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Protein

Rod outer segment membrane protein 1

Gene

Rom1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Rod outer segment membrane protein 1
Short name:
ROSP1
Gene namesi
Name:Rom1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1306070. Rom1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919CytoplasmicSequence analysisAdd
BLAST
Transmembranei20 – 4425HelicalSequence analysisAdd
BLAST
Topological domaini45 – 6420LumenalSequence analysisAdd
BLAST
Transmembranei65 – 8420HelicalSequence analysisAdd
BLAST
Topological domaini85 – 10218CytoplasmicSequence analysisAdd
BLAST
Transmembranei103 – 12523HelicalSequence analysisAdd
BLAST
Topological domaini126 – 263138LumenalSequence analysisAdd
BLAST
Transmembranei264 – 28623HelicalSequence analysisAdd
BLAST
Topological domaini287 – 35165CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Rod outer segment membrane protein 1PRO_0000168113Add
BLAST

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ5PPM7.
PRIDEiQ5PPM7.

Expressioni

Tissue specificityi

Retina (photoreceptor). In rim region of ROS (rod outer segment) disks.

Gene expression databases

GenevisibleiQ5PPM7. RN.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Probably forms a complex with a PRPH2 homodimer. Other proteins could associate with this complex in rods (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026897.

Family & Domainsi

Sequence similaritiesi

Belongs to the PRPH2/ROM1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00390000016192.
HOGENOMiHOG000026780.
HOVERGENiHBG004964.
InParanoidiQ5PPM7.
KOiK17344.
OMAiCCNPHSP.
OrthoDBiEOG7T1RBG.
PhylomeDBiQ5PPM7.
TreeFamiTF331684.

Family and domain databases

InterProiIPR000830. Peripherin/rom-1.
IPR018498. Peripherin/rom-1_CS.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PRINTSiPR00218. PERIPHERNRDS.
SUPFAMiSSF48652. SSF48652. 2 hits.
PROSITEiPS00930. RDS_ROM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PPM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVLPVVLP LQPRIRLAQG TWLLSWLLAL AGGLTLLCSG HLLVQLWHLG
60 70 80 90 100
TFLAPSCSFP ALPQTALAAG AVALGTGLGG AGASRASLDA AQYPPWRGVL
110 120 130 140 150
TPLLVVGTAA GGGLLTLGLG LALALPVSLH QGLEEGLQAA LAHYKDTEVP
160 170 180 190 200
GHCQAKRLMD ELQLRYHCCG RHGYKDWFGV QWVSSRYLDP NDQDVVDRIQ
210 220 230 240 250
SNVEGLYLID GVPFSCCNPH SPRPCLQSQL SDPYAHPLFD PRQPNLNLWA
260 270 280 290 300
QGCHEVLVGH LQGLSGTLGS ILAVTLLLQV LVLLGLRYLQ TALEGLGGVI
310 320 330 340 350
DGEGETQGYL LPGGLKDILQ TAWLQGGLAH KPAPEEAPPD EEPPKEVLAE

A
Length:351
Mass (Da):37,237
Last modified:January 4, 2005 - v1
Checksum:i5EAA6FB4F0E14C69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY212508 mRNA. Translation: AAO46095.1.
BC087605 mRNA. Translation: AAH87605.1.
RefSeqiNP_001009690.1. NM_001009690.1.
UniGeneiRn.145021.

Genome annotation databases

EnsembliENSRNOT00000026897; ENSRNOP00000026897; ENSRNOG00000019858.
GeneIDi309201.
KEGGirno:309201.
UCSCiRGD:1306070. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY212508 mRNA. Translation: AAO46095.1.
BC087605 mRNA. Translation: AAH87605.1.
RefSeqiNP_001009690.1. NM_001009690.1.
UniGeneiRn.145021.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026897.

Proteomic databases

PaxDbiQ5PPM7.
PRIDEiQ5PPM7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026897; ENSRNOP00000026897; ENSRNOG00000019858.
GeneIDi309201.
KEGGirno:309201.
UCSCiRGD:1306070. rat.

Organism-specific databases

CTDi6094.
RGDi1306070. Rom1.

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00390000016192.
HOGENOMiHOG000026780.
HOVERGENiHBG004964.
InParanoidiQ5PPM7.
KOiK17344.
OMAiCCNPHSP.
OrthoDBiEOG7T1RBG.
PhylomeDBiQ5PPM7.
TreeFamiTF331684.

Miscellaneous databases

NextBioi660421.
PROiQ5PPM7.

Gene expression databases

GenevisibleiQ5PPM7. RN.

Family and domain databases

InterProiIPR000830. Peripherin/rom-1.
IPR018498. Peripherin/rom-1_CS.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PRINTSiPR00218. PERIPHERNRDS.
SUPFAMiSSF48652. SSF48652. 2 hits.
PROSITEiPS00930. RDS_ROM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Defining changes in retinal gene expression after prolonged exposure to light and light induced oxidative stress."
    Kelln R.M., Patterson M.L., Darrow R.M., Barsalou L., Organisciak D.T., Wong P.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Retina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiROM1_RAT
AccessioniPrimary (citable) accession number: Q5PPM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: January 4, 2005
Last modified: November 11, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.