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Reviewed, UniProtKB/Swiss-Prot Q5PQJ6 (P5CR3_RAT)

Last modified November 25, 2008. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Pyrroline-5-carboxylate reductase 3
      Short name=P5C reductase 3
      Short name=P5CR 3
    EC=1.5.1.2
Alternative name(s):
    Pyrroline-5-carboxylate reductase-like protein
Gene names
Name: Pycrl
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

L-proline + NAD(P)(+) = 1-pyrroline-5-carboxylate + NAD(P)H.

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.

Subunit structure

Homodecamer; composed of 5 homodimers By similarity.

Sequence similarities

Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274Pyrroline-5-carboxylate reductase 3
PRO_0000324564

Sequences

Sequence LengthMass (Da)Tools
Q5PQJ6-1 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: 0DE4B1076C12B7AE

FASTA27428,878
        10         20         30         40         50         60 
MADEMSEPRR VGFVGAGRMA EAIAQGLIRA GKVEAKQVLA SAPTDKNLCH FRALGCQTTH 

        70         80         90        100        110        120 
SNHEVLQNCP LVIFATKPQV LPAVLAEVAP VVTTEHIIVS VAAGISLSSM EELLPPKTRV 

       130        140        150        160        170        180 
LRVSPNLPCV VQEGAMVMTR GHHAGNEDAK LLQNLLEACG QCIEVPESYV DIHTGLSGSG 

       190        200        210        220        230        240 
VAFVCTFSEA LAEGAIKMGM PSDLAHRIAA QTLLGTAKML QQEGKHPAQL RTDVLTPAGT 

       250        260        270 
TIHGLHALEQ GGFRAAAMSA VEAATCRAKE LSKK 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

BC087166 mRNA. Translation: AAH87166.1.
RefSeqNP_001011993.1.
UniGeneRn.40859

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSRNOG00000008708. Rattus norvegicus. [Contig view]
GeneID300035.
KEGGrno:300035.

Organism-specific databases

RGD1309115. Pycrl.

Phylogenomic databases

HOVERGENQ5PQJ6.

Gene expression databases

ArrayExpressQ5PQJ6.

Family and domain databases

InterProIPR016040. NAD(P)-bd.
IPR004455. NADP_OxRdtase_F420.
IPR000304. P5CR.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR11645. P5CR. 1 hit.
PfamPF03807. F420_oxidored. 1 hit.
[Graphical view]
PIRSFPIRSF000193. Pyrrol-5-carb_rd. 1 hit.
TIGRFAMsTIGR00112. proC. 1 hit.
PROSITEPS00521. P5CR. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio646175.

Entry information

Entry nameP5CR3_RAT
AccessionPrimary (citable) accession number: Q5PQJ6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 4, 2005
Last modified: November 25, 2008
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents