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Protein

Septin-10

Gene

Sept10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).By similarityCurated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei105 – 1051GTP; via amide nitrogenBy similarity
Binding sitei240 – 2401GTP; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei255 – 2551GTPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi50 – 578GTPBy similarity
Nucleotide bindingi186 – 1949GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-10
Gene namesi
Name:Sept10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359307. Sept10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Septin-10PRO_0000173541Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei418 – 4181PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5PQK1.
PRIDEiQ5PQK1.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064265.

Structurei

3D structure databases

ProteinModelPortaliQ5PQK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 306267Septin-type GAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
HOVERGENiHBG065093.
InParanoidiQ5PQK1.
KOiK16940.
OMAiVHQEERM.
OrthoDBiEOG7J9VQK.
PhylomeDBiQ5PQK1.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PQK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASCDEVRQL KKEHTRSLTM CGHVGFESLP DQLVDRSIEQ GFCFNILCVG
60 70 80 90 100
ETGIGKSTLI NTLFNTNFEE LESSHFCPCV RLRAQTYELQ ESNVRLKLTI
110 120 130 140 150
VNTVGFGDQI NKEESYQPIV DYIDNQFEAY LQEELKIKRA LFNYHDSRIH
160 170 180 190 200
VCLYFIAPTG HSLRTLDLLT MKSLDNKVNI IPLIAKADTI SKSELQKFKM
210 220 230 240 250
KLMSELVING VQIYQFPTDD DTTAKINGAM NGHLPFAVVG SMDEIKVGNK
260 270 280 290 300
MVKARQYPWG IVQVENENHC DFVKLREMLI CTNMEDLREQ THMRHYELYR
310 320 330 340 350
RCKLQEMGFI DIGPENKPLS LQETYEAKRH EFCGERQRKE EQMKQMFVQR
360 370 380 390 400
VKEKEAILKE AERELQAKFE HLKRIHQEER MKLEEKRRML EEESVAFAKK
410 420 430 440 450
KATCELFPHQ SFLASGSSIR RDKDRKKTDG ASAFCDCITA QENVRLCISS

QRKEMD
Length:456
Mass (Da):53,039
Last modified:January 4, 2005 - v1
Checksum:iC4EB9C1793BE75E9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 392IE → TS AA sequence (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087157 mRNA. Translation: AAH87157.1.
RefSeqiNP_001014055.1. NM_001014033.1.
UniGeneiRn.27246.

Genome annotation databases

GeneIDi309891.
KEGGirno:309891.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087157 mRNA. Translation: AAH87157.1.
RefSeqiNP_001014055.1. NM_001014033.1.
UniGeneiRn.27246.

3D structure databases

ProteinModelPortaliQ5PQK1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064265.

Proteomic databases

PaxDbiQ5PQK1.
PRIDEiQ5PQK1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi309891.
KEGGirno:309891.

Organism-specific databases

CTDi151011.
RGDi1359307. Sept10.

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
HOVERGENiHBG065093.
InParanoidiQ5PQK1.
KOiK16940.
OMAiVHQEERM.
OrthoDBiEOG7J9VQK.
PhylomeDBiQ5PQK1.

Miscellaneous databases

NextBioi661444.
PROiQ5PQK1.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Lubec G., Chen W.-Q.
    Submitted (SEP-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 37-56, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiSEP10_RAT
AccessioniPrimary (citable) accession number: Q5PQK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: January 4, 2005
Last modified: November 11, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.