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Q5PPN2

- RPP25_RAT

UniProt

Q5PPN2 - RPP25_RAT

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Protein

Ribonuclease P protein subunit p25

Gene

Rpp25

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP. This subunit binds to RNA By similarity.By similarity

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  1. poly(A) RNA binding Source: Ensembl
  2. ribonuclease P activity Source: UniProtKB-EC

GO - Biological processi

  1. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p25 (EC:3.1.26.5)
Short name:
RNase P protein subunit p25
Gene namesi
Name:Rpp25
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi1305290. Rpp25.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Ribonuclease P protein subunit p25PRO_0000237584Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei172 – 1721PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

PTM databases

PhosphoSiteiQ5PPN2.

Expressioni

Gene expression databases

GenevestigatoriQ5PPN2.

Interactioni

Subunit structurei

Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. Interacts with the P3 domain of RNase MRP complex. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21 By similarity.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025408.

Structurei

3D structure databases

ProteinModelPortaliQ5PPN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone-like Alba family.Curated

Phylogenomic databases

eggNOGiNOG247262.
GeneTreeiENSGT00390000002564.
HOGENOMiHOG000231665.
HOVERGENiHBG056729.
InParanoidiQ5PPN2.
KOiK14525.
OMAiMENFRKV.
OrthoDBiEOG7XM309.
PhylomeDBiQ5PPN2.
TreeFamiTF325688.

Family and domain databases

Gene3Di3.30.110.20. 1 hit.
InterProiIPR002775. DNA/RNA-bd_Alba-like.
[Graphical view]
PfamiPF01918. Alba. 1 hit.
[Graphical view]
SUPFAMiSSF82704. SSF82704. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5PPN2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENFRKVRSE EAPAGDGDEG GSPSSGPFAD LAPGAVHMRV KEGSKIRNLL
60 70 80 90 100
AFATASMAQP ATRAIVFSGC GRATTKTVTC AEILKRRLAG LHQVTRLRYR
110 120 130 140 150
SVREVWQSLP PGPTPGQTPS DPAASLSVLK NVPSLAILLS KDALDPRQLG
160 170 180 190
YQPPNLSPGP SSPPTVSTSK RSLGESAAGE GTAKRSQPEP EAENEDRTA
Length:199
Mass (Da):20,939
Last modified:January 4, 2005 - v1
Checksum:iFF0CF2AD99BB5BB0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC087592 mRNA. Translation: AAH87592.1.
RefSeqiNP_001012124.1. NM_001012124.1.
UniGeneiRn.13924.

Genome annotation databases

EnsembliENSRNOT00000025410; ENSRNOP00000025408; ENSRNOG00000018812.
GeneIDi315705.
KEGGirno:315705.
UCSCiRGD:1305290. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC087592 mRNA. Translation: AAH87592.1 .
RefSeqi NP_001012124.1. NM_001012124.1.
UniGenei Rn.13924.

3D structure databases

ProteinModelPortali Q5PPN2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000025408.

PTM databases

PhosphoSitei Q5PPN2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000025410 ; ENSRNOP00000025408 ; ENSRNOG00000018812 .
GeneIDi 315705.
KEGGi rno:315705.
UCSCi RGD:1305290. rat.

Organism-specific databases

CTDi 54913.
RGDi 1305290. Rpp25.

Phylogenomic databases

eggNOGi NOG247262.
GeneTreei ENSGT00390000002564.
HOGENOMi HOG000231665.
HOVERGENi HBG056729.
InParanoidi Q5PPN2.
KOi K14525.
OMAi MENFRKV.
OrthoDBi EOG7XM309.
PhylomeDBi Q5PPN2.
TreeFami TF325688.

Miscellaneous databases

NextBioi 669696.
PROi Q5PPN2.

Gene expression databases

Genevestigatori Q5PPN2.

Family and domain databases

Gene3Di 3.30.110.20. 1 hit.
InterProi IPR002775. DNA/RNA-bd_Alba-like.
[Graphical view ]
Pfami PF01918. Alba. 1 hit.
[Graphical view ]
SUPFAMi SSF82704. SSF82704. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiRPP25_RAT
AccessioniPrimary (citable) accession number: Q5PPN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 4, 2005
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3