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Protein

Probable tubulin polyglutamylase TTLL1

Gene

Ttll1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei194 – 1941ATPBy similarity
Binding sitei196 – 1961ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi181 – 1844ATP bindingBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tubulin polyglutamylase TTLL1 (EC:6.-.-.-)
Alternative name(s):
Tubulin polyglutamylase complex subunit 3
Short name:
PGs3
Tubulin--tyrosine ligase-like protein 1
Gene namesi
Name:Ttll1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1309124. Ttll1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Probable tubulin polyglutamylase TTLL1PRO_0000249318Add
BLAST

Proteomic databases

PaxDbiQ5PPI9.
PRIDEiQ5PPI9.

Expressioni

Gene expression databases

GenevisibleiQ5PPI9. RN.

Interactioni

Subunit structurei

Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1.By similarity

Protein-protein interaction databases

BioGridi263866. 1 interaction.
STRINGi10116.ENSRNOP00000052832.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 367367TTLPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the tubulin polyglutamylase family.Curated
Contains 1 TTL domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2157. Eukaryota.
ENOG410XQDM. LUCA.
GeneTreeiENSGT00760000118951.
HOGENOMiHOG000256695.
HOVERGENiHBG066341.
InParanoidiQ5PPI9.
KOiK16599.
OMAiKMGSRWK.
OrthoDBiEOG7N0C4F.
PhylomeDBiQ5PPI9.

Family and domain databases

InterProiIPR004344. TTL/TTLL_fam.
IPR027750. TTLL1.
[Graphical view]
PANTHERiPTHR12241:SF31. PTHR12241:SF31. 1 hit.
PfamiPF03133. TTL. 1 hit.
[Graphical view]
PROSITEiPS51221. TTL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PPI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRVKWVTD IEKSVLINNF EKRGWVQVTE NEDWNFYWMS VQTIRNVFSV
60 70 80 90 100
ETGYRLSDDQ IVNHFPNHYE LTRKDLMVKN IKRYRKELEK EGSPLAEKDE
110 120 130 140 150
NGKYLYLDFV PVTYMLPADY NLFVEEFRKS PSSTWIMKPC GKAQGKGIFL
160 170 180 190 200
INKLSQIKKW SRDSKTSSFV SQSTKEAYVI SLYINNPLLI GGRKFDLRLY
210 220 230 240 250
VLVSTYRPLR CYMYKLGFCR FCTVKYTPST SELDNMFVHL TNVAIQKHGE
260 270 280 290 300
DYNHIHGGKW TVNNLRLYLE STRGREVTSK LFDEIHWIIV QSLKAVAPVM
310 320 330 340 350
NNDKHCFECY GYDIIIDDKL KPWLIEVNAS PSLTSSTAND RILKYNLIND
360 370 380 390 400
TLNIAVPNGE IPDCKWNKSP PKEVLGNYEI LYDEELAQGD GAERELRSRP
410 420
GQPVGPRTGR SRDSGRNVLT TWK
Length:423
Mass (Da):49,140
Last modified:January 4, 2005 - v1
Checksum:i2CFD33685EAC642F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087669 mRNA. Translation: AAH87669.1.
RefSeqiNP_001012200.1. NM_001012200.1.
XP_006242166.1. XM_006242104.1.
XP_008763986.1. XM_008765764.1.
UniGeneiRn.99535.

Genome annotation databases

EnsembliENSRNOT00000055978; ENSRNOP00000052832; ENSRNOG00000010141.
GeneIDi362969.
KEGGirno:362969.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087669 mRNA. Translation: AAH87669.1.
RefSeqiNP_001012200.1. NM_001012200.1.
XP_006242166.1. XM_006242104.1.
XP_008763986.1. XM_008765764.1.
UniGeneiRn.99535.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi263866. 1 interaction.
STRINGi10116.ENSRNOP00000052832.

Proteomic databases

PaxDbiQ5PPI9.
PRIDEiQ5PPI9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000055978; ENSRNOP00000052832; ENSRNOG00000010141.
GeneIDi362969.
KEGGirno:362969.

Organism-specific databases

CTDi25809.
RGDi1309124. Ttll1.

Phylogenomic databases

eggNOGiKOG2157. Eukaryota.
ENOG410XQDM. LUCA.
GeneTreeiENSGT00760000118951.
HOGENOMiHOG000256695.
HOVERGENiHBG066341.
InParanoidiQ5PPI9.
KOiK16599.
OMAiKMGSRWK.
OrthoDBiEOG7N0C4F.
PhylomeDBiQ5PPI9.

Miscellaneous databases

PROiQ5PPI9.

Gene expression databases

GenevisibleiQ5PPI9. RN.

Family and domain databases

InterProiIPR004344. TTL/TTLL_fam.
IPR027750. TTLL1.
[Graphical view]
PANTHERiPTHR12241:SF31. PTHR12241:SF31. 1 hit.
PfamiPF03133. TTL. 1 hit.
[Graphical view]
PROSITEiPS51221. TTL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiTTLL1_RAT
AccessioniPrimary (citable) accession number: Q5PPI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: January 4, 2005
Last modified: June 8, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.