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Protein

Endophilin-B2

Gene

Sh3glb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Endophilin-B2
Alternative name(s):
SH3 domain-containing GRB2-like protein B2
Gene namesi
Name:Sh3glb2Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1305886. Sh3glb2.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Endophilin-B2PRO_0000307713Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei404 – 4041PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5PPJ9.
PRIDEiQ5PPJ9.

PTM databases

iPTMnetiQ5PPJ9.
PhosphoSiteiQ5PPJ9.

Interactioni

Subunit structurei

Homodimer, and heterodimer with SH3GLB1.By similarity

Protein-protein interaction databases

IntActiQ5PPJ9. 1 interaction.
STRINGi10116.ENSRNOP00000023527.

Structurei

3D structure databases

ProteinModelPortaliQ5PPJ9.
SMRiQ5PPJ9. Positions 343-404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 291268BARPROSITE-ProRule annotationAdd
BLAST
Domaini344 – 40461SH3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2727Membrane-binding amphipathic helixBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili209 – 23931Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the endophilin family.Sequence analysis
Contains 1 BAR domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiKOG3725. Eukaryota.
ENOG410XPA6. LUCA.
HOGENOMiHOG000232056.
HOVERGENiHBG054448.
InParanoidiQ5PPJ9.
KOiK11248.
PhylomeDBiQ5PPJ9.

Family and domain databases

Gene3Di1.20.1270.60. 2 hits.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PPJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFNMKKLAS DAGIFFTRAV QFTEEKFGQA EKTELDAHFE NLLARADSTK
60 70 80 90 100
NWTERILRQT EVLLQPNPSA RVEEFLYEKL DRKVPSRVTN GELLAQYMAE
110 120 130 140 150
AASELGPNTP YGKTLMKVSE AEKRLGAAER DFIHTASLSF LTPLRNFLEG
160 170 180 190 200
DWKTISKERR LLQNRRLDLD ACKARLKKAK AAEAKATCEG DTVPDFQETR
210 220 230 240 250
PRNYILSASA SALWNDEVDK AEQELRAAQT EFDRQAEVTR LLLEGISSAH
260 270 280 290 300
VNHLRCLHEF VKSQTTYYAQ CYRHMLDLQK QLGSSQGAIF PGTFVGTTEP
310 320 330 340 350
ASPPLSSTSP TTTAATMPVV PTGAGLAPPE EAALCLEEVA PPASGTRKAR
360 370 380 390 400
VLYDYEAADS SELALLADEL ITVYSLPGMD PDWLIGERGN KKGKVPVTYL

ELLS
Length:404
Mass (Da):44,853
Last modified:October 23, 2007 - v2
Checksum:i8E387EE5AEC33CDE
GO

Sequence cautioni

The sequence AAH87652.1 differs from that shown. Reason: Frameshift at position 112. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087652 mRNA. Translation: AAH87652.1. Frameshift.
RefSeqiNP_001009692.1. NM_001009692.1.
XP_006233880.1. XM_006233818.2.
UniGeneiRn.26881.

Genome annotation databases

GeneIDi311848.
KEGGirno:311848.
UCSCiRGD:1305886. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087652 mRNA. Translation: AAH87652.1. Frameshift.
RefSeqiNP_001009692.1. NM_001009692.1.
XP_006233880.1. XM_006233818.2.
UniGeneiRn.26881.

3D structure databases

ProteinModelPortaliQ5PPJ9.
SMRiQ5PPJ9. Positions 343-404.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5PPJ9. 1 interaction.
STRINGi10116.ENSRNOP00000023527.

PTM databases

iPTMnetiQ5PPJ9.
PhosphoSiteiQ5PPJ9.

Proteomic databases

PaxDbiQ5PPJ9.
PRIDEiQ5PPJ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi311848.
KEGGirno:311848.
UCSCiRGD:1305886. rat.

Organism-specific databases

CTDi56904.
RGDi1305886. Sh3glb2.

Phylogenomic databases

eggNOGiKOG3725. Eukaryota.
ENOG410XPA6. LUCA.
HOGENOMiHOG000232056.
HOVERGENiHBG054448.
InParanoidiQ5PPJ9.
KOiK11248.
PhylomeDBiQ5PPJ9.

Miscellaneous databases

PROiQ5PPJ9.

Family and domain databases

Gene3Di1.20.1270.60. 2 hits.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-404, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSHLB2_RAT
AccessioniPrimary (citable) accession number: Q5PPJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: June 8, 2016
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.