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Protein

Nuclear protein MDM1

Gene

Mdm1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear protein MDM1
Gene namesi
Name:Mdm1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1561092. Mdm1.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
  • Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity

  • Note: Localizes to the centriole lumen.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 719719Nuclear protein MDM1PRO_0000299062Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei124 – 1241PhosphoserineCombined sources
Modified residuei127 – 1271PhosphoserineCombined sources
Modified residuei266 – 2661PhosphoserineCombined sources
Modified residuei283 – 2831PhosphoserineCombined sources
Modified residuei286 – 2861PhosphoserineCombined sources
Modified residuei314 – 3141PhosphoserineBy similarity
Modified residuei565 – 5651PhosphoserineBy similarity
Modified residuei566 – 5661PhosphoserineBy similarity
Modified residuei591 – 5911PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5PQN4.
PRIDEiQ5PQN4.

PTM databases

iPTMnetiQ5PQN4.
PhosphoSiteiQ5PQN4.

Expressioni

Gene expression databases

ExpressionAtlasiQ5PQN4. baseline and differential.
GenevisibleiQ5PQN4. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041359.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili339 – 36426Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi9 – 157ST]-E-Y-X(3)-F motif 1; required for efficient microtubule binding and stabilizationBy similarity
Motifi192 – 1987ST]-E-Y-X(3)-F motif 2; required for efficient microtubule binding and stabilizationBy similarity
Motifi235 – 2417ST]-E-Y-X(3)-F motif 3; required for efficient microtubule binding and stabilizationBy similarity
Motifi306 – 3127ST]-E-Y-X(3)-F motif 4; required for efficient microtubule binding and stabilizationBy similarity

Sequence similaritiesi

Belongs to the MDM1 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410II1Y. Eukaryota.
ENOG410Y0E2. LUCA.
GeneTreeiENSGT00390000004106.
HOGENOMiHOG000113507.
HOVERGENiHBG108124.
InParanoidiQ5PQN4.
KOiK17886.
OMAiHQRLGKV.
OrthoDBiEOG7P2XVF.
PhylomeDBiQ5PQN4.
TreeFamiTF331015.

Family and domain databases

InterProiIPR029136. MDM1.
[Graphical view]
PANTHERiPTHR32078:SF1. PTHR32078:SF1. 1 hit.
PfamiPF15501. MDM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PQN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVRFKGLSE YQRNFLWKKS YLSESYNPSV GQKYTWAGLR SDQLGITKEP
60 70 80 90 100
SFISKRRVPY YDPQISKYLE WNGTVRENDA LAPPEPQIIR TPKPQEAEQR
110 120 130 140 150
EDANHETVLP QEASRVPKRT RSHSADSRAE GASDGVEKHQ DVTKNHSLVN
160 170 180 190 200
ADVELRPSTK PLPESIEPRL DRHLRKKAGL AVVPLNNALR NSEYQRQFVW
210 220 230 240 250
KTCKETAPVC AANQVFRNKS QVIPQFQGNT FIHESEYKRN FKGLTPVKEP
260 270 280 290 300
KLREYLKGNS SFEILSPEKK ADEPLDLEVD MASEDSDQPI KKPAPWRHQR
310 320 330 340 350
LGKVNSEYRA KFLSPAQYLY KAGAWTRVKE SLSHQGSLNA MWYAEVKELR
360 370 380 390 400
EKAESYRKRV QGTHFSRDHL NQIMSDSNCC WDVSSVASSE GTISSNIQAL
410 420 430 440 450
DLAGDLTSHR TLQKHPPTKL EEKKVALAEQ PLENTIRSLE LPEAPTMARR
460 470 480 490 500
KLAWDAAEGT QKEDTQEEPS GEEDGREARG KDKQVCAGEL QKVDMQTSKA
510 520 530 540 550
DGPTEGSETS SVSSGKGGRL PTPRLRELGI QRTHHDLTTP AVGGAVLVSP
560 570 580 590 600
AKAKPSALEQ RRRPSSQDGL ETLKKGITKK GKHRPLSLLT SPTAGMKTVD
610 620 630 640 650
PLPLRQDCDA NVLRVAEGTL PVLKNLDHQT NTPGQPSPCT LPYCHPSSRI
660 670 680 690 700
QGRLRDPEFQ HNIGKPRMNN TQLLPHGAFN DEDADRLSEI SARSAVSSLQ
710
AFQTLARAQK RKENFWGKP
Length:719
Mass (Da):80,698
Last modified:August 21, 2007 - v2
Checksum:i322429903762FEE0
GO

Sequence cautioni

The sequence AAH87101.1 differs from that shown. Reason: Frameshift at position 118. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087101 mRNA. Translation: AAH87101.1. Frameshift.
RefSeqiNP_001017459.2. NM_001017459.2.
UniGeneiRn.162942.

Genome annotation databases

EnsembliENSRNOT00000048765; ENSRNOP00000041359; ENSRNOG00000007286.
GeneIDi314859.
KEGGirno:314859.
UCSCiRGD:1561092. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087101 mRNA. Translation: AAH87101.1. Frameshift.
RefSeqiNP_001017459.2. NM_001017459.2.
UniGeneiRn.162942.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041359.

PTM databases

iPTMnetiQ5PQN4.
PhosphoSiteiQ5PQN4.

Proteomic databases

PaxDbiQ5PQN4.
PRIDEiQ5PQN4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000048765; ENSRNOP00000041359; ENSRNOG00000007286.
GeneIDi314859.
KEGGirno:314859.
UCSCiRGD:1561092. rat.

Organism-specific databases

CTDi56890.
RGDi1561092. Mdm1.

Phylogenomic databases

eggNOGiENOG410II1Y. Eukaryota.
ENOG410Y0E2. LUCA.
GeneTreeiENSGT00390000004106.
HOGENOMiHOG000113507.
HOVERGENiHBG108124.
InParanoidiQ5PQN4.
KOiK17886.
OMAiHQRLGKV.
OrthoDBiEOG7P2XVF.
PhylomeDBiQ5PQN4.
TreeFamiTF331015.

Miscellaneous databases

PROiQ5PQN4.

Gene expression databases

ExpressionAtlasiQ5PQN4. baseline and differential.
GenevisibleiQ5PQN4. RN.

Family and domain databases

InterProiIPR029136. MDM1.
[Graphical view]
PANTHERiPTHR32078:SF1. PTHR32078:SF1. 1 hit.
PfamiPF15501. MDM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124; SER-127; SER-266; SER-283 AND SER-286, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMDM1_RAT
AccessioniPrimary (citable) accession number: Q5PQN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: July 6, 2016
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.