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Protein

Endophilin-B2

Gene

Sh3glb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Endophilin-B2
Alternative name(s):
SH3 domain-containing GRB2-like protein B2
Gene namesi
Name:Sh3glb2Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1305886 Sh3glb2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003077131 – 404Endophilin-B2Add BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei10PhosphoserineBy similarity1
Modified residuei404PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5PPJ9
PRIDEiQ5PPJ9

PTM databases

iPTMnetiQ5PPJ9
PhosphoSitePlusiQ5PPJ9
SwissPalmiQ5PPJ9

Interactioni

Subunit structurei

Homodimer, and heterodimer with SH3GLB1.By similarity

Protein-protein interaction databases

IntActiQ5PPJ9, 1 interactor
STRINGi10116.ENSRNOP00000023527

Structurei

3D structure databases

ProteinModelPortaliQ5PPJ9
SMRiQ5PPJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 291BARPROSITE-ProRule annotationAdd BLAST268
Domaini344 – 404SH3PROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 27Membrane-binding amphipathic helixBy similarityAdd BLAST27

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili209 – 239Sequence analysisAdd BLAST31

Sequence similaritiesi

Belongs to the endophilin family.Sequence analysis

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiKOG3725 Eukaryota
ENOG410XPA6 LUCA
HOGENOMiHOG000232056
HOVERGENiHBG054448
InParanoidiQ5PPJ9
KOiK21269
PhylomeDBiQ5PPJ9

Family and domain databases

CDDicd11944 SH3_Endophilin_B2, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR004148 BAR_dom
IPR035640 Endophilin_B2_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR028500 SH3GLB2
PANTHERiPTHR44071:SF2 PTHR44071:SF2, 1 hit
PfamiView protein in Pfam
PF03114 BAR, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00721 BAR, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 2 hits
SSF50044 SSF50044, 2 hits
PROSITEiView protein in PROSITE
PS51021 BAR, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q5PPJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFNMKKLAS DAGIFFTRAV QFTEEKFGQA EKTELDAHFE NLLARADSTK
60 70 80 90 100
NWTERILRQT EVLLQPNPSA RVEEFLYEKL DRKVPSRVTN GELLAQYMAE
110 120 130 140 150
AASELGPNTP YGKTLMKVSE AEKRLGAAER DFIHTASLSF LTPLRNFLEG
160 170 180 190 200
DWKTISKERR LLQNRRLDLD ACKARLKKAK AAEAKATCEG DTVPDFQETR
210 220 230 240 250
PRNYILSASA SALWNDEVDK AEQELRAAQT EFDRQAEVTR LLLEGISSAH
260 270 280 290 300
VNHLRCLHEF VKSQTTYYAQ CYRHMLDLQK QLGSSQGAIF PGTFVGTTEP
310 320 330 340 350
ASPPLSSTSP TTTAATMPVV PTGAGLAPPE EAALCLEEVA PPASGTRKAR
360 370 380 390 400
VLYDYEAADS SELALLADEL ITVYSLPGMD PDWLIGERGN KKGKVPVTYL

ELLS
Length:404
Mass (Da):44,853
Last modified:October 23, 2007 - v2
Checksum:i8E387EE5AEC33CDE
GO

Sequence cautioni

The sequence AAH87652 differs from that shown. Reason: Frameshift at position 112.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087652 mRNA Translation: AAH87652.1 Frameshift.
RefSeqiNP_001009692.1, NM_001009692.1
XP_006233880.1, XM_006233818.3
UniGeneiRn.26881

Genome annotation databases

GeneIDi311848
KEGGirno:311848
UCSCiRGD:1305886 rat

Similar proteinsi

Entry informationi

Entry nameiSHLB2_RAT
AccessioniPrimary (citable) accession number: Q5PPJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: May 23, 2018
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health