Q5PPN2 (RPP25_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease P protein subunit p25
Short name=RNase P protein subunit p25
EC=3.1.26.5

Gene names

Name:

Rpp25

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP. This subunit binds to RNA By similarity.
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
Subunit structure	Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. Interacts with the P3 domain of RNase MRP complex. RNase MRP consists of a RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21 By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the histone-like Alba family.

Ontologies

Keywords
Biological process	tRNA processing
Cellular component	Nucleus
Ligand	RNA-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	centrosome Inferred from electronic annotation. Source: Compara mitochondrion Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW ribonuclease P activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	Ribonuclease P protein subunit p25		PRO_0000237584
Amino acid modifications
	Modified residue	172	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5PPN2 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: FF0CF2AD99BB5BB0	FASTA	199	20,939
	10 20 30 40 50 60 MENFRKVRSE EAPAGDGDEG GSPSSGPFAD LAPGAVHMRV KEGSKIRNLL AFATASMAQP 70 80 90 100 110 120 ATRAIVFSGC GRATTKTVTC AEILKRRLAG LHQVTRLRYR SVREVWQSLP PGPTPGQTPS 130 140 150 160 170 180 DPAASLSVLK NVPSLAILLS KDALDPRQLG YQPPNLSPGP SSPPTVSTSK RSLGESAAGE 190 GTAKRSQPEP EAENEDRTA

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC087592 mRNA. Translation: AAH87592.1.
IPI	IPI00194381.
RefSeq	NP_001012124.1. NM_001012124.1.
UniGene	Rn.13924.
3D structure databases
ProteinModelPortal	Q5PPN2.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000025408.
PTM databases
PhosphoSite	Q5PPN2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000025410; ENSRNOP00000025408; ENSRNOG00000018812.
GeneID	315705.
KEGG	rno:315705.
UCSC	RGD:1305290. rat.
Organism-specific databases
CTD	54913.
RGD	1305290. Rpp25.
Phylogenomic databases
eggNOG	NOG247262.
GeneTree	ENSGT00390000002564.
HOGENOM	HOG000231665.
HOVERGEN	HBG056729.
InParanoid	Q5PPN2.
KO	K14525.
OMA	AVHMRVK.
OrthoDB	EOG49ZXQR.
Gene expression databases
Genevestigator	Q5PPN2.
GermOnline	ENSRNOG00000018812. Rattus norvegicus.
Family and domain databases
InterPro	IPR002775. DNA/RNA-bd_Alba-like. [Graphical view]
Pfam	PF01918. Alba. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	669696.

Entry information

Entry name

RPP25_RAT

Accession

Primary (citable) accession number: Q5PPN2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	January 4, 2005
Last modified:	April 3, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program