ5PQP2.
SwissPalmiQ5PQP2.

Proteomic databases

PaxDbiQ5PQP2.
PRIDEiQ5PQP2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005705; ENSRNOP00000005705; ENSRNOG00000004220.
GeneIDi299864.
KEGGirno:299864.
UCSCiRGD:1307293. rat.

Organism-specific databases

CTDi9166.
RGDi1307293. Ebag9.

Phylogenomic databases

eggNOGiENOG410IE57. Eukaryota.
ENOG41101KS. LUCA.
GeneTreeiENSGT00390000004040.
HOGENOMiHOG000073537.
HOVERGENiHBG059707.
InParanoidiQ5PQP2.
OMAiFRLFKIC.
OrthoDBiEOG091G0L0F.
PhylomeDBiQ5PQP2.
TreeFamiTF326584.

Miscellaneous databases

PROiQ5PQP2.

Gene expression databases

BgeeiENSRNOG00000004220.
GenevisibleiQ5PQP2. RN.

Family and domain databases

InterProiIPR017025. Cancer-assoc_antigen_RCAS1.
[Graphical view]
PANTHERiPTHR15208. PTHR15208. 1 hit.
PIRSFiPIRSF034247. RCAS1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRCAS1_RAT
AccessioniPrimary (citable) accession number: Q5PQP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: January 4, 2005
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.