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Protein

Neurocalcin-delta

Gene

Ncald

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi73 – 84121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi109 – 120122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi157 – 168123PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • actin binding Source: RGD
  • alpha-tubulin binding Source: RGD
  • calcium ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-451308. Activation of Ca-permeable Kainate Receptor.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurocalcin-delta
Gene namesi
Name:Ncald
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1560287. Ncald.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
  • extracellular exosome Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 193192Neurocalcin-deltaPRO_0000249733Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiQ5PQN0.
PRIDEiQ5PQN0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000042978.
GenevisibleiQ5PQN0. RN.

Interactioni

GO - Molecular functioni

  • actin binding Source: RGD
  • alpha-tubulin binding Source: RGD

Protein-protein interaction databases

BioGridi275016. 4 interactions.
STRINGi10116.ENSRNOP00000062447.

Structurei

3D structure databases

ProteinModelPortaliQ5PQN0.
SMRiQ5PQN0. Positions 5-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 5836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini60 – 9536EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini96 – 13136EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini144 – 17936EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the recoverin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOVERGENiHBG108179.
InParanoidiQ5PQN0.
KOiK19695.
OMAiQCDPSAQ.
PhylomeDBiQ5PQN0.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5PQN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKQNSKLRP EVMQDLLEST DFTEHEIQEW YKGFLRDCPS GHLSMEEFKK
60 70 80 90 100
IYGNFFPYGD ASKFAEHVFR TFDANGDGTI DFREFIIALS VTSRGKLEQK
110 120 130 140 150
LKWAFSMYDL DGNGYISKAE MLEIVQAIYK MVSSVMKMPE DESTPEKRTE
160 170 180 190
KIFRQMDTNR DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA GQF
Length:193
Mass (Da):22,245
Last modified:January 23, 2007 - v3
Checksum:i20DD8B6FF47C4CBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087105 mRNA. Translation: AAH87105.1.
RefSeqiNP_001019542.1. NM_001024371.1.
XP_008763678.1. XM_008765456.1.
UniGeneiRn.13744.

Genome annotation databases

EnsembliENSRNOT00000064513; ENSRNOP00000062447; ENSRNOG00000042978.
ENSRNOT00000080024; ENSRNOP00000073597; ENSRNOG00000042978.
GeneIDi553106.
KEGGirno:553106.
UCSCiRGD:1560287. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087105 mRNA. Translation: AAH87105.1.
RefSeqiNP_001019542.1. NM_001024371.1.
XP_008763678.1. XM_008765456.1.
UniGeneiRn.13744.

3D structure databases

ProteinModelPortaliQ5PQN0.
SMRiQ5PQN0. Positions 5-185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275016. 4 interactions.
STRINGi10116.ENSRNOP00000062447.

Proteomic databases

PaxDbiQ5PQN0.
PRIDEiQ5PQN0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000064513; ENSRNOP00000062447; ENSRNOG00000042978.
ENSRNOT00000080024; ENSRNOP00000073597; ENSRNOG00000042978.
GeneIDi553106.
KEGGirno:553106.
UCSCiRGD:1560287. rat.

Organism-specific databases

CTDi83988.
RGDi1560287. Ncald.

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOVERGENiHBG108179.
InParanoidiQ5PQN0.
KOiK19695.
OMAiQCDPSAQ.
PhylomeDBiQ5PQN0.

Enzyme and pathway databases

ReactomeiR-RNO-451308. Activation of Ca-permeable Kainate Receptor.

Miscellaneous databases

PROiQ5PQN0.

Gene expression databases

BgeeiENSRNOG00000042978.
GenevisibleiQ5PQN0. RN.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNCALD_RAT
AccessioniPrimary (citable) accession number: Q5PQN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.