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Protein

Bifunctional apoptosis regulator

Gene

Bfar

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri34 – 7441RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional apoptosis regulator
Gene namesi
Name:Bfar
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1304791. Bfar.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 140140CytoplasmicSequence analysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence analysisAdd
BLAST
Topological domaini162 – 331170ExtracellularSequence analysisAdd
BLAST
Transmembranei332 – 35221HelicalSequence analysisAdd
BLAST
Topological domaini353 – 3608CytoplasmicSequence analysis
Transmembranei361 – 38121HelicalSequence analysisAdd
BLAST
Topological domaini382 – 40423ExtracellularSequence analysisAdd
BLAST
Transmembranei405 – 42521HelicalSequence analysisAdd
BLAST
Topological domaini426 – 45025CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Bifunctional apoptosis regulatorPRO_0000055824Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5PQN2.
PRIDEiQ5PQN2.

Expressioni

Gene expression databases

GenevisibleiQ5PQN2. RN.

Interactioni

Subunit structurei

Interacts with CASP8, BCL2 and BCL2L1 through SAM domain and also with HIP1, IFT57, ESRRBL1 and BCAP31.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004217.

Structurei

3D structure databases

ProteinModelPortaliQ5PQN2.
SMRiQ5PQN2. Positions 170-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini182 – 24968SAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri34 – 7441RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG4159. Eukaryota.
COG2802. LUCA.
GeneTreeiENSGT00390000005386.
HOGENOMiHOG000285958.
HOVERGENiHBG056789.
InParanoidiQ5PQN2.
KOiK15684.
OMAiKNECPEC.
OrthoDBiEOG7PP56P.
PhylomeDBiQ5PQN2.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001660. SAM.
IPR013761. SAM/pointed.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PQN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEPQKNDLS MRGQEEDHPV RSSGPQISVS EFSCHCCYDT LVNPTTLNCG
60 70 80 90 100
HSFCRHCLAL WWMSSKKTEC PECREKWEGF PKVNILLRDA IEKLFPDAIK
110 120 130 140 150
MRVEDIQQNN DVVQSLAAFQ KYGNDQNPLA PSTGRVNQQR GGGFFSGVLT
160 170 180 190 200
ALTGVAVILL VYHWRSRESE HGLLVHKAVD KWTTEEVVLW LEQLGPWASL
210 220 230 240 250
YRDRFLSERV NGRLLLTLTE EEFSRAPYTI ENSSHRRVIL MELERVRALG
260 270 280 290 300
VKPPQNLWEY KAVNPGRSLF LLYALKSSPR LGLLYLYLFD YTDSFLPFIH
310 320 330 340 350
TICPLQEDSF GEDIFTKLLD LREPTWKQWR EFLIKYSFLP YQLIAEFAWD
360 370 380 390 400
WLEVHYWTSR FLIVNAMLLS VLELFSFWRI WSRSELKTVP QRMWSHFWKV
410 420 430 440 450
STQGLFMAMF WPLIPQFVCN CLFYWALYFN PIINIDLVVK EIRRLETQVF
Length:450
Mass (Da):53,024
Last modified:January 4, 2005 - v1
Checksum:iF089F94F8DE354DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087103 mRNA. Translation: AAH87103.1.
RefSeqiNP_001013143.1. NM_001013125.1.
UniGeneiRn.159939.

Genome annotation databases

EnsembliENSRNOT00000004217; ENSRNOP00000004217; ENSRNOG00000003151.
GeneIDi304709.
KEGGirno:304709.
UCSCiRGD:1304791. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087103 mRNA. Translation: AAH87103.1.
RefSeqiNP_001013143.1. NM_001013125.1.
UniGeneiRn.159939.

3D structure databases

ProteinModelPortaliQ5PQN2.
SMRiQ5PQN2. Positions 170-248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004217.

Proteomic databases

PaxDbiQ5PQN2.
PRIDEiQ5PQN2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004217; ENSRNOP00000004217; ENSRNOG00000003151.
GeneIDi304709.
KEGGirno:304709.
UCSCiRGD:1304791. rat.

Organism-specific databases

CTDi51283.
RGDi1304791. Bfar.

Phylogenomic databases

eggNOGiKOG4159. Eukaryota.
COG2802. LUCA.
GeneTreeiENSGT00390000005386.
HOGENOMiHOG000285958.
HOVERGENiHBG056789.
InParanoidiQ5PQN2.
KOiK15684.
OMAiKNECPEC.
OrthoDBiEOG7PP56P.
PhylomeDBiQ5PQN2.

Miscellaneous databases

NextBioi653497.
PROiQ5PQN2.

Gene expression databases

GenevisibleiQ5PQN2. RN.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001660. SAM.
IPR013761. SAM/pointed.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiBFAR_RAT
AccessioniPrimary (citable) accession number: Q5PQN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 4, 2005
Last modified: May 11, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.