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Protein

Kinesin light chain 4

Gene

Klc4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin light chain 4
Short name:
KLC 4
Alternative name(s):
Kinesin-like protein 8
Gene namesi
Name:Klc4
Synonyms:Knsl8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1306555. Klc4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 619618Kinesin light chain 4PRO_0000384582Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei174 – 1741PhosphoserineBy similarity
Modified residuei449 – 4491PhosphotyrosineBy similarity
Modified residuei460 – 4601PhosphoserineBy similarity
Modified residuei565 – 5651PhosphoserineCombined sources
Modified residuei566 – 5661PhosphoserineCombined sources
Modified residuei590 – 5901PhosphoserineCombined sources
Modified residuei612 – 6121PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5PQM2.
PRIDEiQ5PQM2.

PTM databases

iPTMnetiQ5PQM2.
PhosphoSiteiQ5PQM2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018168.
GenevisibleiQ5PQM2. RN.

Interactioni

Subunit structurei

Oligomeric complex composed of two heavy chains and two light chains.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038363.

Structurei

3D structure databases

ProteinModelPortaliQ5PQM2.
SMRiQ5PQM2. Positions 230-494.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati55 – 8834TPR 1Add
BLAST
Repeati211 – 24434TPR 2Add
BLAST
Repeati253 – 28634TPR 3Add
BLAST
Repeati295 – 32834TPR 4Add
BLAST
Repeati337 – 37034TPR 5Add
BLAST
Repeati379 – 41234TPR 6Add
BLAST
Repeati464 – 49734TPR 7Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili32 – 150119Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the kinesin light chain family.Curated
Contains 7 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000006393.
HOGENOMiHOG000261663.
InParanoidiQ5PQM2.
KOiK10407.
OMAiMSKSRHR.
OrthoDBiEOG091G05DM.
PhylomeDBiQ5PQM2.
TreeFamiTF314010.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR002151. Kinesin_light.
IPR015792. Kinesin_light_repeat.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13374. TPR_10. 2 hits.
[Graphical view]
PRINTSiPR00381. KINESINLIGHT.
SMARTiSM00028. TPR. 5 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS01160. KINESIN_LIGHT. 3 hits.
PS50005. TPR. 6 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5PQM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGLVLGQRD EPAGHRLSQE EILGSTRLVS QGLESLHSEH QAVLQSLSHT
60 70 80 90 100
IECLQQGGHE EGLVHEKARQ LRRSMENIEL GLSEAQVMLA LASHLSTVES
110 120 130 140 150
EKQKLRAQVR RLCQENQWLR DELAGTQQRL QRSEQAVAQL EEEKKHLEFL
160 170 180 190 200
RQLRQYDEDG HSMEEKEGDA SKDSLDDLFP NEEEEDSSND LSRGQGAAAA
210 220 230 240 250
QQGGYEIPAR LRTLHNLVIQ YAAQGRYEVA VPLCKQALED LERTSGRGHP
260 270 280 290 300
DVATMLNILA LVYRDQNKYK EAAHLLNDAL SIRESTLGRD HPAVAATLNN
310 320 330 340 350
LAVLYGKRGK YKEAEPLCQR ALEIREKVLG TDHPDVAKQL NNLALLCQNQ
360 370 380 390 400
GKYEAVERYY QRALAIYERQ LGPDNPNVAR TKNNLASCYL KQGKYSEAET
410 420 430 440 450
LYKEILTRAH VQEFGSVDDD HKPIWMHAEE REEMSRSRSR ESGTPYAEYG
460 470 480 490 500
GWYKACRVSS PTVNTTLRNL GALYRRQGKL EAAETLEECA LRSRKQGTDP
510 520 530 540 550
ISQTKVAELL GEGDGRKTMQ EGPGDSVKFE GGEDASVAVE WSGDGSGTLQ
560 570 580 590 600
RSGSLGKIRD VLRRSSELLV RKLQGTEPRP SSSNMKRAAS LNYLNQPNAA
610
PLQTSRGLSA STVDLSSSS
Length:619
Mass (Da):68,964
Last modified:January 4, 2005 - v1
Checksum:i6873D2D80C174BB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087116 mRNA. Translation: AAH87116.1.
RefSeqiNP_001009601.1. NM_001009601.1.
XP_006244578.1. XM_006244516.2.
XP_006244579.1. XM_006244517.2.
UniGeneiRn.16800.

Genome annotation databases

EnsembliENSRNOT00000031625; ENSRNOP00000038363; ENSRNOG00000018168.
ENSRNOT00000087413; ENSRNOP00000071889; ENSRNOG00000018168.
GeneIDi316226.
KEGGirno:316226.
UCSCiRGD:1306555. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087116 mRNA. Translation: AAH87116.1.
RefSeqiNP_001009601.1. NM_001009601.1.
XP_006244578.1. XM_006244516.2.
XP_006244579.1. XM_006244517.2.
UniGeneiRn.16800.

3D structure databases

ProteinModelPortaliQ5PQM2.
SMRiQ5PQM2. Positions 230-494.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038363.

PTM databases

iPTMnetiQ5PQM2.
PhosphoSiteiQ5PQM2.

Proteomic databases

PaxDbiQ5PQM2.
PRIDEiQ5PQM2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000031625; ENSRNOP00000038363; ENSRNOG00000018168.
ENSRNOT00000087413; ENSRNOP00000071889; ENSRNOG00000018168.
GeneIDi316226.
KEGGirno:316226.
UCSCiRGD:1306555. rat.

Organism-specific databases

CTDi89953.
RGDi1306555. Klc4.

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000006393.
HOGENOMiHOG000261663.
InParanoidiQ5PQM2.
KOiK10407.
OMAiMSKSRHR.
OrthoDBiEOG091G05DM.
PhylomeDBiQ5PQM2.
TreeFamiTF314010.

Miscellaneous databases

PROiQ5PQM2.

Gene expression databases

BgeeiENSRNOG00000018168.
GenevisibleiQ5PQM2. RN.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR002151. Kinesin_light.
IPR015792. Kinesin_light_repeat.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13374. TPR_10. 2 hits.
[Graphical view]
PRINTSiPR00381. KINESINLIGHT.
SMARTiSM00028. TPR. 5 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS01160. KINESIN_LIGHT. 3 hits.
PS50005. TPR. 6 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLC4_RAT
AccessioniPrimary (citable) accession number: Q5PQM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: January 4, 2005
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.