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Protein

Tripartite motif-containing protein 55

Gene

Trim55

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May regulate gene expression and protein turnover in muscle cells.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri26 – 82RING-typePROSITE-ProRule annotationAdd BLAST57
Zinc fingeri119 – 161B box-typePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 55
Alternative name(s):
Muscle-specific RING finger protein 2
Short name:
MuRF-2
Short name:
MuRF2
RING finger protein 29
Gene namesi
Name:Trim55
Synonyms:Murf2, Rnf29
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1306943. Trim55.

Subcellular locationi

  • Cytoplasm
  • Nucleus

  • Note: Nuclear under atrophic conditions and upon mechanical signals. Localizes to the sarcomeric M-band in cardiomyocytes. Colocalizes in part with microtubules.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562871 – 545Tripartite motif-containing protein 55Add BLAST545

Proteomic databases

PaxDbiQ5PQN5.
PRIDEiQ5PQN5.

PTM databases

PhosphoSitePlusiQ5PQN5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000012723.

Interactioni

Subunit structurei

Homooligomer and heterooligomer (Probable). Interacts with titin/TTN. Interacts with myosins. Interacts with SQSTM1 and NBR1. Probably interacts with TRIM63 and TRIM54 (By similarity).By similarityCurated

Protein-protein interaction databases

BioGridi265529. 1 interactor.
STRINGi10116.ENSRNOP00000017125.

Structurei

3D structure databases

ProteinModelPortaliQ5PQN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini269 – 327COSPROSITE-ProRule annotationAdd BLAST59

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili219 – 258Sequence analysisAdd BLAST40

Sequence similaritiesi

Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 COS domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri26 – 82RING-typePROSITE-ProRule annotationAdd BLAST57
Zinc fingeri119 – 161B box-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITG3. Eukaryota.
ENOG410YBZG. LUCA.
GeneTreeiENSGT00760000118878.
HOGENOMiHOG000231156.
HOVERGENiHBG071242.
InParanoidiQ5PQN5.
KOiK10654.
OMAiQIGFEAP.
OrthoDBiEOG091G071N.
PhylomeDBiQ5PQN5.
TreeFamiTF331669.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR017903. COS_domain.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS51262. COS. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PQN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSLNYKSF SKEQQTMDNL EKQLICPICL EMFTKPVVIL PCQHNLCRKC
60 70 80 90 100
ASDIFQASNP YLPTRGGTTV ASGGRFRCPS CRHEVVLDRH GVYGLQRNLL
110 120 130 140 150
VENIIDIYKQ ESTRPEKKLD QPMCEEHEEE RINIYCLNCE VPTCSLCKVF
160 170 180 190 200
GAHKDCQVAP LTHVFQRQKS ELSDGIAVLV GSNDRVQGVI SQLEDTCKTI
210 220 230 240 250
EECCRKQKQD LCEKFDHLYS ILEERKTEMT QAITRTQEEK LEHVRTLIRK
260 270 280 290 300
YSDHLENVSK LVESGIQFMD EPEMAVFLQN AKTLLQKITE ASKAFQMEKI
310 320 330 340 350
EQGYEIMNNF TVNLNREEKI IREIDFSREE EDEDDEGEVD EEGEGEDAVE
360 370 380 390 400
VEEAENVQVA SSGEEETLEK AAEPSELAAE IQAASGPLLA SSPDSVSSLP
410 420 430 440 450
PAADVLVTQG EVVPTDSQQT TQSETSGPSA AETADPLFYP SWYKGQSRKM
460 470 480 490 500
ISNPPHTPGG EGLSQIGPSA AEDSSVQSAE VAEAAANEQA AVSGKESSST
510 520 530 540
AATSQIGFEA SSPQGQAAAL GSGGGADSEP ARHVFSFSWL NSLNE
Length:545
Mass (Da):59,980
Last modified:January 4, 2005 - v1
Checksum:i2B884C66708CCB36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087100 mRNA. Translation: AAH87100.1.
RefSeqiNP_001012218.1. NM_001012218.1.
UniGeneiRn.76142.

Genome annotation databases

EnsembliENSRNOT00000017125; ENSRNOP00000017125; ENSRNOG00000012723.
GeneIDi365751.
KEGGirno:365751.
UCSCiRGD:1306943. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087100 mRNA. Translation: AAH87100.1.
RefSeqiNP_001012218.1. NM_001012218.1.
UniGeneiRn.76142.

3D structure databases

ProteinModelPortaliQ5PQN5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi265529. 1 interactor.
STRINGi10116.ENSRNOP00000017125.

PTM databases

PhosphoSitePlusiQ5PQN5.

Proteomic databases

PaxDbiQ5PQN5.
PRIDEiQ5PQN5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000017125; ENSRNOP00000017125; ENSRNOG00000012723.
GeneIDi365751.
KEGGirno:365751.
UCSCiRGD:1306943. rat.

Organism-specific databases

CTDi84675.
RGDi1306943. Trim55.

Phylogenomic databases

eggNOGiENOG410ITG3. Eukaryota.
ENOG410YBZG. LUCA.
GeneTreeiENSGT00760000118878.
HOGENOMiHOG000231156.
HOVERGENiHBG071242.
InParanoidiQ5PQN5.
KOiK10654.
OMAiQIGFEAP.
OrthoDBiEOG091G071N.
PhylomeDBiQ5PQN5.
TreeFamiTF331669.

Miscellaneous databases

PROiQ5PQN5.

Gene expression databases

BgeeiENSRNOG00000012723.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR017903. COS_domain.
IPR027370. Znf-RING_LisH.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS51262. COS. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRI55_RAT
AccessioniPrimary (citable) accession number: Q5PQN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: January 4, 2005
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.