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Protein

Ribonuclease P protein subunit p25

Gene

Rpp25

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP. This subunit binds to RNA (By similarity).By similarity

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p25 (EC:3.1.26.5)
Short name:
RNase P protein subunit p25
Gene namesi
Name:Rpp25
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1305290. Rpp25.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002375841 – 199Ribonuclease P protein subunit p25Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei172PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5PPN2.

PTM databases

iPTMnetiQ5PPN2.
PhosphoSitePlusiQ5PPN2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018812.
GenevisibleiQ5PPN2. RN.

Interactioni

Subunit structurei

Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. Interacts with the P3 domain of RNase MRP complex. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025408.

Structurei

3D structure databases

ProteinModelPortaliQ5PPN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone-like Alba family.Curated

Phylogenomic databases

eggNOGiKOG2567. Eukaryota.
ENOG4111WGZ. LUCA.
GeneTreeiENSGT00390000002564.
HOGENOMiHOG000231665.
HOVERGENiHBG056729.
InParanoidiQ5PPN2.
KOiK14525.
OMAiDALDPCQ.
OrthoDBiEOG091G0OAF.
PhylomeDBiQ5PPN2.
TreeFamiTF325688.

Family and domain databases

Gene3Di3.30.110.20. 1 hit.
InterProiIPR002775. DNA/RNA-bd_Alba-like.
[Graphical view]
PfamiPF01918. Alba. 1 hit.
[Graphical view]
SUPFAMiSSF82704. SSF82704. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5PPN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENFRKVRSE EAPAGDGDEG GSPSSGPFAD LAPGAVHMRV KEGSKIRNLL
60 70 80 90 100
AFATASMAQP ATRAIVFSGC GRATTKTVTC AEILKRRLAG LHQVTRLRYR
110 120 130 140 150
SVREVWQSLP PGPTPGQTPS DPAASLSVLK NVPSLAILLS KDALDPRQLG
160 170 180 190
YQPPNLSPGP SSPPTVSTSK RSLGESAAGE GTAKRSQPEP EAENEDRTA
Length:199
Mass (Da):20,939
Last modified:January 4, 2005 - v1
Checksum:iFF0CF2AD99BB5BB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087592 mRNA. Translation: AAH87592.1.
RefSeqiNP_001012124.1. NM_001012124.1.
UniGeneiRn.13924.

Genome annotation databases

EnsembliENSRNOT00000025410; ENSRNOP00000025408; ENSRNOG00000018812.
GeneIDi315705.
KEGGirno:315705.
UCSCiRGD:1305290. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087592 mRNA. Translation: AAH87592.1.
RefSeqiNP_001012124.1. NM_001012124.1.
UniGeneiRn.13924.

3D structure databases

ProteinModelPortaliQ5PPN2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025408.

PTM databases

iPTMnetiQ5PPN2.
PhosphoSitePlusiQ5PPN2.

Proteomic databases

PaxDbiQ5PPN2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025410; ENSRNOP00000025408; ENSRNOG00000018812.
GeneIDi315705.
KEGGirno:315705.
UCSCiRGD:1305290. rat.

Organism-specific databases

CTDi54913.
RGDi1305290. Rpp25.

Phylogenomic databases

eggNOGiKOG2567. Eukaryota.
ENOG4111WGZ. LUCA.
GeneTreeiENSGT00390000002564.
HOGENOMiHOG000231665.
HOVERGENiHBG056729.
InParanoidiQ5PPN2.
KOiK14525.
OMAiDALDPCQ.
OrthoDBiEOG091G0OAF.
PhylomeDBiQ5PPN2.
TreeFamiTF325688.

Enzyme and pathway databases

ReactomeiR-RNO-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

PROiQ5PPN2.

Gene expression databases

BgeeiENSRNOG00000018812.
GenevisibleiQ5PPN2. RN.

Family and domain databases

Gene3Di3.30.110.20. 1 hit.
InterProiIPR002775. DNA/RNA-bd_Alba-like.
[Graphical view]
PfamiPF01918. Alba. 1 hit.
[Graphical view]
SUPFAMiSSF82704. SSF82704. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRPP25_RAT
AccessioniPrimary (citable) accession number: Q5PPN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 4, 2005
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.