Reviewed, UniProtKB/Swiss-Prot Q5PQJ6 (P5CR3_RAT)

Names and origin

Protein names

Recommended name:
    Pyrroline-5-carboxylate reductase 3
      Short name=P5C reductase 3
      Short name=P5CR 3
    EC=1.5.1.2
Alternative name(s):
    Pyrroline-5-carboxylate reductase-like protein

Gene names

Name:

Pycrl

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subunit structure	Homodecamer; composed of 5 homodimers By similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
PTM	Acetylation
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	Pyrroline-5-carboxylate reductase 3		PRO_0000324564
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5PQJ6-1 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: 0DE4B1076C12B7AE	FASTA	274	28,878
	10 20 30 40 50 60 MADEMSEPRR VGFVGAGRMA EAIAQGLIRA GKVEAKQVLA SAPTDKNLCH FRALGCQTTH 70 80 90 100 110 120 SNHEVLQNCP LVIFATKPQV LPAVLAEVAP VVTTEHIIVS VAAGISLSSM EELLPPKTRV 130 140 150 160 170 180 LRVSPNLPCV VQEGAMVMTR GHHAGNEDAK LLQNLLEACG QCIEVPESYV DIHTGLSGSG 190 200 210 220 230 240 VAFVCTFSEA LAEGAIKMGM PSDLAHRIAA QTLLGTAKML QQEGKHPAQL RTDVLTPAGT 250 260 270 TIHGLHALEQ GGFRAAAMSA VEAATCRAKE LSKK

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC087166 mRNA. Translation: AAH87166.1.
IPI	IPI00366422.
RefSeq	NP_001011993.1.
UniGene	Rn.40859
3D structure databases
SMR	Q5PQJ6. Positions 9-274.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5PQJ6.
Genome annotation databases
Ensembl	ENSRNOT00000056517; ENSRNOP00000053357; ENSRNOG00000008708; Rattus norvegicus. [Genome view]
GeneID	300035.
KEGG	rno:300035.
UCSC	NM_001011993. rat.
Organism-specific databases
CTD	300035.
RGD	1309115. Pycrl.
Phylogenomic databases
eggNOG	roNOG09480.
HOVERGEN	Q5PQJ6.
InParanoid	Q5PQJ6.
PhylomeDB	Q5PQJ6.
Enzyme and pathway databases
BRENDA	1.5.1.2. 248.
Gene expression databases
ArrayExpress	Q5PQJ6.
Genevestigator	Q5PQJ6.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
TIGRFAMs	TIGR00112. proC. 1 hit.
PROSITE	PS00521. P5CR. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	646175.

Entry information

Entry name

P5CR3_RAT

Accession

Primary (citable) accession number: Q5PQJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	January 4, 2005
Last modified:	February 9, 2010
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)