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Protein

Rod outer segment membrane protein 1

Gene

Rom1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Rod outer segment membrane protein 1
Short name:
ROSP1
Gene namesi
Name:Rom1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1306070. Rom1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 44HelicalSequence analysisAdd BLAST25
Topological domaini45 – 64LumenalSequence analysisAdd BLAST20
Transmembranei65 – 84HelicalSequence analysisAdd BLAST20
Topological domaini85 – 102CytoplasmicSequence analysisAdd BLAST18
Transmembranei103 – 125HelicalSequence analysisAdd BLAST23
Topological domaini126 – 263LumenalSequence analysisAdd BLAST138
Transmembranei264 – 286HelicalSequence analysisAdd BLAST23
Topological domaini287 – 351CytoplasmicSequence analysisAdd BLAST65

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001681131 – 351Rod outer segment membrane protein 1Add BLAST351

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ5PPM7.
PRIDEiQ5PPM7.

Expressioni

Tissue specificityi

Retina (photoreceptor). In rim region of ROS (rod outer segment) disks.

Gene expression databases

BgeeiENSRNOG00000019858.
GenevisibleiQ5PPM7. RN.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Probably forms a complex with a PRPH2 homodimer. Other proteins could associate with this complex in rods (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026897.

Family & Domainsi

Sequence similaritiesi

Belongs to the PRPH2/ROM1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00390000016192.
HOGENOMiHOG000026780.
HOVERGENiHBG004964.
InParanoidiQ5PPM7.
KOiK17344.
OMAiCCNPHSP.
OrthoDBiEOG091G0956.
PhylomeDBiQ5PPM7.
TreeFamiTF331684.

Family and domain databases

InterProiIPR000830. Peripherin/rom-1.
IPR018498. Peripherin/rom-1_CS.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PRINTSiPR00218. PERIPHERNRDS.
SUPFAMiSSF48652. SSF48652. 2 hits.
PROSITEiPS00930. RDS_ROM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PPM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVLPVVLP LQPRIRLAQG TWLLSWLLAL AGGLTLLCSG HLLVQLWHLG
60 70 80 90 100
TFLAPSCSFP ALPQTALAAG AVALGTGLGG AGASRASLDA AQYPPWRGVL
110 120 130 140 150
TPLLVVGTAA GGGLLTLGLG LALALPVSLH QGLEEGLQAA LAHYKDTEVP
160 170 180 190 200
GHCQAKRLMD ELQLRYHCCG RHGYKDWFGV QWVSSRYLDP NDQDVVDRIQ
210 220 230 240 250
SNVEGLYLID GVPFSCCNPH SPRPCLQSQL SDPYAHPLFD PRQPNLNLWA
260 270 280 290 300
QGCHEVLVGH LQGLSGTLGS ILAVTLLLQV LVLLGLRYLQ TALEGLGGVI
310 320 330 340 350
DGEGETQGYL LPGGLKDILQ TAWLQGGLAH KPAPEEAPPD EEPPKEVLAE

A
Length:351
Mass (Da):37,237
Last modified:January 4, 2005 - v1
Checksum:i5EAA6FB4F0E14C69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY212508 mRNA. Translation: AAO46095.1.
BC087605 mRNA. Translation: AAH87605.1.
RefSeqiNP_001009690.1. NM_001009690.1.
UniGeneiRn.145021.

Genome annotation databases

EnsembliENSRNOT00000026897; ENSRNOP00000026897; ENSRNOG00000019858.
GeneIDi309201.
KEGGirno:309201.
UCSCiRGD:1306070. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY212508 mRNA. Translation: AAO46095.1.
BC087605 mRNA. Translation: AAH87605.1.
RefSeqiNP_001009690.1. NM_001009690.1.
UniGeneiRn.145021.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026897.

Proteomic databases

PaxDbiQ5PPM7.
PRIDEiQ5PPM7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026897; ENSRNOP00000026897; ENSRNOG00000019858.
GeneIDi309201.
KEGGirno:309201.
UCSCiRGD:1306070. rat.

Organism-specific databases

CTDi6094.
RGDi1306070. Rom1.

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00390000016192.
HOGENOMiHOG000026780.
HOVERGENiHBG004964.
InParanoidiQ5PPM7.
KOiK17344.
OMAiCCNPHSP.
OrthoDBiEOG091G0956.
PhylomeDBiQ5PPM7.
TreeFamiTF331684.

Miscellaneous databases

PROiQ5PPM7.

Gene expression databases

BgeeiENSRNOG00000019858.
GenevisibleiQ5PPM7. RN.

Family and domain databases

InterProiIPR000830. Peripherin/rom-1.
IPR018498. Peripherin/rom-1_CS.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PRINTSiPR00218. PERIPHERNRDS.
SUPFAMiSSF48652. SSF48652. 2 hits.
PROSITEiPS00930. RDS_ROM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiROM1_RAT
AccessioniPrimary (citable) accession number: Q5PPM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: January 4, 2005
Last modified: September 7, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.