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Protein

Kinesin light chain 4

Gene

Klc4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionMotor protein

Enzyme and pathway databases

ReactomeiR-RNO-2132295 MHC class II antigen presentation
R-RNO-5625970 RHO GTPases activate KTN1
R-RNO-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-RNO-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin light chain 4
Short name:
KLC 4
Alternative name(s):
Kinesin-like protein 8
Gene namesi
Name:Klc4
Synonyms:Knsl8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1306555 Klc4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003845822 – 619Kinesin light chain 4Add BLAST618

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei174PhosphoserineBy similarity1
Modified residuei192PhosphoserineBy similarity1
Modified residuei460PhosphoserineBy similarity1
Modified residuei565PhosphoserineCombined sources1
Modified residuei566PhosphoserineCombined sources1
Modified residuei590PhosphoserineCombined sources1
Modified residuei609PhosphoserineBy similarity1
Modified residuei611PhosphoserineBy similarity1
Modified residuei612PhosphothreonineBy similarity1
Modified residuei616PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5PQM2
PRIDEiQ5PQM2

PTM databases

iPTMnetiQ5PQM2
PhosphoSitePlusiQ5PQM2

Expressioni

Gene expression databases

BgeeiENSRNOG00000018168
GenevisibleiQ5PQM2 RN

Interactioni

Subunit structurei

Oligomeric complex composed of two heavy chains and two light chains.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038363

Structurei

3D structure databases

ProteinModelPortaliQ5PQM2
SMRiQ5PQM2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati55 – 88TPR 1Add BLAST34
Repeati211 – 244TPR 2Add BLAST34
Repeati253 – 286TPR 3Add BLAST34
Repeati295 – 328TPR 4Add BLAST34
Repeati337 – 370TPR 5Add BLAST34
Repeati379 – 412TPR 6Add BLAST34
Repeati464 – 497TPR 7Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili32 – 150Sequence analysisAdd BLAST119

Sequence similaritiesi

Belongs to the kinesin light chain family.Curated

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1840 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00390000006393
HOGENOMiHOG000261663
InParanoidiQ5PQM2
KOiK10407
OMAiQHSGYEI
OrthoDBiEOG091G05DM
PhylomeDBiQ5PQM2
TreeFamiTF314010

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR002151 Kinesin_light
IPR015792 Kinesin_light_repeat
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PRINTSiPR00381 KINESINLIGHT
SMARTiView protein in SMART
SM00028 TPR, 5 hits
SUPFAMiSSF48452 SSF48452, 3 hits
PROSITEiView protein in PROSITE
PS01160 KINESIN_LIGHT, 3 hits
PS50005 TPR, 6 hits
PS50293 TPR_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5PQM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGLVLGQRD EPAGHRLSQE EILGSTRLVS QGLESLHSEH QAVLQSLSHT
60 70 80 90 100
IECLQQGGHE EGLVHEKARQ LRRSMENIEL GLSEAQVMLA LASHLSTVES
110 120 130 140 150
EKQKLRAQVR RLCQENQWLR DELAGTQQRL QRSEQAVAQL EEEKKHLEFL
160 170 180 190 200
RQLRQYDEDG HSMEEKEGDA SKDSLDDLFP NEEEEDSSND LSRGQGAAAA
210 220 230 240 250
QQGGYEIPAR LRTLHNLVIQ YAAQGRYEVA VPLCKQALED LERTSGRGHP
260 270 280 290 300
DVATMLNILA LVYRDQNKYK EAAHLLNDAL SIRESTLGRD HPAVAATLNN
310 320 330 340 350
LAVLYGKRGK YKEAEPLCQR ALEIREKVLG TDHPDVAKQL NNLALLCQNQ
360 370 380 390 400
GKYEAVERYY QRALAIYERQ LGPDNPNVAR TKNNLASCYL KQGKYSEAET
410 420 430 440 450
LYKEILTRAH VQEFGSVDDD HKPIWMHAEE REEMSRSRSR ESGTPYAEYG
460 470 480 490 500
GWYKACRVSS PTVNTTLRNL GALYRRQGKL EAAETLEECA LRSRKQGTDP
510 520 530 540 550
ISQTKVAELL GEGDGRKTMQ EGPGDSVKFE GGEDASVAVE WSGDGSGTLQ
560 570 580 590 600
RSGSLGKIRD VLRRSSELLV RKLQGTEPRP SSSNMKRAAS LNYLNQPNAA
610
PLQTSRGLSA STVDLSSSS
Length:619
Mass (Da):68,964
Last modified:January 4, 2005 - v1
Checksum:i6873D2D80C174BB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087116 mRNA Translation: AAH87116.1
RefSeqiNP_001009601.1, NM_001009601.1
XP_006244578.1, XM_006244516.3
XP_006244579.1, XM_006244517.3
UniGeneiRn.16800

Genome annotation databases

EnsembliENSRNOT00000031625; ENSRNOP00000038363; ENSRNOG00000018168
ENSRNOT00000087413; ENSRNOP00000071889; ENSRNOG00000018168
GeneIDi316226
KEGGirno:316226
UCSCiRGD:1306555 rat

Similar proteinsi

Entry informationi

Entry nameiKLC4_RAT
AccessioniPrimary (citable) accession number: Q5PQM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: January 4, 2005
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health