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Q5PPN2

- RPP25_RAT

UniProt

Q5PPN2 - RPP25_RAT

Protein

Ribonuclease P protein subunit p25

Gene

Rpp25

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP. This subunit binds to RNA By similarity.By similarity

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

    GO - Molecular functioni

    1. ribonuclease P activity Source: UniProtKB-EC
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease P protein subunit p25 (EC:3.1.26.5)
    Short name:
    RNase P protein subunit p25
    Gene namesi
    Name:Rpp25
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi1305290. Rpp25.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. mitochondrion Source: Ensembl
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 199199Ribonuclease P protein subunit p25PRO_0000237584Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei172 – 1721PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    PTM databases

    PhosphoSiteiQ5PPN2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5PPN2.

    Interactioni

    Subunit structurei

    Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. Interacts with the P3 domain of RNase MRP complex. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000025408.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5PPN2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histone-like Alba family.Curated

    Phylogenomic databases

    eggNOGiNOG247262.
    GeneTreeiENSGT00390000002564.
    HOGENOMiHOG000231665.
    HOVERGENiHBG056729.
    InParanoidiQ5PPN2.
    KOiK14525.
    OMAiMENFRKV.
    OrthoDBiEOG7XM309.
    PhylomeDBiQ5PPN2.
    TreeFamiTF325688.

    Family and domain databases

    Gene3Di3.30.110.20. 1 hit.
    InterProiIPR002775. DNA/RNA-bd_Alba-like.
    [Graphical view]
    PfamiPF01918. Alba. 1 hit.
    [Graphical view]
    SUPFAMiSSF82704. SSF82704. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5PPN2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENFRKVRSE EAPAGDGDEG GSPSSGPFAD LAPGAVHMRV KEGSKIRNLL    50
    AFATASMAQP ATRAIVFSGC GRATTKTVTC AEILKRRLAG LHQVTRLRYR 100
    SVREVWQSLP PGPTPGQTPS DPAASLSVLK NVPSLAILLS KDALDPRQLG 150
    YQPPNLSPGP SSPPTVSTSK RSLGESAAGE GTAKRSQPEP EAENEDRTA 199
    Length:199
    Mass (Da):20,939
    Last modified:January 4, 2005 - v1
    Checksum:iFF0CF2AD99BB5BB0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC087592 mRNA. Translation: AAH87592.1.
    RefSeqiNP_001012124.1. NM_001012124.1.
    UniGeneiRn.13924.

    Genome annotation databases

    EnsembliENSRNOT00000025410; ENSRNOP00000025408; ENSRNOG00000018812.
    GeneIDi315705.
    KEGGirno:315705.
    UCSCiRGD:1305290. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC087592 mRNA. Translation: AAH87592.1 .
    RefSeqi NP_001012124.1. NM_001012124.1.
    UniGenei Rn.13924.

    3D structure databases

    ProteinModelPortali Q5PPN2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000025408.

    PTM databases

    PhosphoSitei Q5PPN2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000025410 ; ENSRNOP00000025408 ; ENSRNOG00000018812 .
    GeneIDi 315705.
    KEGGi rno:315705.
    UCSCi RGD:1305290. rat.

    Organism-specific databases

    CTDi 54913.
    RGDi 1305290. Rpp25.

    Phylogenomic databases

    eggNOGi NOG247262.
    GeneTreei ENSGT00390000002564.
    HOGENOMi HOG000231665.
    HOVERGENi HBG056729.
    InParanoidi Q5PPN2.
    KOi K14525.
    OMAi MENFRKV.
    OrthoDBi EOG7XM309.
    PhylomeDBi Q5PPN2.
    TreeFami TF325688.

    Miscellaneous databases

    NextBioi 669696.
    PROi Q5PPN2.

    Gene expression databases

    Genevestigatori Q5PPN2.

    Family and domain databases

    Gene3Di 3.30.110.20. 1 hit.
    InterProi IPR002775. DNA/RNA-bd_Alba-like.
    [Graphical view ]
    Pfami PF01918. Alba. 1 hit.
    [Graphical view ]
    SUPFAMi SSF82704. SSF82704. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiRPP25_RAT
    AccessioniPrimary (citable) accession number: Q5PPN2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3